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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20384

FusionGeneSummary for LTF_CFB

check button Fusion gene summary
Fusion gene informationFusion gene name: LTF_CFB
Fusion gene ID: 20384
HgeneTgene
Gene symbol

LTF

CFB

Gene ID

4057

629

Gene namelactotransferrincomplement factor B
SynonymsGIG12|HEL110|HLF2|LFAHUS4|ARMD14|BF|BFD|CFAB|CFBD|FB|FBI12|GBG|H2-Bf|PBF2
Cytomap

3p21.31

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionlactotransferrinepididymis luminal protein 110growth-inhibiting protein 12kaliocin-1lactoferricinlactoferroxinneutrophil lactoferrintalalactoferrincomplement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor B
Modification date2018052720180520
UniProtAcc

P02788

P00751

Ensembl transtripts involved in fusion geneENST00000231751, ENST00000426532, 
ENST00000417439, ENST00000493056, 
ENST00000556679, ENST00000456570, 
ENST00000477310, ENST00000425368, 
ENST00000497841, ENST00000417261, 
ENST00000427888, ENST00000459734, 
ENST00000455591, ENST00000433503, 
ENST00000474621, ENST00000424727, 
ENST00000436692, ENST00000473139, 
ENST00000399981, ENST00000419920, 
ENST00000465211, ENST00000375455, 
ENST00000489605, ENST00000426239, 
ENST00000419411, ENST00000460958, 
Fusion gene scores* DoF score5 X 1 X 4=2011 X 5 X 7=385
# samples 615
** MAII scorelog2(6/20*10)=1.58496250072116
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/385*10)=-1.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LTF [Title/Abstract] AND CFB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLTF

GO:0001817

regulation of cytokine production

20345905

HgeneLTF

GO:0002227

innate immune response in mucosa

12037568

HgeneLTF

GO:0019731

antibacterial humoral response

1599934|18714013

HgeneLTF

GO:0019732

antifungal humoral response

11083624

HgeneLTF

GO:0031640

killing of cells of other organism

9727055

HgeneLTF

GO:0031665

negative regulation of lipopolysaccharide-mediated signaling pathway

20345905

HgeneLTF

GO:0032680

regulation of tumor necrosis factor production

20345905

HgeneLTF

GO:0033690

positive regulation of osteoblast proliferation

15166119

HgeneLTF

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

20345905

HgeneLTF

GO:0045669

positive regulation of osteoblast differentiation

15166119

HgeneLTF

GO:0051092

positive regulation of NF-kappaB transcription factor activity

20345905

HgeneLTF

GO:0060349

bone morphogenesis

15166119

HgeneLTF

GO:0071902

positive regulation of protein serine/threonine kinase activity

20345905

HgeneLTF

GO:1900229

negative regulation of single-species biofilm formation in or on host organism

12037568

HgeneLTF

GO:1902732

positive regulation of chondrocyte proliferation

15166119

HgeneLTF

GO:2000117

negative regulation of cysteine-type endopeptidase activity

12788072


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-PE-A5DE-01ALTFchr3

46477510

-CFBchr6

31913427

+
TCGARVPRADTCGA-HC-7079-01ALTFchr3

46477510

-CFBchr6

31913427

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000231751ENST00000556679LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000456570LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000477310LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000425368LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000497841LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000417261LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000427888LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000459734LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000455591LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000433503LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000474621LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000424727LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000436692LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000473139LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000399981LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000419920LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000465211LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000375455LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000489605LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000426239LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000419411LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000231751ENST00000460958LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000556679LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000456570LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000477310LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000425368LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000497841LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000417261LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000427888LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000459734LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000455591LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000433503LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000474621LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000424727LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000436692LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000473139LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000399981LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000419920LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000465211LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000375455LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000489605LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000426239LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000419411LTFchr3

46477510

-CFBchr6

31913427

+
5CDS-intronENST00000426532ENST00000460958LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000556679LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000456570LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000477310LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000425368LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000497841LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000417261LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000427888LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000459734LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000455591LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000433503LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000474621LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000424727LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000436692LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000473139LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000399981LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000419920LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000465211LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000375455LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000489605LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000426239LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000419411LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000417439ENST00000460958LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000556679LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000456570LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000477310LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000425368LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000497841LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000417261LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000427888LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000459734LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000455591LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000433503LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000474621LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000424727LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000436692LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000473139LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000399981LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000419920LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000465211LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000375455LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000489605LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000426239LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000419411LTFchr3

46477510

-CFBchr6

31913427

+
intron-intronENST00000493056ENST00000460958LTFchr3

46477510

-CFBchr6

31913427

+

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FusionProtFeatures for LTF_CFB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LTF

P02788

CFB

P00751


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LTF_CFB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LTF_CFB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LTFSGK1, MUC7, LYZ, CD14, CP, CALM1, SIRT7, UBC, MAPK15, CCDC148, POLL, DDX19B, SIRPG, TMEM237, FN3KRP, ICE2, ZNF250, EPPIN, CLU, NTRK1, WWP2, DDX31, SNX27, HBM, FRMD1, CDK15, APCDD1, PRAP1, PIGA, DHX30, CYLDCFBCFP, C3, ALB, FN1, RPA2, LAMC3, LAMTOR5, GDPD1, DDX19B, PTEN, NPC2, NME2, OAF, RSPRY1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LTF_CFB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneLTFP02788DB08439ParecoxibLactotransferrinsmall moleculeapproved
HgeneLTFP02788DB04743NimesulideLactotransferrinsmall moleculeapproved|investigational|withdrawn
TgeneCFBP00751DB01593ZincComplement factor Bsmall moleculeapproved|investigational

Top

RelatedDiseases for LTF_CFB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLTFC0029456Osteoporosis2CTD_human
HgeneLTFC0006849Oral candidiasis1CTD_human
HgeneLTFC0009324Ulcerative Colitis1CTD_human
HgeneLTFC0009375Colonic Neoplasms1CTD_human
HgeneLTFC0011991Diarrhea1CTD_human
HgeneLTFC0014175Endometriosis1CTD_human
HgeneLTFC0017181Gastrointestinal Hemorrhage1CTD_human
HgeneLTFC0020538Hypertensive disease1CTD_human
HgeneLTFC0020649Hypotension1CTD_human
HgeneLTFC0021368Inflammation1CTD_human
HgeneLTFC0022408Arthropathy1CTD_human
HgeneLTFC0023903Liver neoplasms1CTD_human
HgeneLTFC0151526Premature Birth1CTD_human
HgeneLTFC0392622Toxic effect of carbon tetrachloride1CTD_human
HgeneLTFC0520459Necrotizing Enterocolitis1CTD_human
HgeneLTFC0700345Candidiasis, Vulvovaginal1CTD_human
HgeneLTFC1262477Weight decreased1CTD_human
HgeneLTFC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneCFBC2752038HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 42ORPHANET;UNIPROT
TgeneCFBC0024141Lupus Erythematosus, Systemic1CTD_human
TgeneCFBC0026896Myasthenia Gravis1CTD_human
TgeneCFBC0242383Age related macular degeneration1CTD_human
TgeneCFBC2931788Atypical Hemolytic Uremic Syndrome1CTD_human