FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 20377

FusionGeneSummary for LTBP4_POU2F2

check button Fusion gene summary
Fusion gene informationFusion gene name: LTBP4_POU2F2
Fusion gene ID: 20377
HgeneTgene
Gene symbol

LTBP4

POU2F2

Gene ID

8425

5452

Gene namelatent transforming growth factor beta binding protein 4POU class 2 homeobox 2
SynonymsARCL1C|LTBP-4|LTBP4L|LTBP4SOCT2|OTF2|Oct-2
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionlatent-transforming growth factor beta-binding protein 4latent transforming growth factor-beta binding protein 4LPOU domain, class 2, transcription factor 2OTF-2homeobox proteinlymphoid-restricted immunoglobulin octamer-binding protein NF-A2octamer-binding protein 2octamer-binding transcription factor 2
Modification date2018052220180519
UniProtAcc

Q8N2S1

P09086

Ensembl transtripts involved in fusion geneENST00000602240, ENST00000204005, 
ENST00000545697, ENST00000308370, 
ENST00000396819, ENST00000243562, 
ENST00000389341, ENST00000342301, 
ENST00000533720, ENST00000526816, 
ENST00000529067, ENST00000560558, 
ENST00000560398, ENST00000529952, 
ENST00000524801, 
Fusion gene scores* DoF score5 X 7 X 4=1404 X 7 X 4=112
# samples 78
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LTBP4 [Title/Abstract] AND POU2F2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLTBP4

GO:0030162

regulation of proteolysis

9660815


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPCPGTCGA-WB-A81S-01ALTBP4chr19

41106083

+POU2F2chr19

42664544

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000602240ENST00000389341LTBP4chr19

41106083

+POU2F2chr19

42664544

-
3UTR-intronENST00000602240ENST00000342301LTBP4chr19

41106083

+POU2F2chr19

42664544

-
3UTR-intronENST00000602240ENST00000533720LTBP4chr19

41106083

+POU2F2chr19

42664544

-
3UTR-intronENST00000602240ENST00000526816LTBP4chr19

41106083

+POU2F2chr19

42664544

-
3UTR-intronENST00000602240ENST00000529067LTBP4chr19

41106083

+POU2F2chr19

42664544

-
3UTR-intronENST00000602240ENST00000560558LTBP4chr19

41106083

+POU2F2chr19

42664544

-
3UTR-intronENST00000602240ENST00000560398LTBP4chr19

41106083

+POU2F2chr19

42664544

-
3UTR-intronENST00000602240ENST00000529952LTBP4chr19

41106083

+POU2F2chr19

42664544

-
3UTR-5UTRENST00000602240ENST00000524801LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000204005ENST00000389341LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000204005ENST00000342301LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000204005ENST00000533720LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000204005ENST00000526816LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000204005ENST00000529067LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000204005ENST00000560558LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000204005ENST00000560398LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000204005ENST00000529952LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-5UTRENST00000204005ENST00000524801LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5UTR-intronENST00000545697ENST00000389341LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5UTR-intronENST00000545697ENST00000342301LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5UTR-intronENST00000545697ENST00000533720LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5UTR-intronENST00000545697ENST00000526816LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5UTR-intronENST00000545697ENST00000529067LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5UTR-intronENST00000545697ENST00000560558LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5UTR-intronENST00000545697ENST00000560398LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5UTR-intronENST00000545697ENST00000529952LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5UTR-5UTRENST00000545697ENST00000524801LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000308370ENST00000389341LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000308370ENST00000342301LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000308370ENST00000533720LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000308370ENST00000526816LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000308370ENST00000529067LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000308370ENST00000560558LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000308370ENST00000560398LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-intronENST00000308370ENST00000529952LTBP4chr19

41106083

+POU2F2chr19

42664544

-
5CDS-5UTRENST00000308370ENST00000524801LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000396819ENST00000389341LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000396819ENST00000342301LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000396819ENST00000533720LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000396819ENST00000526816LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000396819ENST00000529067LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000396819ENST00000560558LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000396819ENST00000560398LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000396819ENST00000529952LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-5UTRENST00000396819ENST00000524801LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000243562ENST00000389341LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000243562ENST00000342301LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000243562ENST00000533720LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000243562ENST00000526816LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000243562ENST00000529067LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000243562ENST00000560558LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000243562ENST00000560398LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-intronENST00000243562ENST00000529952LTBP4chr19

41106083

+POU2F2chr19

42664544

-
intron-5UTRENST00000243562ENST00000524801LTBP4chr19

41106083

+POU2F2chr19

42664544

-

Top

FusionProtFeatures for LTBP4_POU2F2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LTBP4

Q8N2S1

POU2F2

P09086

May be involved in the assembly, secretion and targetingof TGFB1 to sites at which it is stored and/or activated. May playcritical roles in controlling and directing the activity of TGFB1.May have a structural role in the extracellular matrix (ECM) (Bysimilarity). {ECO:0000250}. Transcription factor that specifically binds to theoctamer motif (5'-ATTTGCAT-3'). Regulates transcription in anumber of tissues in addition to activating immunoglobulin geneexpression. Modulates transcription transactivation by NR3C1, ARand PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA)promoter. {ECO:0000269|PubMed:1739980, ECO:0000269|PubMed:2328728,ECO:0000269|PubMed:2901913, ECO:0000269|PubMed:2904654}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LTBP4_POU2F2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LTBP4_POU2F2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LTBP4TRIB3, ATXN7, CACNA1A, CRKL, ITSN2, ATN1, GFI1B, FRAT1, FBLN1, RAC1, CRY1, FBXO6, ZNF707, ZFP41, NLRP3, ZNF408, DNAJC10, ZNF331, ZNF669, ZNF169, NELL1, ZNF263, E4F1, ZNF517, ZNF324B, ZNF563, ZNF574, ZNF550, C4orf26, VWCE, NELL2POU2F2GAPDH, ESR1, NR3C1, AR, PGR, MNAT1, XRCC6, HMGB2, POU2F2, RXRA, TXNRD1, TBP, HMGA1, TLE4, TEAD2, FOXC2, FOXJ2, FOXS1, TMEM108


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LTBP4_POU2F2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for LTBP4_POU2F2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLTBP4C0017636Glioblastoma1CTD_human
HgeneLTBP4C0027643Neoplasm Recurrence, Local1CTD_human
HgeneLTBP4C2750804Cutis Laxa With Severe Pulmonary, Gastrointestinal, And Urinary Abnormalities1CTD_human;ORPHANET;UNIPROT