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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20374

FusionGeneSummary for LTBP3_TSPAN32

check button Fusion gene summary
Fusion gene informationFusion gene name: LTBP3_TSPAN32
Fusion gene ID: 20374
HgeneTgene
Gene symbol

LTBP3

TSPAN32

Gene ID

4054

10077

Gene namelatent transforming growth factor beta binding protein 3tetraspanin 32
SynonymsDASS|GPHYSD3|LTBP-3|LTBP2|STHAG6|pp6425ART1|PHEMX|PHMX|TSSC6
Cytomap

11q13.1

11p15.5

Type of geneprotein-codingprotein-coding
Descriptionlatent-transforming growth factor beta-binding protein 3latent TGF beta binding protein 3tetraspanin-32pan-hematopoietic expression proteinprotein Phemxtumor-suppressing STF cDNA 6tumor-suppressing subchromosomal transferable fragment cDNA 6tumor-suppressing subtransferable candidate 6
Modification date2018052220180523
UniProtAcc

Q9NS15

Q96QS1

Ensembl transtripts involved in fusion geneENST00000322147, ENST00000301873, 
ENST00000530785, ENST00000529189, 
ENST00000532932, ENST00000536982, 
ENST00000182290, ENST00000483227, 
ENST00000381121, ENST00000451520, 
Fusion gene scores* DoF score6 X 6 X 3=1082 X 2 X 2=8
# samples 62
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: LTBP3 [Title/Abstract] AND TSPAN32 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-92-8065-01ALTBP3chr11

65306430

-TSPAN32chr11

2338629

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000322147ENST00000182290LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000322147ENST00000483227LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000322147ENST00000381121LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000322147ENST00000451520LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-3CDSENST00000301873ENST00000182290LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000301873ENST00000483227LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000301873ENST00000381121LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000301873ENST00000451520LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-3CDSENST00000530785ENST00000182290LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000530785ENST00000483227LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000530785ENST00000381121LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000530785ENST00000451520LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-3CDSENST00000529189ENST00000182290LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000529189ENST00000483227LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000529189ENST00000381121LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000529189ENST00000451520LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-3CDSENST00000532932ENST00000182290LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000532932ENST00000483227LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000532932ENST00000381121LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000532932ENST00000451520LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-3CDSENST00000536982ENST00000182290LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000536982ENST00000483227LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000536982ENST00000381121LTBP3chr11

65306430

-TSPAN32chr11

2338629

+
intron-intronENST00000536982ENST00000451520LTBP3chr11

65306430

-TSPAN32chr11

2338629

+

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FusionProtFeatures for LTBP3_TSPAN32


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LTBP3

Q9NS15

TSPAN32

Q96QS1

May be involved in the assembly, secretion and targetingof TGFB1 to sites at which it is stored and/or activated. May playcritical roles in controlling and directing the activity of TGFB1.May have a structural role in the extracellular matrix (ECM).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LTBP3_TSPAN32


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LTBP3_TSPAN32


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LTBP3CACNA1A, PRPF40A, RAC1, CCNG1, PIK3R2, GORASP2, PELI2, FBXO6, DNAJC10TSPAN32


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LTBP3_TSPAN32


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LTBP3_TSPAN32


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLTBP3C0018273Growth Disorders2CTD_human
HgeneLTBP3C0029408Degenerative polyarthritis2CTD_human
HgeneLTBP3C0029464Osteosclerosis2CTD_human;HPO
HgeneLTBP3C0376634Craniofacial Abnormalities2CTD_human
HgeneLTBP3C0399352Developmental absence of tooth2CTD_human
HgeneLTBP3C0002452Amelogenesis Imperfecta1CTD_human;HPO
HgeneLTBP3C0005940Bone Diseases1CTD_human
HgeneLTBP3C0022821Kyphosis deformity of spine1CTD_human
HgeneLTBP3C0026267Mitral Valve Prolapse Syndrome1CTD_human;HPO
HgeneLTBP3C0432228Brachyolmia1CTD_human