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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20358

FusionGeneSummary for LTBP1_BRE

check button Fusion gene summary
Fusion gene informationFusion gene name: LTBP1_BRE
Fusion gene ID: 20358
HgeneTgene
Gene symbol

LTBP1

BRE

Gene ID

4052

Gene namelatent transforming growth factor beta binding protein 1
Synonyms-
Cytomap

2p22.3

Type of geneprotein-coding
Descriptionlatent-transforming growth factor beta-binding protein 1LTBP-1TGF-beta1-BP-1transforming growth factor beta-1-binding protein 1
Modification date20180522
UniProtAcc

Q14766

Ensembl transtripts involved in fusion geneENST00000404816, ENST00000354476, 
ENST00000390003, ENST00000418533, 
ENST00000402934, ENST00000404525, 
ENST00000407925, ENST00000272273, 
ENST00000498013, 
ENST00000344773, 
ENST00000379624, ENST00000342045, 
ENST00000379632, ENST00000361704, 
ENST00000603461, 
Fusion gene scores* DoF score8 X 7 X 9=50411 X 7 X 7=539
# samples 1512
** MAII scorelog2(15/504*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/539*10)=-2.16725086714399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LTBP1 [Title/Abstract] AND BRE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-1511-01ALTBP1chr2

33174012

+BREchr2

28352138

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000404816ENST00000344773LTBP1chr2

33174012

+BREchr2

28352138

+
Frame-shiftENST00000404816ENST00000379624LTBP1chr2

33174012

+BREchr2

28352138

+
Frame-shiftENST00000404816ENST00000342045LTBP1chr2

33174012

+BREchr2

28352138

+
Frame-shiftENST00000404816ENST00000379632LTBP1chr2

33174012

+BREchr2

28352138

+
Frame-shiftENST00000404816ENST00000361704LTBP1chr2

33174012

+BREchr2

28352138

+
5CDS-intronENST00000404816ENST00000603461LTBP1chr2

33174012

+BREchr2

28352138

+
Frame-shiftENST00000354476ENST00000344773LTBP1chr2

33174012

+BREchr2

28352138

+
Frame-shiftENST00000354476ENST00000379624LTBP1chr2

33174012

+BREchr2

28352138

+
Frame-shiftENST00000354476ENST00000342045LTBP1chr2

33174012

+BREchr2

28352138

+
Frame-shiftENST00000354476ENST00000379632LTBP1chr2

33174012

+BREchr2

28352138

+
Frame-shiftENST00000354476ENST00000361704LTBP1chr2

33174012

+BREchr2

28352138

+
5CDS-intronENST00000354476ENST00000603461LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000390003ENST00000344773LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000390003ENST00000379624LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000390003ENST00000342045LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000390003ENST00000379632LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000390003ENST00000361704LTBP1chr2

33174012

+BREchr2

28352138

+
intron-intronENST00000390003ENST00000603461LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000418533ENST00000344773LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000418533ENST00000379624LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000418533ENST00000342045LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000418533ENST00000379632LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000418533ENST00000361704LTBP1chr2

33174012

+BREchr2

28352138

+
intron-intronENST00000418533ENST00000603461LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000402934ENST00000344773LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000402934ENST00000379624LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000402934ENST00000342045LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000402934ENST00000379632LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000402934ENST00000361704LTBP1chr2

33174012

+BREchr2

28352138

+
intron-intronENST00000402934ENST00000603461LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000404525ENST00000344773LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000404525ENST00000379624LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000404525ENST00000342045LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000404525ENST00000379632LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000404525ENST00000361704LTBP1chr2

33174012

+BREchr2

28352138

+
intron-intronENST00000404525ENST00000603461LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000407925ENST00000344773LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000407925ENST00000379624LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000407925ENST00000342045LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000407925ENST00000379632LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000407925ENST00000361704LTBP1chr2

33174012

+BREchr2

28352138

+
intron-intronENST00000407925ENST00000603461LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000272273ENST00000344773LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000272273ENST00000379624LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000272273ENST00000342045LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000272273ENST00000379632LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000272273ENST00000361704LTBP1chr2

33174012

+BREchr2

28352138

+
intron-intronENST00000272273ENST00000603461LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000498013ENST00000344773LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000498013ENST00000379624LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000498013ENST00000342045LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000498013ENST00000379632LTBP1chr2

33174012

+BREchr2

28352138

+
intron-3CDSENST00000498013ENST00000361704LTBP1chr2

33174012

+BREchr2

28352138

+
intron-intronENST00000498013ENST00000603461LTBP1chr2

33174012

+BREchr2

28352138

+

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FusionProtFeatures for LTBP1_BRE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LTBP1

Q14766

BRE

May be involved in the assembly, secretion and targetingof TGFB1 to sites at which it is stored and/or activated. May playcritical roles in controlling and directing the activity of TGFB1.May have a structural role in the extracellular matrix (ECM). Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LTBP1_BRE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LTBP1_BRE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LTBP1TGFB1, CACNA1A, ATN1, SMURF1, FBXO6, HLA-DPA1, GINM1, ZFP41, IGFBP3, IGFBP5, MED23, ALKBH3, ZNF131, PTPN4, BCHE, KLRG2, ZNF408, KBTBD7, PCDHB11, PCDH20, PCDH12, CSN1S1, EFEMP1, MMP10, VWCE, PCDHGB4, PCDHGA5, PCDHA4, CDH5, DEFA5, MMP3, C4orf26, PCDHA12, LOXL3BREBABAM1, BRCC3, FAM175B, BARD1, BRCA1, BRCA2, RAD51, TP53, UBE2D1, UIMC1, PHB, RPN2, SHMT2, SSR3, USP7, LRPPRC, SLC25A13, ATG2A, TTC28, FKBP8, DHRS7B, TMX3, UGGT2, MMS19, FAM175A, TNFRSF1A, FAS, COPS5, NCOA3, UBC, SUMO2, GFI1B, GRB2, MDC1, PAXIP1, AKAP2, HNRNPA2B1, OPTN, TFG, DEF6, CHI3L1, HIST1H2BG, EGFR, WWP2, FAM189B, TENC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LTBP1_BRE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LTBP1_BRE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLTBP1C0023893Liver Cirrhosis, Experimental1CTD_human