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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2032

FusionGeneSummary for AP1G2_PTMS

check button Fusion gene summary
Fusion gene informationFusion gene name: AP1G2_PTMS
Fusion gene ID: 2032
HgeneTgene
Gene symbol

AP1G2

PTMS

Gene ID

8906

5763

Gene nameadaptor related protein complex 1 subunit gamma 2parathymosin
SynonymsG2ADParaT
Cytomap

14q11.2

12p13.31

Type of geneprotein-codingprotein-coding
DescriptionAP-1 complex subunit gamma-like 2adaptor related protein complex 1 gamma 2 subunitclathrin-associated/assembly/adaptor protein, large, gamma-2gamma2-adaptinparathymosin
Modification date2018051920180519
UniProtAcc

O75843

P20962

Ensembl transtripts involved in fusion geneENST00000308724, ENST00000397120, 
ENST00000556277, 
ENST00000389462, 
ENST00000309083, ENST00000538057, 
Fusion gene scores* DoF score2 X 2 X 1=47 X 6 X 3=126
# samples 27
** MAII scorelog2(2/4*10)=2.32192809488736log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AP1G2 [Title/Abstract] AND PTMS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA570469AP1G2chr14

24032086

-PTMSchr12

6880070

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000308724ENST00000389462AP1G2chr14

24032086

-PTMSchr12

6880070

+
intron-3UTRENST00000308724ENST00000309083AP1G2chr14

24032086

-PTMSchr12

6880070

+
intron-3UTRENST00000308724ENST00000538057AP1G2chr14

24032086

-PTMSchr12

6880070

+
intron-intronENST00000397120ENST00000389462AP1G2chr14

24032086

-PTMSchr12

6880070

+
intron-3UTRENST00000397120ENST00000309083AP1G2chr14

24032086

-PTMSchr12

6880070

+
intron-3UTRENST00000397120ENST00000538057AP1G2chr14

24032086

-PTMSchr12

6880070

+
intron-intronENST00000556277ENST00000389462AP1G2chr14

24032086

-PTMSchr12

6880070

+
intron-3UTRENST00000556277ENST00000309083AP1G2chr14

24032086

-PTMSchr12

6880070

+
intron-3UTRENST00000556277ENST00000538057AP1G2chr14

24032086

-PTMSchr12

6880070

+

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FusionProtFeatures for AP1G2_PTMS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AP1G2

O75843

PTMS

P20962

May function in protein sorting in late endosomes ormultivesucular bodies (MVBs). {ECO:0000269|PubMed:9733768}. (Microbial infection) Involved in MVB-assistedmaturation of hepatitis B virus (HBV).{ECO:0000269|PubMed:16867982, ECO:0000269|PubMed:17553870}. Parathymosin may mediate immune function by blocking theeffect of prothymosin alpha which confers resistance to certainopportunistic infections.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AP1G2_PTMS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AP1G2_PTMS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AP1G2_PTMS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AP1G2_PTMS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource