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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20317

FusionGeneSummary for LSG1_EIF2B5

check button Fusion gene summary
Fusion gene informationFusion gene name: LSG1_EIF2B5
Fusion gene ID: 20317
HgeneTgene
Gene symbol

LSG1

EIF2B5

Gene ID

55341

8893

Gene namelarge 60S subunit nuclear export GTPase 1eukaryotic translation initiation factor 2B subunit epsilon
Synonyms-CACH|CLE|EIF-2B|EIF2Bepsilon|LVWM
Cytomap

3q29

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionlarge subunit GTPase 1 homologhLsg1translation initiation factor eIF-2B subunit epsiloneIF-2B GDP-GTP exchange factor subunit epsiloneukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
Modification date2018052620180523
UniProtAcc

Q9H089

Q13144

Ensembl transtripts involved in fusion geneENST00000265245, ENST00000480853, 
ENST00000444495, ENST00000273783, 
ENST00000432569, ENST00000498831, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: LSG1 [Title/Abstract] AND EIF2B5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLSG1

GO:0051168

nuclear export

16209721

TgeneEIF2B5

GO:0006413

translational initiation

16289705

TgeneEIF2B5

GO:0050852

T cell receptor signaling pathway

8626696


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-63-A5MP-01ALSG1chr3

194371619

-EIF2B5chr3

183862672

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000265245ENST00000444495LSG1chr3

194371619

-EIF2B5chr3

183862672

+
intron-intronENST00000265245ENST00000273783LSG1chr3

194371619

-EIF2B5chr3

183862672

+
intron-intronENST00000265245ENST00000432569LSG1chr3

194371619

-EIF2B5chr3

183862672

+
intron-intronENST00000265245ENST00000498831LSG1chr3

194371619

-EIF2B5chr3

183862672

+
intron-intronENST00000480853ENST00000444495LSG1chr3

194371619

-EIF2B5chr3

183862672

+
intron-intronENST00000480853ENST00000273783LSG1chr3

194371619

-EIF2B5chr3

183862672

+
intron-intronENST00000480853ENST00000432569LSG1chr3

194371619

-EIF2B5chr3

183862672

+
intron-intronENST00000480853ENST00000498831LSG1chr3

194371619

-EIF2B5chr3

183862672

+

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FusionProtFeatures for LSG1_EIF2B5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LSG1

Q9H089

EIF2B5

Q13144

GTPase required for the XPO1/CRM1-mediated nuclearexport of the 60S ribosomal subunit. Probably acts by mediatingthe release of NMD3 from the 60S ribosomal subunit after exportinto the cytoplasm (Probable). {ECO:0000305|PubMed:16209721}. Catalyzes the exchange of eukaryotic initiation factor2-bound GDP for GTP.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LSG1_EIF2B5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LSG1_EIF2B5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LSG1ZNF622, MOV10, NXF1, FGL1, DEGS1, LPPR1, SLC39A1, TTC29, VAPB, NTRK1, TMEM216, RPL10, VAPA, NOP56EIF2B5EIF2B1, EIF2B2, EIF2B3, EIF2B4, CHMP2A, APP, EGFR, VTI1B, EFNB2, STX12, COMTD1, CA14, CD68, GPR183, IGSF8, PNKD, P2RX4, OPN3, SPN, PTGER3, EIF3I, EIF3K, EIF3L, EIF4G3, NTRK1, XPO1, GYPB, TMEM206, SYT1, EPHA1, SIGLECL1, ILVBL, UXS1, FZD10, SMDT1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LSG1_EIF2B5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LSG1_EIF2B5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEIF2B5C1858991Childhood Ataxia with Central Nervous System Hypomyelinization6ORPHANET;UNIPROT
TgeneEIF2B5C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneEIF2B5C1847967OVARIOLEUKODYSTROPHY1CTD_human;ORPHANET