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Fusion gene ID: 20317 |
FusionGeneSummary for LSG1_EIF2B5 |
Fusion gene summary |
Fusion gene information | Fusion gene name: LSG1_EIF2B5 | Fusion gene ID: 20317 | Hgene | Tgene | Gene symbol | LSG1 | EIF2B5 | Gene ID | 55341 | 8893 |
Gene name | large 60S subunit nuclear export GTPase 1 | eukaryotic translation initiation factor 2B subunit epsilon | |
Synonyms | - | CACH|CLE|EIF-2B|EIF2Bepsilon|LVWM | |
Cytomap | 3q29 | 3q27.1 | |
Type of gene | protein-coding | protein-coding | |
Description | large subunit GTPase 1 homologhLsg1 | translation initiation factor eIF-2B subunit epsiloneIF-2B GDP-GTP exchange factor subunit epsiloneukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa | |
Modification date | 20180526 | 20180523 | |
UniProtAcc | Q9H089 | Q13144 | |
Ensembl transtripts involved in fusion gene | ENST00000265245, ENST00000480853, | ENST00000444495, ENST00000273783, ENST00000432569, ENST00000498831, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: LSG1 [Title/Abstract] AND EIF2B5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LSG1 | GO:0051168 | nuclear export | 16209721 |
Tgene | EIF2B5 | GO:0006413 | translational initiation | 16289705 |
Tgene | EIF2B5 | GO:0050852 | T cell receptor signaling pathway | 8626696 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-63-A5MP-01A | LSG1 | chr3 | 194371619 | - | EIF2B5 | chr3 | 183862672 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000265245 | ENST00000444495 | LSG1 | chr3 | 194371619 | - | EIF2B5 | chr3 | 183862672 | + |
intron-intron | ENST00000265245 | ENST00000273783 | LSG1 | chr3 | 194371619 | - | EIF2B5 | chr3 | 183862672 | + |
intron-intron | ENST00000265245 | ENST00000432569 | LSG1 | chr3 | 194371619 | - | EIF2B5 | chr3 | 183862672 | + |
intron-intron | ENST00000265245 | ENST00000498831 | LSG1 | chr3 | 194371619 | - | EIF2B5 | chr3 | 183862672 | + |
intron-intron | ENST00000480853 | ENST00000444495 | LSG1 | chr3 | 194371619 | - | EIF2B5 | chr3 | 183862672 | + |
intron-intron | ENST00000480853 | ENST00000273783 | LSG1 | chr3 | 194371619 | - | EIF2B5 | chr3 | 183862672 | + |
intron-intron | ENST00000480853 | ENST00000432569 | LSG1 | chr3 | 194371619 | - | EIF2B5 | chr3 | 183862672 | + |
intron-intron | ENST00000480853 | ENST00000498831 | LSG1 | chr3 | 194371619 | - | EIF2B5 | chr3 | 183862672 | + |
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FusionProtFeatures for LSG1_EIF2B5 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
LSG1 | EIF2B5 |
GTPase required for the XPO1/CRM1-mediated nuclearexport of the 60S ribosomal subunit. Probably acts by mediatingthe release of NMD3 from the 60S ribosomal subunit after exportinto the cytoplasm (Probable). {ECO:0000305|PubMed:16209721}. | Catalyzes the exchange of eukaryotic initiation factor2-bound GDP for GTP. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LSG1_EIF2B5 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LSG1_EIF2B5 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LSG1 | ZNF622, MOV10, NXF1, FGL1, DEGS1, LPPR1, SLC39A1, TTC29, VAPB, NTRK1, TMEM216, RPL10, VAPA, NOP56 | EIF2B5 | EIF2B1, EIF2B2, EIF2B3, EIF2B4, CHMP2A, APP, EGFR, VTI1B, EFNB2, STX12, COMTD1, CA14, CD68, GPR183, IGSF8, PNKD, P2RX4, OPN3, SPN, PTGER3, EIF3I, EIF3K, EIF3L, EIF4G3, NTRK1, XPO1, GYPB, TMEM206, SYT1, EPHA1, SIGLECL1, ILVBL, UXS1, FZD10, SMDT1, TRIM25 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LSG1_EIF2B5 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LSG1_EIF2B5 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | EIF2B5 | C1858991 | Childhood Ataxia with Central Nervous System Hypomyelinization | 6 | ORPHANET;UNIPROT |
Tgene | EIF2B5 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Tgene | EIF2B5 | C1847967 | OVARIOLEUKODYSTROPHY | 1 | CTD_human;ORPHANET |