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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20301

FusionGeneSummary for LRRTM4_TRAF3IP3

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRTM4_TRAF3IP3
Fusion gene ID: 20301
HgeneTgene
Gene symbol

LRRTM4

TRAF3IP3

Gene ID

80059

80342

Gene nameleucine rich repeat transmembrane neuronal 4TRAF3 interacting protein 3
Synonyms-T3JAM
Cytomap

2p12

1q32.2

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat transmembrane neuronal protein 4TRAF3-interacting JNK-activating modulatorTRAF3 interacting Jun N terminal kinase (JNK) activating modulator
Modification date2018052320180519
UniProtAcc

Q86VH4

Q9Y228

Ensembl transtripts involved in fusion geneENST00000409911, ENST00000409884, 
ENST00000409093, ENST00000409088, 
ENST00000409282, ENST00000491242, 
ENST00000400959, ENST00000367025, 
ENST00000367026, ENST00000367024, 
ENST00000010338, ENST00000367023, 
ENST00000477431, ENST00000467830, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 2=32
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LRRTM4 [Title/Abstract] AND TRAF3IP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI656375LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000409911ENST00000400959LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409911ENST00000367025LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409911ENST00000367026LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409911ENST00000367024LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409911ENST00000010338LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409911ENST00000367023LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409911ENST00000477431LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409911ENST00000467830LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409884ENST00000400959LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409884ENST00000367025LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409884ENST00000367026LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409884ENST00000367024LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409884ENST00000010338LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409884ENST00000367023LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409884ENST00000477431LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409884ENST00000467830LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409093ENST00000400959LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409093ENST00000367025LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409093ENST00000367026LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409093ENST00000367024LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409093ENST00000010338LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409093ENST00000367023LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409093ENST00000477431LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409093ENST00000467830LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409088ENST00000400959LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409088ENST00000367025LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409088ENST00000367026LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409088ENST00000367024LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409088ENST00000010338LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409088ENST00000367023LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409088ENST00000477431LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409088ENST00000467830LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409282ENST00000400959LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409282ENST00000367025LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409282ENST00000367026LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409282ENST00000367024LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409282ENST00000010338LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409282ENST00000367023LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409282ENST00000477431LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000409282ENST00000467830LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000491242ENST00000400959LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000491242ENST00000367025LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000491242ENST00000367026LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000491242ENST00000367024LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000491242ENST00000010338LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000491242ENST00000367023LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000491242ENST00000477431LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-
intron-intronENST00000491242ENST00000467830LRRTM4chr2

76999362

-TRAF3IP3chr1

209952293

-

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FusionProtFeatures for LRRTM4_TRAF3IP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRRTM4

Q86VH4

TRAF3IP3

Q9Y228

May play a role in the development and maintenance ofthe vertebrate nervous system. Exhibits strong synaptogenicactivity, restricted to excitatory presynaptic differentiation (Bysimilarity). {ECO:0000250}. May function as an adapter molecule that regulatesTRAF3-mediated JNK activation. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LRRTM4_TRAF3IP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LRRTM4_TRAF3IP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LRRTM4_TRAF3IP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRRTM4_TRAF3IP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource