FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 20285

FusionGeneSummary for LRRFIP2_BGN

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRFIP2_BGN
Fusion gene ID: 20285
HgeneTgene
Gene symbol

LRRFIP2

BGN

Gene ID

9209

633

Gene nameLRR binding FLII interacting protein 2biglycan
SynonymsHUFI-2DSPG1|MRLS|PG-S1|PGI|SEMDX|SLRR1A
Cytomap

3p22.2

Xq28

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat flightless-interacting protein 2LRR FLII-interacting protein 2leucine rich repeat (in FLII) interacting protein 2biglycanbone/cartilage proteoglycan-Idermatan sulphate proteoglycan Ismall leucine-rich protein 1A
Modification date2018052220180522
UniProtAcc

Q9Y608

P21810

Ensembl transtripts involved in fusion geneENST00000421307, ENST00000354379, 
ENST00000336686, ENST00000421276, 
ENST00000396428, ENST00000440230, 
ENST00000490597, 
ENST00000331595, 
ENST00000480756, 
Fusion gene scores* DoF score5 X 4 X 4=807 X 7 X 2=98
# samples 57
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRRFIP2 [Title/Abstract] AND BGN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1ES309565LRRFIP2chr3

37190498

-BGNchrX

152774210

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000421307ENST00000331595LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000421307ENST00000480756LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000354379ENST00000331595LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000354379ENST00000480756LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000336686ENST00000331595LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000336686ENST00000480756LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000421276ENST00000331595LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000421276ENST00000480756LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000396428ENST00000331595LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000396428ENST00000480756LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000440230ENST00000331595LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000440230ENST00000480756LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000490597ENST00000331595LRRFIP2chr3

37190498

-BGNchrX

152774210

+
intron-3UTRENST00000490597ENST00000480756LRRFIP2chr3

37190498

-BGNchrX

152774210

+

Top

FusionProtFeatures for LRRFIP2_BGN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRRFIP2

Q9Y608

BGN

P21810

May function as activator of the canonical Wnt signalingpathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signalingin response to agonist probably by competing with the negativeFLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333,ECO:0000269|PubMed:19265123}. May be involved in collagen fiber assembly.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LRRFIP2_BGN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LRRFIP2_BGN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LRRFIP2_BGN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for LRRFIP2_BGN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBGNC0003873Rheumatoid Arthritis1CTD_human
TgeneBGNC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneBGNC1848097Spondyloepimetaphyseal Dysplasia, X-Linked1ORPHANET;UNIPROT