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Fusion gene ID: 20284 |
FusionGeneSummary for LRRFIP1_WDR81 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRRFIP1_WDR81 | Fusion gene ID: 20284 | Hgene | Tgene | Gene symbol | LRRFIP1 | WDR81 | Gene ID | 9208 | 124997 |
| Gene name | LRR binding FLII interacting protein 1 | WD repeat domain 81 | |
| Synonyms | FLAP-1|FLAP1|FLIIAP1|GCF-2|GCF2|HUFI-1|TRIP | CAMRQ2|PPP1R166|SORF-2 | |
| Cytomap | 2q37.3 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leucine-rich repeat flightless-interacting protein 1GC-binding factor 2LRR FLII-interacting protein 1NEDD8-conjugating enzymeTAR RNA-interacting proteinleucine rich repeat (in FLII) interacting protein 1 | WD repeat-containing protein 81protein phosphatase 1, regulatory subunit 166 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q32MZ4 | Q562E7 | |
| Ensembl transtripts involved in fusion gene | ENST00000308482, ENST00000468950, ENST00000289175, ENST00000244815, ENST00000392000, | ENST00000437219, ENST00000309182, ENST00000446363, ENST00000419248, ENST00000409644, ENST00000545662, | |
| Fusion gene scores | * DoF score | 8 X 8 X 5=320 | 3 X 3 X 3=27 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LRRFIP1 [Title/Abstract] AND WDR81 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LRRFIP1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 14522076 |
| Tgene | WDR81 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | READ | TCGA-G5-6572-02A | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000308482 | ENST00000437219 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000308482 | ENST00000309182 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000308482 | ENST00000446363 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000308482 | ENST00000419248 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000308482 | ENST00000409644 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000308482 | ENST00000545662 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| intron-3CDS | ENST00000468950 | ENST00000437219 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| intron-3CDS | ENST00000468950 | ENST00000309182 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| intron-3CDS | ENST00000468950 | ENST00000446363 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| intron-3CDS | ENST00000468950 | ENST00000419248 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| intron-3CDS | ENST00000468950 | ENST00000409644 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| intron-3CDS | ENST00000468950 | ENST00000545662 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000289175 | ENST00000437219 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000289175 | ENST00000309182 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000289175 | ENST00000446363 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000289175 | ENST00000419248 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000289175 | ENST00000409644 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000289175 | ENST00000545662 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000244815 | ENST00000437219 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000244815 | ENST00000309182 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000244815 | ENST00000446363 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000244815 | ENST00000419248 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000244815 | ENST00000409644 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000244815 | ENST00000545662 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000392000 | ENST00000437219 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000392000 | ENST00000309182 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000392000 | ENST00000446363 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000392000 | ENST00000419248 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000392000 | ENST00000409644 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
| Frame-shift | ENST00000392000 | ENST00000545662 | LRRFIP1 | chr2 | 238617273 | + | WDR81 | chr17 | 1635619 | + |
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FusionProtFeatures for LRRFIP1_WDR81 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRRFIP1 | WDR81 |
| Transcriptional repressor which preferentially binds tothe GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and mayregulate expression of TNF, EGFR and PDGFA. May control smoothmuscle cells proliferation following artery injury through PDGFArepression. May also bind double-stranded RNA. Positivelyregulates Toll-like receptor (TLR) signaling in response toagonist probably by competing with the negative FLII regulator forMYD88-binding. {ECO:0000269|PubMed:10364563,ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883,ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRRFIP1_WDR81 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRRFIP1_WDR81 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LRRFIP1 | FLII, MYD88, DPY30, FKBP3, DYNC1H1, C14orf166, RTCB, DDX1, DHX9, EPRS, RPLP0, MRE11A, PRKDC, RFC2, LGR4, MED4, CEP44, RNF2, TMOD1, NTRK1, IFI16, SH2D2A, DBN1, IQGAP1, U2AF2, CDH1, TMOD3, TMOD4, TFR2, CCNB1, IFT74, TCEAL2, GAS2L1, MCTS1, BRCA1, SERPINB5 | WDR81 | PPP4C, BLNK, CUL3, MAPK15, ENO1, SHMT2, MOV10, NXF1, NTRK1, TMEM237, XPO1, WFDC2, BECN1, SQSTM1, MAP1LC3C, UBC, WDR91 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRRFIP1_WDR81 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRRFIP1_WDR81 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LRRFIP1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | WDR81 | C2750234 | Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 2 | 1 | UNIPROT |
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