|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 20219 |
FusionGeneSummary for LRRC28_EIF4EBP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRRC28_EIF4EBP1 | Fusion gene ID: 20219 | Hgene | Tgene | Gene symbol | LRRC28 | EIF4EBP1 | Gene ID | 123355 | 1978 |
| Gene name | leucine rich repeat containing 28 | eukaryotic translation initiation factor 4E binding protein 1 | |
| Synonyms | - | 4E-BP1|4EBP1|BP-1|PHAS-I | |
| Cytomap | 15q26.3 | 8p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leucine-rich repeat-containing protein 28 | eukaryotic translation initiation factor 4E-binding protein 1eIF4E-binding protein 1phosphorylated heat- and acid-stable protein regulated by insulin 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q86X40 | Q13541 | |
| Ensembl transtripts involved in fusion gene | ENST00000558879, ENST00000301981, ENST00000422500, ENST00000442993, ENST00000447360, ENST00000331450, ENST00000559399, | ENST00000338825, ENST00000520657, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 9 X 1 X 5=45 |
| # samples | 2 | 9 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(9/45*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LRRC28 [Title/Abstract] AND EIF4EBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | EIF4EBP1 | GO:0031929 | TOR signaling | 12150926|22578813 |
| Tgene | EIF4EBP1 | GO:0045947 | negative regulation of translational initiation | 22578813 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A7-A0D9-01A | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000558879 | ENST00000338825 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| intron-3UTR | ENST00000558879 | ENST00000520657 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| In-frame | ENST00000301981 | ENST00000338825 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| 5CDS-3UTR | ENST00000301981 | ENST00000520657 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| In-frame | ENST00000422500 | ENST00000338825 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| 5CDS-3UTR | ENST00000422500 | ENST00000520657 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| 3UTR-3CDS | ENST00000442993 | ENST00000338825 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| 3UTR-3UTR | ENST00000442993 | ENST00000520657 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| In-frame | ENST00000447360 | ENST00000338825 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| 5CDS-3UTR | ENST00000447360 | ENST00000520657 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| intron-3CDS | ENST00000331450 | ENST00000338825 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| intron-3UTR | ENST00000331450 | ENST00000520657 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| intron-3CDS | ENST00000559399 | ENST00000338825 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
| intron-3UTR | ENST00000559399 | ENST00000520657 | LRRC28 | chr15 | 99901716 | + | EIF4EBP1 | chr8 | 37914599 | + |
Top |
FusionProtFeatures for LRRC28_EIF4EBP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRRC28 | EIF4EBP1 |
| Repressor of translation initiation that regulates EIF4Eactivity by preventing its assembly into the eIF4F complex:hypophosphorylated form competes with EIF4G1/EIF4G3 and stronglybinds to EIF4E, leading to repress translation. In contrast,hyperphosphorylated form dissociates from EIF4E, allowinginteraction between EIF4G1/EIF4G3 and EIF4E, leading to initiationof translation. Mediates the regulation of protein translation byhormones, growth factors and other stimuli that signal through theMAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813,ECO:0000269|PubMed:7935836}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for LRRC28_EIF4EBP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LRRC28_ENST00000301981_chr15_99901716_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_361aa MASELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKL QCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLP SLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLYNKVIGCSGCGAPIQVSEVKLLSFSSGQRTVFLPAEVKAIGTEHDHV LPLQELAMRGLYHTYHSLLKGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI >In-frame_LRRC28_ENST00000422500_chr15_99901716_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_292aa MASELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKL QCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPDLGRSRELQYVYVDNNIHLKGLPSYLYNKVIGCSGCGAPIQVSEVKLLSFSS GQRTVFLPAEVKAIGTEHDHVLPLQELAMRGLYHTYHSLLKGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSH >In-frame_LRRC28_ENST00000447360_chr15_99901716_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_361aa MASELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKL QCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLP SLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLYNKVIGCSGCGAPIQVSEVKLLSFSSGQRTVFLPAEVKAIGTEHDHV LPLQELAMRGLYHTYHSLLKGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LRRC28_ENST00000301981_chr15_99901716_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_1083nt ATGGCGTCCGAACTTTGTAAGACGATCTCTGTGGCAAGGCTAGAAAAGCACAAGAATTTGTTCTTAAATTATAGGAATCTGCACCATTTT CCATTGGAGTTACTGAAAGATGAGGGACTGCAGTACTTGGAGAGACTCTATATGAAAAGGAACTCCCTGACATCCTTGCCAGAAAACCTT GCTCAGAAGCTTCCAAACCTTGTGGAACTATACCTGCACTCAAATAACATAGTTGTGGTTCCGGAAGCCATTGGGTCTCTTGTAAAACTC CAATGTCTGGATCTTAGTGACAATGCCTTAGAAATTGTTTGCCCAGAAATTGGTCGTCTGAGAGCTTTACGTCATCTTCGATTAGCTAAT AACCAACTGCAATTCCTACCTCCAGAGGTTGGCGATTTGAAGGAGCTGCAGACACTAGACATTTCTACCAATCGTTTGCTAACTTTACCC GAGAGGCTTCACATGTGCCTTTCTCTGCAGTACCTCACTGTGGACCGAAATCGTCTATGGTATGTGCCGCGCCATCTCTGCCAGCTGCCC AGCCTCAATGAGCTCTCCATGGCTGGAAACCGTCTTGCATTTTTGCCACTTGATTTAGGTCGATCTCGAGAACTACAGTATGTATACGTG GATAACAACATTCACCTGAAAGGCTTGCCATCTTATCTGTACAATAAAGTCATCGGGTGCAGTGGCTGTGGTGCTCCCATTCAAGTTTCC GAGGTGAAGCTGCTTTCCTTTTCATCAGGGCAGCGAACCGTTTTCCTCCCAGCTGAGGTGAAGGCCATAGGGACGGAGCATGATCACGTC CTCCCTCTGCAGGAATTGGCTATGAGAGGGCTGTATCATACCTACCACAGCTTGCTGAAAGGTACCAGGATCATCTATGACCGGAAATTC CTGATGGAGTGTCGGAACTCACCTGTGACCAAAACACCCCCAAGGGATCTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAGTGATGAG CCCCCCATGGAAGCCAGCCAGAGCCACCTGCGCAATAGCCCAGAAGATAAGCGGGCGGGCGGTGAAGAGTCACAGTTTGAGATGGACATT >In-frame_LRRC28_ENST00000422500_chr15_99901716_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_876nt ATGGCGTCCGAACTTTGTAAGACGATCTCTGTGGCAAGGCTAGAAAAGCACAAGAATTTGTTCTTAAATTATAGGAATCTGCACCATTTT CCATTGGAGTTACTGAAAGATGAGGGACTGCAGTACTTGGAGAGACTCTATATGAAAAGGAACTCCCTGACATCCTTGCCAGAAAACCTT GCTCAGAAGCTTCCAAACCTTGTGGAACTATACCTGCACTCAAATAACATAGTTGTGGTTCCGGAAGCCATTGGGTCTCTTGTAAAACTC CAATGTCTGGATCTTAGTGACAATGCCTTAGAAATTGTTTGCCCAGAAATTGGTCGTCTGAGAGCTTTACGTCATCTTCGATTAGCTAAT AACCAACTGCAATTCCTACCTCCAGATTTAGGTCGATCTCGAGAACTACAGTATGTATACGTGGATAACAACATTCACCTGAAAGGCTTG CCATCTTATCTGTACAATAAAGTCATCGGGTGCAGTGGCTGTGGTGCTCCCATTCAAGTTTCCGAGGTGAAGCTGCTTTCCTTTTCATCA GGGCAGCGAACCGTTTTCCTCCCAGCTGAGGTGAAGGCCATAGGGACGGAGCATGATCACGTCCTCCCTCTGCAGGAATTGGCTATGAGA GGGCTGTATCATACCTACCACAGCTTGCTGAAAGGTACCAGGATCATCTATGACCGGAAATTCCTGATGGAGTGTCGGAACTCACCTGTG ACCAAAACACCCCCAAGGGATCTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAGTGATGAGCCCCCCATGGAAGCCAGCCAGAGCCAC >In-frame_LRRC28_ENST00000447360_chr15_99901716_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_1083nt ATGGCGTCCGAACTTTGTAAGACGATCTCTGTGGCAAGGCTAGAAAAGCACAAGAATTTGTTCTTAAATTATAGGAATCTGCACCATTTT CCATTGGAGTTACTGAAAGATGAGGGACTGCAGTACTTGGAGAGACTCTATATGAAAAGGAACTCCCTGACATCCTTGCCAGAAAACCTT GCTCAGAAGCTTCCAAACCTTGTGGAACTATACCTGCACTCAAATAACATAGTTGTGGTTCCGGAAGCCATTGGGTCTCTTGTAAAACTC CAATGTCTGGATCTTAGTGACAATGCCTTAGAAATTGTTTGCCCAGAAATTGGTCGTCTGAGAGCTTTACGTCATCTTCGATTAGCTAAT AACCAACTGCAATTCCTACCTCCAGAGGTTGGCGATTTGAAGGAGCTGCAGACACTAGACATTTCTACCAATCGTTTGCTAACTTTACCC GAGAGGCTTCACATGTGCCTTTCTCTGCAGTACCTCACTGTGGACCGAAATCGTCTATGGTATGTGCCGCGCCATCTCTGCCAGCTGCCC AGCCTCAATGAGCTCTCCATGGCTGGAAACCGTCTTGCATTTTTGCCACTTGATTTAGGTCGATCTCGAGAACTACAGTATGTATACGTG GATAACAACATTCACCTGAAAGGCTTGCCATCTTATCTGTACAATAAAGTCATCGGGTGCAGTGGCTGTGGTGCTCCCATTCAAGTTTCC GAGGTGAAGCTGCTTTCCTTTTCATCAGGGCAGCGAACCGTTTTCCTCCCAGCTGAGGTGAAGGCCATAGGGACGGAGCATGATCACGTC CTCCCTCTGCAGGAATTGGCTATGAGAGGGCTGTATCATACCTACCACAGCTTGCTGAAAGGTACCAGGATCATCTATGACCGGAAATTC CTGATGGAGTGTCGGAACTCACCTGTGACCAAAACACCCCCAAGGGATCTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAGTGATGAG CCCCCCATGGAAGCCAGCCAGAGCCACCTGCGCAATAGCCCAGAAGATAAGCGGGCGGGCGGTGAAGAGTCACAGTTTGAGATGGACATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LRRC28_ENST00000301981_chr15_99901716_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_1753nt CCCGCTCCCTCTTCCCCAGCTCCCTCTGGCGCGGGTTCCGCTCCACCCCCGGAGCCCCGCCCCCGACGCCCGGCGCTCCGCCCCGCCCTC GCCTGGCTCCCTGCCCCGCCCCGCCCGCCGTCCCCCGCTTGGCTTCCAGCGCCGCTTGCGCTCCGGAGCGCTGGCTCTGCTGGCGCTGAG AAATGGACCAATTTTGACAAGATATAGTGCTGCAGCGTGCCTGATGGGATATATTCAGTCATGGCGTCCGAACTTTGTAAGACGATCTCT GTGGCAAGGCTAGAAAAGCACAAGAATTTGTTCTTAAATTATAGGAATCTGCACCATTTTCCATTGGAGTTACTGAAAGATGAGGGACTG CAGTACTTGGAGAGACTCTATATGAAAAGGAACTCCCTGACATCCTTGCCAGAAAACCTTGCTCAGAAGCTTCCAAACCTTGTGGAACTA TACCTGCACTCAAATAACATAGTTGTGGTTCCGGAAGCCATTGGGTCTCTTGTAAAACTCCAATGTCTGGATCTTAGTGACAATGCCTTA GAAATTGTTTGCCCAGAAATTGGTCGTCTGAGAGCTTTACGTCATCTTCGATTAGCTAATAACCAACTGCAATTCCTACCTCCAGAGGTT GGCGATTTGAAGGAGCTGCAGACACTAGACATTTCTACCAATCGTTTGCTAACTTTACCCGAGAGGCTTCACATGTGCCTTTCTCTGCAG TACCTCACTGTGGACCGAAATCGTCTATGGTATGTGCCGCGCCATCTCTGCCAGCTGCCCAGCCTCAATGAGCTCTCCATGGCTGGAAAC CGTCTTGCATTTTTGCCACTTGATTTAGGTCGATCTCGAGAACTACAGTATGTATACGTGGATAACAACATTCACCTGAAAGGCTTGCCA TCTTATCTGTACAATAAAGTCATCGGGTGCAGTGGCTGTGGTGCTCCCATTCAAGTTTCCGAGGTGAAGCTGCTTTCCTTTTCATCAGGG CAGCGAACCGTTTTCCTCCCAGCTGAGGTGAAGGCCATAGGGACGGAGCATGATCACGTCCTCCCTCTGCAGGAATTGGCTATGAGAGGG CTGTATCATACCTACCACAGCTTGCTGAAAGGTACCAGGATCATCTATGACCGGAAATTCCTGATGGAGTGTCGGAACTCACCTGTGACC AAAACACCCCCAAGGGATCTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAGTGATGAGCCCCCCATGGAAGCCAGCCAGAGCCACCTG CGCAATAGCCCAGAAGATAAGCGGGCGGGCGGTGAAGAGTCACAGTTTGAGATGGACATTTAAAGCACCAGCCATCGTGTGGAGCACTAC CAAGGGGCCCCTCAGGGCCTTCCTGGGAGGAGTCCCACCAGCCAGGCCTTATGAAAGTGATCATACTGGGCAGGCGTTGGCGTGGGGTCG GACACCCCAGCCCTTTCTCCCTCACTCAGGGCACCTGCCCCCTCCTCTTCGTGAACACCAGCAGATACCTCCTTGTGCCTCCACTGATGC AGGAGCTGCCACCCCAAGGGGAGTGACCCCTGCCAGCACACCCTGCAGCCAAGGGCCAGGAAGTGGACAAGAACGAACCCTTCCTTCCGA ATGATCAGCAGTTCCAGCCCCTCGCTGCTGGGGGCGCAACCACCCCTTCCTTAGGTTGATGTGCTTGGGAAAGCTCCCTCCCCCTCCTTC >In-frame_LRRC28_ENST00000422500_chr15_99901716_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_1420nt GCTTGGCTTCCAGCGCCGCTTGCGCTCCGGAGCGCTGGCTCTGCTGGCGCTGAGAAATGGACCAATTTTGACAAGATATAGTGCTGCAGC GTGCCTGATGGGATATATTCAGTCATGGCGTCCGAACTTTGTAAGACGATCTCTGTGGCAAGGCTAGAAAAGCACAAGAATTTGTTCTTA AATTATAGGAATCTGCACCATTTTCCATTGGAGTTACTGAAAGATGAGGGACTGCAGTACTTGGAGAGACTCTATATGAAAAGGAACTCC CTGACATCCTTGCCAGAAAACCTTGCTCAGAAGCTTCCAAACCTTGTGGAACTATACCTGCACTCAAATAACATAGTTGTGGTTCCGGAA GCCATTGGGTCTCTTGTAAAACTCCAATGTCTGGATCTTAGTGACAATGCCTTAGAAATTGTTTGCCCAGAAATTGGTCGTCTGAGAGCT TTACGTCATCTTCGATTAGCTAATAACCAACTGCAATTCCTACCTCCAGATTTAGGTCGATCTCGAGAACTACAGTATGTATACGTGGAT AACAACATTCACCTGAAAGGCTTGCCATCTTATCTGTACAATAAAGTCATCGGGTGCAGTGGCTGTGGTGCTCCCATTCAAGTTTCCGAG GTGAAGCTGCTTTCCTTTTCATCAGGGCAGCGAACCGTTTTCCTCCCAGCTGAGGTGAAGGCCATAGGGACGGAGCATGATCACGTCCTC CCTCTGCAGGAATTGGCTATGAGAGGGCTGTATCATACCTACCACAGCTTGCTGAAAGGTACCAGGATCATCTATGACCGGAAATTCCTG ATGGAGTGTCGGAACTCACCTGTGACCAAAACACCCCCAAGGGATCTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAGTGATGAGCCC CCCATGGAAGCCAGCCAGAGCCACCTGCGCAATAGCCCAGAAGATAAGCGGGCGGGCGGTGAAGAGTCACAGTTTGAGATGGACATTTAA AGCACCAGCCATCGTGTGGAGCACTACCAAGGGGCCCCTCAGGGCCTTCCTGGGAGGAGTCCCACCAGCCAGGCCTTATGAAAGTGATCA TACTGGGCAGGCGTTGGCGTGGGGTCGGACACCCCAGCCCTTTCTCCCTCACTCAGGGCACCTGCCCCCTCCTCTTCGTGAACACCAGCA GATACCTCCTTGTGCCTCCACTGATGCAGGAGCTGCCACCCCAAGGGGAGTGACCCCTGCCAGCACACCCTGCAGCCAAGGGCCAGGAAG TGGACAAGAACGAACCCTTCCTTCCGAATGATCAGCAGTTCCAGCCCCTCGCTGCTGGGGGCGCAACCACCCCTTCCTTAGGTTGATGTG >In-frame_LRRC28_ENST00000447360_chr15_99901716_+_EIF4EBP1_ENST00000338825_chr8_37914599_+_1610nt GCTTGCGCTCCGGAGCGCTGGCTCTGCTGGCGCTGAGAAATGGACCAATTTTGACAAGATATAGTGCTGCAGCGTGCCTGATGGGATATA TTCAGTCATGGCGTCCGAACTTTGTAAGACGATCTCTGTGGCAAGGCTAGAAAAGCACAAGAATTTGTTCTTAAATTATAGGAATCTGCA CCATTTTCCATTGGAGTTACTGAAAGATGAGGGACTGCAGTACTTGGAGAGACTCTATATGAAAAGGAACTCCCTGACATCCTTGCCAGA AAACCTTGCTCAGAAGCTTCCAAACCTTGTGGAACTATACCTGCACTCAAATAACATAGTTGTGGTTCCGGAAGCCATTGGGTCTCTTGT AAAACTCCAATGTCTGGATCTTAGTGACAATGCCTTAGAAATTGTTTGCCCAGAAATTGGTCGTCTGAGAGCTTTACGTCATCTTCGATT AGCTAATAACCAACTGCAATTCCTACCTCCAGAGGTTGGCGATTTGAAGGAGCTGCAGACACTAGACATTTCTACCAATCGTTTGCTAAC TTTACCCGAGAGGCTTCACATGTGCCTTTCTCTGCAGTACCTCACTGTGGACCGAAATCGTCTATGGTATGTGCCGCGCCATCTCTGCCA GCTGCCCAGCCTCAATGAGCTCTCCATGGCTGGAAACCGTCTTGCATTTTTGCCACTTGATTTAGGTCGATCTCGAGAACTACAGTATGT ATACGTGGATAACAACATTCACCTGAAAGGCTTGCCATCTTATCTGTACAATAAAGTCATCGGGTGCAGTGGCTGTGGTGCTCCCATTCA AGTTTCCGAGGTGAAGCTGCTTTCCTTTTCATCAGGGCAGCGAACCGTTTTCCTCCCAGCTGAGGTGAAGGCCATAGGGACGGAGCATGA TCACGTCCTCCCTCTGCAGGAATTGGCTATGAGAGGGCTGTATCATACCTACCACAGCTTGCTGAAAGGTACCAGGATCATCTATGACCG GAAATTCCTGATGGAGTGTCGGAACTCACCTGTGACCAAAACACCCCCAAGGGATCTGCCCACCATTCCGGGGGTCACCAGCCCTTCCAG TGATGAGCCCCCCATGGAAGCCAGCCAGAGCCACCTGCGCAATAGCCCAGAAGATAAGCGGGCGGGCGGTGAAGAGTCACAGTTTGAGAT GGACATTTAAAGCACCAGCCATCGTGTGGAGCACTACCAAGGGGCCCCTCAGGGCCTTCCTGGGAGGAGTCCCACCAGCCAGGCCTTATG AAAGTGATCATACTGGGCAGGCGTTGGCGTGGGGTCGGACACCCCAGCCCTTTCTCCCTCACTCAGGGCACCTGCCCCCTCCTCTTCGTG AACACCAGCAGATACCTCCTTGTGCCTCCACTGATGCAGGAGCTGCCACCCCAAGGGGAGTGACCCCTGCCAGCACACCCTGCAGCCAAG GGCCAGGAAGTGGACAAGAACGAACCCTTCCTTCCGAATGATCAGCAGTTCCAGCCCCTCGCTGCTGGGGGCGCAACCACCCCTTCCTTA |
Top |
FusionGenePPI for LRRC28_EIF4EBP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LRRC28 | HSPD1, HSP90AB4P, HSPA1B, HSPA8, HSPA6, HSPA1L, CCT7, CUL5, NFATC1 | EIF4EBP1 | CHTF8, EIF4E, UBAC1, ATM, MTOR, LRPAP1, PPP2R2A, RPTOR, GSK3B, IRAK4, PRKCA, KLHL25, MAPK1, AGO2, LRRK2, MAPK14, STK3, PPP2R4, PRKDC, LATS1, SLMAP, MLST8, REL, TCF4, AKT2, AKT3, CCDC94, CHMP2A, DDX1, FLNB, GGA1, HNRNPA1, SHMT2, HNRNPAB, AKT1, BUB1, MAPKAPK5, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for LRRC28_EIF4EBP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for LRRC28_EIF4EBP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LRRC28 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | EIF4EBP1 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | EIF4EBP1 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Tgene | EIF4EBP1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | EIF4EBP1 | C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|