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Fusion gene ID: 20206 |
FusionGeneSummary for LRRC1_DAAM2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRRC1_DAAM2 | Fusion gene ID: 20206 | Hgene | Tgene | Gene symbol | LRRC1 | DAAM2 | Gene ID | 55227 | 23500 |
| Gene name | leucine rich repeat containing 1 | dishevelled associated activator of morphogenesis 2 | |
| Synonyms | LANO|dJ523E19.1 | dJ90A20A.1 | |
| Cytomap | 6p12.1 | 6p21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leucine-rich repeat-containing protein 1LANO adapter proteinLAP (leucine-rich repeats and PDZ) and no PDZ proteinLAP and no PDZ protein | disheveled-associated activator of morphogenesis 2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9BTT6 | Q86T65 | |
| Ensembl transtripts involved in fusion gene | ENST00000370888, ENST00000370882, | ENST00000274867, ENST00000398904, ENST00000538976, ENST00000405961, ENST00000494405, | |
| Fusion gene scores | * DoF score | 7 X 3 X 6=126 | 2 X 2 X 2=8 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/126*10)=-0.333423733725192 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: LRRC1 [Title/Abstract] AND DAAM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AR-A24Z-01A | LRRC1 | chr6 | 53707025 | + | DAAM2 | chr6 | 39824023 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000370888 | ENST00000274867 | LRRC1 | chr6 | 53707025 | + | DAAM2 | chr6 | 39824023 | + |
| 5CDS-5UTR | ENST00000370888 | ENST00000398904 | LRRC1 | chr6 | 53707025 | + | DAAM2 | chr6 | 39824023 | + |
| 5CDS-5UTR | ENST00000370888 | ENST00000538976 | LRRC1 | chr6 | 53707025 | + | DAAM2 | chr6 | 39824023 | + |
| 5CDS-5UTR | ENST00000370888 | ENST00000405961 | LRRC1 | chr6 | 53707025 | + | DAAM2 | chr6 | 39824023 | + |
| 5CDS-5UTR | ENST00000370888 | ENST00000494405 | LRRC1 | chr6 | 53707025 | + | DAAM2 | chr6 | 39824023 | + |
| 5CDS-5UTR | ENST00000370882 | ENST00000274867 | LRRC1 | chr6 | 53707025 | + | DAAM2 | chr6 | 39824023 | + |
| 5CDS-5UTR | ENST00000370882 | ENST00000398904 | LRRC1 | chr6 | 53707025 | + | DAAM2 | chr6 | 39824023 | + |
| 5CDS-5UTR | ENST00000370882 | ENST00000538976 | LRRC1 | chr6 | 53707025 | + | DAAM2 | chr6 | 39824023 | + |
| 5CDS-5UTR | ENST00000370882 | ENST00000405961 | LRRC1 | chr6 | 53707025 | + | DAAM2 | chr6 | 39824023 | + |
| 5CDS-5UTR | ENST00000370882 | ENST00000494405 | LRRC1 | chr6 | 53707025 | + | DAAM2 | chr6 | 39824023 | + |
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FusionProtFeatures for LRRC1_DAAM2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRRC1 | DAAM2 |
| Key regulator of the Wnt signaling pathway, which isrequired for various processes during development, such as dorsalpatterning, determination of left/right symmetry or myelination inthe central nervous system. Acts downstream of Wnt ligands andupstream of beta-catenin (CTNNB1). Required for canonical Wntsignaling pathway during patterning in the dorsal spinal cord bypromoting the aggregation of Disheveled (Dvl) complexes, therebyclustering and formation of Wnt receptor signalosomes andpotentiating Wnt activity. During dorsal patterning of the spinalcord, inhibits oligodendrocytes differentiation via interactionwith PIP5K1A. Also regulates non-canonical Wnt signaling pathway.Acts downstream of PITX2 in the developing gut and is required forleft/right asymmetry within dorsal mesentery: affects mesenchymalcondensation by lengthening cadherin-based junctions through WNT5Aand non-canonical Wnt signaling, inducing polarized condensationin the left dorsal mesentery necessary to initiate gut rotation.Together with DAAM1, required for myocardial maturation andsarcomere assembly. {ECO:0000250|UniProtKB:Q80U19}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRRC1_DAAM2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LRRC1_DAAM2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LRRC1 | CRMP1, KIAA1377, ERBB2IP, DLG4, DLG1, SLX4, ELAVL1, APP, MAPRE2, CLK3, CNPY3, PPP1CC, PPP1CA, MAPK14, RBM23, GAR1, NLRP5, CDC5L, PPP1CB, IL1R2, KCNJ6, ZNF550, STX11 | DAAM2 | MDFI, RBMY1A1, REL, KRT40, RBMY1F, KRTAP10-7, KRTAP10-1, KRTAP10-8, KRTAP10-3, RHOC, SCGB2A1, ACVR2A, CD320, PRAME, LGR4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRRC1_DAAM2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRRC1_DAAM2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DAAM2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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