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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20198

FusionGeneSummary for LRRC15_DYSF

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRC15_DYSF
Fusion gene ID: 20198
HgeneTgene
Gene symbol

LRRC15

DYSF

Gene ID

131578

8291

Gene nameleucine rich repeat containing 15dysferlin
SynonymsLIBFER1L1|LGMD2B|MMD1
Cytomap

3q29

2p13.2

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat-containing protein 15hLibleucine-rich repeat protein induced by beta amyloidleucine-rich repeat protein induced by beta-amyloid homologdysferlindystrophy-associated fer-1-like 1fer-1-like family member 1fer-1-like protein 1limb girdle muscular dystrophy 2B (autosomal recessive)
Modification date2018052320180519
UniProtAcc

Q8TF66

O75923

Ensembl transtripts involved in fusion geneENST00000439944, ENST00000347624, 
ENST00000428839, 
ENST00000429174, 
ENST00000409762, ENST00000413539, 
ENST00000409582, ENST00000258104, 
ENST00000410020, ENST00000409744, 
ENST00000409651, ENST00000410041, 
ENST00000409366, ENST00000394120, 
ENST00000479049, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 4 X 3=48
# samples 35
** MAII scorelog2(3/4*10)=2.90689059560852log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LRRC15 [Title/Abstract] AND DYSF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI053549LRRC15chr3

194086206

+DYSFchr2

71764093

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000439944ENST00000429174LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000439944ENST00000409762LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000439944ENST00000413539LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000439944ENST00000409582LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000439944ENST00000258104LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000439944ENST00000410020LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000439944ENST00000409744LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000439944ENST00000409651LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000439944ENST00000410041LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000439944ENST00000409366LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000439944ENST00000394120LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000439944ENST00000479049LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000347624ENST00000429174LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000347624ENST00000409762LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000347624ENST00000413539LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000347624ENST00000409582LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000347624ENST00000258104LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000347624ENST00000410020LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000347624ENST00000409744LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000347624ENST00000409651LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000347624ENST00000410041LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000347624ENST00000409366LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000347624ENST00000394120LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000347624ENST00000479049LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000428839ENST00000429174LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000428839ENST00000409762LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000428839ENST00000413539LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000428839ENST00000409582LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000428839ENST00000258104LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000428839ENST00000410020LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000428839ENST00000409744LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000428839ENST00000409651LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000428839ENST00000410041LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000428839ENST00000409366LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000428839ENST00000394120LRRC15chr3

194086206

+DYSFchr2

71764093

-
intron-intronENST00000428839ENST00000479049LRRC15chr3

194086206

+DYSFchr2

71764093

-

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FusionProtFeatures for LRRC15_DYSF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRRC15

Q8TF66

DYSF

O75923


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LRRC15_DYSF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LRRC15_DYSF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LRRC15_DYSF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRRC15_DYSF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDYSFC1850808Miyoshi myopathy19CTD_human;ORPHANET;UNIPROT
TgeneDYSFC1850889MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2B8CTD_human;ORPHANET;UNIPROT
TgeneDYSFC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneDYSFC3495559Juvenile arthritis1CTD_human