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Fusion gene ID: 2018 |
FusionGeneSummary for AP1B1_CLCN3 |
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Fusion gene information | Fusion gene name: AP1B1_CLCN3 | Fusion gene ID: 2018 | Hgene | Tgene | Gene symbol | AP1B1 | CLCN3 | Gene ID | 162 | 1182 |
Gene name | adaptor related protein complex 1 subunit beta 1 | chloride voltage-gated channel 3 | |
Synonyms | ADTB1|AP105A|BAM22|CLAPB2 | CLC3|ClC-3 | |
Cytomap | 22q12.2 | 4q33 | |
Type of gene | protein-coding | protein-coding | |
Description | AP-1 complex subunit beta-1ADTB1, CLAPB2Golgi adaptor HA1/AP1 adaptin beta subunitadapter-related protein complex 1 subunit beta-1adaptor protein complex AP-1 subunit beta-1adaptor related protein complex 1 beta 1 subunitbeta-1-adaptinbeta-adaptin | H(+)/Cl(-) exchange transporter 3chloride channel 3chloride channel protein 3chloride channel, voltage-sensitive 3chloride transporter ClC-3 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q10567 | P51790 | |
Ensembl transtripts involved in fusion gene | ENST00000356015, ENST00000432560, ENST00000357586, ENST00000405198, ENST00000317368, ENST00000402502, ENST00000415447, ENST00000472057, | ENST00000513761, ENST00000347613, ENST00000360642, ENST00000504131, ENST00000506924, | |
Fusion gene scores | * DoF score | 7 X 7 X 5=245 | 36 X 4 X 19=2736 |
# samples | 7 | 39 | |
** MAII score | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(39/2736*10)=-2.81052220113629 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AP1B1 [Title/Abstract] AND CLCN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CLCN3 | GO:1902476 | chloride transmembrane transport | 11274166 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-BT-A3PH-01A | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000356015 | ENST00000513761 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000356015 | ENST00000347613 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000356015 | ENST00000360642 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000356015 | ENST00000504131 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000356015 | ENST00000506924 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000432560 | ENST00000513761 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000432560 | ENST00000347613 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000432560 | ENST00000360642 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000432560 | ENST00000504131 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000432560 | ENST00000506924 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000357586 | ENST00000513761 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000357586 | ENST00000347613 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000357586 | ENST00000360642 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000357586 | ENST00000504131 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000357586 | ENST00000506924 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000405198 | ENST00000513761 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000405198 | ENST00000347613 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000405198 | ENST00000360642 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000405198 | ENST00000504131 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000405198 | ENST00000506924 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000317368 | ENST00000513761 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000317368 | ENST00000347613 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000317368 | ENST00000360642 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000317368 | ENST00000504131 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000317368 | ENST00000506924 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000402502 | ENST00000513761 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000402502 | ENST00000347613 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000402502 | ENST00000360642 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000402502 | ENST00000504131 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000402502 | ENST00000506924 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000415447 | ENST00000513761 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000415447 | ENST00000347613 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000415447 | ENST00000360642 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000415447 | ENST00000504131 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000415447 | ENST00000506924 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000472057 | ENST00000513761 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000472057 | ENST00000347613 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000472057 | ENST00000360642 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000472057 | ENST00000504131 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
intron-intron | ENST00000472057 | ENST00000506924 | AP1B1 | chr22 | 29723671 | - | CLCN3 | chr4 | 170623929 | + |
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FusionProtFeatures for AP1B1_CLCN3 |
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Hgene | Tgene |
AP1B1 | CLCN3 |
Subunit of clathrin-associated adaptor protein complex 1that plays a role in protein sorting in the late-Golgi/trans-Golginetwork (TGN) and/or endosomes. The AP complexes mediate both therecruitment of clathrin to membranes and the recognition ofsorting signals within the cytosolic tails of transmembrane cargomolecules. | Mediates the exchange of chloride ions against protons.Functions as antiporter and contributes to the acidification ofthe endosome and synaptic vesicle lumen, and may thereby affectvesicle trafficking and exocytosis. May play an important role inneuronal cell function through regulation of membrane excitabilityby protein kinase C. It could help neuronal cells to establishshort-term memory. {ECO:0000269|PubMed:11967229}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AP1B1_CLCN3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AP1B1_CLCN3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AP1B1 | AP1G1, PRKDC, ATM, ATR, ARF1, CLINT1, AMPH, CLTC, CABIN1, KIF13A, AP2M1, AP1M1, SNCA, SIRT7, CUL3, CDK2, COPS5, SHBG, EPN1, EPS15, SNAP91, AP1S2, AP1S1, BARD1, VCP, NTRK2, PPP6R3, ABCE1, DIABLO, INTS9, TBC1D2, TRIP10, TRMT61A, RPA3, RPA2, RPA1, EGFR, CCDC183, NECAP2, LRFN4, PNKD, AP1M2, CCNL2, AP2A1, AP2A2, CBS, ARHGAP1, FLNB, PRKAB1, TTC37, UBA1, NTRK1, ARRB2, TMEM17, XPO1, GTSE1, SNW1, CDC5L, AP2S1, ARFGAP1, RUNDC3A, GPR156, SNX9, PPP6R2, LSR, GPBP1L1, FBXO4, FCHO1, STAMBPL1, HIP1R, SIGLECL1, SHC1, MTUS2, MTNR1B, DLD, TRIM25, SLC2A8 | CLCN3 | CLCN3, SLC9A3R1, PDZK1, GOPC, CFTR, LGALS3, LGALS8, LGALS9, LYPD3, HSPB1, TMEM9B, GGA1, TPCN2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AP1B1_CLCN3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AP1B1_CLCN3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CLCN3 | C0017638 | Glioma | 1 | CTD_human |
Tgene | CLCN3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | CLCN3 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |