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Fusion gene ID: 20156 |
FusionGeneSummary for LRP5_CLPB |
Fusion gene summary |
Fusion gene information | Fusion gene name: LRP5_CLPB | Fusion gene ID: 20156 | Hgene | Tgene | Gene symbol | LRP5 | CLPB | Gene ID | 4041 | 81570 |
Gene name | LDL receptor related protein 5 | ClpB homolog, mitochondrial AAA ATPase chaperonin | |
Synonyms | BMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2 | ANKCLB|HSP78|MEGCANN|MGCA7|SKD3 | |
Cytomap | 11q13.2 | 11q13.4 | |
Type of gene | protein-coding | protein-coding | |
Description | low-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7 | caseinolytic peptidase B protein homologClpB caseinolytic peptidase B homologankyrin-repeat containing bacterial clp fusionsuppressor of potassium transport defect 3testicular secretory protein Li 11 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O75197 | Q9H078 | |
Ensembl transtripts involved in fusion gene | ENST00000294304, ENST00000529481, | ENST00000294053, ENST00000538039, ENST00000437826, ENST00000340729, ENST00000543042, ENST00000445069, ENST00000538021, ENST00000542555, | |
Fusion gene scores | * DoF score | 21 X 16 X 9=3024 | 8 X 7 X 7=392 |
# samples | 22 | 8 | |
** MAII score | log2(22/3024*10)=-3.78088271069641 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/392*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LRP5 [Title/Abstract] AND CLPB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LRP5 | GO:0008284 | positive regulation of cell proliferation | 9790987 |
Hgene | LRP5 | GO:0016055 | Wnt signaling pathway | 17955262 |
Hgene | LRP5 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification | 11029007 |
Hgene | LRP5 | GO:0045840 | positive regulation of mitotic nuclear division | 9790987 |
Hgene | LRP5 | GO:0045893 | positive regulation of transcription, DNA-templated | 15035989|17955262 |
Hgene | LRP5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12857724 |
Hgene | LRP5 | GO:0060070 | canonical Wnt signaling pathway | 12121999|12857724|15035989 |
Tgene | CLPB | GO:0034605 | cellular response to heat | 2745427 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-CV-7418-01A | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000294304 | ENST00000294053 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
In-frame | ENST00000294304 | ENST00000538039 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
In-frame | ENST00000294304 | ENST00000437826 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
In-frame | ENST00000294304 | ENST00000340729 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
In-frame | ENST00000294304 | ENST00000543042 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
In-frame | ENST00000294304 | ENST00000445069 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
5CDS-intron | ENST00000294304 | ENST00000538021 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
5CDS-intron | ENST00000294304 | ENST00000542555 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
intron-3CDS | ENST00000529481 | ENST00000294053 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
intron-3CDS | ENST00000529481 | ENST00000538039 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
intron-3CDS | ENST00000529481 | ENST00000437826 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
intron-3CDS | ENST00000529481 | ENST00000340729 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
intron-3CDS | ENST00000529481 | ENST00000543042 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
intron-3CDS | ENST00000529481 | ENST00000445069 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
intron-intron | ENST00000529481 | ENST00000538021 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
intron-intron | ENST00000529481 | ENST00000542555 | LRP5 | chr11 | 68080273 | + | CLPB | chr11 | 72070052 | - |
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FusionProtFeatures for LRP5_CLPB |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
LRP5 | CLPB |
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggersbeta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surfacecoreceptor of Wnt/beta-catenin signaling, which plays a pivotalrole in bone formation. Plays a role in norrin (NDP) signaltransduction (PubMed:27228167). The Wnt-induced Fzd/LRP6coreceptor complex recruits DVL1 polymers to the plasma membranewhich, in turn, recruits the AXIN1/GSK3B-complex to the cellsurface promoting the formation of signalsomes and inhibitingAXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascularregression in the eye (By similarity). Required for posteriorpatterning of the epiblast during gastrulation (By similarity).{ECO:0000250|UniProtKB:Q91VN0, ECO:0000269|PubMed:11336703,ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154,ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503,ECO:0000269|PubMed:27228167}. | May function as a regulatory ATPase and be related tosecretion/protein trafficking process. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >CLPB | chr11:68080273 | chr11:72070052 | ENST00000294053 | - | 4 | 17 | 381_388 | 245 | 708 | Nucleotide binding | ATP |
Tgene | >CLPB | chr11:68080273 | chr11:72070052 | ENST00000340729 | - | 2 | 15 | 381_388 | 186 | 649 | Nucleotide binding | ATP |
Tgene | >CLPB | chr11:68080273 | chr11:72070052 | ENST00000437826 | - | 5 | 18 | 381_388 | 200 | 663 | Nucleotide binding | ATP |
Tgene | >CLPB | chr11:68080273 | chr11:72070052 | ENST00000538039 | - | 3 | 16 | 381_388 | 215 | 678 | Nucleotide binding | ATP |
Tgene | >CLPB | chr11:68080273 | chr11:72070052 | ENST00000294053 | - | 4 | 17 | 265_295 | 245 | 708 | Repeat | Note=ANK 3 |
Tgene | >CLPB | chr11:68080273 | chr11:72070052 | ENST00000294053 | - | 4 | 17 | 298_327 | 245 | 708 | Repeat | Note=ANK 4 |
Tgene | >CLPB | chr11:68080273 | chr11:72070052 | ENST00000340729 | - | 2 | 15 | 265_295 | 186 | 649 | Repeat | Note=ANK 3 |
Tgene | >CLPB | chr11:68080273 | chr11:72070052 | ENST00000340729 | - | 2 | 15 | 298_327 | 186 | 649 | Repeat | Note=ANK 4 |
Tgene | >CLPB | chr11:68080273 | chr11:72070052 | ENST00000437826 | - | 5 | 18 | 265_295 | 200 | 663 | Repeat | Note=ANK 3 |
Tgene | >CLPB | chr11:68080273 | chr11:72070052 | ENST00000437826 | - | 5 | 18 | 298_327 | 200 | 663 | Repeat | Note=ANK 4 |
Tgene | >CLPB | chr11:68080273 | chr11:72070052 | ENST00000538039 | - | 3 | 16 | 265_295 | 215 | 678 | Repeat | Note=ANK 3 |
Tgene | >CLPB | chr11:68080273 | chr11:72070052 | ENST00000538039 | - | 3 | 16 | 298_327 | 215 | 678 | Repeat | Note=ANK 4 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1495_1610 | 30 | 1616 | Compositional bias | Note=Pro-rich |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1213_1254 | 30 | 1616 | Domain | Note=EGF-like 4 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1258_1296 | 30 | 1616 | Domain | LDL-receptor class A 1 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1297_1333 | 30 | 1616 | Domain | LDL-receptor class A 2 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1335_1371 | 30 | 1616 | Domain | LDL-receptor class A 3 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 295_337 | 30 | 1616 | Domain | Note=EGF-like 1 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 601_641 | 30 | 1616 | Domain | Note=EGF-like 2 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 902_942 | 30 | 1616 | Domain | Note=EGF-like 3 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1500_1506 | 30 | 1616 | Motif | Note=PPPSP motif A |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1538_1545 | 30 | 1616 | Motif | Note=PPPSP motif B |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1574_1581 | 30 | 1616 | Motif | Note=PPPSP motif C |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1591_1596 | 30 | 1616 | Motif | Note=PPPSP motif D |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1605_1612 | 30 | 1616 | Motif | Note=PPPSP motif E |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 32_288 | 30 | 1616 | Region | Note=Beta-propeller 1 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 341_602 | 30 | 1616 | Region | Note=Beta-propeller 2 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 644_903 | 30 | 1616 | Region | Note=Beta-propeller 3 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 945_1212 | 30 | 1616 | Region | Note=Beta-propeller 4 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1036_1078 | 30 | 1616 | Repeat | Note=LDL-receptor class B 17 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1079_1123 | 30 | 1616 | Repeat | Note=LDL-receptor class B 18 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1124_1164 | 30 | 1616 | Repeat | Note=LDL-receptor class B 19 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1165_1207 | 30 | 1616 | Repeat | Note=LDL-receptor class B 20 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 120_162 | 30 | 1616 | Repeat | Note=LDL-receptor class B 2 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 123_126 | 30 | 1616 | Repeat | Note=YWTD 2 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 163_206 | 30 | 1616 | Repeat | Note=LDL-receptor class B 3 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 166_169 | 30 | 1616 | Repeat | Note=YWTD 3 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 207_247 | 30 | 1616 | Repeat | Note=LDL-receptor class B 4 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 248_290 | 30 | 1616 | Repeat | Note=LDL-receptor class B 5 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 251_254 | 30 | 1616 | Repeat | Note=YWTD 4 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 385_427 | 30 | 1616 | Repeat | Note=LDL-receptor class B 6 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 388_391 | 30 | 1616 | Repeat | Note=YWTD 5 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 428_470 | 30 | 1616 | Repeat | Note=LDL-receptor class B 7 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 431_434 | 30 | 1616 | Repeat | Note=YWTD 6 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 471_514 | 30 | 1616 | Repeat | Note=LDL-receptor class B 8 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 474_477 | 30 | 1616 | Repeat | Note=YWTD 7 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 515_557 | 30 | 1616 | Repeat | Note=LDL-receptor class B 9 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 558_600 | 30 | 1616 | Repeat | Note=LDL-receptor class B 10 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 559_562 | 30 | 1616 | Repeat | Note=YWTD 8 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 687_729 | 30 | 1616 | Repeat | Note=LDL-receptor class B 11 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 690_693 | 30 | 1616 | Repeat | Note=YWTD 9 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 730_772 | 30 | 1616 | Repeat | Note=LDL-receptor class B 12 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 75_119 | 30 | 1616 | Repeat | Note=LDL-receptor class B 1 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 773_815 | 30 | 1616 | Repeat | Note=LDL-receptor class B 13 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 78_81 | 30 | 1616 | Repeat | Note=YWTD 1 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 816_855 | 30 | 1616 | Repeat | Note=LDL-receptor class B 14 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 819_822 | 30 | 1616 | Repeat | Note=YWTD 10 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 856_898 | 30 | 1616 | Repeat | Note=LDL-receptor class B 15 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 859_862 | 30 | 1616 | Repeat | Note=YWTD 11 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 989_1035 | 30 | 1616 | Repeat | Note=LDL-receptor class B 16 |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1408_1615 | 30 | 1616 | Topological domain | Cytoplasmic |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 32_1384 | 30 | 1616 | Topological domain | Extracellular |
Hgene | >LRP5 | chr11:68080273 | chr11:72070052 | ENST00000294304 | + | 1 | 23 | 1385_1407 | 30 | 1616 | Transmembrane | Helical |
Tgene | CLPB | chr11:68080273 | chr11:72070052 | ENST00000294053 | - | 4 | 17 | 133_162 | 245 | 708 | Repeat | Note=ANK 1 |
Tgene | CLPB | chr11:68080273 | chr11:72070052 | ENST00000294053 | - | 4 | 17 | 166_195 | 245 | 708 | Repeat | Note=ANK 2 |
Tgene | CLPB | chr11:68080273 | chr11:72070052 | ENST00000340729 | - | 2 | 15 | 133_162 | 186 | 649 | Repeat | Note=ANK 1 |
Tgene | CLPB | chr11:68080273 | chr11:72070052 | ENST00000340729 | - | 2 | 15 | 166_195 | 186 | 649 | Repeat | Note=ANK 2 |
Tgene | CLPB | chr11:68080273 | chr11:72070052 | ENST00000437826 | - | 5 | 18 | 133_162 | 200 | 663 | Repeat | Note=ANK 1 |
Tgene | CLPB | chr11:68080273 | chr11:72070052 | ENST00000437826 | - | 5 | 18 | 166_195 | 200 | 663 | Repeat | Note=ANK 2 |
Tgene | CLPB | chr11:68080273 | chr11:72070052 | ENST00000538039 | - | 3 | 16 | 133_162 | 215 | 678 | Repeat | Note=ANK 1 |
Tgene | CLPB | chr11:68080273 | chr11:72070052 | ENST00000538039 | - | 3 | 16 | 166_195 | 215 | 678 | Repeat | Note=ANK 2 |
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FusionGeneSequence for LRP5_CLPB |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000294053_chr11_72070052_-_493aa MEAAPPGPPWPLLLLLLLLLALCGCPAPAAVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY AREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTA KYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTID CKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSE LIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPE >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000538039_chr11_72070052_-_493aa MEAAPPGPPWPLLLLLLLLLALCGCPAPAAVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY AREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTA KYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTID CKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSE LIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPE >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000437826_chr11_72070052_-_493aa MEAAPPGPPWPLLLLLLLLLALCGCPAPAAVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY AREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTA KYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTID CKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSE LIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPE >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000340729_chr11_72070052_-_493aa MEAAPPGPPWPLLLLLLLLLALCGCPAPAAVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY AREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTA KYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTID CKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSE LIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPE >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000543042_chr11_72070052_-_493aa MEAAPPGPPWPLLLLLLLLLALCGCPAPAAVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY AREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTA KYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTID CKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSE LIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPE >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000445069_chr11_72070052_-_103aa MEAAPPGPPWPLLLLLLLLLALCGCPAPAAVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGSSRELSPHSPRHPSYT |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000294053_chr11_72070052_-_1479nt ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG GTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTTGCACTATGCTGTTCTT GCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACACACACCCTTGGATTAT GCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAGCGGCGC CGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGGAGGAAGGAG AATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAGACAGCC AAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTTATTGGG TCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTCTTTGATGAA GTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAGACCATTGAT TGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCTTTGGAG ATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAGAATGTGATT CGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGCCACTCGGAG CTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGCGAGGTG GCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAGCTGGCA GCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAAAGCCCAGAA CTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGACATCCGG >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000538039_chr11_72070052_-_1479nt ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG GTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTTGCACTATGCTGTTCTT GCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACACACACCCTTGGATTAT GCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAGCGGCGC CGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGGAGGAAGGAG AATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAGACAGCC AAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTTATTGGG TCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTCTTTGATGAA GTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAGACCATTGAT TGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCTTTGGAG ATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAGAATGTGATT CGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGCCACTCGGAG CTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGCGAGGTG GCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAGCTGGCA GCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAAAGCCCAGAA CTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGACATCCGG >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000437826_chr11_72070052_-_1479nt ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG GTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTTGCACTATGCTGTTCTT GCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACACACACCCTTGGATTAT GCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAGCGGCGC CGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGGAGGAAGGAG AATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAGACAGCC AAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTTATTGGG TCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTCTTTGATGAA GTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAGACCATTGAT TGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCTTTGGAG ATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAGAATGTGATT CGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGCCACTCGGAG CTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGCGAGGTG GCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAGCTGGCA GCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAAAGCCCAGAA CTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGACATCCGG >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000340729_chr11_72070052_-_1479nt ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG GTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTTGCACTATGCTGTTCTT GCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACACACACCCTTGGATTAT GCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAGCGGCGC CGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGGAGGAAGGAG AATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAGACAGCC AAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTTATTGGG TCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTCTTTGATGAA GTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAGACCATTGAT TGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCTTTGGAG ATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAGAATGTGATT CGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGCCACTCGGAG CTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGCGAGGTG GCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAGCTGGCA GCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAAAGCCCAGAA CTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGACATCCGG >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000543042_chr11_72070052_-_1479nt ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG GTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTTGCACTATGCTGTTCTT GCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACACACACCCTTGGATTAT GCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAGCGGCGC CGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGCGATCCGGAGGAAGGAG AATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAGACAGCC AAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTTATTGGG TCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTGGTGCTCTTTGATGAA GTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAAAGGGAAGACCATTGAT TGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCTTTGGAG ATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAGAATGTGATT CGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCCCTTCTGCCACTCGGAG CTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGCGAGGTG GCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAGCTGGCA GCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCTACTCAAAAGCCCAGAA CTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGACATCCGG >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000445069_chr11_72070052_-_309nt ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCG GTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTTGCACTATGCTGTTCTT GCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGTTCCTCCAGAGAATTGAGCCCTCATTCTCCAAGGCATCCATCGTACACA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000294053_chr11_72070052_-_2527nt GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG CCCGGCCCCCGCCGCGGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTT GCACTATGCTGTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACA CACACCCTTGGATTATGCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGA GGCTGAGGAGCGGCGCCGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGC GATCCGGAGGAAGGAGAATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCT GGCCAAGCAGACAGCCAAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGT GGCCAAGTTTATTGGGTCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGT GGTGCTCTTTGATGAAGTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAA AGGGAAGACCATTGATTGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAG GCAGGAAGCTTTGGAGATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTT CAAGGAGAATGTGATTCGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCC CTTCTGCCACTCGGAGCTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCT CTGGGACCGCGAGGTGGCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGT GGTGAACCAGCTGGCAGCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCT ACTCAAAAGCCCAGAACTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCG CAGACTGGACATCCGGGCACCACTGCACCCTGAGAAGGTGTGCAACACCATCTAGCAGCCACCTGCCTGCTCCTATGTGCCCTCACCATC CAATAAAGGCCCCTTGGCTGTGGCATGGCAACTGACTTACCTTCCCCTCATGCCGCTCCCATCTCTACCCAGTCTCAGGCCTGCTTACCT CCTCACAGCCCATGAAGACCCCTTCTCAGCCCCAAAACCTGAAGGAGGAATTTCGCCCTACTCTGGCCCCTTTGTTGTGGGCCCATAACC TGCTAACAAGCCTTCAGGAGAGGAGCTGCCTTTCCACCCCCTTCAAGGCAAGGAGGGATGGAGGTCCCTTATTTCCTTCAGAATGATCCC CATCCCCCATAGTCGCCAGACTTTCTCATGTTCCCAGGAAGCTCAGAAGTATGGCAGCTAAGAACACAGCTGGCTGGAAGAAGACAGGGA CCAGACTGAACTGCCACCCTCTGCTAGTCCTCATGCAACTCAGTCCCCAGAATGGCTCCACTGGGAGTGGAGGAAGAGCTCAGAGGCCCA GGTGCAGATAGTTCTGCAATTTAGTCTGTAGCCTCCTCGTTCCCTACCCTAAAATTCTAAGGGGAAGGGACCCATAGAGGCTTGCCTGTT TCCGCTACTATATTATGCCCAGTGTTCCTCCTCACCCCACGTCCTGGGGTCAGGCCAGACCATGTTTCGTCAGCCTTGGGGACTAGGCCA GTGTTGGGCACCTCCAGGAGGAGGCCTGACTGGTTCATTACCCTCCCCTACTCAGACTGAGCAGCAGTCCCAGATAACCAAGCAAGCTCA GCTCTGTGGGGGCCTCCTTCAAAAGACCAACATCGCAGACATTAGGAAGCTGTAGGAAGAGAGATCATGGGTTTGACCTCTGCCCACATG GCCATGGAGTCAGCCTCAGCCCTGTCTGTACTGCTCGTCCAGCTAAACGAGCCTGGAATAAACATGCAGTTTATTCAGTCTGCATGTTAG >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000538039_chr11_72070052_-_2506nt GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG CCCGGCCCCCGCCGCGGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTT GCACTATGCTGTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACA CACACCCTTGGATTATGCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGA GGCTGAGGAGCGGCGCCGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGC GATCCGGAGGAAGGAGAATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCT GGCCAAGCAGACAGCCAAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGT GGCCAAGTTTATTGGGTCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGT GGTGCTCTTTGATGAAGTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAA AGGGAAGACCATTGATTGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAG GCAGGAAGCTTTGGAGATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTT CAAGGAGAATGTGATTCGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCC CTTCTGCCACTCGGAGCTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCT CTGGGACCGCGAGGTGGCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGT GGTGAACCAGCTGGCAGCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCT ACTCAAAAGCCCAGAACTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCG CAGACTGGACATCCGGGCACCACTGCACCCTGAGAAGGTGTGCAACACCATCTAGCAGCCACCTGCCTGCTCCTATGTGCCCTCACCATC CAATAAAGGCCCCTTGGCTGTGGCATGGCAACTGACTTACCTTCCCCTCATGCCGCTCCCATCTCTACCCAGTCTCAGGCCTGCTTACCT CCTCACAGCCCATGAAGACCCCTTCTCAGCCCCAAAACCTGAAGGAGGAATTTCGCCCTACTCTGGCCCCTTTGTTGTGGGCCCATAACC TGCTAACAAGCCTTCAGGAGAGGAGCTGCCTTTCCACCCCCTTCAAGGCAAGGAGGGATGGAGGTCCCTTATTTCCTTCAGAATGATCCC CATCCCCCATAGTCGCCAGACTTTCTCATGTTCCCAGGAAGCTCAGAAGTATGGCAGCTAAGAACACAGCTGGCTGGAAGAAGACAGGGA CCAGACTGAACTGCCACCCTCTGCTAGTCCTCATGCAACTCAGTCCCCAGAATGGCTCCACTGGGAGTGGAGGAAGAGCTCAGAGGCCCA GGTGCAGATAGTTCTGCAATTTAGTCTGTAGCCTCCTCGTTCCCTACCCTAAAATTCTAAGGGGAAGGGACCCATAGAGGCTTGCCTGTT TCCGCTACTATATTATGCCCAGTGTTCCTCCTCACCCCACGTCCTGGGGTCAGGCCAGACCATGTTTCGTCAGCCTTGGGGACTAGGCCA GTGTTGGGCACCTCCAGGAGGAGGCCTGACTGGTTCATTACCCTCCCCTACTCAGACTGAGCAGCAGTCCCAGATAACCAAGCAAGCTCA GCTCTGTGGGGGCCTCCTTCAAAAGACCAACATCGCAGACATTAGGAAGCTGTAGGAAGAGAGATCATGGGTTTGACCTCTGCCCACATG >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000437826_chr11_72070052_-_1649nt GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG CCCGGCCCCCGCCGCGGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTT GCACTATGCTGTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACA CACACCCTTGGATTATGCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGA GGCTGAGGAGCGGCGCCGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGC GATCCGGAGGAAGGAGAATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCT GGCCAAGCAGACAGCCAAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGT GGCCAAGTTTATTGGGTCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGT GGTGCTCTTTGATGAAGTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAA AGGGAAGACCATTGATTGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAG GCAGGAAGCTTTGGAGATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTT CAAGGAGAATGTGATTCGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCC CTTCTGCCACTCGGAGCTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCT CTGGGACCGCGAGGTGGCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGT GGTGAACCAGCTGGCAGCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCT ACTCAAAAGCCCAGAACTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCG CAGACTGGACATCCGGGCACCACTGCACCCTGAGAAGGTGTGCAACACCATCTAGCAGCCACCTGCCTGCTCCTATGTGCCCTCACCATC >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000340729_chr11_72070052_-_1649nt GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG CCCGGCCCCCGCCGCGGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTT GCACTATGCTGTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACA CACACCCTTGGATTATGCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGA GGCTGAGGAGCGGCGCCGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGC GATCCGGAGGAAGGAGAATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCT GGCCAAGCAGACAGCCAAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGT GGCCAAGTTTATTGGGTCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGT GGTGCTCTTTGATGAAGTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAA AGGGAAGACCATTGATTGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAG GCAGGAAGCTTTGGAGATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTT CAAGGAGAATGTGATTCGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCC CTTCTGCCACTCGGAGCTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCT CTGGGACCGCGAGGTGGCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGT GGTGAACCAGCTGGCAGCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCT ACTCAAAAGCCCAGAACTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCG CAGACTGGACATCCGGGCACCACTGCACCCTGAGAAGGTGTGCAACACCATCTAGCAGCCACCTGCCTGCTCCTATGTGCCCTCACCATC >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000543042_chr11_72070052_-_1643nt GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG CCCGGCCCCCGCCGCGGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTT GCACTATGCTGTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGAGCCAACCCCCTGCAGAGGAATGAAATGGGACA CACACCCTTGGATTATGCCCGAGAAGGGGAAGTGATGAAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGA GGCTGAGGAGCGGCGCCGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGTGCTGC GATCCGGAGGAAGGAGAATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGATCATCTGGAATAGGAAAAACAGAGCT GGCCAAGCAGACAGCCAAATATATGCACAAAGATGCTAAAAAGGGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGT GGCCAAGTTTATTGGGTCTCCACCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGT GGTGCTCTTTGATGAAGTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGGCTGACAGATGGAAA AGGGAAGACCATTGATTGCAAGGACGCCATCTTCATCATGACCTCCAATGTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAG GCAGGAAGCTTTGGAGATGAGCCGTAACCGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTT CAAGGAGAATGTGATTCGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATCGTCTACTTCCTCCC CTTCTGCCACTCGGAGCTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCCAAGAGAGCCAAGCAAAGGCACAACATCACGCTGCT CTGGGACCGCGAGGTGGCAGATGTGCTGGTCGACGGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGT GGTGAACCAGCTGGCAGCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGACAAGCAGCT ACTCAAAAGCCCAGAACTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTGGAGATCATCGACAAGGACAGCAAGACTCG CAGACTGGACATCCGGGCACCACTGCACCCTGAGAAGGTGTGCAACACCATCTAGCAGCCACCTGCCTGCTCCTATGTGCCCTCACCATC >In-frame_LRP5_ENST00000294304_chr11_68080273_+_CLPB_ENST00000445069_chr11_72070052_-_449nt GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG CCCGGCCCCCGCCGCGGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGCTGCACGGCCTT GCACTATGCTGTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGTTCCTCCAGAGAATTGAGCCCTCATTCTCCAAG |
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FusionGenePPI for LRP5_CLPB |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LRP5 | AXIN1, SMAD9, CAPRIN2, SOST, DKK1, FZD8, TAZ, RASD2, SUSD4, PARP16, POMK, B3GALT2, ETV6, CHST9, LIPH, PRSS37, CSNK1A1, TGIF2LY, DKKL1, SERPINA12, ST8SIA4, SCGB1D1, DKK4, MGAT4C, F9, FAM3B, C4orf26, FCGRT, PODN, ADAM33, BRINP3, LRRC4C, CLPSL1, NXPH2, TRIM25 | CLPB | TTF2, COPS6, UCHL3, USP30, OSBPL10, TERF2, CUL3, SMAD9, MDFI, HDAC11, IRS4, CEP70, ERCC6L, TSEN2, MGEA5, NTRK1, XPO1, MCM2, NDUFA4, PTPMT1, DHRS4, COQ9, C15orf48, CISD3, C2orf47, FAM136A, OPA3, TRUB2, COQ10B, OCIAD1, ADCK3, WBSCR16, ADCK4, NDUFS3, PAK7, ADCK2, CHCHD10, C17orf89, CDKN3, CLUH, KIAA1191, PAG1, ARFIP1, SETDB1, TRIM11, MTIF2, MDM2, GTPBP10, EXOG, EIF5, NAP1L5, FBXL13 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRP5_CLPB |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRP5_CLPB |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LRP5 | C0432252 | Osteoporosis with pseudoglioma | 8 | CTD_human;ORPHANET;UNIPROT |
Hgene | LRP5 | C1866176 | EXUDATIVE VITREORETINOPATHY 4 (disorder) | 8 | CTD_human;UNIPROT |
Hgene | LRP5 | C1866079 | BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 1 | 5 | UNIPROT |
Hgene | LRP5 | C0242852 | Proliferative vitreoretinopathy | 1 | CTD_human |
Hgene | LRP5 | C0432273 | Worth disease | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | LRP5 | C1843330 | OSTEOPETROSIS, AUTOSOMAL DOMINANT 1 | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | LRP5 | C1851402 | Exudative vitreoretinopathy 1 | 1 | ORPHANET;UNIPROT |
Tgene | CLPB | C4225393 | 3-METHYLGLUTACONIC ACIDURIA WITH CATARACTS, NEUROLOGIC INVOLVEMENT, AND NEUTROPENIA | 2 | ORPHANET;UNIPROT |