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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20129

FusionGeneSummary for LRP1_KLK3

check button Fusion gene summary
Fusion gene informationFusion gene name: LRP1_KLK3
Fusion gene ID: 20129
HgeneTgene
Gene symbol

LRP1

KLK3

Gene ID

10438

354

Gene nameC1D nuclear receptor corepressorkallikrein related peptidase 3
SynonymsLRP1|Rrp47|SUN-CoR|SUNCOR|hC1DAPS|KLK2A1|PSA|hK3
Cytomap

2p14

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionnuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressorprostate-specific antigenP-30 antigengamma-seminoproteinkallikrein-3semenogelaseseminin
Modification date2018051920180523
UniProtAcc

Q07954

P07288

Ensembl transtripts involved in fusion geneENST00000553277, ENST00000243077, 
ENST00000338962, ENST00000554174, 
ENST00000553446, 
ENST00000326003, 
ENST00000597483, ENST00000593997, 
ENST00000595952, ENST00000360617, 
Fusion gene scores* DoF score16 X 14 X 7=156811 X 8 X 2=176
# samples 1713
** MAII scorelog2(17/1568*10)=-3.20531890797751
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/176*10)=-0.437063805608843
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRP1 [Title/Abstract] AND KLK3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKLK3

GO:0002778

antibacterial peptide production

18714013


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-SU-A7E7-01ALRP1chr12

57548153

+KLK3chr19

51358191

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000553277ENST00000326003LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-5UTRENST00000553277ENST00000597483LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-5UTRENST00000553277ENST00000593997LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-intronENST00000553277ENST00000595952LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-intronENST00000553277ENST00000360617LRP1chr12

57548153

+KLK3chr19

51358191

+
5CDS-5UTRENST00000243077ENST00000326003LRP1chr12

57548153

+KLK3chr19

51358191

+
5CDS-5UTRENST00000243077ENST00000597483LRP1chr12

57548153

+KLK3chr19

51358191

+
5CDS-5UTRENST00000243077ENST00000593997LRP1chr12

57548153

+KLK3chr19

51358191

+
5CDS-intronENST00000243077ENST00000595952LRP1chr12

57548153

+KLK3chr19

51358191

+
5CDS-intronENST00000243077ENST00000360617LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-5UTRENST00000338962ENST00000326003LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-5UTRENST00000338962ENST00000597483LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-5UTRENST00000338962ENST00000593997LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-intronENST00000338962ENST00000595952LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-intronENST00000338962ENST00000360617LRP1chr12

57548153

+KLK3chr19

51358191

+
5CDS-5UTRENST00000554174ENST00000326003LRP1chr12

57548153

+KLK3chr19

51358191

+
5CDS-5UTRENST00000554174ENST00000597483LRP1chr12

57548153

+KLK3chr19

51358191

+
5CDS-5UTRENST00000554174ENST00000593997LRP1chr12

57548153

+KLK3chr19

51358191

+
5CDS-intronENST00000554174ENST00000595952LRP1chr12

57548153

+KLK3chr19

51358191

+
5CDS-intronENST00000554174ENST00000360617LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-5UTRENST00000553446ENST00000326003LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-5UTRENST00000553446ENST00000597483LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-5UTRENST00000553446ENST00000593997LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-intronENST00000553446ENST00000595952LRP1chr12

57548153

+KLK3chr19

51358191

+
intron-intronENST00000553446ENST00000360617LRP1chr12

57548153

+KLK3chr19

51358191

+

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FusionProtFeatures for LRP1_KLK3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP1

Q07954

KLK3

P07288

Endocytic receptor involved in endocytosis and inphagocytosis of apoptotic cells. Required for early embryonicdevelopment. Involved in cellular lipid homeostasis. Involved inthe plasma clearance of chylomicron remnants and activated LRPAP1(alpha 2-macroglobulin), as well as the local metabolism ofcomplexes between plasminogen activators and their endogenousinhibitors. May modulate cellular events, such as APP metabolism,kinase-dependent intracellular signaling, neuronal calciumsignaling as well as neurotransmission (PubMed:11907044,PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).{ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657,ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:26142438}. (Microbial infection) Functions as a receptor forPseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}. Hydrolyzes semenogelin-1 thus leading to theliquefaction of the seminal coagulum.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LRP1_KLK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LRP1_KLK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LRP1SERPINE1, CANX, CALR, PDIA2, MMP14, KAT5, CALCR, SHC1, THBS1, GIPC1, MAPK8IP1, DLG4, MAPK8IP2, SYNJ2BP, NOS1AP, SCN3A, APBA2, DAB1, ITGB1BP1, ANAPC10, A2M, PDGFB, SRC, DAB2, MDK, F8, GULP1, PLAUR, PLAT, F9, LRPAP1, LPL, LIPC, SNX17, APBB1, USP3, CACNA1A, APOE, RIC8B, CC2D1A, SNRNP70, ANKS1B, PID1, HNRNPDL, MAPRE1, FBXO6, CUBN, CHFR, SKIL, RANBP9, APP, COPS5, EGFR, ZFP41, DIAPH1, FOXB1, KCTD18, INTS6, TNKS2, TNKS, FOXF2, BCKDHB, TUBB8, SAMD1, TUBA4A, TUBB3, LOXL2, MTG2, SLC25A6, SLC25A30, GATB, SMOC1, C17orf80, GSG2, NME4, HARS2, TUBA1A, TUBB4A, SLC25A23, LCOR, CCRN4L, FAM115A, SLC25A25, MTO1, C1orf85, PC, PTGES2, SLC26A6, GFPT2, GFPT1, HSPA5, RPL23, TUBB2A, NPC2, MTPAP, TUBB4B, RPUSD3, GNB2, NPRL3, FAM132B, ERAL1, GCNT1, TUBB2B, PTCD2, SENP1, MAP2K7, RTEL1, LGALS9KLK3SERPINA1, A2M, SERPINA5, ALB, UBA52, HSPA5, MIF4GD, AR, FN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LRP1_KLK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneLRP1Q07954DB00031TenecteplaseProlow-density lipoprotein receptor-related protein 1biotechapproved
HgeneLRP1Q07954DB00025Antihemophilic factor, human recombinantProlow-density lipoprotein receptor-related protein 1biotechapproved|investigational
HgeneLRP1Q07954DB00100Coagulation Factor IX (Recombinant)Prolow-density lipoprotein receptor-related protein 1biotechapproved|investigational
TgeneKLK3P07288DB00834MifepristoneProstate-specific antigensmall moleculeapproved|investigational
TgeneKLK3P07288DB04839Cyproterone acetateProstate-specific antigensmall moleculeapproved|investigational

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RelatedDiseases for LRP1_KLK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLRP1C0036341Schizophrenia1CTD_human
HgeneLRP1C0041696Unipolar Depression1PSYGENET
HgeneLRP1C0149931Migraine Disorders1CTD_human
HgeneLRP1C0338480Common Migraine1CTD_human
HgeneLRP1C1269683Major Depressive Disorder1PSYGENET
TgeneKLK3C0033578Prostatic Neoplasms10CTD_human
TgeneKLK3C0027643Neoplasm Recurrence, Local1CTD_human
TgeneKLK3C1334615Malignant Phyllodes Tumor of Prostate1CTD_human
TgeneKLK3C2937421Prostatic Hyperplasia1CTD_human