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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20111

FusionGeneSummary for LRP12_RALGPS1

check button Fusion gene summary
Fusion gene informationFusion gene name: LRP12_RALGPS1
Fusion gene ID: 20111
HgeneTgene
Gene symbol

LRP12

RALGPS1

Gene ID

29967

9649

Gene nameLDL receptor related protein 12Ral GEF with PH domain and SH3 binding motif 1
SynonymsST7RALGEF2|RALGPS1A
Cytomap

8q22.3

9q33.3

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor-related protein 12suppressor of tumorigenicity 7 proteinras-specific guanine nucleotide-releasing factor RalGPS1Ral guanine nucleotide exchange factor RalGPS1ARalGEF 2ral GEF with PH domain and SH3-binding motif 1ral guanine nucleotide exchange factor 2ralA exchange factor RalGPS1
Modification date2018051920180519
UniProtAcc

Q9Y561

Q5JS13

Ensembl transtripts involved in fusion geneENST00000424843, ENST00000276654, 
ENST00000518375, 		ENST00000424082, 
ENST00000259351, ENST00000394022, 
ENST00000373436, ENST00000373434, 
ENST00000394011, ENST00000480993, 
Fusion gene scores* DoF score8 X 3 X 4=967 X 6 X 5=210
# samples 107
** MAII scorelog2(10/96*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRP12 [Title/Abstract] AND RALGPS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLRP12

GO:0001764

neuron migration

26639854

HgeneLRP12

GO:0031175

neuron projection development

26639854

TgeneRALGPS1

GO:0032485

regulation of Ral protein signal transduction

10747847


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D3-A3MO-06ALRP12chr8

105601047

-RALGPS1chr9

129724504

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000424843ENST00000424082LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-5UTRENST00000424843ENST00000259351LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-5UTRENST00000424843ENST00000394022LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-5UTRENST00000424843ENST00000373436LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-5UTRENST00000424843ENST00000373434LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-5UTRENST00000424843ENST00000394011LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-3UTRENST00000424843ENST00000480993LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-5UTRENST00000276654ENST00000424082LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-5UTRENST00000276654ENST00000259351LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-5UTRENST00000276654ENST00000394022LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-5UTRENST00000276654ENST00000373436LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-5UTRENST00000276654ENST00000373434LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-5UTRENST00000276654ENST00000394011LRP12chr8

105601047

-RALGPS1chr9

129724504

+
5CDS-3UTRENST00000276654ENST00000480993LRP12chr8

105601047

-RALGPS1chr9

129724504

+
intron-5UTRENST00000518375ENST00000424082LRP12chr8

105601047

-RALGPS1chr9

129724504

+
intron-5UTRENST00000518375ENST00000259351LRP12chr8

105601047

-RALGPS1chr9

129724504

+
intron-5UTRENST00000518375ENST00000394022LRP12chr8

105601047

-RALGPS1chr9

129724504

+
intron-5UTRENST00000518375ENST00000373436LRP12chr8

105601047

-RALGPS1chr9

129724504

+
intron-5UTRENST00000518375ENST00000373434LRP12chr8

105601047

-RALGPS1chr9

129724504

+
intron-5UTRENST00000518375ENST00000394011LRP12chr8

105601047

-RALGPS1chr9

129724504

+
intron-3UTRENST00000518375ENST00000480993LRP12chr8

105601047

-RALGPS1chr9

129724504

+

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FusionProtFeatures for LRP12_RALGPS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP12

Q9Y561

RALGPS1

Q5JS13

Probable receptor, which may be involved in theinternalization of lipophilic molecules and/or signaltransduction. May act as a tumor suppressor.{ECO:0000269|PubMed:12809483}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LRP12_RALGPS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LRP12_RALGPS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LRP12KLRAP1, SPINT2, GLRA2, MRAP2, HTR3A, ASIC4, TMED6, TCTN2, PSG1, IL17RC, FAM189B, MPPE1, ADAM33, KIR3DL2, ZNRF4, DEFA1, SCNN1DRALGPS1RALA, GRB2, NCK1, APP, C2orf88


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LRP12_RALGPS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRP12_RALGPS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRALGPS1C0005695Bladder Neoplasm1CTD_human