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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20107

FusionGeneSummary for LRP11_ULBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: LRP11_ULBP2
Fusion gene ID: 20107
HgeneTgene
Gene symbol

LRP11

ULBP2

Gene ID

84918

80328

Gene nameLDL receptor related protein 11UL16 binding protein 2
SynonymsMANSC3|bA350J20.3ALCAN-alpha|N2DL2|NKG2DL2|RAET1H|RAET1L
Cytomap

6q25.1

6q25.1

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor-related protein 11LRP-11UL16-binding protein 2NKG2D ligand 2retinoic acid early transcript 1Hretinoic acid early transcript 1L
Modification date2018051920180523
UniProtAcc

Q86VZ4

Q9BZM5

Ensembl transtripts involved in fusion geneENST00000239367, ENST00000546019, 
ENST00000463728, ENST00000367368, 
ENST00000367351, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: LRP11 [Title/Abstract] AND ULBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneULBP2

GO:0030101

natural killer cell activation

11239445

TgeneULBP2

GO:0042267

natural killer cell mediated cytotoxicity

11239445


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A07F-01ALRP11chr6

150147400

-ULBP2chr6

150269859

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000239367ENST00000367351LRP11chr6

150147400

-ULBP2chr6

150269859

+
5CDS-3UTRENST00000546019ENST00000367351LRP11chr6

150147400

-ULBP2chr6

150269859

+
intron-3UTRENST00000463728ENST00000367351LRP11chr6

150147400

-ULBP2chr6

150269859

+
intron-3UTRENST00000367368ENST00000367351LRP11chr6

150147400

-ULBP2chr6

150269859

+

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FusionProtFeatures for LRP11_ULBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP11

Q86VZ4

ULBP2

Q9BZM5

Binds and activates the KLRK1/NKG2D receptor, mediatingnatural killer cell cytotoxicity. {ECO:0000269|PubMed:11777960}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LRP11_ULBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LRP11_ULBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LRP11ARRB2, SRPRB, CD1B, ZPBP2, GINM1, ANTXR1, PON2, FAM19A3, LYZL2, LRRTM1, PLA2G10, P2RX2, FAM19A4, LYPD1, ST8SIA4, IL27RA, CLEC12AULBP2PIGK, PDGFRA, HOXB5, ANKRD12, TNFSF8, RAET1E, GJB7, TMEM30B, MED21, SLC4A8, FCGRT, SLC39A5, DUS4L, IDO2, DUSP22, MTUS2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LRP11_ULBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LRP11_ULBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneULBP2C0038356Stomach Neoplasms1CTD_human