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Fusion gene ID: 20099 |
FusionGeneSummary for LRIG3_DTX3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRIG3_DTX3 | Fusion gene ID: 20099 | Hgene | Tgene | Gene symbol | LRIG3 | DTX3 | Gene ID | 121227 | 196403 |
| Gene name | leucine rich repeats and immunoglobulin like domains 3 | deltex E3 ubiquitin ligase 3 | |
| Synonyms | LIG3 | RNF154|deltex3 | |
| Cytomap | 12q14.1 | 12q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leucine-rich repeats and immunoglobulin-like domains protein 3LIG-3 | probable E3 ubiquitin-protein ligase DTX3RING finger protein 154RING-type E3 ubiquitin transferase DTX3deltex 3, E3 ubiquitin ligasedeltex homolog 3protein deltex-3 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6UXM1 | Q8N9I9 | |
| Ensembl transtripts involved in fusion gene | ENST00000379141, ENST00000320743, | ENST00000548804, ENST00000337737, ENST00000548198, ENST00000551632, | |
| Fusion gene scores | * DoF score | 7 X 3 X 4=84 | 4 X 3 X 3=36 |
| # samples | 7 | 5 | |
| ** MAII score | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LRIG3 [Title/Abstract] AND DTX3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A1AH-01A | LRIG3 | chr12 | 59307763 | - | DTX3 | chr12 | 58002860 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000379141 | ENST00000548804 | LRIG3 | chr12 | 59307763 | - | DTX3 | chr12 | 58002860 | + |
| Frame-shift | ENST00000379141 | ENST00000337737 | LRIG3 | chr12 | 59307763 | - | DTX3 | chr12 | 58002860 | + |
| Frame-shift | ENST00000379141 | ENST00000548198 | LRIG3 | chr12 | 59307763 | - | DTX3 | chr12 | 58002860 | + |
| In-frame | ENST00000379141 | ENST00000551632 | LRIG3 | chr12 | 59307763 | - | DTX3 | chr12 | 58002860 | + |
| Frame-shift | ENST00000320743 | ENST00000548804 | LRIG3 | chr12 | 59307763 | - | DTX3 | chr12 | 58002860 | + |
| Frame-shift | ENST00000320743 | ENST00000337737 | LRIG3 | chr12 | 59307763 | - | DTX3 | chr12 | 58002860 | + |
| Frame-shift | ENST00000320743 | ENST00000548198 | LRIG3 | chr12 | 59307763 | - | DTX3 | chr12 | 58002860 | + |
| In-frame | ENST00000320743 | ENST00000551632 | LRIG3 | chr12 | 59307763 | - | DTX3 | chr12 | 58002860 | + |
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FusionProtFeatures for LRIG3_DTX3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRIG3 | DTX3 |
| May play a role in craniofacial and inner earmorphogenesis during embryonic development. May act within theotic vesicle epithelium to control formation of the lateralsemicircular canal in the inner ear, possibly by restricting theexpression of NTN1 (By similarity). {ECO:0000250}. | Regulator of Notch signaling, a signaling pathwayinvolved in cell-cell communications that regulates a broadspectrum of cell-fate determinations. Probably acts both as apositive and negative regulator of Notch, depending on thedevelopmental and cell context (By similarity). Functions as anubiquitin ligase protein in vitro, suggesting that it may regulatethe Notch pathway via some ubiquitin ligase activity.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LRIG3_DTX3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LRIG3_ENST00000379141_chr12_59307763_-_DTX3_ENST00000551632_chr12_58002860_+_93aa MVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLFGYPDPTYLTRVQEELRAKGIT >In-frame_LRIG3_ENST00000320743_chr12_59307763_-_DTX3_ENST00000551632_chr12_58002860_+_153aa MSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LRIG3_ENST00000379141_chr12_59307763_-_DTX3_ENST00000551632_chr12_58002860_+_279nt ATGGTGGACGTACTTCTGTTGTTCTCCCTCTGCTTGCTTTTTCACATTAGCAGACCGGACTTAAGTCACAACAGATTATCTTTCATCAAG GCAAGTTCCATGAGCCACCTTCAAAGCCTTCGAGAAGTGAAACTGAACAACAATGAATTGGAGACCATTCCAAATCTGGGACCAGTCTCG GCAAATATTACACTTCTCTCCTTGTTTGGGTACCCAGACCCCACCTACCTGACCCGGGTGCAAGAGGAGCTGAGAGCGAAGGGTATCACA >In-frame_LRIG3_ENST00000320743_chr12_59307763_-_DTX3_ENST00000551632_chr12_58002860_+_459nt ATGAGCGCGCCGAGCCTCCGTGCGCGCGCCGCGGGGTTGGGGCTGCTGCTGTGCGCGGTGCTGGGGCGCGCTGGCCGGTCAGACAGCGGC GGTCGCGGGGAACTCGGGCAGCCCTCTGGGGTAGCCGCCGAGCGCCCATGCCCCACTACCTGCCGCTGCCTCGGGGACCTGCTGGACTGC AGTCGTAAGCGGCTAGCGCGTCTTCCCGAGCCACTCCCGTCCTGGGTCGCTCGGCTGGACTTAAGTCACAACAGATTATCTTTCATCAAG GCAAGTTCCATGAGCCACCTTCAAAGCCTTCGAGAAGTGAAACTGAACAACAATGAATTGGAGACCATTCCAAATCTGGGACCAGTCTCG GCAAATATTACACTTCTCTCCTTGTTTGGGTACCCAGACCCCACCTACCTGACCCGGGTGCAAGAGGAGCTGAGAGCGAAGGGTATCACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LRIG3_ENST00000379141_chr12_59307763_-_DTX3_ENST00000551632_chr12_58002860_+_995nt GTAACTGAAGTCAGGCTTTTCATTTGGGAAGCCCCCTCAACAGAATTCGGTCATTCTCCAAGTTATGGTGGACGTACTTCTGTTGTTCTC CCTCTGCTTGCTTTTTCACATTAGCAGACCGGACTTAAGTCACAACAGATTATCTTTCATCAAGGCAAGTTCCATGAGCCACCTTCAAAG CCTTCGAGAAGTGAAACTGAACAACAATGAATTGGAGACCATTCCAAATCTGGGACCAGTCTCGGCAAATATTACACTTCTCTCCTTGTT TGGGTACCCAGACCCCACCTACCTGACCCGGGTGCAAGAGGAGCTGAGAGCGAAGGGTATCACAGATGACTGAAGGACATCGCCTTTGCC AAGGCCCCTGCTGTCTGCCTCTACTAGGACCCAGCAGAAGCCTCTTTCTCCTCTCTGCCCCCTGCCCCCCACACCACACCTGTAGGGGAC CTGTCTGACTGGGAAGGGAGTTCCGAGAGGGAGGGGGCAATCCCTTCCCCCATCCCCCACTGGCCAAGTGTTTCAATGCAGTGTGAGCCA CTCCCTTCTGGCAGAGGCCGACCTCCAAGGCTCTGTTCTCCCCTCCCCGTGTACATATACTCCCGGTTTCCCTGCCCCTCCATTGCCCTT GGCTTTTTCTGGTATGTGCTGTGCTCCACGACCAAGCCGAGAAAGGACCTAGGGTGGGGAAGGGAGGGTCTCTTGATTCCTAACCGCCCC CACATACTGCTCCACCGCTGAACTTCGGGTGCCGGGGAGGAGAAATTGGGCTGATGTGAGCTCCCCGTCACCCGCCATGGAGCCGGCTGT GTGTGTTCATCAGATACAGTTCTCCCTTAACCTTGTCCTTTCTCTCCTGTGTCTCAGTCTCCGTCAGTCTGTCTTTCTCCGCTCTTCTCT GACCCCTGTGAGGAACCTCCTTACCCTGTTCTGGAATCGCTGCCAGACTGTAGCTTTTAATTTAATAAAAATAAAGTAAAATATGCAACT >In-frame_LRIG3_ENST00000320743_chr12_59307763_-_DTX3_ENST00000551632_chr12_58002860_+_1398nt GGCGAAAAAGTTTCTTTTGCAGACAAGAAGGGGCTTCGGCGAGCCGACGCTGCTCAAGCTGCAACTCTGTTGCAGTTGGCAGTTCTTTTC GGTTTCCCTCCTGCTGTTTGGGGGCATGAAAGGGCTTCGCCGCCGGGAGTAAAAGAAGGAATTGACCGGGCAGCGCGAGGGAGGAGCGCG CACGCGACCGCGAGGGCGGGCGTGCACCCTCGGCTGGAAGTTTGTGCCGGGCCCCGAGCGCGCGCCGGCTGGGAGCTTCGGGTAGAGACC TAGGCCGCTGGACCGCGATGAGCGCGCCGAGCCTCCGTGCGCGCGCCGCGGGGTTGGGGCTGCTGCTGTGCGCGGTGCTGGGGCGCGCTG GCCGGTCAGACAGCGGCGGTCGCGGGGAACTCGGGCAGCCCTCTGGGGTAGCCGCCGAGCGCCCATGCCCCACTACCTGCCGCTGCCTCG GGGACCTGCTGGACTGCAGTCGTAAGCGGCTAGCGCGTCTTCCCGAGCCACTCCCGTCCTGGGTCGCTCGGCTGGACTTAAGTCACAACA GATTATCTTTCATCAAGGCAAGTTCCATGAGCCACCTTCAAAGCCTTCGAGAAGTGAAACTGAACAACAATGAATTGGAGACCATTCCAA ATCTGGGACCAGTCTCGGCAAATATTACACTTCTCTCCTTGTTTGGGTACCCAGACCCCACCTACCTGACCCGGGTGCAAGAGGAGCTGA GAGCGAAGGGTATCACAGATGACTGAAGGACATCGCCTTTGCCAAGGCCCCTGCTGTCTGCCTCTACTAGGACCCAGCAGAAGCCTCTTT CTCCTCTCTGCCCCCTGCCCCCCACACCACACCTGTAGGGGACCTGTCTGACTGGGAAGGGAGTTCCGAGAGGGAGGGGGCAATCCCTTC CCCCATCCCCCACTGGCCAAGTGTTTCAATGCAGTGTGAGCCACTCCCTTCTGGCAGAGGCCGACCTCCAAGGCTCTGTTCTCCCCTCCC CGTGTACATATACTCCCGGTTTCCCTGCCCCTCCATTGCCCTTGGCTTTTTCTGGTATGTGCTGTGCTCCACGACCAAGCCGAGAAAGGA CCTAGGGTGGGGAAGGGAGGGTCTCTTGATTCCTAACCGCCCCCACATACTGCTCCACCGCTGAACTTCGGGTGCCGGGGAGGAGAAATT GGGCTGATGTGAGCTCCCCGTCACCCGCCATGGAGCCGGCTGTGTGTGTTCATCAGATACAGTTCTCCCTTAACCTTGTCCTTTCTCTCC TGTGTCTCAGTCTCCGTCAGTCTGTCTTTCTCCGCTCTTCTCTGACCCCTGTGAGGAACCTCCTTACCCTGTTCTGGAATCGCTGCCAGA |
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FusionGenePPI for LRIG3_DTX3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LRIG3 | CAND1, TAZ, TNFSF13B, PVRIG, GINM1, LPAR6, PTPRK, PTGER3, GAL3ST1, LRIG1, LRRN2, TMPRSS3 | DTX3 | UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2L6, UBE2K, UBE2E1, UBE2E3, UBE2H, UBE2L3, UBE2V1, UBE2W, UBE2E2, UEVLD, UBE2DNL, USP2, USP1, USP21, LYN, RNF141, XIAP, RNF38, TRAF4, ZDHHC17, FARSB, NARFL, NDUFAF5, CHFR, ITSN1, MAPK9, NMD3, NDUFS6, RNF114, GDA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LRIG3_DTX3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRIG3_DTX3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DTX3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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