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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20052

FusionGeneSummary for LPXN_PAM16

check button Fusion gene summary
Fusion gene informationFusion gene name: LPXN_PAM16
Fusion gene ID: 20052
HgeneTgene
Gene symbol

LPXN

PAM16

Gene ID

9404

51025

Gene nameleupaxinpresequence translocase associated motor 16
SynonymsLDPLCGI-136|MAGMAS|SMDMDM|TIM16|TIMM16
Cytomap

11q12.1

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionleupaxinmitochondrial import inner membrane translocase subunit TIM16magmas-like proteinmitochondria associated protein involved in granulocyte macrophage colony stimulating factor signal transductionmitochondria-associated granulocyte macrophage CSF-signaling
Modification date2018051920180523
UniProtAcc

O60711

Q9Y3D7

Ensembl transtripts involved in fusion geneENST00000395074, ENST00000528954, 
ENST00000528489, 
ENST00000577031, 
ENST00000318059, ENST00000573553, 
ENST00000575848, ENST00000571941, 
ENST00000576217, ENST00000575942, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 2=8
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: LPXN [Title/Abstract] AND PAM16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLPXN

GO:0007162

negative regulation of cell adhesion

20543562

HgeneLPXN

GO:0050859

negative regulation of B cell receptor signaling pathway

17640867

TgenePAM16

GO:0032780

negative regulation of ATPase activity

19564938|20053669


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA829953LPXNchr11

58294572

+PAM16chr16

4394810

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000395074ENST00000577031LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000395074ENST00000318059LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000395074ENST00000573553LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000395074ENST00000575848LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000395074ENST00000571941LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000395074ENST00000576217LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000395074ENST00000575942LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528954ENST00000577031LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528954ENST00000318059LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528954ENST00000573553LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528954ENST00000575848LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528954ENST00000571941LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528954ENST00000576217LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528954ENST00000575942LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528489ENST00000577031LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528489ENST00000318059LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528489ENST00000573553LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528489ENST00000575848LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528489ENST00000571941LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528489ENST00000576217LPXNchr11

58294572

+PAM16chr16

4394810

+
intron-intronENST00000528489ENST00000575942LPXNchr11

58294572

+PAM16chr16

4394810

+

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FusionProtFeatures for LPXN_PAM16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LPXN

O60711

PAM16

Q9Y3D7

Transcriptional coactivator for androgen receptor (AR)and serum response factor (SRF). Contributes to the regulation ofcell adhesion, spreading and cell migration and acts as a negativeregulator in integrin-mediated cell adhesion events. Suppressesthe integrin-induced tyrosine phosphorylation of paxillin (PXN).May play a critical role as an adapter protein in the formation ofthe adhesion zone in osteoclasts. Negatively regulates B-cellantigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867,ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331,ECO:0000269|PubMed:20543562}. Regulates ATP-dependent protein translocation into themitochondrial matrix. Inhibits DNAJC19 stimulation ofHSPA9/Mortalin ATPase activity. {ECO:0000269|PubMed:20053669}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LPXN_PAM16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LPXN_PAM16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LPXN_PAM16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LPXN_PAM16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLPXNC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePAM16C2750075Chondrodysplasia, Megarbane-Dagher-Melki Type1ORPHANET;UNIPROT