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Fusion gene ID: 20035 |
FusionGeneSummary for LPP_HRASLS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LPP_HRASLS | Fusion gene ID: 20035 | Hgene | Tgene | Gene symbol | LPP | HRASLS | Gene ID | 4026 | 57110 |
| Gene name | LIM domain containing preferred translocation partner in lipoma | HRAS like suppressor | |
| Synonyms | - | A-C1|H-REV107|HRASLS1|HRSL1|HSD28 | |
| Cytomap | 3q27.3-q28 | 3q29 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lipoma-preferred partnerLIM proteinlipoma preferred partner | phospholipid-metabolizing enzyme A-C1H-REV107 protein-related proteinHRAS-like suppressor 1phospholipase A | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q93052 | Q9HDD0 | |
| Ensembl transtripts involved in fusion gene | ENST00000448637, ENST00000312675, ENST00000543006, ENST00000471917, | ENST00000602513, ENST00000264735, | |
| Fusion gene scores | * DoF score | 29 X 22 X 11=7018 | 1 X 1 X 1=1 |
| # samples | 37 | 1 | |
| ** MAII score | log2(37/7018*10)=-4.24546277188585 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: LPP [Title/Abstract] AND HRASLS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-SI-AA8B-01A | LPP | chr3 | 188202492 | + | HRASLS | chr3 | 192973440 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000448637 | ENST00000602513 | LPP | chr3 | 188202492 | + | HRASLS | chr3 | 192973440 | + |
| In-frame | ENST00000448637 | ENST00000264735 | LPP | chr3 | 188202492 | + | HRASLS | chr3 | 192973440 | + |
| In-frame | ENST00000312675 | ENST00000602513 | LPP | chr3 | 188202492 | + | HRASLS | chr3 | 192973440 | + |
| In-frame | ENST00000312675 | ENST00000264735 | LPP | chr3 | 188202492 | + | HRASLS | chr3 | 192973440 | + |
| In-frame | ENST00000543006 | ENST00000602513 | LPP | chr3 | 188202492 | + | HRASLS | chr3 | 192973440 | + |
| In-frame | ENST00000543006 | ENST00000264735 | LPP | chr3 | 188202492 | + | HRASLS | chr3 | 192973440 | + |
| intron-3CDS | ENST00000471917 | ENST00000602513 | LPP | chr3 | 188202492 | + | HRASLS | chr3 | 192973440 | + |
| intron-3CDS | ENST00000471917 | ENST00000264735 | LPP | chr3 | 188202492 | + | HRASLS | chr3 | 192973440 | + |
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FusionProtFeatures for LPP_HRASLS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LPP | HRASLS |
| May play a structural role at sites of cell adhesion inmaintaining cell shape and motility. In addition to thesestructural functions, it may also be implicated in signalingevents and activation of gene transcription. May be involved insignal transduction from cell adhesion sites to the nucleusallowing successful integration of signals arising from solublefactors and cell-cell adhesion sites. Also suggested to serve as ascaffold protein upon which distinct protein complexes areassembled in the cytoplasm and in the nucleus.{ECO:0000269|PubMed:10637295, ECO:0000269|Ref.2}. | Exhibits calcium-independent phospholipase activitytowards phosphatidylcholine (PC) and phosphatidylethanolamine(PE). Also shows acyltransferase activities, transferring an acylgroup of PCs to the amino group of PEs and the hydroxyl group oflyso PCs. {ECO:0000269|PubMed:21880860}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >HRASLS | chr3:188202492 | chr3:192973440 | ENST00000602513 | + | 0 | 4 | 164_168 | 0 | 169 | Topological domain | Lumenal |
| Tgene | >HRASLS | chr3:188202492 | chr3:192973440 | ENST00000602513 | + | 0 | 4 | 1_139 | 0 | 169 | Topological domain | Cytoplasmic |
| Tgene | >HRASLS | chr3:188202492 | chr3:192973440 | ENST00000602513 | + | 0 | 4 | 140_163 | 0 | 169 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LPP | chr3:188202492 | chr3:192973440 | ENST00000312675 | + | 4 | 11 | 41_370 | 102 | 613 | Compositional bias | Note=Pro-rich |
| Hgene | >LPP | chr3:188202492 | chr3:192973440 | ENST00000543006 | + | 4 | 11 | 41_370 | 102 | 613 | Compositional bias | Note=Pro-rich |
| Hgene | >LPP | chr3:188202492 | chr3:192973440 | ENST00000312675 | + | 4 | 11 | 414_473 | 102 | 613 | Domain | LIM zinc-binding 1 |
| Hgene | >LPP | chr3:188202492 | chr3:192973440 | ENST00000312675 | + | 4 | 11 | 474_534 | 102 | 613 | Domain | LIM zinc-binding 2 |
| Hgene | >LPP | chr3:188202492 | chr3:192973440 | ENST00000312675 | + | 4 | 11 | 535_603 | 102 | 613 | Domain | LIM zinc-binding 3 |
| Hgene | >LPP | chr3:188202492 | chr3:192973440 | ENST00000543006 | + | 4 | 11 | 414_473 | 102 | 613 | Domain | LIM zinc-binding 1 |
| Hgene | >LPP | chr3:188202492 | chr3:192973440 | ENST00000543006 | + | 4 | 11 | 474_534 | 102 | 613 | Domain | LIM zinc-binding 2 |
| Hgene | >LPP | chr3:188202492 | chr3:192973440 | ENST00000543006 | + | 4 | 11 | 535_603 | 102 | 613 | Domain | LIM zinc-binding 3 |
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FusionGeneSequence for LPP_HRASLS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LPP_ENST00000448637_chr3_188202492_+_HRASLS_ENST00000602513_chr3_192973440_+_271aa MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPP PPPLDEEAFKVQMAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGND TYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAVGVFSFLGLFPKGQRAKYY >In-frame_LPP_ENST00000448637_chr3_188202492_+_HRASLS_ENST00000264735_chr3_192973440_+_271aa MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPP PPPLDEEAFKVQMAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGND TYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAVGVFSFLGLFPKGQRAKYY >In-frame_LPP_ENST00000312675_chr3_188202492_+_HRASLS_ENST00000602513_chr3_192973440_+_271aa MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPP PPPLDEEAFKVQMAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGND TYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAVGVFSFLGLFPKGQRAKYY >In-frame_LPP_ENST00000312675_chr3_188202492_+_HRASLS_ENST00000264735_chr3_192973440_+_271aa MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPP PPPLDEEAFKVQMAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGND TYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAVGVFSFLGLFPKGQRAKYY >In-frame_LPP_ENST00000543006_chr3_188202492_+_HRASLS_ENST00000602513_chr3_192973440_+_271aa MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPP PPPLDEEAFKVQMAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGND TYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAVGVFSFLGLFPKGQRAKYY >In-frame_LPP_ENST00000543006_chr3_188202492_+_HRASLS_ENST00000264735_chr3_192973440_+_271aa MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPP PPPLDEEAFKVQMAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGND TYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAVGVFSFLGLFPKGQRAKYY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LPP_ENST00000448637_chr3_188202492_+_HRASLS_ENST00000602513_chr3_192973440_+_813nt ATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGG AACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAA CCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCT CCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGG GACTTGATCGAAGTGTTCCGTCCTGGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGC ATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGAC ACATACAGAATAAACAATAAATACGATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAG GAGGTGGCCTATAACTTACTTGTCAACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGA GCGATAAGTACCGTTGAGTTTGTGACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTAT >In-frame_LPP_ENST00000448637_chr3_188202492_+_HRASLS_ENST00000264735_chr3_192973440_+_813nt ATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGG AACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAA CCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCT CCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGG GACTTGATCGAAGTGTTCCGTCCTGGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGC ATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGAC ACATACAGAATAAACAATAAATACGATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAG GAGGTGGCCTATAACTTACTTGTCAACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGA GCGATAAGTACCGTTGAGTTTGTGACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTAT >In-frame_LPP_ENST00000312675_chr3_188202492_+_HRASLS_ENST00000602513_chr3_192973440_+_813nt ATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGG AACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAA CCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCT CCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGG GACTTGATCGAAGTGTTCCGTCCTGGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGC ATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGAC ACATACAGAATAAACAATAAATACGATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAG GAGGTGGCCTATAACTTACTTGTCAACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGA GCGATAAGTACCGTTGAGTTTGTGACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTAT >In-frame_LPP_ENST00000312675_chr3_188202492_+_HRASLS_ENST00000264735_chr3_192973440_+_813nt ATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGG AACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAA CCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCT CCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGG GACTTGATCGAAGTGTTCCGTCCTGGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGC ATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGAC ACATACAGAATAAACAATAAATACGATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAG GAGGTGGCCTATAACTTACTTGTCAACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGA GCGATAAGTACCGTTGAGTTTGTGACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTAT >In-frame_LPP_ENST00000543006_chr3_188202492_+_HRASLS_ENST00000602513_chr3_192973440_+_813nt ATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGG AACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAA CCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCT CCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGG GACTTGATCGAAGTGTTCCGTCCTGGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGC ATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGAC ACATACAGAATAAACAATAAATACGATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAG GAGGTGGCCTATAACTTACTTGTCAACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGA GCGATAAGTACCGTTGAGTTTGTGACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTAT >In-frame_LPP_ENST00000543006_chr3_188202492_+_HRASLS_ENST00000264735_chr3_192973440_+_813nt ATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGG AACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAA CCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCT CCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGG GACTTGATCGAAGTGTTCCGTCCTGGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGC ATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGAC ACATACAGAATAAACAATAAATACGATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAG GAGGTGGCCTATAACTTACTTGTCAACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGA GCGATAAGTACCGTTGAGTTTGTGACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LPP_ENST00000448637_chr3_188202492_+_HRASLS_ENST00000602513_chr3_192973440_+_1108nt ATTTCTCTTCCGAGAGCTTCAGTTTCCTCACGTGCCAAGCGGACGGGTTGGAAGTTGGTCTTTGCCAGCTCTGACACCTTCATTGCAGTT GGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAGATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCA CTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCAC CCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCAC CTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTAC AGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGGGACTTGATCGAAGTGTTCCGTCCTGGCTATCAGC ACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGCATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTAT TCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGACACATACAGAATAAACAATAAATACGATGAAACGT ACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAGGAGGTGGCCTATAACTTACTTGTCAACAACTGTG AACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGAGCGATAAGTACCGTTGAGTTTGTGACAGCTGCTG TTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTATTAACAATTTACCAAAGAGATATTGATATTGAAGG AATTTGGGAGGAGGAAAAGAAACCTGGGGTGAATACTTATTTTCAGTGCATCATTACTGTTCCAGATTCCTATGATGGATGGCAGACTCT >In-frame_LPP_ENST00000448637_chr3_188202492_+_HRASLS_ENST00000264735_chr3_192973440_+_1109nt ATTTCTCTTCCGAGAGCTTCAGTTTCCTCACGTGCCAAGCGGACGGGTTGGAAGTTGGTCTTTGCCAGCTCTGACACCTTCATTGCAGTT GGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAGATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCA CTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCAC CCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCAC CTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTAC AGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGGGACTTGATCGAAGTGTTCCGTCCTGGCTATCAGC ACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGCATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTAT TCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGACACATACAGAATAAACAATAAATACGATGAAACGT ACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAGGAGGTGGCCTATAACTTACTTGTCAACAACTGTG AACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGAGCGATAAGTACCGTTGAGTTTGTGACAGCTGCTG TTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTATTAACAATTTACCAAAGAGATATTGATATTGAAGG AATTTGGGAGGAGGAAAAGAAACCTGGGGTGAATACTTATTTTCAGTGCATCATTACTGTTCCAGATTCCTATGATGGATGGCAGACTCT >In-frame_LPP_ENST00000312675_chr3_188202492_+_HRASLS_ENST00000602513_chr3_192973440_+_1208nt GTCACTTTTATTTGGGGGTGTGGACAGCTGCTTTCCCAGGGGAGTACTTCTTACAGTGGGATTTCAAGACAAGATCGGCCTGAAGAAAAA TTATATTTGTATATTTTTTAAAAAGTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCT GCTTTTTTCATTGTTCCACTGGACGCTCATCAGAGGGAAGATCTTTTTCCTCAATTGATTCCAACAATGTCTCACCCATCTTGGCTGCCA CCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACA CAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTT CCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCT TTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGGGACTTGATCGAAGTGTTCCGTCCT GGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGCATTCCTGCGTCCTTTACAAGCGCC AAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGACACATACAGAATAAACAATAAATAC GATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAGGAGGTGGCCTATAACTTACTTGTC AACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGAGCGATAAGTACCGTTGAGTTTGTG ACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTATTAACAATTTACCAAAGAGATATTG ATATTGAAGGAATTTGGGAGGAGGAAAAGAAACCTGGGGTGAATACTTATTTTCAGTGCATCATTACTGTTCCAGATTCCTATGATGGAT >In-frame_LPP_ENST00000312675_chr3_188202492_+_HRASLS_ENST00000264735_chr3_192973440_+_1209nt GTCACTTTTATTTGGGGGTGTGGACAGCTGCTTTCCCAGGGGAGTACTTCTTACAGTGGGATTTCAAGACAAGATCGGCCTGAAGAAAAA TTATATTTGTATATTTTTTAAAAAGTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCT GCTTTTTTCATTGTTCCACTGGACGCTCATCAGAGGGAAGATCTTTTTCCTCAATTGATTCCAACAATGTCTCACCCATCTTGGCTGCCA CCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACA CAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTT CCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCT TTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGGGACTTGATCGAAGTGTTCCGTCCT GGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGCATTCCTGCGTCCTTTACAAGCGCC AAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGACACATACAGAATAAACAATAAATAC GATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAGGAGGTGGCCTATAACTTACTTGTC AACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGAGCGATAAGTACCGTTGAGTTTGTG ACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTATTAACAATTTACCAAAGAGATATTG ATATTGAAGGAATTTGGGAGGAGGAAAAGAAACCTGGGGTGAATACTTATTTTCAGTGCATCATTACTGTTCCAGATTCCTATGATGGAT >In-frame_LPP_ENST00000543006_chr3_188202492_+_HRASLS_ENST00000602513_chr3_192973440_+_1151nt GTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCTGCTTTTTTCATTGTTCCACTGGAC GCTCATCAGAGGGAAGATCTTTTTCCTCAATTGCATTGCAGTTGGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAG ATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCAT TCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCA TACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAAC TTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCC TGCCCAGGGGACTTGATCGAAGTGTTCCGTCCTGGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCT GTAGATGGCATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTG GGAAATGACACATACAGAATAAACAATAAATACGATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTA ATTGGACAGGAGGTGGCCTATAACTTACTTGTCAACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAG GCCAACCGAGCGATAAGTACCGTTGAGTTTGTGACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCA AAATACTATTAACAATTTACCAAAGAGATATTGATATTGAAGGAATTTGGGAGGAGGAAAAGAAACCTGGGGTGAATACTTATTTTCAGT >In-frame_LPP_ENST00000543006_chr3_188202492_+_HRASLS_ENST00000264735_chr3_192973440_+_1152nt GTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCTGCTTTTTTCATTGTTCCACTGGAC GCTCATCAGAGGGAAGATCTTTTTCCTCAATTGCATTGCAGTTGGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAG ATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCAT TCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCA TACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAAC TTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCC TGCCCAGGGGACTTGATCGAAGTGTTCCGTCCTGGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCT GTAGATGGCATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTG GGAAATGACACATACAGAATAAACAATAAATACGATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTA ATTGGACAGGAGGTGGCCTATAACTTACTTGTCAACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAG GCCAACCGAGCGATAAGTACCGTTGAGTTTGTGACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCA AAATACTATTAACAATTTACCAAAGAGATATTGATATTGAAGGAATTTGGGAGGAGGAAAAGAAACCTGGGGTGAATACTTATTTTCAGT |
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FusionGenePPI for LPP_HRASLS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LPP | ATP5J2, PPP2R1A, ELAVL1, EGLN2, VHL, CLNS1A, PNPO, HNRNPL, CPT1A, HSPA5, AGFG1, ALAD, ARPC3, ARPC4, CALR, DBNL, HSPBP1, IPO11, P3H1, DPP9, EFTUD1, FEN1, FKBP10, RPRD1B, SAE1, SURF2, UFM1, NIF3L1, NPLOC4, OGT, PPME1, PPP2R5D, RANGAP1, RDX, SH3GLB1, TPRKB, UBE3A, ZPR1, SUZ12, RNF2, COPS5, GMPPA, PICALM, NINL, XPO1, CDH1, PTPN21, PPP2R3A, WDYHV1, SERPINB2, PDLIM7, LPXN, CBLC, MRPL38, WASF3, MTNR1A, G3BP1, TES | HRASLS | APP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LPP_HRASLS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LPP_HRASLS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LPP | C3495559 | Juvenile arthritis | 1 | CTD_human |
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