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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20029

FusionGeneSummary for LPP_CLPTM1L

check button Fusion gene summary
Fusion gene informationFusion gene name: LPP_CLPTM1L
Fusion gene ID: 20029
HgeneTgene
Gene symbol

LPP

CLPTM1L

Gene ID

4026

81037

Gene nameLIM domain containing preferred translocation partner in lipomaCLPTM1 like
Synonyms-CRR9
Cytomap

3q27.3-q28

5p15.33

Type of geneprotein-codingprotein-coding
Descriptionlipoma-preferred partnerLIM proteinlipoma preferred partnercleft lip and palate transmembrane protein 1-like proteinCLPTM1-like proteincisplatin resistance related protein CRR9pcisplatin resistance-related protein 9
Modification date2018051920180519
UniProtAcc

Q93052

Q96KA5

Ensembl transtripts involved in fusion geneENST00000448637, ENST00000312675, 
ENST00000543006, ENST00000471917, 
ENST00000320895, ENST00000507807, 
ENST00000320927, ENST00000506641, 
Fusion gene scores* DoF score29 X 22 X 11=701812 X 8 X 6=576
# samples 3712
** MAII scorelog2(37/7018*10)=-4.24546277188585
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/576*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LPP [Title/Abstract] AND CLPTM1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-BC-A8YO-01ALPPchr3

188478070

+CLPTM1Lchr5

1338097

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000448637ENST00000320895LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
intron-3CDSENST00000448637ENST00000507807LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
intron-3CDSENST00000448637ENST00000320927LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
intron-intronENST00000448637ENST00000506641LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
Frame-shiftENST00000312675ENST00000320895LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
Frame-shiftENST00000312675ENST00000507807LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
Frame-shiftENST00000312675ENST00000320927LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
5CDS-intronENST00000312675ENST00000506641LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
Frame-shiftENST00000543006ENST00000320895LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
Frame-shiftENST00000543006ENST00000507807LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
Frame-shiftENST00000543006ENST00000320927LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
5CDS-intronENST00000543006ENST00000506641LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
intron-3CDSENST00000471917ENST00000320895LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
intron-3CDSENST00000471917ENST00000507807LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
intron-3CDSENST00000471917ENST00000320927LPPchr3

188478070

+CLPTM1Lchr5

1338097

-
intron-intronENST00000471917ENST00000506641LPPchr3

188478070

+CLPTM1Lchr5

1338097

-

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FusionProtFeatures for LPP_CLPTM1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LPP

Q93052

CLPTM1L

Q96KA5

May play a structural role at sites of cell adhesion inmaintaining cell shape and motility. In addition to thesestructural functions, it may also be implicated in signalingevents and activation of gene transcription. May be involved insignal transduction from cell adhesion sites to the nucleusallowing successful integration of signals arising from solublefactors and cell-cell adhesion sites. Also suggested to serve as ascaffold protein upon which distinct protein complexes areassembled in the cytoplasm and in the nucleus.{ECO:0000269|PubMed:10637295, ECO:0000269|Ref.2}. Enhances cisplatin-mediated apoptosis, whenoverexpressed. {ECO:0000269|PubMed:11162647}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LPP_CLPTM1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LPP_CLPTM1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LPPATP5J2, PPP2R1A, ELAVL1, EGLN2, VHL, CLNS1A, PNPO, HNRNPL, CPT1A, HSPA5, AGFG1, ALAD, ARPC3, ARPC4, CALR, DBNL, HSPBP1, IPO11, P3H1, DPP9, EFTUD1, FEN1, FKBP10, RPRD1B, SAE1, SURF2, UFM1, NIF3L1, NPLOC4, OGT, PPME1, PPP2R5D, RANGAP1, RDX, SH3GLB1, TPRKB, UBE3A, ZPR1, SUZ12, RNF2, COPS5, GMPPA, PICALM, NINL, XPO1, CDH1, PTPN21, PPP2R3A, WDYHV1, SERPINB2, PDLIM7, LPXN, CBLC, MRPL38, WASF3, MTNR1A, G3BP1, TESCLPTM1LPIK3C3, TMEM173, UNC93B1, SPTAN1, MRPL47, UQCRQ, GK, EMC7, NTRK1, TCTN2, TCTN3, TUBG1, ZBTB33, NCSTN, NDE1, NCDN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LPP_CLPTM1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LPP_CLPTM1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLPPC3495559Juvenile arthritis1CTD_human
TgeneCLPTM1LC0024121Lung Neoplasms3CTD_human
TgeneCLPTM1LC0005695Bladder Neoplasm1CTD_human
TgeneCLPTM1LC0007117Basal cell carcinoma1CTD_human
TgeneCLPTM1LC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneCLPTM1LC0007873Uterine Cervical Neoplasm1CTD_human
TgeneCLPTM1LC0023448Lymphoid leukemia1CTD_human
TgeneCLPTM1LC0026640Mouth Neoplasms1CTD_human
TgeneCLPTM1LC0033578Prostatic Neoplasms1CTD_human
TgeneCLPTM1LC0152013Adenocarcinoma of lung (disorder)1CTD_human