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Fusion gene ID: 20002 |
FusionGeneSummary for LPHN1_LGALS4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LPHN1_LGALS4 | Fusion gene ID: 20002 | Hgene | Tgene | Gene symbol | LPHN1 | LGALS4 | Gene ID | 22859 | 3960 |
| Gene name | adhesion G protein-coupled receptor L1 | galectin 4 | |
| Synonyms | CIRL1|CL1|LEC2|LPHN1 | GAL4|L36LBP | |
| Cytomap | 19p13.12 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adhesion G protein-coupled receptor L1CIRL-1calcium-independent alpha-latrotoxin receptor 1latrophilin-1lectomedin-2 | galectin-4L-36 lactose-binding proteinantigen NY-CO-27gal-4lactose-binding lectin 4lectin, galactoside-binding, soluble, 4 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P56470 | ||
| Ensembl transtripts involved in fusion gene | ENST00000340736, ENST00000361434, ENST00000591528, | ENST00000307751, ENST00000597803, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 4 X 4=80 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LPHN1 [Title/Abstract] AND LGALS4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-L5-A891-01A | LPHN1 | chr19 | 14288343 | - | LGALS4 | chr19 | 39299588 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000340736 | ENST00000307751 | LPHN1 | chr19 | 14288343 | - | LGALS4 | chr19 | 39299588 | - |
| 5CDS-intron | ENST00000340736 | ENST00000597803 | LPHN1 | chr19 | 14288343 | - | LGALS4 | chr19 | 39299588 | - |
| In-frame | ENST00000361434 | ENST00000307751 | LPHN1 | chr19 | 14288343 | - | LGALS4 | chr19 | 39299588 | - |
| 5CDS-intron | ENST00000361434 | ENST00000597803 | LPHN1 | chr19 | 14288343 | - | LGALS4 | chr19 | 39299588 | - |
| intron-3CDS | ENST00000591528 | ENST00000307751 | LPHN1 | chr19 | 14288343 | - | LGALS4 | chr19 | 39299588 | - |
| intron-intron | ENST00000591528 | ENST00000597803 | LPHN1 | chr19 | 14288343 | - | LGALS4 | chr19 | 39299588 | - |
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FusionProtFeatures for LPHN1_LGALS4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LPHN1 | LGALS4 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Galectin that binds lactose and a related range ofsugars. May be involved in the assembly of adherens junctions. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >LGALS4 | chr19:14288343 | chr19:39299588 | ENST00000307751 | - | 1 | 10 | 194_323 | 44 | 324 | Domain | Galectin 2 |
| Tgene | >LGALS4 | chr19:14288343 | chr19:39299588 | ENST00000307751 | - | 1 | 10 | 256_262 | 44 | 324 | Region | Beta-galactoside binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | LGALS4 | chr19:14288343 | chr19:39299588 | ENST00000307751 | - | 1 | 10 | 19_150 | 44 | 324 | Domain | Galectin 1 |
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FusionGeneSequence for LPHN1_LGALS4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LPHN1_ENST00000340736_chr19_14288343_-_LGALS4_ENST00000307751_chr19_39299588_-_374aa MARLAAVLWNLCVTAVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFK IMSQRFFVNFVVGQDPGSDVAFHFNPRFDGWDKVVFNTLQGGKWGSEERKRSMPFKKGAAFELVFIVLAEHYKVVVNGNPFYEYGHRLPL QMVTHLQVDGDLQLQSINFIGGQPLRPQGPPMMPPYPGPGHCHQQLNSLPTMEGPPTFNPPVPYFGRLQGGLTARRTIIIKGYVPPTGKS FAINFKVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKITHNPFGPGQFFDLSIRCGLDRFKVYANGQHLFDFAHRLSAFQRVDTL >In-frame_LPHN1_ENST00000361434_chr19_14288343_-_LGALS4_ENST00000307751_chr19_39299588_-_374aa MARLAAVLWNLCVTAVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFK IMSQRFFVNFVVGQDPGSDVAFHFNPRFDGWDKVVFNTLQGGKWGSEERKRSMPFKKGAAFELVFIVLAEHYKVVVNGNPFYEYGHRLPL QMVTHLQVDGDLQLQSINFIGGQPLRPQGPPMMPPYPGPGHCHQQLNSLPTMEGPPTFNPPVPYFGRLQGGLTARRTIIIKGYVPPTGKS FAINFKVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKITHNPFGPGQFFDLSIRCGLDRFKVYANGQHLFDFAHRLSAFQRVDTL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LPHN1_ENST00000340736_chr19_14288343_-_LGALS4_ENST00000307751_chr19_39299588_-_1122nt ATGGCCCGCCTAGCCGCAGTGCTCTGGAATCTGTGTGTCACCGCCGTCCTGGTCACCTCGGCCACCCAAGGCCTGAGCCGGGCCGGGCTC CCGTTCGGGCTGATGCGCCGGGAGCTGGCGTGTGAAGGCTACCCCATCGAGCTGCGGTGCCCCGGCAGCGACGTCATCATGGTGGAGAAT GCCAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAATGTGCAGTGCTACCTGCCGGACGCCTTCAAG ATCATGTCACAGAGGTTCTTCGTGAACTTTGTGGTTGGGCAGGATCCGGGCTCAGACGTCGCCTTCCACTTCAATCCGCGGTTTGACGGC TGGGACAAGGTGGTCTTCAACACGTTGCAGGGCGGGAAGTGGGGCAGCGAGGAGAGGAAGAGGAGCATGCCCTTCAAAAAGGGTGCCGCC TTTGAGCTGGTCTTCATAGTCCTGGCTGAGCACTACAAGGTGGTGGTAAATGGAAATCCCTTCTATGAGTACGGGCACCGGCTTCCCCTA CAGATGGTCACCCACCTGCAAGTGGATGGGGATCTGCAACTTCAATCAATCAACTTCATCGGAGGCCAGCCCCTCCGGCCCCAGGGACCC CCGATGATGCCACCTTACCCTGGTCCCGGACATTGCCATCAACAGCTGAACAGCCTGCCCACCATGGAAGGACCCCCAACCTTCAACCCG CCTGTGCCATATTTCGGGAGGCTGCAAGGAGGGCTCACAGCTCGAAGAACCATCATCATCAAGGGCTATGTGCCTCCCACAGGCAAGAGC TTTGCTATCAACTTCAAGGTGGGCTCCTCAGGGGACATAGCTCTGCACATTAATCCCCGCATGGGCAACGGTACCGTGGTCCGGAACAGC CTTCTGAATGGCTCGTGGGGATCCGAGGAGAAGAAGATCACCCACAACCCATTTGGTCCCGGACAGTTCTTTGATCTGTCCATTCGCTGT GGCTTGGATCGCTTCAAGGTTTACGCCAATGGCCAGCACCTCTTTGACTTTGCCCATCGCCTCTCGGCCTTCCAGAGGGTGGACACATTG >In-frame_LPHN1_ENST00000361434_chr19_14288343_-_LGALS4_ENST00000307751_chr19_39299588_-_1122nt ATGGCCCGCCTAGCCGCAGTGCTCTGGAATCTGTGTGTCACCGCCGTCCTGGTCACCTCGGCCACCCAAGGCCTGAGCCGGGCCGGGCTC CCGTTCGGGCTGATGCGCCGGGAGCTGGCGTGTGAAGGCTACCCCATCGAGCTGCGGTGCCCCGGCAGCGACGTCATCATGGTGGAGAAT GCCAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAATGTGCAGTGCTACCTGCCGGACGCCTTCAAG ATCATGTCACAGAGGTTCTTCGTGAACTTTGTGGTTGGGCAGGATCCGGGCTCAGACGTCGCCTTCCACTTCAATCCGCGGTTTGACGGC TGGGACAAGGTGGTCTTCAACACGTTGCAGGGCGGGAAGTGGGGCAGCGAGGAGAGGAAGAGGAGCATGCCCTTCAAAAAGGGTGCCGCC TTTGAGCTGGTCTTCATAGTCCTGGCTGAGCACTACAAGGTGGTGGTAAATGGAAATCCCTTCTATGAGTACGGGCACCGGCTTCCCCTA CAGATGGTCACCCACCTGCAAGTGGATGGGGATCTGCAACTTCAATCAATCAACTTCATCGGAGGCCAGCCCCTCCGGCCCCAGGGACCC CCGATGATGCCACCTTACCCTGGTCCCGGACATTGCCATCAACAGCTGAACAGCCTGCCCACCATGGAAGGACCCCCAACCTTCAACCCG CCTGTGCCATATTTCGGGAGGCTGCAAGGAGGGCTCACAGCTCGAAGAACCATCATCATCAAGGGCTATGTGCCTCCCACAGGCAAGAGC TTTGCTATCAACTTCAAGGTGGGCTCCTCAGGGGACATAGCTCTGCACATTAATCCCCGCATGGGCAACGGTACCGTGGTCCGGAACAGC CTTCTGAATGGCTCGTGGGGATCCGAGGAGAAGAAGATCACCCACAACCCATTTGGTCCCGGACAGTTCTTTGATCTGTCCATTCGCTGT GGCTTGGATCGCTTCAAGGTTTACGCCAATGGCCAGCACCTCTTTGACTTTGCCCATCGCCTCTCGGCCTTCCAGAGGGTGGACACATTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LPHN1_ENST00000340736_chr19_14288343_-_LGALS4_ENST00000307751_chr19_39299588_-_1505nt TCTTTTTTTTTTTTTTTCCTAATTTTTGGTCGGCGGCGGTGCTGGGCCAGGGGAAGGAAGGGACACGGAGGCCGCCCTCGTCCCGCCACC TCCTACCCGCTTCCCCCCAGCCCCGGCTCCGGGAGATGTGCCGGGCGGGGGGCCCGGGTTCGCCGAGCCGCAGGAGAGACACGCTGGGCC GACCCCAGAGAGGCGCTGGACAGGCTGGTGGTCCAGGCCGTGGTGCCTGCCAGGTGATGTGGGGCAAAGCCCCCCGCACAGGCCACTGAG AGCTCCGGACACGCACCCGGCTGCCACCATGGCCCGCCTAGCCGCAGTGCTCTGGAATCTGTGTGTCACCGCCGTCCTGGTCACCTCGGC CACCCAAGGCCTGAGCCGGGCCGGGCTCCCGTTCGGGCTGATGCGCCGGGAGCTGGCGTGTGAAGGCTACCCCATCGAGCTGCGGTGCCC CGGCAGCGACGTCATCATGGTGGAGAATGCCAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAATGT GCAGTGCTACCTGCCGGACGCCTTCAAGATCATGTCACAGAGGTTCTTCGTGAACTTTGTGGTTGGGCAGGATCCGGGCTCAGACGTCGC CTTCCACTTCAATCCGCGGTTTGACGGCTGGGACAAGGTGGTCTTCAACACGTTGCAGGGCGGGAAGTGGGGCAGCGAGGAGAGGAAGAG GAGCATGCCCTTCAAAAAGGGTGCCGCCTTTGAGCTGGTCTTCATAGTCCTGGCTGAGCACTACAAGGTGGTGGTAAATGGAAATCCCTT CTATGAGTACGGGCACCGGCTTCCCCTACAGATGGTCACCCACCTGCAAGTGGATGGGGATCTGCAACTTCAATCAATCAACTTCATCGG AGGCCAGCCCCTCCGGCCCCAGGGACCCCCGATGATGCCACCTTACCCTGGTCCCGGACATTGCCATCAACAGCTGAACAGCCTGCCCAC CATGGAAGGACCCCCAACCTTCAACCCGCCTGTGCCATATTTCGGGAGGCTGCAAGGAGGGCTCACAGCTCGAAGAACCATCATCATCAA GGGCTATGTGCCTCCCACAGGCAAGAGCTTTGCTATCAACTTCAAGGTGGGCTCCTCAGGGGACATAGCTCTGCACATTAATCCCCGCAT GGGCAACGGTACCGTGGTCCGGAACAGCCTTCTGAATGGCTCGTGGGGATCCGAGGAGAAGAAGATCACCCACAACCCATTTGGTCCCGG ACAGTTCTTTGATCTGTCCATTCGCTGTGGCTTGGATCGCTTCAAGGTTTACGCCAATGGCCAGCACCTCTTTGACTTTGCCCATCGCCT CTCGGCCTTCCAGAGGGTGGACACATTGGAAATCCAGGGTGATGTCACCTTGTCCTATGTCCAGATCTAATCTATTCCTGGGGCCATAAC >In-frame_LPHN1_ENST00000361434_chr19_14288343_-_LGALS4_ENST00000307751_chr19_39299588_-_1487nt CTAATTTTTGGTCGGCGGCGGTGCTGGGCCAGGGGAAGGAAGGGACACGGAGGCCGCCCTCGTCCCGCCACCTCCTACCCGCTTCCCCCC AGCCCCGGCTCCGGGAGATGTGCCGGGCGGGGGGCCCGGGTTCGCCGAGCCGCAGGAGAGACACGCTGGGCCGACCCCAGAGAGGCGCTG GACAGGCTGGTGGTCCAGGCCGTGGTGCCTGCCAGGTGATGTGGGGCAAAGCCCCCCGCACAGGCCACTGAGAGCTCCGGACACGCACCC GGCTGCCACCATGGCCCGCCTAGCCGCAGTGCTCTGGAATCTGTGTGTCACCGCCGTCCTGGTCACCTCGGCCACCCAAGGCCTGAGCCG GGCCGGGCTCCCGTTCGGGCTGATGCGCCGGGAGCTGGCGTGTGAAGGCTACCCCATCGAGCTGCGGTGCCCCGGCAGCGACGTCATCAT GGTGGAGAATGCCAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAATGTGCAGTGCTACCTGCCGGA CGCCTTCAAGATCATGTCACAGAGGTTCTTCGTGAACTTTGTGGTTGGGCAGGATCCGGGCTCAGACGTCGCCTTCCACTTCAATCCGCG GTTTGACGGCTGGGACAAGGTGGTCTTCAACACGTTGCAGGGCGGGAAGTGGGGCAGCGAGGAGAGGAAGAGGAGCATGCCCTTCAAAAA GGGTGCCGCCTTTGAGCTGGTCTTCATAGTCCTGGCTGAGCACTACAAGGTGGTGGTAAATGGAAATCCCTTCTATGAGTACGGGCACCG GCTTCCCCTACAGATGGTCACCCACCTGCAAGTGGATGGGGATCTGCAACTTCAATCAATCAACTTCATCGGAGGCCAGCCCCTCCGGCC CCAGGGACCCCCGATGATGCCACCTTACCCTGGTCCCGGACATTGCCATCAACAGCTGAACAGCCTGCCCACCATGGAAGGACCCCCAAC CTTCAACCCGCCTGTGCCATATTTCGGGAGGCTGCAAGGAGGGCTCACAGCTCGAAGAACCATCATCATCAAGGGCTATGTGCCTCCCAC AGGCAAGAGCTTTGCTATCAACTTCAAGGTGGGCTCCTCAGGGGACATAGCTCTGCACATTAATCCCCGCATGGGCAACGGTACCGTGGT CCGGAACAGCCTTCTGAATGGCTCGTGGGGATCCGAGGAGAAGAAGATCACCCACAACCCATTTGGTCCCGGACAGTTCTTTGATCTGTC CATTCGCTGTGGCTTGGATCGCTTCAAGGTTTACGCCAATGGCCAGCACCTCTTTGACTTTGCCCATCGCCTCTCGGCCTTCCAGAGGGT GGACACATTGGAAATCCAGGGTGATGTCACCTTGTCCTATGTCCAGATCTAATCTATTCCTGGGGCCATAACTCATGGGAAAACAGAATT |
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FusionGenePPI for LPHN1_LGALS4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LPHN1 | APC, CACNA1A, ELAVL1, PSMA3, CD1B, NRG1, TMEM30A, VSIG4, FAM189A2, EDIL3, FLRT1, FAM189B, PCDHGB1, TMEM30B, CLEC2D, ZNRF4, B4GAT1, UPK1A, GPR21, PCDHA12, VNN2, NRN1, ATP6V0D1, TMPRSS11B, TRIM25 | LGALS4 | ARPC3, RRAS2, MLH1, CFTR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LPHN1_LGALS4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LPHN1_LGALS4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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