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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19982

FusionGeneSummary for LPAR6_TPP2

check button Fusion gene summary
Fusion gene informationFusion gene name: LPAR6_TPP2
Fusion gene ID: 19982
HgeneTgene
Gene symbol

LPAR6

TPP2

Gene ID

10161

7174

Gene namelysophosphatidic acid receptor 6tripeptidyl peptidase 2
SynonymsARWH1|HYPT8|LAH3|P2RY5|P2Y5TPP-2|TPP-II|TPPII
Cytomap

13q14.2

13q33.1

Type of geneprotein-codingprotein-coding
Descriptionlysophosphatidic acid receptor 6G-protein coupled purinergic receptor P2Y5LPA receptor 6LPA-6P2Y purinoceptor 5RB intron encoded G-protein coupled receptoroleoyl-L-alpha-lysophosphatidic acid receptorpurinergic receptor 5purinergic receptor P2Y G tripeptidyl-peptidase 2tripeptidyl aminopeptidasetripeptidyl-peptidase II
Modification date2018052320180519
UniProtAcc

P43657

P29144

Ensembl transtripts involved in fusion geneENST00000378434, ENST00000345941, 
ENST00000465365, 
ENST00000376065, 
ENST00000376052, ENST00000466153, 
Fusion gene scores* DoF score3 X 2 X 2=122 X 2 X 2=8
# samples 32
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: LPAR6 [Title/Abstract] AND TPP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-4Z-AA7Q-01ALPAR6chr13

48986557

-TPP2chr13

103257143

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000378434ENST00000376065LPAR6chr13

48986557

-TPP2chr13

103257143

+
intron-3CDSENST00000378434ENST00000376052LPAR6chr13

48986557

-TPP2chr13

103257143

+
intron-intronENST00000378434ENST00000466153LPAR6chr13

48986557

-TPP2chr13

103257143

+
intron-3CDSENST00000345941ENST00000376065LPAR6chr13

48986557

-TPP2chr13

103257143

+
intron-3CDSENST00000345941ENST00000376052LPAR6chr13

48986557

-TPP2chr13

103257143

+
intron-intronENST00000345941ENST00000466153LPAR6chr13

48986557

-TPP2chr13

103257143

+
intron-3CDSENST00000465365ENST00000376065LPAR6chr13

48986557

-TPP2chr13

103257143

+
intron-3CDSENST00000465365ENST00000376052LPAR6chr13

48986557

-TPP2chr13

103257143

+
intron-intronENST00000465365ENST00000466153LPAR6chr13

48986557

-TPP2chr13

103257143

+

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FusionProtFeatures for LPAR6_TPP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LPAR6

P43657

TPP2

P29144

Component of the proteolytic cascade acting downstreamof the 26S proteasome in the ubiquitin-proteasome pathway. May beable to complement the 26S proteasome function to some extentunder conditions in which the latter is inhibited. Stimulatesadipogenesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LPAR6_TPP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LPAR6_TPP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LPAR6RARS2, ARL5B, LMBRD2, ATP8B2, TTI1, ZDHHC17, KDELR3, ATM, LRIG3, IPO11, COG1, VMP1, BDH1, PKP2, ATL3, TNPO2, TYK2, JAK1, TMEM184B, NLRX1, INTS3, MTX3, EXOC2, FASTKD1, PDXDC1, ERBB2, GLMN, ALG10, ND1, FAM126A, KNTC1, DEGS1, CAV1, DMD, STK17B, SLC25A24, ABCB8, LPCAT3, ARL6IP5, TSPAN15, WRB, LMBR1, PTPRD, ATL2, STX10, GPR89B, TUBGCP3, PXMP2, BRAT1, SLC7A3, SFXN5, SLC5A3, ORAI1, RAB32, ABHD17A, SLC38A2, NDUFC2TPP2SIRT7, CDK2, PLOD2, PPP1R12A, TRIM47, EHHADH, POLB, PPP1R16A, NXF1, DOK3, CHIA, C9orf41, DENND2D, CYP1A1, ADAM8, HK2, TIPRL, CSE1L, MSH2, NTRK1, KRAS, SCLT1, NANOG, POU5F1, PTPRD, RALB, ALOX5, GTF2E2, SNRNP27, PCDHGB4, NAA40, KBTBD7, KLHL36, CDH19, MTNR1A, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LPAR6_TPP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LPAR6_TPP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLPAR6C1854310Hypotrichosis simplex1CTD_human;ORPHANET
HgeneLPAR6C3279470HYPOTRICHOSIS 81UNIPROT