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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19959

FusionGeneSummary for LONP2_CHRM3

check button Fusion gene summary
Fusion gene informationFusion gene name: LONP2_CHRM3
Fusion gene ID: 19959
HgeneTgene
Gene symbol

LONP2

CHRM3

Gene ID

83752

1131

Gene namelon peptidase 2, peroxisomalcholinergic receptor muscarinic 3
SynonymsLONP|LONPL|PLON|PSLONEGBRS|HM3|PBS
Cytomap

16q12.1

1q43

Type of geneprotein-codingprotein-coding
Descriptionlon protease homolog 2, peroxisomallon protease 2lon protease-like protein 2peroxisomal LON protease likeperoxisomal Lon protease homolog 2muscarinic acetylcholine receptor M3acetylcholine receptor, muscarinic 3m3 muscarinic receptor
Modification date2018052320180523
UniProtAcc

Q86WA8

P20309

Ensembl transtripts involved in fusion geneENST00000285737, ENST00000535754, 
ENST00000564259, 
ENST00000468573, 
ENST00000255380, 
Fusion gene scores* DoF score5 X 3 X 4=6012 X 12 X 4=576
# samples 413
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/576*10)=-2.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LONP2 [Title/Abstract] AND CHRM3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-S9-A89Z-01ALONP2chr16

48368269

+CHRM3chr1

240070733

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000285737ENST00000468573LONP2chr16

48368269

+CHRM3chr1

240070733

+
5CDS-5UTRENST00000285737ENST00000255380LONP2chr16

48368269

+CHRM3chr1

240070733

+
5CDS-intronENST00000535754ENST00000468573LONP2chr16

48368269

+CHRM3chr1

240070733

+
5CDS-5UTRENST00000535754ENST00000255380LONP2chr16

48368269

+CHRM3chr1

240070733

+
intron-intronENST00000564259ENST00000468573LONP2chr16

48368269

+CHRM3chr1

240070733

+
intron-5UTRENST00000564259ENST00000255380LONP2chr16

48368269

+CHRM3chr1

240070733

+

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FusionProtFeatures for LONP2_CHRM3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LONP2

Q86WA8

CHRM3

P20309

ATP-dependent serine protease that mediates theselective degradation of misfolded and unassembled polypeptides inthe peroxisomal matrix. Necessary for type 2 peroxisome targetingsignal (PTS2)-containing protein processing and facilitatesperoxisome matrix protein import (By similarity). May indirectlyregulate peroxisomal fatty acid beta-oxidation through degradationof the self-processed forms of TYSND1. {ECO:0000255|HAMAP-Rule:MF_03121, ECO:0000269|PubMed:22002062}. The muscarinic acetylcholine receptor mediates variouscellular responses, including inhibition of adenylate cyclase,breakdown of phosphoinositides and modulation of potassiumchannels through the action of G proteins. Primary transducingeffect is Pi turnover. {ECO:0000269|PubMed:7565628}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LONP2_CHRM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LONP2_CHRM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LONP2AMOT, ELAVL1, PEX5, WWOX, OS9, RSPH9, IL17A, DCN, FBXW11, MTMR10, PCDHA12, IL1R2, DKK3, TMOD3, CDC16, MAP7D2, PCDHA4, PCDHA9, SUCLA2, TRIM25CHRM3ARF1, ARF6, CSNK1A1, SET, ATP1A4, TUBA3C, CCRN4L, PLD2, SLC4A7, FARP2, HEATR3, CAV1, YIPF4, GTPBP2, PTRH2, DCP2, IPO9, GBF1, USP46, GPN3, IPO13, DYM, STARD3, HOOK2, EXOC2, TUBA4A, PI4KA, ATL2, FASTKD1, TTI1, DNAJA3, FTSJ1, CAND2, TUBB3, C1orf112, LRP10, PIK3CB, JPH1, PPP6R1, LTN1, TUBB8, PIGX, PBXIP1, C10orf35, IPO7, ARL10, TELO2, NARS2, FLT4, STX18


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LONP2_CHRM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCHRM3P20309DB00185CevimelineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00202SuccinylcholineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00246ZiprasidoneMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00280DisopyramideMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00321AmitriptylineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00332Ipratropium bromideMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00340MetixeneMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00363ClozapineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00376TrihexyphenidylMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00383OxyphencyclimineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00387ProcyclidineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00408LoxapineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00411CarbacholMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00424HyoscyamineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00434CyproheptadineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00458ImipramineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00540NortriptylineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00725Homatropine MethylbromideMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00777PropiomazineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00835BrompheniramineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB01019BethanecholMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB01224QuetiapineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB01226MivacuriumMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB01337PancuroniumMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB01338PipecuroniumMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB01409TiotropiumMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB01591SolifenacinMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB03128AcetylcholineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB04843MepenzolateMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB06702FesoterodineMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB06787HexocycliumMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB08897AclidiniumMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB09076UmeclidiniumMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB09167DosulepinMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB09357DexpanthenolMuscarinic acetylcholine receptor M3small moleculeapproved
TgeneCHRM3P20309DB00193TramadolMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB00334OlanzapineMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB00496DarifenacinMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB00622NicardipineMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB00715ParoxetineMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB00747ScopolamineMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB00809TropicamideMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB00934MaprotilineMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB01036TolterodineMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB01062OxybutyninMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB01069PromethazineMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB01085PilocarpineMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB01142DoxepinMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB01151DesipramineMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB01238AripiprazoleMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB01403MethotrimeprazineMuscarinic acetylcholine receptor M3small moleculeapproved|investigational
TgeneCHRM3P20309DB00477ChlorpromazineMuscarinic acetylcholine receptor M3small moleculeapproved|investigational|vet_approved
TgeneCHRM3P20309DB00986GlycopyrroniumMuscarinic acetylcholine receptor M3small moleculeapproved|investigational|vet_approved
TgeneCHRM3P20309DB09300ButylscopolamineMuscarinic acetylcholine receptor M3small moleculeapproved|investigational|vet_approved
TgeneCHRM3P20309DB01239ChlorprothixeneMuscarinic acetylcholine receptor M3small moleculeapproved|investigational|withdrawn
TgeneCHRM3P20309DB00420PromazineMuscarinic acetylcholine receptor M3small moleculeapproved|vet_approved
TgeneCHRM3P20309DB00572AtropineMuscarinic acetylcholine receptor M3small moleculeapproved|vet_approved
TgeneCHRM3P20309DB00599ThiopentalMuscarinic acetylcholine receptor M3small moleculeapproved|vet_approved
TgeneCHRM3P20309DB01625IsopropamideMuscarinic acetylcholine receptor M3small moleculeapproved|vet_approved
TgeneCHRM3P20309DB00342TerfenadineMuscarinic acetylcholine receptor M3small moleculeapproved|withdrawn

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RelatedDiseases for LONP2_CHRM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHRM3C0003962Ascites1CTD_human
TgeneCHRM3C0005586Bipolar Disorder1PSYGENET
TgeneCHRM3C0005686Urinary Bladder Diseases1CTD_human
TgeneCHRM3C0010417Cryptorchidism1CTD_human;HPO
TgeneCHRM3C0023890Liver Cirrhosis1CTD_human
TgeneCHRM3C0033770Prune Belly Syndrome1CTD_human;HPO;ORPHANET
TgeneCHRM3C0041696Unipolar Depression1PSYGENET
TgeneCHRM3C0525045Mood Disorders1PSYGENET
TgeneCHRM3C1269683Major Depressive Disorder1PSYGENET
TgeneCHRM3C4277682Chemical and Drug Induced Liver Injury1CTD_human