|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 19927 |
FusionGeneSummary for LMTK3_NOSIP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LMTK3_NOSIP | Fusion gene ID: 19927 | Hgene | Tgene | Gene symbol | LMTK3 | NOSIP | Gene ID | 114783 | 51070 |
| Gene name | lemur tyrosine kinase 3 | nitric oxide synthase interacting protein | |
| Synonyms | LMR3|PPP1R101|TYKLM3 | CGI-25 | |
| Cytomap | 19q13.33 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase LMTK3protein phosphatase 1, regulatory subunit 101 | nitric oxide synthase-interacting proteinE3 ubiquitin-protein ligase NOSIPRING-type E3 ubiquitin transferase NOSIPeNOS-interacting protein | |
| Modification date | 20180519 | 20180524 | |
| UniProtAcc | Q96Q04 | Q9Y314 | |
| Ensembl transtripts involved in fusion gene | ENST00000600059, ENST00000270238, | ENST00000339093, ENST00000596358, ENST00000391853, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 2 X 5=50 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/50*10)=0 | |
| Context | PubMed: LMTK3 [Title/Abstract] AND NOSIP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LMTK3 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Tgene | NOSIP | GO:0043086 | negative regulation of catalytic activity | 11149895 |
| Tgene | NOSIP | GO:0051001 | negative regulation of nitric-oxide synthase activity | 11149895 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-IR-A3LH-01A | LMTK3 | chr19 | 49000650 | - | NOSIP | chr19 | 50063949 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000600059 | ENST00000339093 | LMTK3 | chr19 | 49000650 | - | NOSIP | chr19 | 50063949 | - |
| 5CDS-5UTR | ENST00000600059 | ENST00000596358 | LMTK3 | chr19 | 49000650 | - | NOSIP | chr19 | 50063949 | - |
| 5CDS-5UTR | ENST00000600059 | ENST00000391853 | LMTK3 | chr19 | 49000650 | - | NOSIP | chr19 | 50063949 | - |
| 5CDS-5UTR | ENST00000270238 | ENST00000339093 | LMTK3 | chr19 | 49000650 | - | NOSIP | chr19 | 50063949 | - |
| 5CDS-5UTR | ENST00000270238 | ENST00000596358 | LMTK3 | chr19 | 49000650 | - | NOSIP | chr19 | 50063949 | - |
| 5CDS-5UTR | ENST00000270238 | ENST00000391853 | LMTK3 | chr19 | 49000650 | - | NOSIP | chr19 | 50063949 | - |
Top |
FusionProtFeatures for LMTK3_NOSIP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LMTK3 | NOSIP |
| Protein kinase which phosphorylates ESR1 (in vitro) andprotects it against proteasomal degradation. May also regulateESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where itdecreases the activity of PKC and the phosphorylation of AKT,thereby increasing binding of transcriptional activator FOXO3 tothe ESR1 promoter and increasing ESR1 transcription(PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).{ECO:0000250|UniProtKB:Q5XJV6, ECO:0000269|PubMed:21602804}. | E3 ubiquitin-protein ligase that is essential for properdevelopment of the forebrain, the eye, and the face. Catalyzesmonoubiquitination of serine/threonine-protein phosphatase 2A(PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negativelyregulates nitric oxide production by inducing NOS1 and NOS3translocation to actin cytoskeleton and inhibiting their enzymaticactivity (PubMed:11149895, PubMed:15548660, PubMed:16135813).{ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895,ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for LMTK3_NOSIP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for LMTK3_NOSIP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LMTK3 | ZBTB16, REV3L, MYC | NOSIP | EPOR, CUL3, KPNA1, NOS3, DDX42, HECW2, WWOX, POLL, SLC25A21, FAM212B, TNNC2, NEU2, HMCES, ATR, DDX17, NF1, MCM2, OTUB1, PPP2CA, PPP2CB, PPP2R1A, PPP2R2A, UBE2D3, EGFR, CUL5, PTPN11, FOXA1, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for LMTK3_NOSIP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for LMTK3_NOSIP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|