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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19908

FusionGeneSummary for LMO2_RNF126

check button Fusion gene summary
Fusion gene informationFusion gene name: LMO2_RNF126
Fusion gene ID: 19908
HgeneTgene
Gene symbol

LMO2

RNF126

Gene ID

4005

55658

Gene nameLIM domain only 2ring finger protein 126
SynonymsLMO-2|RBTN2|RBTNL1|RHOM2|TTG2-
Cytomap

11p13

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionrhombotin-2LIM domain only protein 2T-cell translocation gene 2T-cell translocation protein 2cysteine-rich protein TTG-2rhombotin-like 1E3 ubiquitin-protein ligase RNF126
Modification date2018052220180523
UniProtAcc

P25791

Q9BV68

Ensembl transtripts involved in fusion geneENST00000395833, ENST00000257818, 
ENST00000493667, 
ENST00000292363, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 2 X 4=32
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LMO2 [Title/Abstract] AND RNF126 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLMO2

GO:0042789

mRNA transcription by RNA polymerase II

16314316

HgeneLMO2

GO:0045944

positive regulation of transcription by RNA polymerase II

16314316

HgeneLMO2

GO:0097067

cellular response to thyroid hormone stimulus

19375645

TgeneRNF126

GO:0006511

ubiquitin-dependent protein catabolic process

24981174

TgeneRNF126

GO:0006513

protein monoubiquitination

23277564

TgeneRNF126

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

24981174


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC013977LMO2chr11

33880912

-RNF126chr19

663177

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000395833ENST00000292363LMO2chr11

33880912

-RNF126chr19

663177

-
intron-5UTRENST00000257818ENST00000292363LMO2chr11

33880912

-RNF126chr19

663177

-
intron-5UTRENST00000493667ENST00000292363LMO2chr11

33880912

-RNF126chr19

663177

-

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FusionProtFeatures for LMO2_RNF126


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMO2

P25791

RNF126

Q9BV68

Acts with TAL1/SCL to regulate red blood celldevelopment. Also acts with LDB1 to maintain erythroid precursorsin an immature state. E3 ubiquitin-protein ligase that mediates ubiquitinationoF target proteins (PubMed:23277564, PubMed:24275455,PubMed:24981174). Depending on the associated E2 ligase, mediates'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (Bysimilarity). Part of a BAG6-dependent quality control processensuring that proteins of the secretory pathway that aremislocalized to the cytosol are degraded by the proteasome.Probably acts by providing the ubiquitin ligase activityassociated with the BAG6 complex and be responsible forubiquitination of the hydrophobic mislocalized proteins and theirtargeting to the proteasome (PubMed:24981174, PubMed:29042515).May also play a role in the endosomal recycling of IGF2R, thecation-independent mannose-6-phosphate receptor (PubMed:24275455).May play a role in the endosomal sorting and degradation ofseveral membrane receptors including EGFR, FLT3, MET and CXCR4, bymediating their ubiquitination (PubMed:23418353). Byubiquitinating CDKN1A/p21 and targeting it for degradation, mayalso promote cell proliferation (PubMed:23026136). Maymonoubiquitinate AICDA (PubMed:23277564).{ECO:0000250|UniProtKB:Q91YL2, ECO:0000269|PubMed:23277564,ECO:0000269|PubMed:23418353, ECO:0000269|PubMed:24275455,ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:29042515,ECO:0000305|PubMed:23026136}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LMO2_RNF126


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LMO2_RNF126


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LMO2_RNF126


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LMO2_RNF126


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLMO2C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
HgeneLMO2C0023492Leukemia, T-Cell1CTD_human
HgeneLMO2C0023893Liver Cirrhosis, Experimental1CTD_human