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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19891

FusionGeneSummary for LMF1_KLC2

check button Fusion gene summary
Fusion gene informationFusion gene name: LMF1_KLC2
Fusion gene ID: 19891
HgeneTgene
Gene symbol

LMF1

KLC2

Gene ID

64788

147700

Gene namelipase maturation factor 1kinesin light chain 3
SynonymsC16orf26|HMFN1876|JFP11|TMEM112|TMEM112AKLC2|KLC2L|KLCt|KNS2B
Cytomap

16p13.3

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionlipase maturation factor 1transmembrane protein 112kinesin light chain 3kinesin light chain 2
Modification date2018052320180519
UniProtAcc

Q96S06

Q9H0B6

Ensembl transtripts involved in fusion geneENST00000262301, ENST00000399843, 
ENST00000543238, ENST00000568897, 
ENST00000568268, ENST00000539379, 
ENST00000417856, ENST00000394067, 
ENST00000421552, ENST00000316924, 
ENST00000394078, ENST00000394066, 
ENST00000394065, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 3=48
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LMF1 [Title/Abstract] AND KLC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB046524LMF1chr16

1025938

+KLC2chr11

66035106

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000262301ENST00000417856LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000262301ENST00000394067LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000262301ENST00000421552LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000262301ENST00000316924LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000262301ENST00000394078LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000262301ENST00000394066LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000262301ENST00000394065LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000399843ENST00000417856LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000399843ENST00000394067LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000399843ENST00000421552LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000399843ENST00000316924LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000399843ENST00000394078LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000399843ENST00000394066LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000399843ENST00000394065LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000543238ENST00000417856LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000543238ENST00000394067LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000543238ENST00000421552LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000543238ENST00000316924LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000543238ENST00000394078LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000543238ENST00000394066LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000543238ENST00000394065LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568897ENST00000417856LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568897ENST00000394067LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568897ENST00000421552LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568897ENST00000316924LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568897ENST00000394078LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568897ENST00000394066LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568897ENST00000394065LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568268ENST00000417856LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568268ENST00000394067LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568268ENST00000421552LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568268ENST00000316924LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568268ENST00000394078LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568268ENST00000394066LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000568268ENST00000394065LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000539379ENST00000417856LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000539379ENST00000394067LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000539379ENST00000421552LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000539379ENST00000316924LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000539379ENST00000394078LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000539379ENST00000394066LMF1chr16

1025938

+KLC2chr11

66035106

+
intron-3UTRENST00000539379ENST00000394065LMF1chr16

1025938

+KLC2chr11

66035106

+

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FusionProtFeatures for LMF1_KLC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMF1

Q96S06

KLC2

Q9H0B6

Involved in the maturation of specific proteins in theendoplasmic reticulum. Required for maturation and transport ofactive lipoprotein lipase (LPL) through the secretory pathway.Each LMF1 molecule chaperones 50 or more molecules of LPL.{ECO:0000250|UniProtKB:Q3U3R4, ECO:0000269|PubMed:24909692}. Kinesin is a microtubule-associated force-producingprotein that may play a role in organelle transport. The lightchain may function in coupling of cargo to the heavy chain or inthe modulation of its ATPase activity (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LMF1_KLC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LMF1_KLC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LMF1_KLC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LMF1_KLC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLMF1C0020557Hypertriglyceridemia1CTD_human