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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 19876

FusionGeneSummary for LMBR1_UBE3C

check button Fusion gene summary
Fusion gene informationFusion gene name: LMBR1_UBE3C
Fusion gene ID: 19876
HgeneTgene
Gene symbol

LMBR1

UBE3C

Gene ID

64327

9690

Gene namelimb development membrane protein 1ubiquitin protein ligase E3C
SynonymsACHP|C7orf2|DIF14|LSS|PPD2|THYP|TPT|ZRSHECTH2
Cytomap

7q36.3

7q36.3

Type of geneprotein-codingprotein-coding
Descriptionlimb region 1 protein homologdifferentiation-related gene 14 proteinlimb region 1 homologubiquitin-protein ligase E3CHECT-type ubiquitin transferase E3Cubiquitin-protein isopeptide ligase (E3)
Modification date2018051920180523
UniProtAcc

Q8WVP7

Q15386

Ensembl transtripts involved in fusion geneENST00000353442, ENST00000359422, 
ENST00000354505, ENST00000540390, 
ENST00000430825, 		ENST00000348165, 
ENST00000389103, 
Fusion gene scores* DoF score7 X 5 X 7=2456 X 6 X 3=108
# samples 106
** MAII scorelog2(10/245*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LMBR1 [Title/Abstract] AND UBE3C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBE3C

GO:0000209

protein polyubiquitination

11278995


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A6Z0-01ALMBR1chr7

156685622

-UBE3Cchr7

156979528

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000353442ENST00000348165LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
In-frameENST00000353442ENST00000389103LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
intron-3CDSENST00000359422ENST00000348165LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
intron-3CDSENST00000359422ENST00000389103LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
In-frameENST00000354505ENST00000348165LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
In-frameENST00000354505ENST00000389103LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
In-frameENST00000540390ENST00000348165LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
In-frameENST00000540390ENST00000389103LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
intron-3CDSENST00000430825ENST00000348165LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
intron-3CDSENST00000430825ENST00000389103LMBR1chr7

156685622

-UBE3Cchr7

156979528

+

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FusionProtFeatures for LMBR1_UBE3C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMBR1

Q8WVP7

UBE3C

Q15386

Putative membrane receptor. E3 ubiquitin-protein ligase that accepts ubiquitin fromthe E2 ubiquitin-conjugating enzyme UBE2D1 in the form of athioester and then directly transfers the ubiquitin to targetedsubstrates. Can assemble unanchored poly-ubiquitin chains ineither 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Haspreference for 'Lys-48' linkages. It can target itself forubiquitination in vitro and may promote its own degradation invivo. {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129,ECO:0000269|PubMed:16341092, ECO:0000269|PubMed:16601690}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-1171_1922491Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-1181_1922532Topological domainExtracellular
TgeneUBE3Cchr7:156685622chr7:156979528ENST00000348165+823744_10833811084DomainHECT
TgeneUBE3Cchr7:156685622chr7:156979528ENST00000389103+69744_1083338405DomainHECT

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117250_28722491Coiled coilOntology_term=ECO:0000255
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118250_28722532Coiled coilOntology_term=ECO:0000255
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117132_15122491Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117173_18722491Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117209_29122491Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117313_33922491Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117361_38322491Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117405_42622491Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-11741_6222491Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117448_49022491Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-11784_11022491Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118132_15122532Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118173_18722532Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118209_29122532Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118313_33922532Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118361_38322532Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118405_42622532Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-11841_6222532Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118448_49022532Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-11884_11022532Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117111_13122491TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117152_17222491TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117188_20822491TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-11720_4022491TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117292_31222491TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117340_36022491TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117384_40422491TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117427_44722491TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-11763_8322491TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118111_13122532TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118152_17222532TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118188_20822532TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-11820_4022532TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118292_31222532TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118340_36022532TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118384_40422532TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118427_44722532TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-11863_8322532TransmembraneHelical
TgeneUBE3Cchr7:156685622chr7:156979528ENST00000348165+82345_743811084DomainIQ
TgeneUBE3Cchr7:156685622chr7:156979528ENST00000389103+6945_74338405DomainIQ
TgeneUBE3Cchr7:156685622chr7:156979528ENST00000348165+8231_603811084RegionNote=Cis-determinant of acceptor ubiquitin-binding
TgeneUBE3Cchr7:156685622chr7:156979528ENST00000389103+691_60338405RegionNote=Cis-determinant of acceptor ubiquitin-binding


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FusionGeneSequence for LMBR1_UBE3C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LMBR1_ENST00000353442_chr7_156685622_-_UBE3C_ENST00000348165_chr7_156979528_+_725aa
MEGQDEVSAREQHFHSQVRESTEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMVQHRMMVPKVRLLYSL
AFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTL
EELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLS
EQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPF
LDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQML
VGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQV
VELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSAD
HPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAG

>In-frame_LMBR1_ENST00000353442_chr7_156685622_-_UBE3C_ENST00000389103_chr7_156979528_+_89aa

>In-frame_LMBR1_ENST00000354505_chr7_156685622_-_UBE3C_ENST00000348165_chr7_156979528_+_725aa
MEGQDEVSAREQHFHSQVRESTEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMVQHRMMVPKVRLLYSL
AFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTL
EELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLS
EQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPF
LDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQML
VGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQV
VELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSAD
HPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAG

>In-frame_LMBR1_ENST00000354505_chr7_156685622_-_UBE3C_ENST00000389103_chr7_156979528_+_89aa

>In-frame_LMBR1_ENST00000540390_chr7_156685622_-_UBE3C_ENST00000348165_chr7_156979528_+_728aa
MKEDGRAGRGVGAGAALPQPSAGVHGGWQTVSIIHNRGMPEEAGHKAADQHPAQPGVEGLCERGGLHHHGLRLPHADGAAPHDGTQSQAS
LQFSLXCQVSETSLVSNIFHVNTDDHRVYGTVASGDIQGFSYVFXRFXSNHPTLLSFXLLVXSFTNFHTXXRILRXSHRSCRSKTIINDA
FYFRRADNVVSMPSRCMPGDHQVGLSRNQARSSRRIYYSISEYWSYYXLXNATMHTDGTEKMDSVIXGYHQSSENVEVQRHEEKFLSSKP
LAVRTRRYXSRXGHSALCASIQTCVEVPADGEDRPAAVHPGRGFGVPAAVCVXGKTACCPDRVAFCGSIXGTSKDLSEVDLCRXARSSRR
WSISGWNXCHNKKKLHLXRCLXQTFSRKXAXFEKADPCALAQCPWPGXSWHXWWWYFQRVFKXTTEVRIXPQPGVLXDYXXRASVPQPGC
SDACGRFFCQTLLLPRQNAWKGSLXEHAGGAALCRLLSFQVAWNQCRRGHSPPRLPRPXGVXEFALSEELRRRCGGAWAELHCGEQXPGR
GAGSXTKIRWERHPCHQRQPDCVHPLGGRLQAEQADPPALPGFPPGPCQCRQPRVAPNVXSARNSGINFWCTSSHKPRGPKILYKLFRRL
FCRPSCYXGLLESCGRVHXXRKAQTAEVCNKLLSTPSLGVXGVVSRILYSQRRLRPXAAPHSQHLHEPAEAPRVLXRDTFAKXTSLCDXM

>In-frame_LMBR1_ENST00000540390_chr7_156685622_-_UBE3C_ENST00000389103_chr7_156979528_+_92aa
MKEDGRAGRGVGAGAALPQPSAGVHGGWQTVSIIHNRGMPEEAGHKAADQHPAQPGVEGLCERGGLHHHGLRLPHADGAAPHDGTQSQGV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LMBR1_ENST00000353442_chr7_156685622_-_UBE3C_ENST00000348165_chr7_156979528_+_2175nt
ATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCAGTATCA
TACATAACAGAGGAATGCCTGAAGAAGCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCGAGCGAG
GAGGTCTTCACCACCATGGCCTCCGTCTGCCACACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGCTTCTCTACAGTTTA
GCCTTTAATGCCAGGTTTCTGAGACATCTTTGGTTTCTAATATCTTCCATGTCAACACGGATGATCACAGGGTCTATGGTACCGTTGCTT
CAGGTGATATCCAGGGGTTCTCCTATGTCTTTTGAAGATTCTAGTCGAATCATCCCACTCTTTTATCTTTTTAGCTCCTTGTTTAGTCAT
TCACTAATTTCCATACATGATAACGAATTCTTCGGTGATCCCATAGAAGTTGTAGGTCAAAGACAATCATCAATGATGCCTTTTACTTTA
GAAGAGCTGATAATGTTGTCTCGATGCCTTCGAGATGCATGCCTGGGGATCATCAAGTTGGCTTATCCAGAAACCAAGCCAGAAGTTCGA
GAAGAATATATTACAGCATTTCAGAGTATTGGAGTTACTACTAGCTCTGAAATGCAACAATGCATACAGATGGAACAGAAAAGATGGATT
CAGTTATTTAAGGTTATCACCAATCTAGTGAAAATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCA
GAACAAGAAGATATTAAAGCAGATAAGGTCACTCAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATA
GGCCCGCTGCAGTCCACCCTGGACGTGGGTTTGGAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTG
CCTTTTGTGGTTCCATTTGAGGAACGAGTAAAGATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTT
CTGGATGGAATTAATGTCACAATAAGAAGAAATTACATTTATGAAGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAA
AAGCGGATCCGTGTGCACTTGCTCAATGCCCATGGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAA
CTACTGAAGTCAGGATTTAACCCCAACCAGGGGTTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTT
GTGGGAGATTCTTTTGCCAGACATTACTACTTCCTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTT
GCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACCAGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAAT
TTGCTCTTTCTGAAGAGCTACGAAGACGATGTGGAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTA
GTTGAACTAAAATTCGGTGGGAAAGACATCCCTGTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGGCTGAAC
AGGCAGATCCGCCAGCACTGCCTGGCTTTCCGCCAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAA
ATTCAGGTATTAATTTCTGGTGCACAAGTTCCCATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCTGCAGAC
CATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCT
CGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGC
ACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGC

>In-frame_LMBR1_ENST00000353442_chr7_156685622_-_UBE3C_ENST00000389103_chr7_156979528_+_267nt
ATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCAGTATCA
TACATAACAGAGGAATGCCTGAAGAAGCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCGAGCGAG

>In-frame_LMBR1_ENST00000354505_chr7_156685622_-_UBE3C_ENST00000348165_chr7_156979528_+_2175nt
ATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCAGTATCA
TACATAACAGAGGAATGCCTGAAGAAGCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCGAGCGAG
GAGGTCTTCACCACCATGGCCTCCGTCTGCCACACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGCTTCTCTACAGTTTA
GCCTTTAATGCCAGGTTTCTGAGACATCTTTGGTTTCTAATATCTTCCATGTCAACACGGATGATCACAGGGTCTATGGTACCGTTGCTT
CAGGTGATATCCAGGGGTTCTCCTATGTCTTTTGAAGATTCTAGTCGAATCATCCCACTCTTTTATCTTTTTAGCTCCTTGTTTAGTCAT
TCACTAATTTCCATACATGATAACGAATTCTTCGGTGATCCCATAGAAGTTGTAGGTCAAAGACAATCATCAATGATGCCTTTTACTTTA
GAAGAGCTGATAATGTTGTCTCGATGCCTTCGAGATGCATGCCTGGGGATCATCAAGTTGGCTTATCCAGAAACCAAGCCAGAAGTTCGA
GAAGAATATATTACAGCATTTCAGAGTATTGGAGTTACTACTAGCTCTGAAATGCAACAATGCATACAGATGGAACAGAAAAGATGGATT
CAGTTATTTAAGGTTATCACCAATCTAGTGAAAATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCA
GAACAAGAAGATATTAAAGCAGATAAGGTCACTCAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATA
GGCCCGCTGCAGTCCACCCTGGACGTGGGTTTGGAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTG
CCTTTTGTGGTTCCATTTGAGGAACGAGTAAAGATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTT
CTGGATGGAATTAATGTCACAATAAGAAGAAATTACATTTATGAAGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAA
AAGCGGATCCGTGTGCACTTGCTCAATGCCCATGGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAA
CTACTGAAGTCAGGATTTAACCCCAACCAGGGGTTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTT
GTGGGAGATTCTTTTGCCAGACATTACTACTTCCTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTT
GCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACCAGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAAT
TTGCTCTTTCTGAAGAGCTACGAAGACGATGTGGAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTA
GTTGAACTAAAATTCGGTGGGAAAGACATCCCTGTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGGCTGAAC
AGGCAGATCCGCCAGCACTGCCTGGCTTTCCGCCAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAA
ATTCAGGTATTAATTTCTGGTGCACAAGTTCCCATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCTGCAGAC
CATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCT
CGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGC
ACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGC

>In-frame_LMBR1_ENST00000354505_chr7_156685622_-_UBE3C_ENST00000389103_chr7_156979528_+_267nt
ATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCAGTATCA
TACATAACAGAGGAATGCCTGAAGAAGCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCGAGCGAG

>In-frame_LMBR1_ENST00000540390_chr7_156685622_-_UBE3C_ENST00000348165_chr7_156979528_+_2185nt
ATGAAGGAGGATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACT
GTCAGTATCATACATAACAGAGGAATGCCTGAAGAAGCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTC
TGCGAGCGAGGAGGTCTTCACCACCATGGCCTCCGTCTGCCACACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGCTTCT
CTACAGTTTAGCCTTTAATGCCAGGTTTCTGAGACATCTTTGGTTTCTAATATCTTCCATGTCAACACGGATGATCACAGGGTCTATGGT
ACCGTTGCTTCAGGTGATATCCAGGGGTTCTCCTATGTCTTTTGAAGATTCTAGTCGAATCATCCCACTCTTTTATCTTTTTAGCTCCTT
GTTTAGTCATTCACTAATTTCCATACATGATAACGAATTCTTCGGTGATCCCATAGAAGTTGTAGGTCAAAGACAATCATCAATGATGCC
TTTTACTTTAGAAGAGCTGATAATGTTGTCTCGATGCCTTCGAGATGCATGCCTGGGGATCATCAAGTTGGCTTATCCAGAAACCAAGCC
AGAAGTTCGAGAAGAATATATTACAGCATTTCAGAGTATTGGAGTTACTACTAGCTCTGAAATGCAACAATGCATACAGATGGAACAGAA
AAGATGGATTCAGTTATTTAAGGTTATCACCAATCTAGTGAAAATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCA
CTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAAGGTCACTCAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGAT
GGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGTGGGTTTGGAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCT
GACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACGAGTAAAGATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGA
TGGTCCATTTCTGGATGGAATTAATGTCACAATAAGAAGAAATTACATTTATGAAGATGCTTATGACAAACTTTCTCCAGAAAATGAGCC
TGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAATGCCCATGGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTT
TTTAAATGAACTACTGAAGTCAGGATTTAACCCCAACCAGGGGTTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGC
TCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTACTACTTCCTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGA
GCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACCAGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGACCCTGAGGT
GTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGACGATGTGGAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGACCTGGGAGA
GGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGACATCCCTGTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGTGGCAGACTA
CAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGCTTTCCGCCAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGA
TCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACAAGTTCCCATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTCAGGAGGCTA
TTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAAC
AAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCC
CACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATG

>In-frame_LMBR1_ENST00000540390_chr7_156685622_-_UBE3C_ENST00000389103_chr7_156979528_+_277nt
ATGAAGGAGGATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACT
GTCAGTATCATACATAACAGAGGAATGCCTGAAGAAGCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTC
TGCGAGCGAGGAGGTCTTCACCACCATGGCCTCCGTCTGCCACACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGGTGTA


* Fusion transcript sequences (Full-length transcript).
>In-frame_LMBR1_ENST00000353442_chr7_156685622_-_UBE3C_ENST00000348165_chr7_156979528_+_4029nt
GCCCCGCCCCCGCCCCGCCCCCGACTGCGCGGCGCCCGCCCTCCCTTAGTCAGAGCTGCTCGTCTGAGGCTGCTGAGGCGACGGCCGGTG
TCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCCGGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGGCGGGCGG
ACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGAAGGAGGATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAG
CAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCAGTATCATACATAACAGAGGAATGCCTGAAGAAGCTGGAC
ACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCGAGCGAGGAGGTCTTCACCACCATGGCCTCCGTCTGCCAC
ACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGCTTCTCTACAGTTTAGCCTTTAATGCCAGGTTTCTGAGACATCTTTGG
TTTCTAATATCTTCCATGTCAACACGGATGATCACAGGGTCTATGGTACCGTTGCTTCAGGTGATATCCAGGGGTTCTCCTATGTCTTTT
GAAGATTCTAGTCGAATCATCCCACTCTTTTATCTTTTTAGCTCCTTGTTTAGTCATTCACTAATTTCCATACATGATAACGAATTCTTC
GGTGATCCCATAGAAGTTGTAGGTCAAAGACAATCATCAATGATGCCTTTTACTTTAGAAGAGCTGATAATGTTGTCTCGATGCCTTCGA
GATGCATGCCTGGGGATCATCAAGTTGGCTTATCCAGAAACCAAGCCAGAAGTTCGAGAAGAATATATTACAGCATTTCAGAGTATTGGA
GTTACTACTAGCTCTGAAATGCAACAATGCATACAGATGGAACAGAAAAGATGGATTCAGTTATTTAAGGTTATCACCAATCTAGTGAAA
ATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAAGGTCACT
CAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGTGGGTTTG
GAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACGAGTAAAG
ATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAGAAGAAAT
TACATTTATGAAGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAATGCCCAT
GGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAACCAGGGG
TTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTACTACTTC
CTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACC
AGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGACGATGTG
GAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGACATCCCT
GTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGCTTTCCGC
CAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACAAGTTCCC
ATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTG
GAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTAT
CCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTC
TATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAG
ACCCCTACAGAGAACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAG
CTCCTTCTTTCATTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTT
TTCAAATAACTTAAAATAACACGTTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCT
CAGTGAAATTAACCAAAGATGAAGCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGG
GCTGCACAGGCGGCAGAGATACAGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCAT
TATTAAAACTGAAGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGT
GCTTTTTAAGCCATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGT
GGATGTGAGGTGGGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCT
GCCAAGCTACTGCAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAA
GTGGCGGCTGCATCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCT
TCCTGGATATTTGGGGGTGACTCGCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCAC
ATCCAGGGAAGAGGAGTGTCGGTAGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAG
AAAGCGTTTCAAAGCGTCAGCTGTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTAT
GTCTCGTATTTTACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGA
ATGACACTTTTAAGACAATGAACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTA
GTCTTGATATACAGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATT
TGTATATTTTATTAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATT

>In-frame_LMBR1_ENST00000353442_chr7_156685622_-_UBE3C_ENST00000389103_chr7_156979528_+_837nt
GCCCCGCCCCCGCCCCGCCCCCGACTGCGCGGCGCCCGCCCTCCCTTAGTCAGAGCTGCTCGTCTGAGGCTGCTGAGGCGACGGCCGGTG
TCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCCGGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGGCGGGCGG
ACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGAAGGAGGATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAG
CAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCAGTATCATACATAACAGAGGAATGCCTGAAGAAGCTGGAC
ACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCGAGCGAGGAGGTCTTCACCACCATGGCCTCCGTCTGCCAC
ACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGGTGTACAAATGAATGTGGAGACCTTTGTACCCTGACATGGAAAGATTT
CCGAGACAGATGCGTACATGAAAACCGGGAAGACACAGGACAGTATGTAGAAGAACCGGCTTTTCCTATAAGAAGGATGGAAAAAATAGG
AATATATATTCATATTGCATAAAGAAACTTGGAAGCATATACAAGAAACTCATGAAAGTGAACACTCGTGTCTGAATATGCCGAGGAAGC
TGGGGCTGGAGCAGAAGTGCTCTTCTGAGTACACTATTTTTATATCACTTTTAAGTTTTGGATTAGGTGAATGACTTAATATTTTAAAAT

>In-frame_LMBR1_ENST00000354505_chr7_156685622_-_UBE3C_ENST00000348165_chr7_156979528_+_3946nt
GCCGGTGTCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCCGGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGG
CGGGCGGACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGAAGGAGGATGGAAGGGCAGGACGAGGTGTCGGC
GCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCAGTATCATACATAACAGAGGAATGCCTGAAGAA
GCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCGAGCGAGGAGGTCTTCACCACCATGGCCTCCGT
CTGCCACACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGCTTCTCTACAGTTTAGCCTTTAATGCCAGGTTTCTGAGACA
TCTTTGGTTTCTAATATCTTCCATGTCAACACGGATGATCACAGGGTCTATGGTACCGTTGCTTCAGGTGATATCCAGGGGTTCTCCTAT
GTCTTTTGAAGATTCTAGTCGAATCATCCCACTCTTTTATCTTTTTAGCTCCTTGTTTAGTCATTCACTAATTTCCATACATGATAACGA
ATTCTTCGGTGATCCCATAGAAGTTGTAGGTCAAAGACAATCATCAATGATGCCTTTTACTTTAGAAGAGCTGATAATGTTGTCTCGATG
CCTTCGAGATGCATGCCTGGGGATCATCAAGTTGGCTTATCCAGAAACCAAGCCAGAAGTTCGAGAAGAATATATTACAGCATTTCAGAG
TATTGGAGTTACTACTAGCTCTGAAATGCAACAATGCATACAGATGGAACAGAAAAGATGGATTCAGTTATTTAAGGTTATCACCAATCT
AGTGAAAATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAA
GGTCACTCAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGT
GGGTTTGGAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACG
AGTAAAGATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAG
AAGAAATTACATTTATGAAGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAA
TGCCCATGGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAA
CCAGGGGTTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTA
CTACTTCCTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCT
TGGAACCAGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGA
CGATGTGGAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGA
CATCCCTGTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGC
TTTCCGCCAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACA
AGTTCCCATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAG
AGTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGA
GTTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCC
CGAGTTCTATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTG
GGGTCAGACCCCTACAGAGAACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTC
TCCTAAGCTCCTTCTTTCATTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGAC
ATTGCTTTTCAAATAACTTAAAATAACACGTTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGT
GGCATCTCAGTGAAATTAACCAAAGATGAAGCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTC
AGACAGGGCTGCACAGGCGGCAGAGATACAGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAA
GCCTCATTATTAAAACTGAAGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTT
TATTTGTGCTTTTTAAGCCATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATAC
TGTCTGTGGATGTGAGGTGGGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGG
AGGGTCTGCCAAGCTACTGCAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTG
AACCAAAGTGGCGGCTGCATCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCA
CTTGTCTTCCTGGATATTTGGGGGTGACTCGCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCT
GGTGCACATCCAGGGAAGAGGAGTGTCGGTAGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTA
CAAACAGAAAGCGTTTCAAAGCGTCAGCTGTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCT
CTTCTATGTCTCGTATTTTACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGA
AAGCTGAATGACACTTTTAAGACAATGAACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCT
ATTTGTAGTCTTGATATACAGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTA
GTTAATTTGTATATTTTATTAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTC

>In-frame_LMBR1_ENST00000354505_chr7_156685622_-_UBE3C_ENST00000389103_chr7_156979528_+_754nt
GCCGGTGTCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCCGGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGG
CGGGCGGACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGAAGGAGGATGGAAGGGCAGGACGAGGTGTCGGC
GCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCAGTATCATACATAACAGAGGAATGCCTGAAGAA
GCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCGAGCGAGGAGGTCTTCACCACCATGGCCTCCGT
CTGCCACACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGGTGTACAAATGAATGTGGAGACCTTTGTACCCTGACATGGA
AAGATTTCCGAGACAGATGCGTACATGAAAACCGGGAAGACACAGGACAGTATGTAGAAGAACCGGCTTTTCCTATAAGAAGGATGGAAA
AAATAGGAATATATATTCATATTGCATAAAGAAACTTGGAAGCATATACAAGAAACTCATGAAAGTGAACACTCGTGTCTGAATATGCCG
AGGAAGCTGGGGCTGGAGCAGAAGTGCTCTTCTGAGTACACTATTTTTATATCACTTTTAAGTTTTGGATTAGGTGAATGACTTAATATT

>In-frame_LMBR1_ENST00000540390_chr7_156685622_-_UBE3C_ENST00000348165_chr7_156979528_+_3978nt
AGAGCTGCTCGTCTGAGGCTGCTGAGGCGACGGCCGGTGTCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCC
GGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGGCGGGCGGACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGA
AGGAGGATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCA
GTATCATACATAACAGAGGAATGCCTGAAGAAGCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCG
AGCGAGGAGGTCTTCACCACCATGGCCTCCGTCTGCCACACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGCTTCTCTAC
AGTTTAGCCTTTAATGCCAGGTTTCTGAGACATCTTTGGTTTCTAATATCTTCCATGTCAACACGGATGATCACAGGGTCTATGGTACCG
TTGCTTCAGGTGATATCCAGGGGTTCTCCTATGTCTTTTGAAGATTCTAGTCGAATCATCCCACTCTTTTATCTTTTTAGCTCCTTGTTT
AGTCATTCACTAATTTCCATACATGATAACGAATTCTTCGGTGATCCCATAGAAGTTGTAGGTCAAAGACAATCATCAATGATGCCTTTT
ACTTTAGAAGAGCTGATAATGTTGTCTCGATGCCTTCGAGATGCATGCCTGGGGATCATCAAGTTGGCTTATCCAGAAACCAAGCCAGAA
GTTCGAGAAGAATATATTACAGCATTTCAGAGTATTGGAGTTACTACTAGCTCTGAAATGCAACAATGCATACAGATGGAACAGAAAAGA
TGGATTCAGTTATTTAAGGTTATCACCAATCTAGTGAAAATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGG
CTGTCAGAACAAGAAGATATTAAAGCAGATAAGGTCACTCAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGG
AGGATAGGCCCGCTGCAGTCCACCCTGGACGTGGGTTTGGAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACA
GAGTTGCCTTTTGTGGTTCCATTTGAGGAACGAGTAAAGATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGT
CCATTTCTGGATGGAATTAATGTCACAATAAGAAGAAATTACATTTATGAAGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGAT
TTGAAAAAGCGGATCCGTGTGCACTTGCTCAATGCCCATGGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTA
AATGAACTACTGAAGTCAGGATTTAACCCCAACCAGGGGTTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAG
ATGCTTGTGGGAGATTCTTTTGCCAGACATTACTACTTCCTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTG
CCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACCAGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTAT
AAGAATTTGCTCTTTCTGAAGAGCTACGAAGACGATGTGGAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCG
CAGGTAGTTGAACTAAAATTCGGTGGGAAAGACATCCCTGTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGG
CTGAACAGGCAGATCCGCCAGCACTGCCTGGCTTTCCGCCAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAG
CAAGAAATTCAGGTATTAATTTCTGGTGCACAAGTTCCCATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCT
GCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGC
TGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACA
GCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCC
GCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCCCTACAGAGAACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCC
ACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTCATTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTT
TTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACTTAAAATAACACGTTATGTGCCATGTGGCTACTTTAGTAAT
ATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTAACCAAAGATGAAGCTTTGGCTTTGCTGGTGAGATCAGAGC
CCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGCGGCAGAGATACAGGGTCTGAGGGCTGAGACGCCATGGGGC
CGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTGAAGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTA
GGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTTTTTAAGCCATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATA
CCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGATGTGAGGTGGGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGT
GCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCAAGCTACTGCAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAG
GACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGCATCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATC
CGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATTTGGGGGTGACTCGCCATGCTTGGCACCCTCTGCTTCCTGG
TGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAGAGGAGTGTCGGTAGTTCTTGCAGTAGGCACTTTATCAGGA
CCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCAAAGCGTCAGCTGTGGGAGCAGAGTGACCCTTTGCTGATGC
TGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTTTACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTG
ACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGACACTTTTAAGACAATGAACATTATCAAAACAAAATGTATAATTTCTT
AATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCTTGATATACAGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGG
TTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTATATTTTATTAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAA
TTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATTTATTTATTTGTATGTTCTAATGGCTAAACATTTACATTAA

>In-frame_LMBR1_ENST00000540390_chr7_156685622_-_UBE3C_ENST00000389103_chr7_156979528_+_786nt
AGAGCTGCTCGTCTGAGGCTGCTGAGGCGACGGCCGGTGTCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCC
GGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGGCGGGCGGACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGA
AGGAGGATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCA
GTATCATACATAACAGAGGAATGCCTGAAGAAGCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCG
AGCGAGGAGGTCTTCACCACCATGGCCTCCGTCTGCCACACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGGTGTACAAA
TGAATGTGGAGACCTTTGTACCCTGACATGGAAAGATTTCCGAGACAGATGCGTACATGAAAACCGGGAAGACACAGGACAGTATGTAGA
AGAACCGGCTTTTCCTATAAGAAGGATGGAAAAAATAGGAATATATATTCATATTGCATAAAGAAACTTGGAAGCATATACAAGAAACTC
ATGAAAGTGAACACTCGTGTCTGAATATGCCGAGGAAGCTGGGGCTGGAGCAGAAGTGCTCTTCTGAGTACACTATTTTTATATCACTTT


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FusionGenePPI for LMBR1_UBE3C


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LMBR1EFNB2, ASGR2, GPR52, LPAR6, P2RY12, LYPD3, EDNRA, GPR84, PTGER3, ZACN, LPAR1, TMEM155, LYPD6, EGFR, DPEP1, IPPK, GRPR, GPR21, CLEC2D, LRFN4, LRRC8B, STS, HTR3A, PCDHAC2, GPR161, VNN2, UXS1, S1PR1, SLC22A9, ST3GAL1, TNFRSF1A, C3AR1, FRMD3, YIPF3, TACR1, FAM189B, FPR2, LMNAUBE3CPSMD2, PSMC5, PSMD6, CAND2, MYC, RAD21, ELAVL1, UBC, PSMA2, UBE3C, UBE2D1, UBE2L3, APP, THOC2, RBM15, THOC7, WDR74, KDM1A, PHKA2, CPEB4, USP13, UTRN, ECT2, MTA2, TLK1, EEF2K, PANK4, WDR92, SHFM1, PSMD14, GOLGA2, UBE2D2, EFNB2, VSIG4, SCN2B, NTRK1, ANXA7, UBE2D3, ESR1, CCNB1, FAF2, FAM3C, KIAA1467, TRIM25, MTA1, PCBP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LMBR1_UBE3C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LMBR1_UBE3C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUBE3CC3495559Juvenile arthritis1CTD_human