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Fusion gene ID: 19865 |
FusionGeneSummary for LMAN2_SPOCK1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: LMAN2_SPOCK1 | Fusion gene ID: 19865 | Hgene | Tgene | Gene symbol | LMAN2 | SPOCK1 | Gene ID | 10960 | 6695 |
Gene name | lectin, mannose binding 2 | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 | |
Synonyms | C5orf8|GP36B|VIP36 | SPOCK|TESTICAN|TIC1 | |
Cytomap | 5q35.3 | 5q31.2 | |
Type of gene | protein-coding | protein-coding | |
Description | vesicular integral-membrane protein VIP36glycoprotein GP36bvesicular integral protein of 36 kDavesicular integral-membrane protein 36 | testican-1SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q12907 | Q08629 | |
Ensembl transtripts involved in fusion gene | ENST00000303127, ENST00000515209, ENST00000506310, | ENST00000394945, ENST00000282223, ENST00000509978, | |
Fusion gene scores | * DoF score | 7 X 3 X 7=147 | 4 X 4 X 2=32 |
# samples | 7 | 4 | |
** MAII score | log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: LMAN2 [Title/Abstract] AND SPOCK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SPOCK1 | GO:0010812 | negative regulation of cell-substrate adhesion | 12853036 |
Tgene | SPOCK1 | GO:0010951 | negative regulation of endopeptidase activity | 14511383 |
Tgene | SPOCK1 | GO:0010977 | negative regulation of neuron projection development | 12853036 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | KIRC | TCGA-BP-4986-01A | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000303127 | ENST00000394945 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
Frame-shift | ENST00000303127 | ENST00000282223 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
5CDS-intron | ENST00000303127 | ENST00000509978 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
Frame-shift | ENST00000515209 | ENST00000394945 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
Frame-shift | ENST00000515209 | ENST00000282223 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
5CDS-intron | ENST00000515209 | ENST00000509978 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
intron-3CDS | ENST00000506310 | ENST00000394945 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
intron-3CDS | ENST00000506310 | ENST00000282223 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
intron-intron | ENST00000506310 | ENST00000509978 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
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FusionProtFeatures for LMAN2_SPOCK1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
LMAN2 | SPOCK1 |
Plays a role as an intracellular lectin in the earlysecretory pathway. Interacts with N-acetyl-D-galactosamine andhigh-mannose type glycans and may also bind to O-linked glycans.Involved in the transport and sorting of glycoproteins carryinghigh mannose-type glycans (By similarity). {ECO:0000250}. | May play a role in cell-cell and cell-matrixinteractions. May contribute to various neuronal mechanisms in thecentral nervous system. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LMAN2_SPOCK1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LMAN2_SPOCK1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LMAN2 | ISG15, ATP13A2, FLOT1, UBL4A, ATP4A, FRAT1, MAPK9, SUPT5H, RPA3, RPA2, RPA1, MOV10, NXF1, CCDC8, HEATR3, PLXNB2, CENPH, GPC3, TTYH3, CACNA2D1, NDUFS2, PDIA6, TM9SF4, NDUFS3, TMED10, TMED2, NTRK1, SPPL2B | SPOCK1 | ELAVL1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LMAN2_SPOCK1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LMAN2_SPOCK1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SPOCK1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |