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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19858

FusionGeneSummary for LMAN2L_MRPS5

check button Fusion gene summary
Fusion gene informationFusion gene name: LMAN2L_MRPS5
Fusion gene ID: 19858
HgeneTgene
Gene symbol

LMAN2L

MRPS5

Gene ID

81562

64969

Gene namelectin, mannose binding 2 likemitochondrial ribosomal protein S5
SynonymsMRT52|VIPLMRP-S5|S5mt
Cytomap

2q11.2

2q11.1

Type of geneprotein-codingprotein-coding
DescriptionVIP36-like proteinLMAN2-like protein28S ribosomal protein S5, mitochondrialmitochondrial 28S ribosomal protein S5mitochondrial small ribosomal subunit protein uS5m
Modification date2018052320180523
UniProtAcc

Q9H0V9

P82675

Ensembl transtripts involved in fusion geneENST00000264963, ENST00000377079, 
ENST00000426463, ENST00000537039, 
ENST00000534882, 
ENST00000475040, 
ENST00000272418, 
Fusion gene scores* DoF score4 X 3 X 5=604 X 4 X 2=32
# samples 54
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LMAN2L [Title/Abstract] AND MRPS5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-LL-A7T0-01ALMAN2Lchr2

97399256

-MRPS5chr2

95774153

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264963ENST00000475040LMAN2Lchr2

97399256

-MRPS5chr2

95774153

-
5CDS-intronENST00000264963ENST00000272418LMAN2Lchr2

97399256

-MRPS5chr2

95774153

-
5CDS-intronENST00000377079ENST00000475040LMAN2Lchr2

97399256

-MRPS5chr2

95774153

-
5CDS-intronENST00000377079ENST00000272418LMAN2Lchr2

97399256

-MRPS5chr2

95774153

-
intron-intronENST00000426463ENST00000475040LMAN2Lchr2

97399256

-MRPS5chr2

95774153

-
intron-intronENST00000426463ENST00000272418LMAN2Lchr2

97399256

-MRPS5chr2

95774153

-
5CDS-intronENST00000537039ENST00000475040LMAN2Lchr2

97399256

-MRPS5chr2

95774153

-
5CDS-intronENST00000537039ENST00000272418LMAN2Lchr2

97399256

-MRPS5chr2

95774153

-
intron-intronENST00000534882ENST00000475040LMAN2Lchr2

97399256

-MRPS5chr2

95774153

-
intron-intronENST00000534882ENST00000272418LMAN2Lchr2

97399256

-MRPS5chr2

95774153

-

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FusionProtFeatures for LMAN2L_MRPS5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMAN2L

Q9H0V9

MRPS5

P82675

May be involved in the regulation of export from theendoplasmic reticulum of a subset of glycoproteins. May functionas a regulator of ERGIC-53. {ECO:0000269|PubMed:12878160}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LMAN2L_MRPS5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LMAN2L_MRPS5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LMAN2LZDHHC17, ASGR2, PLVAP, ACOT13, PTGS2, CNTNAP1, ABCA2, ITGA1, SUSD1, TMEM245, TOR1B, LINGO1, TENM3, ANO6, LNPEP, ACP2, CACNA2D1, KIAA0319L, COLEC12, ADAM17, ARSK, TXNDC15, TRDN, ENPP4, TTC17, LINGO2, RNF149, MRC2, TSPAN3, UGT8, MFAP3, CD1E, CLUMRPS5DDX56, ICT1, CUL3, CAND1, MRPS35, MRPL24, MRPS10, TUFM, EEF2, CORO1C, TMEM43, GALNT2, ILF3, UQCRFS1P1, FLOT1, ZMPSTE24, SDHB, C1QBP, TP53, MOV10, NXF1, NOL12, RPL13, TRA2A, RPL6, MRPS2, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZBTB38, ZNF707, LUC7L, MRPS31, MRPS9, MRPS26, PTCD3, MRPS23, MRPS27, DAP3, MRPS18C, MRPS7, MRPS22, MRPS15, MRPS25, MRPS33, MRPS11, MRPS24, RPL23, RPL17, NTRK1, SNX3, MZT1, MRPS34, AURKAIP1, ZBTB48, E4F1, RBM42, PDGFB, HNRNPR, CCDC59, ZNF263, ZFC3H1, RPL18, ZNF331, RPF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LMAN2L_MRPS5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LMAN2L_MRPS5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLMAN2LC0005586Bipolar Disorder1PSYGENET
HgeneLMAN2LC0007134Renal Cell Carcinoma1CTD_human
HgeneLMAN2LC0036341Schizophrenia1PSYGENET
HgeneLMAN2LC4225168MENTAL RETARDATION, AUTOSOMAL RECESSIVE 521UNIPROT