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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19840

FusionGeneSummary for LLGL2_EXOC7

check button Fusion gene summary
Fusion gene informationFusion gene name: LLGL2_EXOC7
Fusion gene ID: 19840
HgeneTgene
Gene symbol

LLGL2

EXOC7

Gene ID

3993

23265

Gene nameLLGL2, scribble cell polarity complex componentexocyst complex component 7
SynonymsHGL|Hugl-2|LGL22-5-3p|BLOM4|EX070|EXO70|EXOC1|Exo70p|YJL085W
Cytomap

17q25.1

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionlethal(2) giant larvae protein homolog 2human giant larvae homologlethal giant larvae homolog 2, scribble cell polarity complex componentexocyst complex component 7exocyst complex component Exo70
Modification date2018052320180522
UniProtAcc

Q6P1M3

Q9UPT5

Ensembl transtripts involved in fusion geneENST00000167462, ENST00000375227, 
ENST00000392550, ENST00000578363, 
ENST00000577200, 
ENST00000607838, 
ENST00000591724, ENST00000332065, 
ENST00000589210, ENST00000335146, 
ENST00000467929, ENST00000405575, 
ENST00000411744, ENST00000406660, 
Fusion gene scores* DoF score12 X 12 X 8=11525 X 4 X 5=100
# samples 145
** MAII scorelog2(14/1152*10)=-3.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LLGL2 [Title/Abstract] AND EXOC7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLLGL2

GO:0032878

regulation of establishment or maintenance of cell polarity

12725730


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-E7-A5KE-01ALLGL2chr17

73521906

+EXOC7chr17

74083801

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000167462ENST00000607838LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000167462ENST00000591724LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000167462ENST00000332065LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000167462ENST00000589210LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000167462ENST00000335146LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000167462ENST00000467929LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000167462ENST00000405575LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000167462ENST00000411744LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000167462ENST00000406660LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-3CDSENST00000375227ENST00000607838LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000375227ENST00000591724LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000375227ENST00000332065LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000375227ENST00000589210LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000375227ENST00000335146LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000375227ENST00000467929LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000375227ENST00000405575LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000375227ENST00000411744LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000375227ENST00000406660LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-3CDSENST00000392550ENST00000607838LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000392550ENST00000591724LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000392550ENST00000332065LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000392550ENST00000589210LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000392550ENST00000335146LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000392550ENST00000467929LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000392550ENST00000405575LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000392550ENST00000411744LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000392550ENST00000406660LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-3CDSENST00000578363ENST00000607838LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000578363ENST00000591724LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000578363ENST00000332065LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000578363ENST00000589210LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000578363ENST00000335146LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000578363ENST00000467929LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000578363ENST00000405575LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000578363ENST00000411744LLGL2chr17

73521906

+EXOC7chr17

74083801

-
5UTR-intronENST00000578363ENST00000406660LLGL2chr17

73521906

+EXOC7chr17

74083801

-
intron-3CDSENST00000577200ENST00000607838LLGL2chr17

73521906

+EXOC7chr17

74083801

-
intron-intronENST00000577200ENST00000591724LLGL2chr17

73521906

+EXOC7chr17

74083801

-
intron-intronENST00000577200ENST00000332065LLGL2chr17

73521906

+EXOC7chr17

74083801

-
intron-intronENST00000577200ENST00000589210LLGL2chr17

73521906

+EXOC7chr17

74083801

-
intron-intronENST00000577200ENST00000335146LLGL2chr17

73521906

+EXOC7chr17

74083801

-
intron-intronENST00000577200ENST00000467929LLGL2chr17

73521906

+EXOC7chr17

74083801

-
intron-intronENST00000577200ENST00000405575LLGL2chr17

73521906

+EXOC7chr17

74083801

-
intron-intronENST00000577200ENST00000411744LLGL2chr17

73521906

+EXOC7chr17

74083801

-
intron-intronENST00000577200ENST00000406660LLGL2chr17

73521906

+EXOC7chr17

74083801

-

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FusionProtFeatures for LLGL2_EXOC7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LLGL2

Q6P1M3

EXOC7

Q9UPT5

Part of a complex with GPSM2/LGN, PRKCI/aPKC andPARD6B/Par-6, which may ensure the correct organization andorientation of bipolar spindles for normal cell division. Thiscomplex plays roles in the initial phase of the establishment ofepithelial cell polarity. {ECO:0000269|PubMed:15632202}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LLGL2_EXOC7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LLGL2_EXOC7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LLGL2PARD6B, PARD6G, PARD6A, PRKCI, LLGL2, PRKCZ, IFI30, BAG5, STUB1, DNAJA1, DNAJA2, DNAJB1, KBTBD7, NUDC, RAD18, SQSTM1, SUGT1, TIMM13, PTEN, CCNB1, LYST, ATF2, BPTF, MTOR, MAP3K1, ALDH18A1, RBBP6, ST5, SVIL, TAF9, SF1, BAG6, MKNK1, EXO1, NOLC1, ZNHIT3, VPRBP, HMGXB4, DNM1L, ABCA7, CASC3, PALLD, ZC3H3, KIAA0556, DAPK2, ATP5S, ECSIT, PHF21A, EPB41L4B, C11orf57, IMP3, IMPACT, IWS1, RNF20, BIRC6, PLEKHG1, RBM26, PHACTR4, BHLHE41, GCC1, ZNF668, KIAA1715, FIP1L1, CD99L2, ZNF707, FMN1, BRWD3, ZMYND8, GSE1, ZNF592, TOPORS, CACTIN, ZNF687, PPFIA1, DDA1, TRIM26, C1QBP, HMG20A, UBE2O, C18orf25, NKTR, HMG20B, NKAP, RCOR3, CSNK2A1, KBTBD6, UBE2A, RAB30, NEK7, RCOR1, GTPBP4, THRAP3, DIEXFEXOC7RHOQ, HGS, ZC3H14, KXD1, IFT20, RTN4IP1, CCDC85B, USHBP1, PRPF19, DLG3, GRIN2B, EXOC4, AKTIP, CDC5L, DISC1, DTNBP1, EXOC2, EXOC5, KIF5B, BBS1, BBS2, BBS4, EGFR, SMARCE1, TRAF4, SSC5D, SHMT2, MOV10, NXF1, CD274, CA14, PNKD, DSN1, IFT57, SCN2B, EXOC6, EXOC6B, EXOC3, FAM103A1, MINA, EXOC8, NTRK1, SNW1, CDC73, IL1R2, COG6, EXOC1, STX11, EPHA1, FCGRT, ABI2, SIGLECL1, POC1B, PTRF, TSKS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LLGL2_EXOC7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LLGL2_EXOC7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource