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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19829

FusionGeneSummary for LITAF_DBNL

check button Fusion gene summary
Fusion gene informationFusion gene name: LITAF_DBNL
Fusion gene ID: 19829
HgeneTgene
Gene symbol

LITAF

DBNL

Gene ID

9516

28988

Gene namelipopolysaccharide induced TNF factordrebrin like
SynonymsPIG7|SIMPLE|TP53I7ABP1|HIP-55|HIP55|SH3P7
Cytomap

16p13.13

7p13

Type of geneprotein-codingprotein-coding
Descriptionlipopolysaccharide-induced tumor necrosis factor-alpha factorLPS-induced TNF-alpha factorlipopolysaccharide-induced TNF-alpha factorp53-induced gene 7 proteinsmall integral membrane protein of lysosome/late endosometumor protein p53 inducible proteindrebrin-like proteinHPK1-interacting protein of 55 kDaSH3 domain-containing protein 7actin-binding protein 1cervical SH3P7cervical mucin-associated proteindrebrin-Fsrc homology 3 domain-containing protein HIP-55
Modification date2018052220180522
UniProtAcc

Q99732

Q9UJU6

Ensembl transtripts involved in fusion geneENST00000571688, ENST00000413364, 
ENST00000339430, ENST00000381810, 
ENST00000570904, ENST00000571459, 
ENST00000572255, ENST00000576036, 
ENST00000574763, ENST00000571976, 
ENST00000574703, 
ENST00000448521, 
ENST00000456905, ENST00000440166, 
ENST00000452943, ENST00000468694, 
ENST00000494774, ENST00000490734, 
ENST00000497184, 
Fusion gene scores* DoF score5 X 5 X 3=753 X 3 X 1=9
# samples 53
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LITAF [Title/Abstract] AND DBNL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE830303LITAFchr16

11642974

-DBNLchr7

44085791

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000571688ENST00000448521LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571688ENST00000456905LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571688ENST00000440166LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571688ENST00000452943LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571688ENST00000468694LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571688ENST00000494774LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571688ENST00000490734LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571688ENST00000497184LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000413364ENST00000448521LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000413364ENST00000456905LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000413364ENST00000440166LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000413364ENST00000452943LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000413364ENST00000468694LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000413364ENST00000494774LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000413364ENST00000490734LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000413364ENST00000497184LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000339430ENST00000448521LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000339430ENST00000456905LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000339430ENST00000440166LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000339430ENST00000452943LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000339430ENST00000468694LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000339430ENST00000494774LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000339430ENST00000490734LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000339430ENST00000497184LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000381810ENST00000448521LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000381810ENST00000456905LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000381810ENST00000440166LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000381810ENST00000452943LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000381810ENST00000468694LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000381810ENST00000494774LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000381810ENST00000490734LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000381810ENST00000497184LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000570904ENST00000448521LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000570904ENST00000456905LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000570904ENST00000440166LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000570904ENST00000452943LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000570904ENST00000468694LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000570904ENST00000494774LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000570904ENST00000490734LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000570904ENST00000497184LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571459ENST00000448521LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571459ENST00000456905LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571459ENST00000440166LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571459ENST00000452943LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571459ENST00000468694LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571459ENST00000494774LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571459ENST00000490734LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571459ENST00000497184LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000572255ENST00000448521LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000572255ENST00000456905LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000572255ENST00000440166LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000572255ENST00000452943LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000572255ENST00000468694LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000572255ENST00000494774LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000572255ENST00000490734LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000572255ENST00000497184LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000576036ENST00000448521LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000576036ENST00000456905LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000576036ENST00000440166LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000576036ENST00000452943LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000576036ENST00000468694LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000576036ENST00000494774LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000576036ENST00000490734LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000576036ENST00000497184LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574763ENST00000448521LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574763ENST00000456905LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574763ENST00000440166LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574763ENST00000452943LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574763ENST00000468694LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574763ENST00000494774LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574763ENST00000490734LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574763ENST00000497184LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571976ENST00000448521LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571976ENST00000456905LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571976ENST00000440166LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571976ENST00000452943LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571976ENST00000468694LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571976ENST00000494774LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571976ENST00000490734LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000571976ENST00000497184LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574703ENST00000448521LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574703ENST00000456905LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574703ENST00000440166LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574703ENST00000452943LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574703ENST00000468694LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574703ENST00000494774LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574703ENST00000490734LITAFchr16

11642974

-DBNLchr7

44085791

+
intron-intronENST00000574703ENST00000497184LITAFchr16

11642974

-DBNLchr7

44085791

+

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FusionProtFeatures for LITAF_DBNL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LITAF

Q99732

DBNL

Q9UJU6

Plays a role in endosomal protein trafficking and intargeting proteins for lysosomal degradation (PubMed:23166352).Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomaldegradation, and thereby helps downregulate downstream signalingcascades (PubMed:23166352). Helps recruit the ESCRT complexcomponents TSG101, HGS and STAM to cytoplasmic membranes(PubMed:23166352). Probably plays a role in regulating proteindegradation via its interaction with NEDD4 (PubMed:15776429). Mayalso contribute to the regulation of gene expression in thenucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro)and may play a synergistic role with STAT6 in the nucleus inregulating the expression of various cytokines (PubMed:15793005).May regulate the expression of numerous cytokines, such as TNF,CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294,PubMed:15793005). {ECO:0000269|PubMed:15793005,ECO:0000269|PubMed:23166352, ECO:0000303|PubMed:15776429,ECO:0000305|PubMed:10200294}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LITAF_DBNL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LITAF_DBNL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LITAF_DBNL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LITAF_DBNL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLITAFC0270913Charcot-Marie-Tooth disease, Type 1C2CTD_human;ORPHANET;UNIPROT
TgeneDBNLC0005586Bipolar Disorder1PSYGENET