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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19816

FusionGeneSummary for LIPE_CEACAM1

check button Fusion gene summary
Fusion gene informationFusion gene name: LIPE_CEACAM1
Fusion gene ID: 19816
HgeneTgene
Gene symbol

LIPE

CEACAM1

Gene ID

3991

634

Gene namelipase E, hormone sensitive typecarcinoembryonic antigen related cell adhesion molecule 1
SynonymsAOMS4|FPLD6|HSL|LHSBGP|BGP1|BGPI
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionhormone-sensitive lipasehormone-sensitive lipase testicular isoformlipase, hormone-sensitivecarcinoembryonic antigen-related cell adhesion molecule 1CD66a antigenantigen CD66carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Modification date2018051920180527
UniProtAcc

Q05469

P13688

Ensembl transtripts involved in fusion geneENST00000244289, ENST00000602000, 
ENST00000352591, ENST00000351134, 
ENST00000161559, ENST00000403444, 
ENST00000403461, ENST00000488639, 
ENST00000358394, ENST00000308072, 
ENST00000599389, 
Fusion gene scores* DoF score3 X 2 X 3=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: LIPE [Title/Abstract] AND CEACAM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCEACAM1

GO:0001915

negative regulation of T cell mediated cytotoxicity

18424730

TgeneCEACAM1

GO:0030334

regulation of cell migration

16291724

TgeneCEACAM1

GO:0043318

negative regulation of cytotoxic T cell degranulation

18424730

TgeneCEACAM1

GO:0044319

wound healing, spreading of cells

16291724

TgeneCEACAM1

GO:0050860

negative regulation of T cell receptor signaling pathway

18424730


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-EE-A2MS-06ALIPEchr19

42927571

-CEACAM1chr19

43016631

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000244289ENST00000352591LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-3CDSENST00000244289ENST00000351134LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-3CDSENST00000244289ENST00000161559LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-3CDSENST00000244289ENST00000403444LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-3CDSENST00000244289ENST00000403461LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-intronENST00000244289ENST00000488639LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-intronENST00000244289ENST00000358394LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-intronENST00000244289ENST00000308072LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-intronENST00000244289ENST00000599389LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-3CDSENST00000602000ENST00000352591LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-3CDSENST00000602000ENST00000351134LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-3CDSENST00000602000ENST00000161559LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-3CDSENST00000602000ENST00000403444LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-3CDSENST00000602000ENST00000403461LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-intronENST00000602000ENST00000488639LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-intronENST00000602000ENST00000358394LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-intronENST00000602000ENST00000308072LIPEchr19

42927571

-CEACAM1chr19

43016631

-
intron-intronENST00000602000ENST00000599389LIPEchr19

42927571

-CEACAM1chr19

43016631

-

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FusionProtFeatures for LIPE_CEACAM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIPE

Q05469

CEACAM1

P13688

In adipose tissue and heart, it primarily hydrolyzesstored triglycerides to free fatty acids, while in steroidogenictissues, it principally converts cholesteryl esters to freecholesterol for steroid hormone production.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LIPE_CEACAM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LIPE_CEACAM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LIPENSFL1C, PTRF, PLIN1, FABP4, PLIN5, PLIN2, PLIN3, MTNR1ACEACAM1ANXA2, CEACAM8, SHC1, PTPN11, PXN, CEACAM6, CEACAM1, CARTPT, CEACAM7, CEACAM5, ADRB2, CEP57


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LIPE_CEACAM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCEACAM1P13688DB00113Technetium Tc-99m arcitumomabCarcinoembryonic antigen-related cell adhesion molecule 1 {ECO:0000303|Ref.8}biotechapproved|investigational

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RelatedDiseases for LIPE_CEACAM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCEACAM1C0000786Spontaneous abortion1CTD_human
TgeneCEACAM1C0001418Adenocarcinoma1CTD_human
TgeneCEACAM1C0024121Lung Neoplasms1CTD_human