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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19815

FusionGeneSummary for LIPE_CALM3

check button Fusion gene summary
Fusion gene informationFusion gene name: LIPE_CALM3
Fusion gene ID: 19815
HgeneTgene
Gene symbol

LIPE

CALM3

Gene ID

3991

808

Gene namelipase E, hormone sensitive typecalmodulin 3
SynonymsAOMS4|FPLD6|HSL|LHSCaM|CaMIII|HEL-S-72|PHKD|PHKD3
Cytomap

19q13.2

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionhormone-sensitive lipasehormone-sensitive lipase testicular isoformlipase, hormone-sensitivecalmodulin-3epididymis secretory protein Li 72phosphorylase kinase subunit deltaprepro-calmodulin 3
Modification date2018051920180523
UniProtAcc

Q05469

Ensembl transtripts involved in fusion geneENST00000244289, ENST00000602000, 
ENST00000391918, ENST00000291295, 
ENST00000597743, ENST00000477244, 
ENST00000598871, ENST00000594523, 
ENST00000599839, ENST00000596362, 
Fusion gene scores* DoF score3 X 2 X 3=188 X 9 X 3=216
# samples 310
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/216*10)=-1.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LIPE [Title/Abstract] AND CALM3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCALM3

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

20226167

TgeneCALM3

GO:0030801

positive regulation of cyclic nucleotide metabolic process

8631777

TgeneCALM3

GO:0032516

positive regulation of phosphoprotein phosphatase activity

8631777

TgeneCALM3

GO:0035307

positive regulation of protein dephosphorylation

8631777

TgeneCALM3

GO:0051343

positive regulation of cyclic-nucleotide phosphodiesterase activity

8631777

TgeneCALM3

GO:0051592

response to calcium ion

7607248

TgeneCALM3

GO:0060316

positive regulation of ryanodine-sensitive calcium-release channel activity

20226167


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-QQ-A8VF-01ALIPEchr19

42916517

-CALM3chr19

47109084

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000244289ENST00000391918LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-5UTRENST00000244289ENST00000291295LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-5UTRENST00000244289ENST00000597743LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-3UTRENST00000244289ENST00000477244LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-intronENST00000244289ENST00000598871LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-5UTRENST00000244289ENST00000594523LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-5UTRENST00000244289ENST00000599839LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-5UTRENST00000244289ENST00000596362LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-5UTRENST00000602000ENST00000391918LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-5UTRENST00000602000ENST00000291295LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-5UTRENST00000602000ENST00000597743LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-3UTRENST00000602000ENST00000477244LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-intronENST00000602000ENST00000598871LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-5UTRENST00000602000ENST00000594523LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-5UTRENST00000602000ENST00000599839LIPEchr19

42916517

-CALM3chr19

47109084

+
intron-5UTRENST00000602000ENST00000596362LIPEchr19

42916517

-CALM3chr19

47109084

+

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FusionProtFeatures for LIPE_CALM3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIPE

Q05469

CALM3

In adipose tissue and heart, it primarily hydrolyzesstored triglycerides to free fatty acids, while in steroidogenictissues, it principally converts cholesteryl esters to freecholesterol for steroid hormone production. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LIPE_CALM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LIPE_CALM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LIPENSFL1C, PTRF, PLIN1, FABP4, PLIN5, PLIN2, PLIN3, MTNR1ACALM3CAMK2A, RIOK3, HNF1A, PINX1, KCNQ2, MYO10, CACNA1A, PCK1, ELAVL1, ARRB2, ARRB1, CUL3, CUL4B, CCND2, LRRK2, GRB2, VAMP2, ADRB2, HECW2, APPBP2, CAMTA2, IQCE, TRIM54, CLEC7A, KIAA1683, C11orf65, MOV10, NXF1, UNK, UBE3B, CD33, MYLK3, CAMK1D, DLST, DNM1L, PDHA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LIPE_CALM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LIPE_CALM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource