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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1980

FusionGeneSummary for ANXA1_TLN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANXA1_TLN1
Fusion gene ID: 1980
HgeneTgene
Gene symbol

ANXA1

TLN1

Gene ID

301

7094

Gene nameannexin A1talin 1
SynonymsANX1|LPC1ILWEQ|TLN|talin-1
Cytomap

9q21.13

9p13.3

Type of geneprotein-codingprotein-coding
Descriptionannexin A1annexin I (lipocortin I)annexin-1calpactin IIcalpactin-2chromobindin-9phospholipase A2 inhibitory proteintalin-1
Modification date2018052220180522
UniProtAcc

P04083

Q9Y490

Ensembl transtripts involved in fusion geneENST00000257497, ENST00000376911, 
ENST00000491192, 
ENST00000314888, 
ENST00000540444, ENST00000464379, 
Fusion gene scores* DoF score4 X 4 X 2=328 X 8 X 5=320
# samples 410
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANXA1 [Title/Abstract] AND TLN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANXA1

GO:0002548

monocyte chemotaxis

15187149

HgeneANXA1

GO:0007187

G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

25664854

HgeneANXA1

GO:0008360

regulation of cell shape

15187149

HgeneANXA1

GO:0018149

peptide cross-linking

10908733

HgeneANXA1

GO:0030216

keratinocyte differentiation

10908733

HgeneANXA1

GO:0031340

positive regulation of vesicle fusion

2138016

HgeneANXA1

GO:0031532

actin cytoskeleton reorganization

15187149

HgeneANXA1

GO:0032743

positive regulation of interleukin-2 production

17008549

HgeneANXA1

GO:0035924

cellular response to vascular endothelial growth factor stimulus

22773844

HgeneANXA1

GO:0042102

positive regulation of T cell proliferation

17008549

HgeneANXA1

GO:0045627

positive regulation of T-helper 1 cell differentiation

17008549

HgeneANXA1

GO:0045629

negative regulation of T-helper 2 cell differentiation

17008549

HgeneANXA1

GO:0071385

cellular response to glucocorticoid stimulus

2936963

HgeneANXA1

GO:0071621

granulocyte chemotaxis

15187149

HgeneANXA1

GO:0090050

positive regulation of cell migration involved in sprouting angiogenesis

22773844

HgeneANXA1

GO:0090303

positive regulation of wound healing

25664854


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-MT-A51X-01AANXA1chr9

75785309

+TLN1chr9

35720506

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000257497ENST00000314888ANXA1chr9

75785309

+TLN1chr9

35720506

-
Frame-shiftENST00000257497ENST00000540444ANXA1chr9

75785309

+TLN1chr9

35720506

-
5CDS-intronENST00000257497ENST00000464379ANXA1chr9

75785309

+TLN1chr9

35720506

-
Frame-shiftENST00000376911ENST00000314888ANXA1chr9

75785309

+TLN1chr9

35720506

-
Frame-shiftENST00000376911ENST00000540444ANXA1chr9

75785309

+TLN1chr9

35720506

-
5CDS-intronENST00000376911ENST00000464379ANXA1chr9

75785309

+TLN1chr9

35720506

-
Frame-shiftENST00000491192ENST00000314888ANXA1chr9

75785309

+TLN1chr9

35720506

-
Frame-shiftENST00000491192ENST00000540444ANXA1chr9

75785309

+TLN1chr9

35720506

-
5CDS-intronENST00000491192ENST00000464379ANXA1chr9

75785309

+TLN1chr9

35720506

-

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FusionProtFeatures for ANXA1_TLN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANXA1

P04083

TLN1

Q9Y490

Plays important roles in the innate immune response aseffector of glucocorticoid-mediated responses and regulator of theinflammatory process. Has anti-inflammatory activity(PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (Bysimilarity). Promotes resolution of inflammation and wound healing(PubMed:25664854). Functions at least in part by activating theformyl peptide receptors and downstream signaling cascades(PubMed:15187149, PubMed:25664854). Promotes chemotaxis ofgranulocytes and monocytes via activation of the formyl peptidereceptors (PubMed:15187149). Contributes to the adaptive immuneresponse by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation ofactivated T-cells (PubMed:17008549). Promotes the differentiationof T-cells into Th1 cells and negatively regulates differentiationinto Th2 cells (PubMed:17008549). Has no effect on unstimulated Tcells (PubMed:17008549). Promotes rearrangement of the actincytoskeleton, cell polarization and cell migration(PubMed:15187149). Negatively regulates hormone exocytosis viaactivation of the formyl peptide receptors and reorganization ofthe actin cytoskeleton (PubMed:19625660). Has high affinity forCa(2+) and can bind up to eight Ca(2+) ions (By similarity).Displays Ca(2+)-dependent binding to phospholipid membranes(PubMed:2532504, PubMed:8557678). Plays a role in the formation ofphagocytic cups and phagosomes. Plays a role in phagocytosis bymediating the Ca(2+)-dependent interaction between phagosomes andthe actin cytoskeleton (By similarity).{ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619,ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:17008549,ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504,ECO:0000269|PubMed:25664854, ECO:0000269|PubMed:2936963,ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}. Probably involved in connections of major cytoskeletalstructures to the plasma membrane. High molecular weightcytoskeletal protein concentrated at regions of cell-substratumcontact and, in lymphocytes, at cell-cell contacts (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANXA1_TLN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANXA1_TLN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANXA1PPM1B, DLG3, S100A11, KRT8, USP25, USPL1, SLX1B, ATG4B, MGMT, UCHL5, UBE3A, CD4, UBE2I, GAPDH, KLHL23, APBB1, CSAD, C1orf123, RPA1, UNC119, OTUB1, C14orf1, XRCC6, KMT2B, CCT7, UBE2D1, COPS6, LRIF1, FAF1, ANXA1, ANXA5, SIRT7, CUL5, CDK2, IKBKG, RIPK1, RELA, ANXA4, FN1, VCAM1, ATF2, ITGA4, HMGA1, BAG3, ATP4A, YWHAQ, HECW2, WWOX, ZBTB1, MEIS2, ENO1, MOV10, NXF1, CUL7, OBSL1, SUMO2, NSL1, UCP2, SOX2, KIR2DS2, DDX19B, UGT1A10, ZSCAN20, TP53BP2, MAP1S, STK4, RASSF10, HNRNPA1, HSPB1, CEP152, CEP128, CEP89, DCTN1, KIF11, PPIA, TFG, GOLT1B, CCDC88A, USP7, MCM2, EGFR, U2AF2, ACTA1, PLA2G4A, CDC73, CDH1, GNB2, FRMD1, RPUSD3, SOD1, TRIM25, G3BP1, BRCA1TLN1ITGB3, PXN, PTK2, ITGA1, PTK2B, ITGB1, TERF2, CDK5, SMURF1, DAG1, TUBA1A, SIRT7, BLNK, CDK2, UBA1, TRIP6, IARS, NAB2, DARS, USP19, TXLNG, TXNDC12, FN1, VCAM1, EGFR, ERBB2, ITGA4, PIP5K1C, YWHAQ, FAM114A1, CC2D1B, FAF1, NUDC, PRDX4, ASB9, SHMT2, MOV10, NXF1, CUL7, OBSL1, BLVRA, CYP1A1, RGCC, NMD3, RNASEH2C, GPKOW, TTC37, WAC, NTRK1, MED4, HNRNPD, KIF11, RBM4, SORT1, VCL, SYNCRIP, MRPL50, SGTB, SAMD1, BAG6, MCM2, SNW1, CDC5L, U2AF2, SRC, CDH1, KANK4, GTF2E2, FGB, SNRNP27, MTNR1A, MTNR1B, DNM1L, DOK1, ITGB7, BRCA1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANXA1_TLN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneANXA1P04083DB00288AmcinonideAnnexin A1small moleculeapproved
HgeneANXA1P04083DB01234DexamethasoneAnnexin A1small moleculeapproved|investigational|vet_approved
HgeneANXA1P04083DB00741HydrocortisoneAnnexin A1small moleculeapproved|vet_approved

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RelatedDiseases for ANXA1_TLN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANXA1C0024667Animal Mammary Neoplasms3CTD_human
HgeneANXA1C0024668Mammary Neoplasms, Experimental2CTD_human
HgeneANXA1C0007137Squamous cell carcinoma1CTD_human
HgeneANXA1C0020538Hypertensive disease1CTD_human
HgeneANXA1C0022658Kidney Diseases1CTD_human
HgeneANXA1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneANXA1C0024232Lymphatic Metastasis1CTD_human
HgeneANXA1C0026640Mouth Neoplasms1CTD_human
HgeneANXA1C0027626Neoplasm Invasiveness1CTD_human
HgeneANXA1C0027627Neoplasm Metastasis1CTD_human
HgeneANXA1C0033578Prostatic Neoplasms1CTD_human
HgeneANXA1C0038354Stomach Diseases1CTD_human
HgeneANXA1C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneANXA1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneANXA1C0376634Craniofacial Abnormalities1CTD_human
TgeneTLN1C0027626Neoplasm Invasiveness1CTD_human
TgeneTLN1C0029456Osteoporosis1CTD_human