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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19790

FusionGeneSummary for LINC00882_SLC12A8

check button Fusion gene summary
Fusion gene informationFusion gene name: LINC00882_SLC12A8
Fusion gene ID: 19790
HgeneTgene
Gene symbol

LINC00882

SLC12A8

Gene ID

100302640

84561

Gene namelong intergenic non-protein coding RNA 882solute carrier family 12 member 8
Synonyms-CCC9
Cytomap

3q13.12

3q21.2

Type of genencRNAprotein-coding
Description-solute carrier family 12 member 8cation-chloride cotransporter 9solute carrier family 12 (sodium/potassium/chloride transporters), member 8
Modification date2018032920180523
UniProtAcc

A0AV02

Ensembl transtripts involved in fusion geneENST00000484698, ENST00000393469, 
ENST00000423114, ENST00000469902, 
ENST00000314584, ENST00000430155, 
ENST00000465475, 
Fusion gene scores* DoF score3 X 3 X 1=97 X 8 X 6=336
# samples 311
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/336*10)=-1.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LINC00882 [Title/Abstract] AND SLC12A8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF375829LINC00882chr3

106794383

+SLC12A8chr3

124806683

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000484698ENST00000393469LINC00882chr3

106794383

+SLC12A8chr3

124806683

+
intron-intronENST00000484698ENST00000423114LINC00882chr3

106794383

+SLC12A8chr3

124806683

+
intron-intronENST00000484698ENST00000469902LINC00882chr3

106794383

+SLC12A8chr3

124806683

+
intron-intronENST00000484698ENST00000314584LINC00882chr3

106794383

+SLC12A8chr3

124806683

+
intron-intronENST00000484698ENST00000430155LINC00882chr3

106794383

+SLC12A8chr3

124806683

+
intron-intronENST00000484698ENST00000465475LINC00882chr3

106794383

+SLC12A8chr3

124806683

+

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FusionProtFeatures for LINC00882_SLC12A8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LINC00882

SLC12A8

A0AV02

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LINC00882_SLC12A8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LINC00882_SLC12A8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LINC00882_SLC12A8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LINC00882_SLC12A8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource