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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19740

FusionGeneSummary for LIMK2_OSBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: LIMK2_OSBP2
Fusion gene ID: 19740
HgeneTgene
Gene symbol

LIMK2

OSBP2

Gene ID

3985

23762

Gene nameLIM domain kinase 2oxysterol binding protein 2
Synonyms-HLM|ORP-4|ORP4|OSBPL1|OSBPL4
Cytomap

22q12.2

22q12.2

Type of geneprotein-codingprotein-coding
DescriptionLIM domain kinase 2oxysterol-binding protein 2OSBP-related protein 4oxysterol binding protein-like 1oxysterol-binding protein-related protein 4
Modification date2018052320180523
UniProtAcc

P53671

Q969R2

Ensembl transtripts involved in fusion geneENST00000406516, ENST00000444929, 
ENST00000331728, ENST00000333611, 
ENST00000340552, ENST00000467301, 
ENST00000403222, ENST00000407373, 
ENST00000332585, ENST00000382310, 
ENST00000446658, ENST00000401475, 
ENST00000437268, ENST00000535268, 
ENST00000496575, 
Fusion gene scores* DoF score6 X 4 X 5=1208 X 4 X 7=224
# samples 68
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LIMK2 [Title/Abstract] AND OSBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A7-A13D-01ALIMK2chr22

31621805

+OSBP2chr22

31266416

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000406516ENST00000403222LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000406516ENST00000407373LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000406516ENST00000332585LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000406516ENST00000382310LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000406516ENST00000446658LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-5UTRENST00000406516ENST00000401475LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-5UTRENST00000406516ENST00000437268LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-intronENST00000406516ENST00000535268LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-intronENST00000406516ENST00000496575LIMK2chr22

31621805

+OSBP2chr22

31266416

+
Frame-shiftENST00000444929ENST00000403222LIMK2chr22

31621805

+OSBP2chr22

31266416

+
Frame-shiftENST00000444929ENST00000407373LIMK2chr22

31621805

+OSBP2chr22

31266416

+
Frame-shiftENST00000444929ENST00000332585LIMK2chr22

31621805

+OSBP2chr22

31266416

+
Frame-shiftENST00000444929ENST00000382310LIMK2chr22

31621805

+OSBP2chr22

31266416

+
Frame-shiftENST00000444929ENST00000446658LIMK2chr22

31621805

+OSBP2chr22

31266416

+
5CDS-5UTRENST00000444929ENST00000401475LIMK2chr22

31621805

+OSBP2chr22

31266416

+
5CDS-5UTRENST00000444929ENST00000437268LIMK2chr22

31621805

+OSBP2chr22

31266416

+
5CDS-intronENST00000444929ENST00000535268LIMK2chr22

31621805

+OSBP2chr22

31266416

+
5CDS-intronENST00000444929ENST00000496575LIMK2chr22

31621805

+OSBP2chr22

31266416

+
Frame-shiftENST00000331728ENST00000403222LIMK2chr22

31621805

+OSBP2chr22

31266416

+
Frame-shiftENST00000331728ENST00000407373LIMK2chr22

31621805

+OSBP2chr22

31266416

+
Frame-shiftENST00000331728ENST00000332585LIMK2chr22

31621805

+OSBP2chr22

31266416

+
Frame-shiftENST00000331728ENST00000382310LIMK2chr22

31621805

+OSBP2chr22

31266416

+
Frame-shiftENST00000331728ENST00000446658LIMK2chr22

31621805

+OSBP2chr22

31266416

+
5CDS-5UTRENST00000331728ENST00000401475LIMK2chr22

31621805

+OSBP2chr22

31266416

+
5CDS-5UTRENST00000331728ENST00000437268LIMK2chr22

31621805

+OSBP2chr22

31266416

+
5CDS-intronENST00000331728ENST00000535268LIMK2chr22

31621805

+OSBP2chr22

31266416

+
5CDS-intronENST00000331728ENST00000496575LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000333611ENST00000403222LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000333611ENST00000407373LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000333611ENST00000332585LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000333611ENST00000382310LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000333611ENST00000446658LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-5UTRENST00000333611ENST00000401475LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-5UTRENST00000333611ENST00000437268LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-intronENST00000333611ENST00000535268LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-intronENST00000333611ENST00000496575LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000340552ENST00000403222LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000340552ENST00000407373LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000340552ENST00000332585LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000340552ENST00000382310LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000340552ENST00000446658LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-5UTRENST00000340552ENST00000401475LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-5UTRENST00000340552ENST00000437268LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-intronENST00000340552ENST00000535268LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-intronENST00000340552ENST00000496575LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000467301ENST00000403222LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000467301ENST00000407373LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000467301ENST00000332585LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000467301ENST00000382310LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-3CDSENST00000467301ENST00000446658LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-5UTRENST00000467301ENST00000401475LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-5UTRENST00000467301ENST00000437268LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-intronENST00000467301ENST00000535268LIMK2chr22

31621805

+OSBP2chr22

31266416

+
intron-intronENST00000467301ENST00000496575LIMK2chr22

31621805

+OSBP2chr22

31266416

+

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FusionProtFeatures for LIMK2_OSBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIMK2

P53671

OSBP2

Q969R2

Displays serine/threonine-specific phosphorylation ofmyelin basic protein and histone (MBP) in vitro.{ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11018042}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LIMK2_OSBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LIMK2_OSBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LIMK2CFL1, ROCK1, LIMK1, MYC, HIST1H1A, MBP, NOTCH1, HSP90AA1, HIPK3, ATP1A1, BAG2, CALU, CDK4, DNAJA1, DNAJA2, EEF2, EMD, FKBP5, HSP90B1, HSPB1, LMNA, RCN1, RCN2, RUVBL2, SLC25A1, SLC25A13, SLC25A22, TUBA4A, USMG5, UNC119, LIMK2, HNRNPLL, TTC1, UBB, SLC18A1, TRIM35OSBP2VIM, TNNT1, ELAVL1, VAPB, LNX1, MOV10, NXF1, BTNL8, PTEN, RNASEH2A, VAPA, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LIMK2_OSBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LIMK2_OSBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLIMK2C0023893Liver Cirrhosis, Experimental1CTD_human