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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19712

FusionGeneSummary for LILRB4_IMPA2

check button Fusion gene summary
Fusion gene informationFusion gene name: LILRB4_IMPA2
Fusion gene ID: 19712
HgeneTgene
Gene symbol

LILRB4

IMPA2

Gene ID

11006

3613

Gene nameleukocyte immunoglobulin like receptor B4inositol monophosphatase 2
SynonymsCD85K|ILT-3|ILT3|LIR-5|LIR5-
Cytomap

19q13.42

18p11.21

Type of geneprotein-codingprotein-coding
Descriptionleukocyte immunoglobulin-like receptor subfamily B member 4CD85 antigen-like family member Kimmunoglobulin-like transcript 3leucocyte Ig-like receptor B4leukocyte immunoglobulin-like receptor 5leukocyte immunoglobulin-like receptor, subfamily B (withinositol monophosphatase 2IMP 2IMPase 2inosine monophosphatase 2inositol monophosphatase 2 variant 1inositol monophosphatase 2 variant 2inositol(myo)-1(or 4)-monophosphatase 2myo-inositol monophosphatase 2myo-inositol monophosphatase A2
Modification date2018051920180523
UniProtAcc

Q8NHJ6

O14732

Ensembl transtripts involved in fusion geneENST00000391736, ENST00000461839, 
ENST00000270452, ENST00000430952, 
ENST00000391734, ENST00000391733, 
ENST00000588752, ENST00000589238, 
ENST00000269159, ENST00000588927, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 5 X 5=150
# samples 26
** MAII scorelog2(2/4*10)=2.32192809488736log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LILRB4 [Title/Abstract] AND IMPA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLILRB4

GO:0045591

positive regulation of regulatory T cell differentiation

22387553

HgeneLILRB4

GO:0045671

negative regulation of osteoclast differentiation

18802077

HgeneLILRB4

GO:0050860

negative regulation of T cell receptor signaling pathway

22387553

HgeneLILRB4

GO:1900181

negative regulation of protein localization to nucleus

22387553

HgeneLILRB4

GO:1902894

negative regulation of pri-miRNA transcription by RNA polymerase II

22387553

TgeneIMPA2

GO:0046855

inositol phosphate dephosphorylation

17068342


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA593969LILRB4chr19

55179589

-IMPA2chr18

12030454

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000391736ENST00000588752LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000391736ENST00000589238LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000391736ENST00000269159LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000391736ENST00000588927LILRB4chr19

55179589

-IMPA2chr18

12030454

-
intron-intronENST00000461839ENST00000588752LILRB4chr19

55179589

-IMPA2chr18

12030454

-
intron-intronENST00000461839ENST00000589238LILRB4chr19

55179589

-IMPA2chr18

12030454

-
intron-intronENST00000461839ENST00000269159LILRB4chr19

55179589

-IMPA2chr18

12030454

-
intron-intronENST00000461839ENST00000588927LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000270452ENST00000588752LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000270452ENST00000589238LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000270452ENST00000269159LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000270452ENST00000588927LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000430952ENST00000588752LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000430952ENST00000589238LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000430952ENST00000269159LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000430952ENST00000588927LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000391734ENST00000588752LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000391734ENST00000589238LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000391734ENST00000269159LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000391734ENST00000588927LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000391733ENST00000588752LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000391733ENST00000589238LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000391733ENST00000269159LILRB4chr19

55179589

-IMPA2chr18

12030454

-
3UTR-intronENST00000391733ENST00000588927LILRB4chr19

55179589

-IMPA2chr18

12030454

-

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FusionProtFeatures for LILRB4_IMPA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LILRB4

Q8NHJ6

IMPA2

O14732

Receptor for class I MHC antigens. Recognizes a broadspectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in thedown-regulation of the immune response and the development oftolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediatedphosphorylation of cellular proteins and mobilization ofintracellular calcium ions. {ECO:0000269|PubMed:11875462,ECO:0000269|PubMed:9151699}. Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacologicaltarget for lithium Li(+) action in brain.{ECO:0000269|PubMed:17068342}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LILRB4_IMPA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LILRB4_IMPA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LILRB4_IMPA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIMPA2O14732DB01356LithiumInositol monophosphatase 2small moleculeapproved

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RelatedDiseases for LILRB4_IMPA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIMPA2C0005586Bipolar Disorder5PSYGENET
TgeneIMPA2C0525045Mood Disorders2PSYGENET
TgeneIMPA2C0009952Febrile Convulsions1CTD_human
TgeneIMPA2C0011570Mental Depression1PSYGENET
TgeneIMPA2C0011581Depressive disorder1PSYGENET
TgeneIMPA2C0014175Endometriosis1CTD_human
TgeneIMPA2C0036341Schizophrenia1PSYGENET