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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 19708

FusionGeneSummary for LIG3_ZFAT

check button Fusion gene summary
Fusion gene informationFusion gene name: LIG3_ZFAT
Fusion gene ID: 19708
HgeneTgene
Gene symbol

LIG3

ZFAT

Gene ID

121227

57623

Gene nameleucine rich repeats and immunoglobulin like domains 3zinc finger and AT-hook domain containing
SynonymsLIG3AITD3|ZFAT1|ZNF406
Cytomap

12q14.1

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeats and immunoglobulin-like domains protein 3LIG-3zinc finger protein ZFATzinc finger gene in autoimmune thyroid diseasezinc finger protein 406zinc-finger gene in AITD susceptibility region
Modification date2018052320180523
UniProtAcc

P49916

Q9P243

Ensembl transtripts involved in fusion geneENST00000378526, ENST00000262327, 
ENST00000586407, 		ENST00000520356, 
ENST00000520727, ENST00000429442, 
ENST00000377838, ENST00000520214, 
ENST00000523399, ENST00000517307, 
Fusion gene scores* DoF score5 X 5 X 2=505 X 5 X 5=125
# samples 55
** MAII scorelog2(5/50*10)=0log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LIG3 [Title/Abstract] AND ZFAT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1RF-01ALIG3chr17

33321450

+ZFATchr8

135490964

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000378526ENST00000520356LIG3chr17

33321450

+ZFATchr8

135490964

-
In-frameENST00000378526ENST00000520727LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000378526ENST00000429442LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000378526ENST00000377838LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000378526ENST00000520214LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000378526ENST00000523399LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000378526ENST00000517307LIG3chr17

33321450

+ZFATchr8

135490964

-
In-frameENST00000262327ENST00000520356LIG3chr17

33321450

+ZFATchr8

135490964

-
In-frameENST00000262327ENST00000520727LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000262327ENST00000429442LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000262327ENST00000377838LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000262327ENST00000520214LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000262327ENST00000523399LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000262327ENST00000517307LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-3CDSENST00000586407ENST00000520356LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-3CDSENST00000586407ENST00000520727LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-intronENST00000586407ENST00000429442LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-intronENST00000586407ENST00000377838LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-intronENST00000586407ENST00000520214LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-intronENST00000586407ENST00000523399LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-intronENST00000586407ENST00000517307LIG3chr17

33321450

+ZFATchr8

135490964

-

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FusionProtFeatures for LIG3_ZFAT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIG3

P49916

ZFAT

Q9P243

Isoform 3 functions as heterodimer with DNA-repairprotein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatmentwith ionizing radiation and alkylating agents. Isoform 1 istargeted to mitochondria, where it functions as DNA ligase inmitochondrial base-excision DNA repair (PubMed:10207110,PubMed:24674627). {ECO:0000269|PubMed:10207110,ECO:0000269|PubMed:24674627}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIG3chr17:33321450chr8:135490964ENST00000262327+92093_185537950Zinc fingerPARP-type
HgeneLIG3chr17:33321450chr8:135490964ENST00000378526+92093_1855371010Zinc fingerPARP-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-14161041_106411641244Zinc fingerC2H2-type 19
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416116_14111641244Zinc fingerC2H2-type 2%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-141612_3511641244Zinc fingerC2H2-type 1
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416271_29311641244Zinc fingerC2H2-type 3
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416299_32111641244Zinc fingerC2H2-type 4
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416326_34911641244Zinc fingerC2H2-type 5
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416354_37711641244Zinc fingerC2H2-type 6
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416404_42611641244Zinc fingerC2H2-type 7
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416432_45411641244Zinc fingerC2H2-type 8
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416458_48111641244Zinc fingerC2H2-type 9
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416742_76411641244Zinc fingerC2H2-type 10
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416770_79311641244Zinc fingerC2H2-type 11
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416798_82211641244Zinc fingerC2H2-type 12
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416830_85311641244Zinc fingerC2H2-type 13
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416880_90311641244Zinc fingerC2H2-type 14%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416909_93111641244Zinc fingerC2H2-type 15
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416937_95911641244Zinc fingerC2H2-type 16
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416966_98811641244Zinc fingerC2H2-type 17
TgeneZFATchr17:33321450chr8:135490964ENST00000377838-1416994_101711641244Zinc fingerC2H2-type 18
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-14161041_106411521232Zinc fingerC2H2-type 19
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416116_14111521232Zinc fingerC2H2-type 2%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-141612_3511521232Zinc fingerC2H2-type 1
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416271_29311521232Zinc fingerC2H2-type 3
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416299_32111521232Zinc fingerC2H2-type 4
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416326_34911521232Zinc fingerC2H2-type 5
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416354_37711521232Zinc fingerC2H2-type 6
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416404_42611521232Zinc fingerC2H2-type 7
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416432_45411521232Zinc fingerC2H2-type 8
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416458_48111521232Zinc fingerC2H2-type 9
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416742_76411521232Zinc fingerC2H2-type 10
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416770_79311521232Zinc fingerC2H2-type 11
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416798_82211521232Zinc fingerC2H2-type 12
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416830_85311521232Zinc fingerC2H2-type 13
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416880_90311521232Zinc fingerC2H2-type 14%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416909_93111521232Zinc fingerC2H2-type 15
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416937_95911521232Zinc fingerC2H2-type 16
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416966_98811521232Zinc fingerC2H2-type 17
TgeneZFATchr17:33321450chr8:135490964ENST00000520214-1416994_101711521232Zinc fingerC2H2-type 18
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-15171041_106411521232Zinc fingerC2H2-type 19
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517116_14111521232Zinc fingerC2H2-type 2%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-151712_3511521232Zinc fingerC2H2-type 1
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517271_29311521232Zinc fingerC2H2-type 3
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517299_32111521232Zinc fingerC2H2-type 4
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517326_34911521232Zinc fingerC2H2-type 5
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517354_37711521232Zinc fingerC2H2-type 6
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517404_42611521232Zinc fingerC2H2-type 7
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517432_45411521232Zinc fingerC2H2-type 8
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517458_48111521232Zinc fingerC2H2-type 9
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517742_76411521232Zinc fingerC2H2-type 10
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517770_79311521232Zinc fingerC2H2-type 11
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517798_82211521232Zinc fingerC2H2-type 12
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517830_85311521232Zinc fingerC2H2-type 13
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517880_90311521232Zinc fingerC2H2-type 14%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517909_93111521232Zinc fingerC2H2-type 15
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517937_95911521232Zinc fingerC2H2-type 16
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517966_98811521232Zinc fingerC2H2-type 17
TgeneZFATchr17:33321450chr8:135490964ENST00000520727-1517994_101711521232Zinc fingerC2H2-type 18
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-13151041_106411021182Zinc fingerC2H2-type 19
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315116_14111021182Zinc fingerC2H2-type 2%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-131512_3511021182Zinc fingerC2H2-type 1
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315271_29311021182Zinc fingerC2H2-type 3
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315299_32111021182Zinc fingerC2H2-type 4
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315326_34911021182Zinc fingerC2H2-type 5
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315354_37711021182Zinc fingerC2H2-type 6
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315404_42611021182Zinc fingerC2H2-type 7
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315432_45411021182Zinc fingerC2H2-type 8
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315458_48111021182Zinc fingerC2H2-type 9
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315742_76411021182Zinc fingerC2H2-type 10
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315770_79311021182Zinc fingerC2H2-type 11
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315798_82211021182Zinc fingerC2H2-type 12
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315830_85311021182Zinc fingerC2H2-type 13
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315880_90311021182Zinc fingerC2H2-type 14%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315909_93111021182Zinc fingerC2H2-type 15
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315937_95911021182Zinc fingerC2H2-type 16
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315966_98811021182Zinc fingerC2H2-type 17
TgeneZFATchr17:33321450chr8:135490964ENST00000523399-1315994_101711021182Zinc fingerC2H2-type 18


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FusionGeneSequence for LIG3_ZFAT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LIG3_ENST00000378526_chr17_33321450_+_ZFAT_ENST00000520356_chr8_135490964_-_617aa
MSLAFKIFFPQTLRALSRKELCLFRKHHWRDVRQFSQWSETDLLHGHPLFLRRKPVLSFQGSHLRSRATYLVFLPGLHVGLCSGPCEMAE
QRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQITQH
IADLSSKAAGTPKKKAVVQAKLTTTGQVTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFRKLC
AMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQ
SKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDV
VERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKNGDHFSYFSRSLKPVLPHKVTE

>In-frame_LIG3_ENST00000378526_chr17_33321450_+_ZFAT_ENST00000520727_chr8_135490964_-_617aa
MSLAFKIFFPQTLRALSRKELCLFRKHHWRDVRQFSQWSETDLLHGHPLFLRRKPVLSFQGSHLRSRATYLVFLPGLHVGLCSGPCEMAE
QRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQITQH
IADLSSKAAGTPKKKAVVQAKLTTTGQVTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFRKLC
AMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQ
SKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDV
VERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKNGDHFSYFSRSLKPVLPHKVTE

>In-frame_LIG3_ENST00000262327_chr17_33321450_+_ZFAT_ENST00000520356_chr8_135490964_-_617aa
MSLAFKIFFPQTLRALSRKELCLFRKHHWRDVRQFSQWSETDLLHGHPLFLRRKPVLSFQGSHLRSRATYLVFLPGLHVGLCSGPCEMAE
QRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQITQH
IADLSSKAAGTPKKKAVVQAKLTTTGQVTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFRKLC
AMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQ
SKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDV
VERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKNGDHFSYFSRSLKPVLPHKVTE

>In-frame_LIG3_ENST00000262327_chr17_33321450_+_ZFAT_ENST00000520727_chr8_135490964_-_617aa
MSLAFKIFFPQTLRALSRKELCLFRKHHWRDVRQFSQWSETDLLHGHPLFLRRKPVLSFQGSHLRSRATYLVFLPGLHVGLCSGPCEMAE
QRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQITQH
IADLSSKAAGTPKKKAVVQAKLTTTGQVTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFRKLC
AMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQ
SKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDV
VERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKNGDHFSYFSRSLKPVLPHKVTE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LIG3_ENST00000378526_chr17_33321450_+_ZFAT_ENST00000520356_chr8_135490964_-_1851nt
ATGTCTTTGGCTTTCAAGATCTTCTTTCCACAAACCCTCCGTGCACTCAGCCGAAAAGAACTGTGCCTATTCCGAAAACATCACTGGCGT
GATGTAAGACAATTCAGCCAGTGGTCAGAAACAGATCTGCTTCATGGACATCCCCTCTTCCTGAGAAGAAAGCCTGTTCTATCATTCCAG
GGAAGCCATCTAAGATCACGTGCCACCTACCTTGTTTTCTTGCCAGGGTTGCATGTGGGACTCTGCAGTGGCCCCTGTGAGATGGCTGAG
CAACGGTTCTGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAAAAAATGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGC
AAAGTGGTGCCCAATCCCTTCTCAGAGTCTGGGGGTGATATGAAAGAGTGGTACCACATTAAATGCATGTTTGAGAAACTAGAGCGGGCC
CGGGCCACCACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTGGGAAGAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCAC
ATTGCAGATCTGTCTTCTAAGGCAGCAGGTACACCAAAGAAGAAAGCTGTTGTCCAGGCTAAGTTGACAACCACTGGCCAGGTGACTTCT
CCAGTGAAAGGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATTTTCTGGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCC
TCGAGCCCCACCCCTAAGAGAAGTCTGTCTTCAAGCAAATGTGACCCCAGGCATAAGGACTGTCTGCTACGGGAGTTTCGAAAGTTATGC
GCCATGGTGGCCGATAATCCTAGCTACAACACGAAGACCCAGATCATCCAGGACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCAC
GGTGATGTGTACCTAACAGTGAAGCTGCTGCTGCCAGGAGTCATTAAGACTGTTTACAACTTGAACGATAAGCAGATTGTGAAGCTTTTC
AGTCGCATTTTTAACTGCAACCCAGATGATATGGCACGGGACCTAGAGCAGGGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAG
AGCAAGTCTTTCCCCCCAGCTGCCAAGAGCCTCCTTACCATCCAGGAAGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTCACCAAGGAG
GATGAGCAGCAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGCCAATGACCTTAAATGCATCATCAGGTTGATCAAACATGATCTG
AAGATGAACTCAGGTGCAAAACATGTGTTAGACGCCCTTGACCCCAATGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTGCAGGATGTG
GTGGAGCGGGTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGGCCAGAGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCT
GTGCAGCCCATGTTGGCGGAGGCCTGCAAGTCCGTTGAGTATGCAATGAAGAAATGTCCCAATGGCATGTTCTCTGAGATCAAGTACGAT
GGAGAGCGAGTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTTCAGCCGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTCACCGAG
GAGGAGCCCAGCTCCAACCACACGGTCATGATCCAGGAGACGGTCCAGCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTG
TCCTCCGACGACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCAGGGCGGGGAGGCCTCGGAGTTCATCGTCTACGTGCAGGAGGCC

>In-frame_LIG3_ENST00000378526_chr17_33321450_+_ZFAT_ENST00000520727_chr8_135490964_-_1851nt
ATGTCTTTGGCTTTCAAGATCTTCTTTCCACAAACCCTCCGTGCACTCAGCCGAAAAGAACTGTGCCTATTCCGAAAACATCACTGGCGT
GATGTAAGACAATTCAGCCAGTGGTCAGAAACAGATCTGCTTCATGGACATCCCCTCTTCCTGAGAAGAAAGCCTGTTCTATCATTCCAG
GGAAGCCATCTAAGATCACGTGCCACCTACCTTGTTTTCTTGCCAGGGTTGCATGTGGGACTCTGCAGTGGCCCCTGTGAGATGGCTGAG
CAACGGTTCTGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAAAAAATGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGC
AAAGTGGTGCCCAATCCCTTCTCAGAGTCTGGGGGTGATATGAAAGAGTGGTACCACATTAAATGCATGTTTGAGAAACTAGAGCGGGCC
CGGGCCACCACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTGGGAAGAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCAC
ATTGCAGATCTGTCTTCTAAGGCAGCAGGTACACCAAAGAAGAAAGCTGTTGTCCAGGCTAAGTTGACAACCACTGGCCAGGTGACTTCT
CCAGTGAAAGGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATTTTCTGGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCC
TCGAGCCCCACCCCTAAGAGAAGTCTGTCTTCAAGCAAATGTGACCCCAGGCATAAGGACTGTCTGCTACGGGAGTTTCGAAAGTTATGC
GCCATGGTGGCCGATAATCCTAGCTACAACACGAAGACCCAGATCATCCAGGACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCAC
GGTGATGTGTACCTAACAGTGAAGCTGCTGCTGCCAGGAGTCATTAAGACTGTTTACAACTTGAACGATAAGCAGATTGTGAAGCTTTTC
AGTCGCATTTTTAACTGCAACCCAGATGATATGGCACGGGACCTAGAGCAGGGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAG
AGCAAGTCTTTCCCCCCAGCTGCCAAGAGCCTCCTTACCATCCAGGAAGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTCACCAAGGAG
GATGAGCAGCAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGCCAATGACCTTAAATGCATCATCAGGTTGATCAAACATGATCTG
AAGATGAACTCAGGTGCAAAACATGTGTTAGACGCCCTTGACCCCAATGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTGCAGGATGTG
GTGGAGCGGGTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGGCCAGAGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCT
GTGCAGCCCATGTTGGCGGAGGCCTGCAAGTCCGTTGAGTATGCAATGAAGAAATGTCCCAATGGCATGTTCTCTGAGATCAAGTACGAT
GGAGAGCGAGTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTTCAGCCGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTCACCGAG
GAGGAGCCCAGCTCCAACCACACGGTCATGATCCAGGAGACGGTCCAGCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTG
TCCTCCGACGACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCAGGGCGGGGAGGCCTCGGAGTTCATCGTCTACGTGCAGGAGGCC

>In-frame_LIG3_ENST00000262327_chr17_33321450_+_ZFAT_ENST00000520356_chr8_135490964_-_1851nt
ATGTCTTTGGCTTTCAAGATCTTCTTTCCACAAACCCTCCGTGCACTCAGCCGAAAAGAACTGTGCCTATTCCGAAAACATCACTGGCGT
GATGTAAGACAATTCAGCCAGTGGTCAGAAACAGATCTGCTTCATGGACATCCCCTCTTCCTGAGAAGAAAGCCTGTTCTATCATTCCAG
GGAAGCCATCTAAGATCACGTGCCACCTACCTTGTTTTCTTGCCAGGGTTGCATGTGGGACTCTGCAGTGGCCCCTGTGAGATGGCTGAG
CAACGGTTCTGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAAAAAATGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGC
AAAGTGGTGCCCAATCCCTTCTCAGAGTCTGGGGGTGATATGAAAGAGTGGTACCACATTAAATGCATGTTTGAGAAACTAGAGCGGGCC
CGGGCCACCACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTGGGAAGAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCAC
ATTGCAGATCTGTCTTCTAAGGCAGCAGGTACACCAAAGAAGAAAGCTGTTGTCCAGGCTAAGTTGACAACCACTGGCCAGGTGACTTCT
CCAGTGAAAGGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATTTTCTGGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCC
TCGAGCCCCACCCCTAAGAGAAGTCTGTCTTCAAGCAAATGTGACCCCAGGCATAAGGACTGTCTGCTACGGGAGTTTCGAAAGTTATGC
GCCATGGTGGCCGATAATCCTAGCTACAACACGAAGACCCAGATCATCCAGGACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCAC
GGTGATGTGTACCTAACAGTGAAGCTGCTGCTGCCAGGAGTCATTAAGACTGTTTACAACTTGAACGATAAGCAGATTGTGAAGCTTTTC
AGTCGCATTTTTAACTGCAACCCAGATGATATGGCACGGGACCTAGAGCAGGGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAG
AGCAAGTCTTTCCCCCCAGCTGCCAAGAGCCTCCTTACCATCCAGGAAGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTCACCAAGGAG
GATGAGCAGCAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGCCAATGACCTTAAATGCATCATCAGGTTGATCAAACATGATCTG
AAGATGAACTCAGGTGCAAAACATGTGTTAGACGCCCTTGACCCCAATGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTGCAGGATGTG
GTGGAGCGGGTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGGCCAGAGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCT
GTGCAGCCCATGTTGGCGGAGGCCTGCAAGTCCGTTGAGTATGCAATGAAGAAATGTCCCAATGGCATGTTCTCTGAGATCAAGTACGAT
GGAGAGCGAGTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTTCAGCCGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTCACCGAG
GAGGAGCCCAGCTCCAACCACACGGTCATGATCCAGGAGACGGTCCAGCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTG
TCCTCCGACGACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCAGGGCGGGGAGGCCTCGGAGTTCATCGTCTACGTGCAGGAGGCC

>In-frame_LIG3_ENST00000262327_chr17_33321450_+_ZFAT_ENST00000520727_chr8_135490964_-_1851nt
ATGTCTTTGGCTTTCAAGATCTTCTTTCCACAAACCCTCCGTGCACTCAGCCGAAAAGAACTGTGCCTATTCCGAAAACATCACTGGCGT
GATGTAAGACAATTCAGCCAGTGGTCAGAAACAGATCTGCTTCATGGACATCCCCTCTTCCTGAGAAGAAAGCCTGTTCTATCATTCCAG
GGAAGCCATCTAAGATCACGTGCCACCTACCTTGTTTTCTTGCCAGGGTTGCATGTGGGACTCTGCAGTGGCCCCTGTGAGATGGCTGAG
CAACGGTTCTGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAAAAAATGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGC
AAAGTGGTGCCCAATCCCTTCTCAGAGTCTGGGGGTGATATGAAAGAGTGGTACCACATTAAATGCATGTTTGAGAAACTAGAGCGGGCC
CGGGCCACCACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTGGGAAGAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCAC
ATTGCAGATCTGTCTTCTAAGGCAGCAGGTACACCAAAGAAGAAAGCTGTTGTCCAGGCTAAGTTGACAACCACTGGCCAGGTGACTTCT
CCAGTGAAAGGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATTTTCTGGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCC
TCGAGCCCCACCCCTAAGAGAAGTCTGTCTTCAAGCAAATGTGACCCCAGGCATAAGGACTGTCTGCTACGGGAGTTTCGAAAGTTATGC
GCCATGGTGGCCGATAATCCTAGCTACAACACGAAGACCCAGATCATCCAGGACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCAC
GGTGATGTGTACCTAACAGTGAAGCTGCTGCTGCCAGGAGTCATTAAGACTGTTTACAACTTGAACGATAAGCAGATTGTGAAGCTTTTC
AGTCGCATTTTTAACTGCAACCCAGATGATATGGCACGGGACCTAGAGCAGGGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAG
AGCAAGTCTTTCCCCCCAGCTGCCAAGAGCCTCCTTACCATCCAGGAAGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTCACCAAGGAG
GATGAGCAGCAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGCCAATGACCTTAAATGCATCATCAGGTTGATCAAACATGATCTG
AAGATGAACTCAGGTGCAAAACATGTGTTAGACGCCCTTGACCCCAATGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTGCAGGATGTG
GTGGAGCGGGTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGGCCAGAGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCT
GTGCAGCCCATGTTGGCGGAGGCCTGCAAGTCCGTTGAGTATGCAATGAAGAAATGTCCCAATGGCATGTTCTCTGAGATCAAGTACGAT
GGAGAGCGAGTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTTCAGCCGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTCACCGAG
GAGGAGCCCAGCTCCAACCACACGGTCATGATCCAGGAGACGGTCCAGCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTG
TCCTCCGACGACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCAGGGCGGGGAGGCCTCGGAGTTCATCGTCTACGTGCAGGAGGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_LIG3_ENST00000378526_chr17_33321450_+_ZFAT_ENST00000520356_chr8_135490964_-_2678nt
GCCTGCGCGCTGCCTCCCGCTCTAGGACCCGGATTTAAAGAGACAGGCGCTCCAACCGTCGTGGGCTGCCCGCGGCCTGTAATGAGCAAG
TTCCGAGGCCTACGGTGAGCGCCGGAGCCGGAGAGGCAGCTATATGTCTTTGGCTTTCAAGATCTTCTTTCCACAAACCCTCCGTGCACT
CAGCCGAAAAGAACTGTGCCTATTCCGAAAACATCACTGGCGTGATGTAAGACAATTCAGCCAGTGGTCAGAAACAGATCTGCTTCATGG
ACATCCCCTCTTCCTGAGAAGAAAGCCTGTTCTATCATTCCAGGGAAGCCATCTAAGATCACGTGCCACCTACCTTGTTTTCTTGCCAGG
GTTGCATGTGGGACTCTGCAGTGGCCCCTGTGAGATGGCTGAGCAACGGTTCTGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAA
AAAATGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGCAAAGTGGTGCCCAATCCCTTCTCAGAGTCTGGGGGTGATATGAAAGA
GTGGTACCACATTAAATGCATGTTTGAGAAACTAGAGCGGGCCCGGGCCACCACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTG
GGAAGAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCACATTGCAGATCTGTCTTCTAAGGCAGCAGGTACACCAAAGAAGAAAGC
TGTTGTCCAGGCTAAGTTGACAACCACTGGCCAGGTGACTTCTCCAGTGAAAGGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATT
TTCTGGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCCTCGAGCCCCACCCCTAAGAGAAGTCTGTCTTCAAGCAAATGTGACCC
CAGGCATAAGGACTGTCTGCTACGGGAGTTTCGAAAGTTATGCGCCATGGTGGCCGATAATCCTAGCTACAACACGAAGACCCAGATCAT
CCAGGACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCACGGTGATGTGTACCTAACAGTGAAGCTGCTGCTGCCAGGAGTCATTAA
GACTGTTTACAACTTGAACGATAAGCAGATTGTGAAGCTTTTCAGTCGCATTTTTAACTGCAACCCAGATGATATGGCACGGGACCTAGA
GCAGGGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAGAGCAAGTCTTTCCCCCCAGCTGCCAAGAGCCTCCTTACCATCCAGGA
AGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTCACCAAGGAGGATGAGCAGCAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGC
CAATGACCTTAAATGCATCATCAGGTTGATCAAACATGATCTGAAGATGAACTCAGGTGCAAAACATGTGTTAGACGCCCTTGACCCCAA
TGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTGCAGGATGTGGTGGAGCGGGTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGG
CCAGAGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCTGTGCAGCCCATGTTGGCGGAGGCCTGCAAGTCCGTTGAGTATGCAAT
GAAGAAATGTCCCAATGGCATGTTCTCTGAGATCAAGTACGATGGAGAGCGAGTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTT
CAGCCGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTCACCGAGGAGGAGCCCAGCTCCAACCACACGGTCATGATCCAGGAGACGGTCCA
GCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTGTCCTCCGACGACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCA
GGGCGGGGAGGCCTCGGAGTTCATCGTCTACGTGCAGGAGGCCATGCAGCCTGTGGAGGAGCAGGCTGTGGAGCAGCCGGCCCAGGAACT
CTAGAGGACATGTGGCATCGGATGGCCACAGGGCGGGGCTGCCAGGCTCTGCAGGCACCCAGGGTGGGGAGGCCACCCTTCCTGCCCTAC
CCGCAGAATGGTGCTCTCCTTTGCCCTCCCTGCCCAGCAGCCTGATAGGACTCTCCTAGTCCAACTTGGGGTGGGCAAGGCAGTCAGCAT
CACCAGCAATACCACAGGACCCTCACCCCAGCATAGACACACACCCCCTGACCCTTACCATCTGCTTCCTGAAAGACTTCAGTGTCAGCT
CCCCTACACACACCCCACACCTTCACCCCTTGCTTCAAGATTCAAACAGAGACTCCCAGTCCCCCTCAGCATCTTCCCTGAATCACAGCC
CCAGCTCCTTGACCCCCATCTAGGTGCCAAATGTTCATCTGCAACCGCTATGCAGTCTGGTGAGAGGGAGACAGCCATCACATAGAAAGT
GACCGTACGGGTTTTTAATCACTGCTGGGTGGGGTGGGGGTAGGGGGATTGTCCTGGCTTTGTCGACAAAGTCCCACTTCCCCGAGTATT
AAGGGCCCTTGGTATCAAGTGAGGTAAATTCACCCATCACAGGGTCTCGCCCTACCATCCTGGAATTATTTCACTTTTAAGATAAATGCA

>In-frame_LIG3_ENST00000378526_chr17_33321450_+_ZFAT_ENST00000520727_chr8_135490964_-_2674nt
GCCTGCGCGCTGCCTCCCGCTCTAGGACCCGGATTTAAAGAGACAGGCGCTCCAACCGTCGTGGGCTGCCCGCGGCCTGTAATGAGCAAG
TTCCGAGGCCTACGGTGAGCGCCGGAGCCGGAGAGGCAGCTATATGTCTTTGGCTTTCAAGATCTTCTTTCCACAAACCCTCCGTGCACT
CAGCCGAAAAGAACTGTGCCTATTCCGAAAACATCACTGGCGTGATGTAAGACAATTCAGCCAGTGGTCAGAAACAGATCTGCTTCATGG
ACATCCCCTCTTCCTGAGAAGAAAGCCTGTTCTATCATTCCAGGGAAGCCATCTAAGATCACGTGCCACCTACCTTGTTTTCTTGCCAGG
GTTGCATGTGGGACTCTGCAGTGGCCCCTGTGAGATGGCTGAGCAACGGTTCTGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAA
AAAATGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGCAAAGTGGTGCCCAATCCCTTCTCAGAGTCTGGGGGTGATATGAAAGA
GTGGTACCACATTAAATGCATGTTTGAGAAACTAGAGCGGGCCCGGGCCACCACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTG
GGAAGAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCACATTGCAGATCTGTCTTCTAAGGCAGCAGGTACACCAAAGAAGAAAGC
TGTTGTCCAGGCTAAGTTGACAACCACTGGCCAGGTGACTTCTCCAGTGAAAGGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATT
TTCTGGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCCTCGAGCCCCACCCCTAAGAGAAGTCTGTCTTCAAGCAAATGTGACCC
CAGGCATAAGGACTGTCTGCTACGGGAGTTTCGAAAGTTATGCGCCATGGTGGCCGATAATCCTAGCTACAACACGAAGACCCAGATCAT
CCAGGACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCACGGTGATGTGTACCTAACAGTGAAGCTGCTGCTGCCAGGAGTCATTAA
GACTGTTTACAACTTGAACGATAAGCAGATTGTGAAGCTTTTCAGTCGCATTTTTAACTGCAACCCAGATGATATGGCACGGGACCTAGA
GCAGGGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAGAGCAAGTCTTTCCCCCCAGCTGCCAAGAGCCTCCTTACCATCCAGGA
AGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTCACCAAGGAGGATGAGCAGCAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGC
CAATGACCTTAAATGCATCATCAGGTTGATCAAACATGATCTGAAGATGAACTCAGGTGCAAAACATGTGTTAGACGCCCTTGACCCCAA
TGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTGCAGGATGTGGTGGAGCGGGTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGG
CCAGAGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCTGTGCAGCCCATGTTGGCGGAGGCCTGCAAGTCCGTTGAGTATGCAAT
GAAGAAATGTCCCAATGGCATGTTCTCTGAGATCAAGTACGATGGAGAGCGAGTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTT
CAGCCGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTCACCGAGGAGGAGCCCAGCTCCAACCACACGGTCATGATCCAGGAGACGGTCCA
GCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTGTCCTCCGACGACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCA
GGGCGGGGAGGCCTCGGAGTTCATCGTCTACGTGCAGGAGGCCATGCAGCCTGTGGAGGAGCAGGCTGTGGAGCAGCCGGCCCAGGAACT
CTAGAGGACATGTGGCATCGGATGGCCACAGGGCGGGGCTGCCAGGCTCTGCAGGCACCCAGGGTGGGGAGGCCACCCTTCCTGCCCTAC
CCGCAGAATGGTGCTCTCCTTTGCCCTCCCTGCCCAGCAGCCTGATAGGACTCTCCTAGTCCAACTTGGGGTGGGCAAGGCAGTCAGCAT
CACCAGCAATACCACAGGACCCTCACCCCAGCATAGACACACACCCCCTGACCCTTACCATCTGCTTCCTGAAAGACTTCAGTGTCAGCT
CCCCTACACACACCCCACACCTTCACCCCTTGCTTCAAGATTCAAACAGAGACTCCCAGTCCCCCTCAGCATCTTCCCTGAATCACAGCC
CCAGCTCCTTGACCCCCATCTAGGTGCCAAATGTTCATCTGCAACCGCTATGCAGTCTGGTGAGAGGGAGACAGCCATCACATAGAAAGT
GACCGTACGGGTTTTTAATCACTGCTGGGTGGGGTGGGGGTAGGGGGATTGTCCTGGCTTTGTCGACAAAGTCCCACTTCCCCGAGTATT
AAGGGCCCTTGGTATCAAGTGAGGTAAATTCACCCATCACAGGGTCTCGCCCTACCATCCTGGAATTATTTCACTTTTAAGATAAATGCA

>In-frame_LIG3_ENST00000262327_chr17_33321450_+_ZFAT_ENST00000520356_chr8_135490964_-_2626nt
CAACCGTCGTGGGCTGCCCGCGGCCTGTAATGAGCAAGTTCCGAGGCCTACGGTGAGCGCCGGAGCCGGAGAGGCAGCTATATGTCTTTG
GCTTTCAAGATCTTCTTTCCACAAACCCTCCGTGCACTCAGCCGAAAAGAACTGTGCCTATTCCGAAAACATCACTGGCGTGATGTAAGA
CAATTCAGCCAGTGGTCAGAAACAGATCTGCTTCATGGACATCCCCTCTTCCTGAGAAGAAAGCCTGTTCTATCATTCCAGGGAAGCCAT
CTAAGATCACGTGCCACCTACCTTGTTTTCTTGCCAGGGTTGCATGTGGGACTCTGCAGTGGCCCCTGTGAGATGGCTGAGCAACGGTTC
TGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAAAAAATGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGCAAAGTGGTG
CCCAATCCCTTCTCAGAGTCTGGGGGTGATATGAAAGAGTGGTACCACATTAAATGCATGTTTGAGAAACTAGAGCGGGCCCGGGCCACC
ACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTGGGAAGAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCACATTGCAGAT
CTGTCTTCTAAGGCAGCAGGTACACCAAAGAAGAAAGCTGTTGTCCAGGCTAAGTTGACAACCACTGGCCAGGTGACTTCTCCAGTGAAA
GGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATTTTCTGGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCCTCGAGCCCC
ACCCCTAAGAGAAGTCTGTCTTCAAGCAAATGTGACCCCAGGCATAAGGACTGTCTGCTACGGGAGTTTCGAAAGTTATGCGCCATGGTG
GCCGATAATCCTAGCTACAACACGAAGACCCAGATCATCCAGGACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCACGGTGATGTG
TACCTAACAGTGAAGCTGCTGCTGCCAGGAGTCATTAAGACTGTTTACAACTTGAACGATAAGCAGATTGTGAAGCTTTTCAGTCGCATT
TTTAACTGCAACCCAGATGATATGGCACGGGACCTAGAGCAGGGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAGAGCAAGTCT
TTCCCCCCAGCTGCCAAGAGCCTCCTTACCATCCAGGAAGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTCACCAAGGAGGATGAGCAG
CAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGCCAATGACCTTAAATGCATCATCAGGTTGATCAAACATGATCTGAAGATGAAC
TCAGGTGCAAAACATGTGTTAGACGCCCTTGACCCCAATGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTGCAGGATGTGGTGGAGCGG
GTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGGCCAGAGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCTGTGCAGCCC
ATGTTGGCGGAGGCCTGCAAGTCCGTTGAGTATGCAATGAAGAAATGTCCCAATGGCATGTTCTCTGAGATCAAGTACGATGGAGAGCGA
GTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTTCAGCCGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTCACCGAGGAGGAGCCC
AGCTCCAACCACACGGTCATGATCCAGGAGACGGTCCAGCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTGTCCTCCGAC
GACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCAGGGCGGGGAGGCCTCGGAGTTCATCGTCTACGTGCAGGAGGCCATGCAGCCT
GTGGAGGAGCAGGCTGTGGAGCAGCCGGCCCAGGAACTCTAGAGGACATGTGGCATCGGATGGCCACAGGGCGGGGCTGCCAGGCTCTGC
AGGCACCCAGGGTGGGGAGGCCACCCTTCCTGCCCTACCCGCAGAATGGTGCTCTCCTTTGCCCTCCCTGCCCAGCAGCCTGATAGGACT
CTCCTAGTCCAACTTGGGGTGGGCAAGGCAGTCAGCATCACCAGCAATACCACAGGACCCTCACCCCAGCATAGACACACACCCCCTGAC
CCTTACCATCTGCTTCCTGAAAGACTTCAGTGTCAGCTCCCCTACACACACCCCACACCTTCACCCCTTGCTTCAAGATTCAAACAGAGA
CTCCCAGTCCCCCTCAGCATCTTCCCTGAATCACAGCCCCAGCTCCTTGACCCCCATCTAGGTGCCAAATGTTCATCTGCAACCGCTATG
CAGTCTGGTGAGAGGGAGACAGCCATCACATAGAAAGTGACCGTACGGGTTTTTAATCACTGCTGGGTGGGGTGGGGGTAGGGGGATTGT
CCTGGCTTTGTCGACAAAGTCCCACTTCCCCGAGTATTAAGGGCCCTTGGTATCAAGTGAGGTAAATTCACCCATCACAGGGTCTCGCCC
TACCATCCTGGAATTATTTCACTTTTAAGATAAATGCACTATTTCACTGTTCGCCTCCCATTCTAAGGAGGTGAGGTGGTTGGAATAAAA

>In-frame_LIG3_ENST00000262327_chr17_33321450_+_ZFAT_ENST00000520727_chr8_135490964_-_2622nt
CAACCGTCGTGGGCTGCCCGCGGCCTGTAATGAGCAAGTTCCGAGGCCTACGGTGAGCGCCGGAGCCGGAGAGGCAGCTATATGTCTTTG
GCTTTCAAGATCTTCTTTCCACAAACCCTCCGTGCACTCAGCCGAAAAGAACTGTGCCTATTCCGAAAACATCACTGGCGTGATGTAAGA
CAATTCAGCCAGTGGTCAGAAACAGATCTGCTTCATGGACATCCCCTCTTCCTGAGAAGAAAGCCTGTTCTATCATTCCAGGGAAGCCAT
CTAAGATCACGTGCCACCTACCTTGTTTTCTTGCCAGGGTTGCATGTGGGACTCTGCAGTGGCCCCTGTGAGATGGCTGAGCAACGGTTC
TGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAAAAAATGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGCAAAGTGGTG
CCCAATCCCTTCTCAGAGTCTGGGGGTGATATGAAAGAGTGGTACCACATTAAATGCATGTTTGAGAAACTAGAGCGGGCCCGGGCCACC
ACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTGGGAAGAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCACATTGCAGAT
CTGTCTTCTAAGGCAGCAGGTACACCAAAGAAGAAAGCTGTTGTCCAGGCTAAGTTGACAACCACTGGCCAGGTGACTTCTCCAGTGAAA
GGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATTTTCTGGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCCTCGAGCCCC
ACCCCTAAGAGAAGTCTGTCTTCAAGCAAATGTGACCCCAGGCATAAGGACTGTCTGCTACGGGAGTTTCGAAAGTTATGCGCCATGGTG
GCCGATAATCCTAGCTACAACACGAAGACCCAGATCATCCAGGACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCACGGTGATGTG
TACCTAACAGTGAAGCTGCTGCTGCCAGGAGTCATTAAGACTGTTTACAACTTGAACGATAAGCAGATTGTGAAGCTTTTCAGTCGCATT
TTTAACTGCAACCCAGATGATATGGCACGGGACCTAGAGCAGGGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAGAGCAAGTCT
TTCCCCCCAGCTGCCAAGAGCCTCCTTACCATCCAGGAAGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTCACCAAGGAGGATGAGCAG
CAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGCCAATGACCTTAAATGCATCATCAGGTTGATCAAACATGATCTGAAGATGAAC
TCAGGTGCAAAACATGTGTTAGACGCCCTTGACCCCAATGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTGCAGGATGTGGTGGAGCGG
GTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGGCCAGAGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCTGTGCAGCCC
ATGTTGGCGGAGGCCTGCAAGTCCGTTGAGTATGCAATGAAGAAATGTCCCAATGGCATGTTCTCTGAGATCAAGTACGATGGAGAGCGA
GTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTTCAGCCGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTCACCGAGGAGGAGCCC
AGCTCCAACCACACGGTCATGATCCAGGAGACGGTCCAGCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTGTCCTCCGAC
GACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCAGGGCGGGGAGGCCTCGGAGTTCATCGTCTACGTGCAGGAGGCCATGCAGCCT
GTGGAGGAGCAGGCTGTGGAGCAGCCGGCCCAGGAACTCTAGAGGACATGTGGCATCGGATGGCCACAGGGCGGGGCTGCCAGGCTCTGC
AGGCACCCAGGGTGGGGAGGCCACCCTTCCTGCCCTACCCGCAGAATGGTGCTCTCCTTTGCCCTCCCTGCCCAGCAGCCTGATAGGACT
CTCCTAGTCCAACTTGGGGTGGGCAAGGCAGTCAGCATCACCAGCAATACCACAGGACCCTCACCCCAGCATAGACACACACCCCCTGAC
CCTTACCATCTGCTTCCTGAAAGACTTCAGTGTCAGCTCCCCTACACACACCCCACACCTTCACCCCTTGCTTCAAGATTCAAACAGAGA
CTCCCAGTCCCCCTCAGCATCTTCCCTGAATCACAGCCCCAGCTCCTTGACCCCCATCTAGGTGCCAAATGTTCATCTGCAACCGCTATG
CAGTCTGGTGAGAGGGAGACAGCCATCACATAGAAAGTGACCGTACGGGTTTTTAATCACTGCTGGGTGGGGTGGGGGTAGGGGGATTGT
CCTGGCTTTGTCGACAAAGTCCCACTTCCCCGAGTATTAAGGGCCCTTGGTATCAAGTGAGGTAAATTCACCCATCACAGGGTCTCGCCC
TACCATCCTGGAATTATTTCACTTTTAAGATAAATGCACTATTTCACTGTTCGCCTCCCATTCTAAGGAGGTGAGGTGGTTGGAATAAAA


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FusionGenePPI for LIG3_ZFAT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LIG3XRCC1, PNKP, NEIL1, NCAPG, THRA, THRB, PARP1, XRCC5, XRCC6, NBN, APP, APTX, CBX8, RPA1, RPA2, RPA3, MOV10, NXF1, PYCARD, CCDC8, EED, TOP3A, PREPL, JMJD4, CLPX, RSAD1, C7orf55, PSME3, NDUFS6, RNF146, POLB, APLF, HIST1H2BA, KIF23, RACGAP1, NTRK1, HIST1H2BG, HIST1H3A, BAX, TMPO, EMC2, EXOSC4, MMGT1, SPC24, JUN, MAX, FOXB1, FOXD3, FOXE1, FOXK2, FOXP1, NF2, NFATC1, NFATC2, H2AFX, RNF166, WDR76, MACROD1, LARS2ZFATYY1AP1, HSPB1, PTAR1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneLIG3chr17:33321450chr8:135490964ENST00000262327+920277_280537950DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000262327+920318_323537950DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000262327+920388_391537950DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000262327+920421_427537950DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000378526+920277_2805371010DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000378526+920318_3235371010DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000378526+920388_3915371010DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000378526+920421_4275371010DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LIG3_ZFAT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneLIG3P49916DB00290BleomycinDNA ligase 3small moleculeapproved|investigational

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RelatedDiseases for LIG3_ZFAT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource