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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1969

FusionGeneSummary for ANTXR2_ANTXR2

check button Fusion gene summary
Fusion gene informationFusion gene name: ANTXR2_ANTXR2
Fusion gene ID: 1969
HgeneTgene
Gene symbol

ANTXR2

ANTXR2

Gene ID

118429

118429

Gene nameANTXR cell adhesion molecule 2ANTXR cell adhesion molecule 2
SynonymsCMG-2|CMG2|HFS|ISH|JHFCMG-2|CMG2|HFS|ISH|JHF
Cytomap

4q21.21

4q21.21

Type of geneprotein-codingprotein-coding
Descriptionanthrax toxin receptor 2capillary morphogenesis gene 2 proteincapillary morphogenesis protein 2anthrax toxin receptor 2capillary morphogenesis gene 2 proteincapillary morphogenesis protein 2
Modification date2018052320180523
UniProtAcc

P58335

P58335

Ensembl transtripts involved in fusion geneENST00000403729, ENST00000482406, 
ENST00000404191, ENST00000346652, 
ENST00000307333, ENST00000295465, 
ENST00000403729, ENST00000482406, 
ENST00000404191, ENST00000346652, 
ENST00000307333, ENST00000295465, 
Fusion gene scores* DoF score5 X 6 X 3=906 X 7 X 3=126
# samples 87
** MAII scorelog2(8/90*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANTXR2 [Title/Abstract] AND ANTXR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN315409ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
ChiTaRS3.1AI000346ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000403729ENST00000403729ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-5UTRENST00000403729ENST00000482406ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-5UTRENST00000403729ENST00000404191ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000403729ENST00000346652ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000403729ENST00000307333ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000403729ENST00000295465ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-3CDSENST00000482406ENST00000403729ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-5UTRENST00000482406ENST00000482406ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-5UTRENST00000482406ENST00000404191ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000482406ENST00000346652ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000482406ENST00000307333ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000482406ENST00000295465ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-3CDSENST00000404191ENST00000403729ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-5UTRENST00000404191ENST00000482406ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-5UTRENST00000404191ENST00000404191ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000404191ENST00000346652ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000404191ENST00000307333ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000404191ENST00000295465ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-3CDSENST00000346652ENST00000403729ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-5UTRENST00000346652ENST00000482406ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-5UTRENST00000346652ENST00000404191ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000346652ENST00000346652ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000346652ENST00000307333ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000346652ENST00000295465ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-3CDSENST00000307333ENST00000403729ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-5UTRENST00000307333ENST00000482406ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-5UTRENST00000307333ENST00000404191ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000307333ENST00000346652ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000307333ENST00000307333ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000307333ENST00000295465ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-3CDSENST00000295465ENST00000403729ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-5UTRENST00000295465ENST00000482406ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-5UTRENST00000295465ENST00000404191ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000295465ENST00000346652ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000295465ENST00000307333ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000295465ENST00000295465ANTXR2chr4

80898796

-ANTXR2chr4

80828590

+
intron-intronENST00000403729ENST00000403729ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000403729ENST00000482406ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000403729ENST00000404191ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000403729ENST00000346652ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000403729ENST00000307333ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000403729ENST00000295465ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000482406ENST00000403729ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000482406ENST00000482406ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000482406ENST00000404191ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000482406ENST00000346652ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000482406ENST00000307333ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000482406ENST00000295465ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000404191ENST00000403729ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000404191ENST00000482406ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000404191ENST00000404191ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000404191ENST00000346652ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000404191ENST00000307333ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000404191ENST00000295465ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000346652ENST00000403729ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000346652ENST00000482406ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000346652ENST00000404191ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000346652ENST00000346652ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000346652ENST00000307333ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000346652ENST00000295465ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000307333ENST00000403729ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000307333ENST00000482406ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000307333ENST00000404191ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000307333ENST00000346652ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000307333ENST00000307333ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000307333ENST00000295465ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000295465ENST00000403729ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000295465ENST00000482406ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000295465ENST00000404191ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000295465ENST00000346652ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000295465ENST00000307333ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+
intron-intronENST00000295465ENST00000295465ANTXR2chr4

80956488

-ANTXR2chr4

80956670

+

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FusionProtFeatures for ANTXR2_ANTXR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANTXR2

P58335

ANTXR2

P58335

Necessary for cellular interactions with laminin and theextracellular matrix. {ECO:0000269|PubMed:11683410,ECO:0000269|PubMed:12973667}. Necessary for cellular interactions with laminin and theextracellular matrix. {ECO:0000269|PubMed:11683410,ECO:0000269|PubMed:12973667}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANTXR2_ANTXR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANTXR2_ANTXR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANTXR2_ANTXR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANTXR2_ANTXR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANTXR2C0009917Contracture2CTD_human
HgeneANTXR2C0016045fibroma2CTD_human
HgeneANTXR2C0017567Gingival Hypertrophy2CTD_human
HgeneANTXR2C0038013Ankylosing spondylitis2CTD_human
HgeneANTXR2C2745948Hyalinosis, Systemic2CTD_human;ORPHANET;UNIPROT
HgeneANTXR2C0029456Osteoporosis1CTD_human
HgeneANTXR2C0221204Lytic lesion1CTD_human
TgeneANTXR2C0009917Contracture2CTD_human
TgeneANTXR2C0016045fibroma2CTD_human
TgeneANTXR2C0017567Gingival Hypertrophy2CTD_human
TgeneANTXR2C0038013Ankylosing spondylitis2CTD_human
TgeneANTXR2C2745948Hyalinosis, Systemic2CTD_human;ORPHANET;UNIPROT
TgeneANTXR2C0029456Osteoporosis1CTD_human
TgeneANTXR2C0221204Lytic lesion1CTD_human