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Fusion gene ID: 19663 |
FusionGeneSummary for LGMN_LGMN |
Fusion gene summary |
Fusion gene information | Fusion gene name: LGMN_LGMN | Fusion gene ID: 19663 | Hgene | Tgene | Gene symbol | LGMN | LGMN | Gene ID | 5641 | 5641 |
Gene name | legumain | legumain | |
Synonyms | AEP|LGMN1|PRSC1 | AEP|LGMN1|PRSC1 | |
Cytomap | 14q32.12 | 14q32.12 | |
Type of gene | protein-coding | protein-coding | |
Description | legumainasparaginyl endopeptidasecysteine protease 1protease, cysteine 1protease, cysteine, 1 (legumain) | legumainasparaginyl endopeptidasecysteine protease 1protease, cysteine 1protease, cysteine, 1 (legumain) | |
Modification date | 20180525 | 20180525 | |
UniProtAcc | Q99538 | Q99538 | |
Ensembl transtripts involved in fusion gene | ENST00000555699, ENST00000334869, ENST00000557434, ENST00000393218, ENST00000557034, | ENST00000555699, ENST00000334869, ENST00000557434, ENST00000393218, ENST00000557034, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 6 X 5 X 3=90 |
# samples | 3 | 6 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LGMN [Title/Abstract] AND LGMN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LGMN | GO:0010447 | response to acidic pH | 18374643 |
Hgene | LGMN | GO:0035729 | cellular response to hepatocyte growth factor stimulus | 21237226 |
Hgene | LGMN | GO:0071277 | cellular response to calcium ion | 21237226 |
Hgene | LGMN | GO:0090026 | positive regulation of monocyte chemotaxis | 18377911 |
Hgene | LGMN | GO:0097202 | activation of cysteine-type endopeptidase activity | 9821970|18374643 |
Hgene | LGMN | GO:0097264 | self proteolysis | 9821970|18374643 |
Hgene | LGMN | GO:1904646 | cellular response to amyloid-beta | 25326800 |
Hgene | LGMN | GO:2001028 | positive regulation of endothelial cell chemotaxis | 18377911 |
Tgene | LGMN | GO:0010447 | response to acidic pH | 18374643 |
Tgene | LGMN | GO:0035729 | cellular response to hepatocyte growth factor stimulus | 21237226 |
Tgene | LGMN | GO:0071277 | cellular response to calcium ion | 21237226 |
Tgene | LGMN | GO:0090026 | positive regulation of monocyte chemotaxis | 18377911 |
Tgene | LGMN | GO:0097202 | activation of cysteine-type endopeptidase activity | 9821970|18374643 |
Tgene | LGMN | GO:0097264 | self proteolysis | 9821970|18374643 |
Tgene | LGMN | GO:1904646 | cellular response to amyloid-beta | 25326800 |
Tgene | LGMN | GO:2001028 | positive regulation of endothelial cell chemotaxis | 18377911 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW753026 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000555699 | ENST00000555699 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000555699 | ENST00000334869 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000555699 | ENST00000557434 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000555699 | ENST00000393218 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-intron | ENST00000555699 | ENST00000557034 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000334869 | ENST00000555699 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000334869 | ENST00000334869 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000334869 | ENST00000557434 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000334869 | ENST00000393218 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-intron | ENST00000334869 | ENST00000557034 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000557434 | ENST00000555699 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000557434 | ENST00000334869 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000557434 | ENST00000557434 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000557434 | ENST00000393218 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-intron | ENST00000557434 | ENST00000557034 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000393218 | ENST00000555699 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000393218 | ENST00000334869 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000393218 | ENST00000557434 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000393218 | ENST00000393218 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-intron | ENST00000393218 | ENST00000557034 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000557034 | ENST00000555699 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000557034 | ENST00000334869 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000557034 | ENST00000557434 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-3CDS | ENST00000557034 | ENST00000393218 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
intron-intron | ENST00000557034 | ENST00000557034 | LGMN | chr14 | 93185212 | + | LGMN | chr14 | 93182515 | - |
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FusionProtFeatures for LGMN_LGMN |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
LGMN | LGMN |
Has a strict specificity for hydrolysis of asparaginylbonds. Can also cleave aspartyl bonds slowly, especially underacidic conditions. Required for normal lysosomal proteindegradation in renal proximal tubules. Required for normaldegradation of internalized EGFR. Plays a role in the regulationof cell proliferation via its role in EGFR degradation (Bysimilarity). May be involved in the processing of proteins for MHCclass II antigen presentation in the lysosomal/endosomal system.{ECO:0000250, ECO:0000269|PubMed:23776206}. | Has a strict specificity for hydrolysis of asparaginylbonds. Can also cleave aspartyl bonds slowly, especially underacidic conditions. Required for normal lysosomal proteindegradation in renal proximal tubules. Required for normaldegradation of internalized EGFR. Plays a role in the regulationof cell proliferation via its role in EGFR degradation (Bysimilarity). May be involved in the processing of proteins for MHCclass II antigen presentation in the lysosomal/endosomal system.{ECO:0000250, ECO:0000269|PubMed:23776206}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LGMN_LGMN |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LGMN_LGMN |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LGMN_LGMN |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LGMN_LGMN |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LGMN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | LGMN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |