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Fusion gene ID: 19659 |
FusionGeneSummary for LGALS9_LGALS9B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LGALS9_LGALS9B | Fusion gene ID: 19659 | Hgene | Tgene | Gene symbol | LGALS9 | LGALS9B | Gene ID | 3965 | 284194 |
| Gene name | galectin 9 | galectin 9B | |
| Synonyms | HUAT|LGALS9A | - | |
| Cytomap | 17q11.2 | 17p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | galectin-9ecalectingal-9lectin, galactoside-binding, soluble, 9tumor antigen HOM-HD-21urate transporter/channel protein | galectin-9Bgal-9Bgalectin-9 likegalectin-9 pseudogenegalectin-9-like protein Alectin, galactoside-binding, soluble, 9B | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | O00182 | Q3B8N2 | |
| Ensembl transtripts involved in fusion gene | ENST00000310394, ENST00000395473, ENST00000302228, ENST00000313648, ENST00000413914, ENST00000448970, | ENST00000423676, ENST00000324290, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: LGALS9 [Title/Abstract] AND LGALS9B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LGALS9 | GO:0006954 | inflammatory response | 23817958 |
| Hgene | LGALS9 | GO:0007565 | female pregnancy | 23242525 |
| Hgene | LGALS9 | GO:0010628 | positive regulation of gene expression | 16116184 |
| Hgene | LGALS9 | GO:0010629 | negative regulation of gene expression | 23408620 |
| Hgene | LGALS9 | GO:0032673 | regulation of interleukin-4 production | 16116184 |
| Hgene | LGALS9 | GO:0032674 | regulation of interleukin-5 production | 16116184 |
| Hgene | LGALS9 | GO:0032689 | negative regulation of interferon-gamma production | 23408620 |
| Hgene | LGALS9 | GO:0032753 | positive regulation of interleukin-4 production | 20209097 |
| Hgene | LGALS9 | GO:0032834 | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response | 20209097 |
| Hgene | LGALS9 | GO:0034134 | toll-like receptor 2 signaling pathway | 16116184 |
| Hgene | LGALS9 | GO:0034142 | toll-like receptor 4 signaling pathway | 16116184 |
| Hgene | LGALS9 | GO:0038066 | p38MAPK cascade | 16116184 |
| Hgene | LGALS9 | GO:0045953 | negative regulation of natural killer cell mediated cytotoxicity | 23408620 |
| Hgene | LGALS9 | GO:0046598 | positive regulation of viral entry into host cell | 21670307 |
| Hgene | LGALS9 | GO:0050718 | positive regulation of interleukin-1 beta secretion | 20209097 |
| Hgene | LGALS9 | GO:0060135 | maternal process involved in female pregnancy | 25578313 |
| Hgene | LGALS9 | GO:0070241 | positive regulation of activated T cell autonomous cell death | 20209097 |
| Hgene | LGALS9 | GO:0070371 | ERK1 and ERK2 cascade | 16116184 |
| Hgene | LGALS9 | GO:0070555 | response to interleukin-1 | 23817958 |
| Hgene | LGALS9 | GO:0071346 | cellular response to interferon-gamma | 23817958 |
| Hgene | LGALS9 | GO:0071636 | positive regulation of transforming growth factor beta production | 20209097 |
| Hgene | LGALS9 | GO:1902715 | positive regulation of interferon-gamma secretion | 20209097 |
| Hgene | LGALS9 | GO:1904469 | positive regulation of tumor necrosis factor secretion | 20209097 |
| Hgene | LGALS9 | GO:2000562 | negative regulation of CD4-positive, alpha-beta T cell proliferation | 20209097 |
| Hgene | LGALS9 | GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation | 16116184 |
| Hgene | LGALS9 | GO:2000667 | positive regulation of interleukin-13 secretion | 20209097 |
| Hgene | LGALS9 | GO:2000670 | positive regulation of dendritic cell apoptotic process | 16116184 |
| Hgene | LGALS9 | GO:2001181 | positive regulation of interleukin-10 secretion | 16116184|20209097 |
| Hgene | LGALS9 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | 16116184 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG980811 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000310394 | ENST00000423676 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000310394 | ENST00000324290 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000395473 | ENST00000423676 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000395473 | ENST00000324290 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000302228 | ENST00000423676 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000302228 | ENST00000324290 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| In-frame | ENST00000313648 | ENST00000423676 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| In-frame | ENST00000313648 | ENST00000324290 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000413914 | ENST00000423676 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000413914 | ENST00000324290 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| intron-3CDS | ENST00000448970 | ENST00000423676 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| intron-3CDS | ENST00000448970 | ENST00000324290 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
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FusionProtFeatures for LGALS9_LGALS9B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LGALS9 | LGALS9B |
| Binds galactosides. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LGALS9_LGALS9B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LGALS9_ENST00000313648_chr17_25975890_+_LGALS9B_ENST00000423676_chr17_20355127_+_0aa >In-frame_LGALS9_ENST00000313648_chr17_25975890_+_LGALS9B_ENST00000324290_chr17_20355127_+_0aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LGALS9_ENST00000313648_chr17_25975890_+_LGALS9B_ENST00000423676_chr17_20355127_+_0nt >In-frame_LGALS9_ENST00000313648_chr17_25975890_+_LGALS9B_ENST00000324290_chr17_20355127_+_0nt |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LGALS9_ENST00000313648_chr17_25975890_+_LGALS9B_ENST00000423676_chr17_20355127_+_0nt >In-frame_LGALS9_ENST00000313648_chr17_25975890_+_LGALS9B_ENST00000324290_chr17_20355127_+_0nt |
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FusionGenePPI for LGALS9_LGALS9B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LGALS9_LGALS9B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LGALS9_LGALS9B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LGALS9 | C0027697 | Nephritis | 1 | CTD_human |
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