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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1965

FusionGeneSummary for ANPEP_ANPEP

check button Fusion gene summary
Fusion gene informationFusion gene name: ANPEP_ANPEP
Fusion gene ID: 1965
HgeneTgene
Gene symbol

ANPEP

ANPEP

Gene ID

290

290

Gene namealanyl aminopeptidase, membranealanyl aminopeptidase, membrane
SynonymsAPN|CD13|GP150|LAP1|P150|PEPNAPN|CD13|GP150|LAP1|P150|PEPN
Cytomap

15q26.1

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionaminopeptidase NAP-MAP-Nalanyl (membrane) aminopeptidaseaminopeptidase MhAPNmembrane alanyl aminopeptidasemicrosomal aminopeptidasemyeloid plasma membrane glycoprotein CD13aminopeptidase NAP-MAP-Nalanyl (membrane) aminopeptidaseaminopeptidase MhAPNmembrane alanyl aminopeptidasemicrosomal aminopeptidasemyeloid plasma membrane glycoprotein CD13
Modification date2018052320180523
UniProtAcc

P15144

P15144

Ensembl transtripts involved in fusion geneENST00000300060, ENST00000558177, 
ENST00000300060, ENST00000558177, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 3=27
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANPEP [Title/Abstract] AND ANPEP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB157580ANPEPchr15

90347130

+ANPEPchr15

90344722

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000300060ENST00000300060ANPEPchr15

90347130

+ANPEPchr15

90344722

-
intron-5UTRENST00000300060ENST00000558177ANPEPchr15

90347130

+ANPEPchr15

90344722

-
intron-3CDSENST00000558177ENST00000300060ANPEPchr15

90347130

+ANPEPchr15

90344722

-
intron-5UTRENST00000558177ENST00000558177ANPEPchr15

90347130

+ANPEPchr15

90344722

-

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FusionProtFeatures for ANPEP_ANPEP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANPEP

P15144

ANPEP

P15144

Broad specificity aminopeptidase which plays a role inthe final digestion of peptides generated from hydrolysis ofproteins by gastric and pancreatic proteases. Also involved in theprocessing of various peptides including peptide hormones, such asangiotensin III and IV, neuropeptides, and chemokines. May also beinvolved the cleavage of peptides bound to majorhistocompatibility complex class II molecules of antigenpresenting cells. May have a role in angiogenesis and promotecholesterol crystallization. {ECO:0000269|PubMed:10605003,ECO:0000269|PubMed:10676659, ECO:0000269|PubMed:11384645,ECO:0000269|PubMed:12473585, ECO:0000269|PubMed:7576235,ECO:0000269|PubMed:8102610, ECO:0000269|PubMed:9056417}. (Microbial infection) Acts as a receptor for humancoronavirus 229E/HCoV-229E. In case of human coronavirus 229E(HCoV-229E) infection, serves as receptor for HCoV-229E spikeglycoprotein. {ECO:0000269|PubMed:12551991,ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485,ECO:0000269|PubMed:9367365}. (Microbial infection) Mediates as well Humancytomegalovirus (HCMV) infection. {ECO:0000269|PubMed:8105105}. Broad specificity aminopeptidase which plays a role inthe final digestion of peptides generated from hydrolysis ofproteins by gastric and pancreatic proteases. Also involved in theprocessing of various peptides including peptide hormones, such asangiotensin III and IV, neuropeptides, and chemokines. May also beinvolved the cleavage of peptides bound to majorhistocompatibility complex class II molecules of antigenpresenting cells. May have a role in angiogenesis and promotecholesterol crystallization. {ECO:0000269|PubMed:10605003,ECO:0000269|PubMed:10676659, ECO:0000269|PubMed:11384645,ECO:0000269|PubMed:12473585, ECO:0000269|PubMed:7576235,ECO:0000269|PubMed:8102610, ECO:0000269|PubMed:9056417}. (Microbial infection) Acts as a receptor for humancoronavirus 229E/HCoV-229E. In case of human coronavirus 229E(HCoV-229E) infection, serves as receptor for HCoV-229E spikeglycoprotein. {ECO:0000269|PubMed:12551991,ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485,ECO:0000269|PubMed:9367365}. (Microbial infection) Mediates as well Humancytomegalovirus (HCMV) infection. {ECO:0000269|PubMed:8105105}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANPEP_ANPEP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANPEP_ANPEP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANPEP_ANPEP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneANPEPP15144DB00973EzetimibeAminopeptidase N {ECO:0000305}small moleculeapproved
HgeneANPEPP15144DB06196IcatibantAminopeptidase N {ECO:0000305}small moleculeapproved|investigational
TgeneANPEPP15144DB00973EzetimibeAminopeptidase N {ECO:0000305}small moleculeapproved
TgeneANPEPP15144DB06196IcatibantAminopeptidase N {ECO:0000305}small moleculeapproved|investigational

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RelatedDiseases for ANPEP_ANPEP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANPEPC0005695Bladder Neoplasm1CTD_human
HgeneANPEPC0041696Unipolar Depression1PSYGENET
HgeneANPEPC0149821ACUTE ALCOHOL WITHDRAWAL1PSYGENET
HgeneANPEPC1269683Major Depressive Disorder1PSYGENET
TgeneANPEPC0005695Bladder Neoplasm1CTD_human
TgeneANPEPC0041696Unipolar Depression1PSYGENET
TgeneANPEPC0149821ACUTE ALCOHOL WITHDRAWAL1PSYGENET
TgeneANPEPC1269683Major Depressive Disorder1PSYGENET