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Fusion gene ID: 19643 |
FusionGeneSummary for LGALS1_TF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LGALS1_TF | Fusion gene ID: 19643 | Hgene | Tgene | Gene symbol | LGALS1 | TF | Gene ID | 3956 | 7018 |
| Gene name | galectin 1 | transferrin | |
| Synonyms | GAL1|GBP | HEL-S-71p|PRO1557|PRO2086|TFQTL1 | |
| Cytomap | 22q13.1 | 3q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | galectin-114 kDa laminin-binding protein14 kDa lectinHBLHLBP14HPLS-Lac lectin 1beta-galactoside-binding lectin L-14-Ibeta-galactoside-binding protein 14kDagal-1galaptinlactose-binding lectin 1lectin, galactoside-binding, soluble, 1putative MA | serotransferrinbeta-1 metal-binding globulinepididymis secretory sperm binding protein Li 71psiderophilin | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P09382 | P02787 | |
| Ensembl transtripts involved in fusion gene | ENST00000215909, ENST00000489315, | ENST00000402696, ENST00000264998, ENST00000475382, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 8 X 7 X 3=168 |
| # samples | 4 | 9 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LGALS1 [Title/Abstract] AND TF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LGALS1 | GO:0046598 | positive regulation of viral entry into host cell | 21670307 |
| Hgene | LGALS1 | GO:2001200 | positive regulation of dendritic cell differentiation | 16116184 |
| Tgene | TF | GO:0048260 | positive regulation of receptor-mediated endocytosis | 12704209 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG769694 | LGALS1 | chr22 | 38074620 | + | TF | chr3 | 133473543 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000215909 | ENST00000402696 | LGALS1 | chr22 | 38074620 | + | TF | chr3 | 133473543 | + |
| 5CDS-intron | ENST00000215909 | ENST00000264998 | LGALS1 | chr22 | 38074620 | + | TF | chr3 | 133473543 | + |
| 5CDS-intron | ENST00000215909 | ENST00000475382 | LGALS1 | chr22 | 38074620 | + | TF | chr3 | 133473543 | + |
| 3UTR-intron | ENST00000489315 | ENST00000402696 | LGALS1 | chr22 | 38074620 | + | TF | chr3 | 133473543 | + |
| 3UTR-intron | ENST00000489315 | ENST00000264998 | LGALS1 | chr22 | 38074620 | + | TF | chr3 | 133473543 | + |
| 3UTR-intron | ENST00000489315 | ENST00000475382 | LGALS1 | chr22 | 38074620 | + | TF | chr3 | 133473543 | + |
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FusionProtFeatures for LGALS1_TF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LGALS1 | TF |
| Lectin that binds beta-galactoside and a wide array ofcomplex carbohydrates. Plays a role in regulating apoptosis, cellproliferation and cell differentiation. Inhibits CD45 proteinphosphatase activity and therefore the dephosphorylation of Lynkinase. Strong inducer of T-cell apoptosis.{ECO:0000269|PubMed:14617626, ECO:0000269|PubMed:18796645,ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:24945728}. | Transferrins are iron binding transport proteins whichcan bind two Fe(3+) ions in association with the binding of ananion, usually bicarbonate. It is responsible for the transport ofiron from sites of absorption and heme degradation to those ofstorage and utilization. Serum transferrin may also have a furtherrole in stimulating cell proliferation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LGALS1_TF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LGALS1_TF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LGALS1_TF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | LGALS1 | P09382 | DB11638 | Artenimol | Galectin-1 | small molecule | approved|investigational |
| Tgene | TF | P02787 | DB00515 | Cisplatin | Serotransferrin | small molecule | approved |
| Tgene | TF | P02787 | DB01592 | Iron | Serotransferrin | small molecule | approved |
| Tgene | TF | P02787 | DB01370 | Aluminium | Serotransferrin | small molecule | approved|investigational |
| Tgene | TF | P02787 | DB01593 | Zinc | Serotransferrin | small molecule | approved|investigational |
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RelatedDiseases for LGALS1_TF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LGALS1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Hgene | LGALS1 | C0022548 | Keloid | 1 | CTD_human |
| Hgene | LGALS1 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Hgene | LGALS1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | LGALS1 | C0027697 | Nephritis | 1 | CTD_human |
| Tgene | TF | C0036341 | Schizophrenia | 3 | PSYGENET |
| Tgene | TF | C0521802 | Congenital atransferrinemia | 3 | CTD_human;HPO;ORPHANET;UNIPROT |
| Tgene | TF | C0001973 | Alcoholic Intoxication, Chronic | 2 | CTD_human |
| Tgene | TF | C0002395 | Alzheimer's Disease | 2 | CTD_human |
| Tgene | TF | C0015695 | Fatty Liver | 2 | CTD_human |
| Tgene | TF | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
| Tgene | TF | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
| Tgene | TF | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | TF | C0013502 | Echinococcosis | 1 | CTD_human |
| Tgene | TF | C0019158 | Hepatitis | 1 | CTD_human |
| Tgene | TF | C0021368 | Inflammation | 1 | CTD_human |
| Tgene | TF | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | TF | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
| Tgene | TF | C0028754 | Obesity | 1 | CTD_human |
| Tgene | TF | C0030524 | Paratuberculosis | 1 | CTD_human |
| Tgene | TF | C0035258 | Restless Legs Syndrome | 1 | CTD_human |
| Tgene | TF | C0036337 | Schizoaffective Disorder | 1 | PSYGENET |
| Tgene | TF | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | TF | C0271901 | Microcytic hypochromic anemia (disorder) | 1 | CTD_human |
| Tgene | TF | C0282193 | Iron Overload | 1 | CTD_human |
| Tgene | TF | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | TF | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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