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Fusion gene ID: 19628 |
FusionGeneSummary for LEPROT_NFIA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LEPROT_NFIA | Fusion gene ID: 19628 | Hgene | Tgene | Gene symbol | LEPROT | NFIA | Gene ID | 54741 | 4774 |
| Gene name | leptin receptor overlapping transcript | nuclear factor I A | |
| Synonyms | LEPR|OB-RGRP|OBRGRP|VPS55 | BRMUTD|CTF|NF-I/A|NF1-A|NFI-A|NFI-L | |
| Cytomap | 1p31.3 | 1p31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leptin receptor gene-related proteinDnaJ (Hsp40) homolog, subfamily C, member 6OB-R gene-related proteinendospaninendospanin-1leptin receptor overlapping transcript protein | nuclear factor 1 A-typeCCAAT-box-binding transcription factorTGGCA-binding protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O15243 | Q12857 | |
| Ensembl transtripts involved in fusion gene | ENST00000371065, ENST00000484243, | ENST00000371191, ENST00000407417, ENST00000479364, ENST00000371189, ENST00000403491, ENST00000371187, ENST00000485903, ENST00000371185, ENST00000371184, ENST00000357977, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 11 X 13 X 6=858 |
| # samples | 6 | 15 | |
| ** MAII score | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/858*10)=-2.51601514700366 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LEPROT [Title/Abstract] AND NFIA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LEPROT | GO:0046426 | negative regulation of JAK-STAT cascade | 18042720 |
| Hgene | LEPROT | GO:0060400 | negative regulation of growth hormone receptor signaling pathway | 19907080 |
| Hgene | LEPROT | GO:2000009 | negative regulation of protein localization to cell surface | 18042720 |
| Tgene | NFIA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17010934 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-L9-A5IP-01A | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000371065 | ENST00000371191 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| Frame-shift | ENST00000371065 | ENST00000407417 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 5CDS-3UTR | ENST00000371065 | ENST00000479364 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 5CDS-3UTR | ENST00000371065 | ENST00000371189 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 5CDS-3UTR | ENST00000371065 | ENST00000403491 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 5CDS-3UTR | ENST00000371065 | ENST00000371187 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 5CDS-3UTR | ENST00000371065 | ENST00000485903 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 5CDS-intron | ENST00000371065 | ENST00000371185 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 5CDS-intron | ENST00000371065 | ENST00000371184 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 5CDS-intron | ENST00000371065 | ENST00000357977 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 3UTR-3CDS | ENST00000484243 | ENST00000371191 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 3UTR-3CDS | ENST00000484243 | ENST00000407417 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 3UTR-3UTR | ENST00000484243 | ENST00000479364 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 3UTR-3UTR | ENST00000484243 | ENST00000371189 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 3UTR-3UTR | ENST00000484243 | ENST00000403491 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 3UTR-3UTR | ENST00000484243 | ENST00000371187 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 3UTR-3UTR | ENST00000484243 | ENST00000485903 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 3UTR-intron | ENST00000484243 | ENST00000371185 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 3UTR-intron | ENST00000484243 | ENST00000371184 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
| 3UTR-intron | ENST00000484243 | ENST00000357977 | LEPROT | chr1 | 65891061 | + | NFIA | chr1 | 61743192 | + |
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FusionProtFeatures for LEPROT_NFIA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LEPROT | NFIA |
| Negatively regulates leptin receptor (LEPR) cell surfaceexpression, and thus decreases response to leptin. Negativelyregulates growth hormone (GH) receptor cell surface expression inliver. May play a role in liver resistance to GH during periods ofreduced nutrient availability. {ECO:0000269|PubMed:18042720,ECO:0000269|PubMed:19907080}. | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and inthe origin of replication of adenovirus type 2. These proteins areindividually capable of activating transcription and replication. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for LEPROT_NFIA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for LEPROT_NFIA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LEPROT | ELAVL1 | NFIA | ELAVL1, TFAP4, SAP18, PCDHA2, NOP2, TRA2A, HNRNPU, TPBG, SRSF7, NOP56, RRS1, RPS13, SON, SRSF10, FTSJ3, RRP7A, UTP14A, ZNF326, RPS6, DDX21, RPS24, SURF4, DHX9, TRIM55, VTN, LUC7L3, RBM25, HP1BP3, ACIN1, ADNP, SRSF3, TRA2B, RPS11, RPL37A, SMAD4, SMAD2, SMAD3, XPO1, CREB1, RBPJ, FOXC2, NFIB, UBC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LEPROT_NFIA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LEPROT_NFIA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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