FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1962

FusionGeneSummary for ANP32E_CTSK

check button Fusion gene summary
Fusion gene informationFusion gene name: ANP32E_CTSK
Fusion gene ID: 1962
HgeneTgene
Gene symbol

ANP32E

CTSK

Gene ID

81611

1513

Gene nameacidic nuclear phosphoprotein 32 family member Ecathepsin K
SynonymsLANP-L|LANPLCTS02|CTSO|CTSO1|CTSO2|PKND|PYCD
Cytomap

1q21.2

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionacidic leucine-rich nuclear phosphoprotein 32 family member ELANP-like proteinacidic (leucine-rich) nuclear phosphoprotein 32 family, member Eleucine-rich acidic nuclear protein likecathepsin Kcathepsin Ocathepsin O1cathepsin O2cathepsin X
Modification date2018052320180523
UniProtAcc

Q9BTT0

P43235

Ensembl transtripts involved in fusion geneENST00000314136, ENST00000369119, 
ENST00000369116, ENST00000436748, 
ENST00000369114, ENST00000369115, 
ENST00000533654, 
ENST00000271651, 
ENST00000480670, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 3 X 2=12
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANP32E [Title/Abstract] AND CTSK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANP32E

GO:0043486

histone exchange

24463511

TgeneCTSK

GO:0030574

collagen catabolic process

22952693

TgeneCTSK

GO:0051603

proteolysis involved in cellular protein catabolic process

22952693


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-61-1918-01AANP32Echr1

150202906

-CTSKchr1

150769374

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000314136ENST00000271651ANP32Echr1

150202906

-CTSKchr1

150769374

-
5CDS-intronENST00000314136ENST00000480670ANP32Echr1

150202906

-CTSKchr1

150769374

-
Frame-shiftENST00000369119ENST00000271651ANP32Echr1

150202906

-CTSKchr1

150769374

-
5CDS-intronENST00000369119ENST00000480670ANP32Echr1

150202906

-CTSKchr1

150769374

-
intron-3CDSENST00000369116ENST00000271651ANP32Echr1

150202906

-CTSKchr1

150769374

-
intron-intronENST00000369116ENST00000480670ANP32Echr1

150202906

-CTSKchr1

150769374

-
intron-3CDSENST00000436748ENST00000271651ANP32Echr1

150202906

-CTSKchr1

150769374

-
intron-intronENST00000436748ENST00000480670ANP32Echr1

150202906

-CTSKchr1

150769374

-
Frame-shiftENST00000369114ENST00000271651ANP32Echr1

150202906

-CTSKchr1

150769374

-
5CDS-intronENST00000369114ENST00000480670ANP32Echr1

150202906

-CTSKchr1

150769374

-
intron-3CDSENST00000369115ENST00000271651ANP32Echr1

150202906

-CTSKchr1

150769374

-
intron-intronENST00000369115ENST00000480670ANP32Echr1

150202906

-CTSKchr1

150769374

-
Frame-shiftENST00000533654ENST00000271651ANP32Echr1

150202906

-CTSKchr1

150769374

-
5CDS-intronENST00000533654ENST00000480670ANP32Echr1

150202906

-CTSKchr1

150769374

-

Top

FusionProtFeatures for ANP32E_CTSK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANP32E

Q9BTT0

CTSK

P43235

Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removesH2A.Z/H2AFZ from its normal sites of deposition, especially fromenhancer and insulator regions. Not involved in deposition ofH2A.Z/H2AFZ in the nucleosome. May stabilize the evictedH2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towardsdissociation and the off-chromatin state (PubMed:24463511).Inhibits activity of protein phosphatase 2A (PP2A). Does notinhibit protein phosphatase 1. May play a role in cerebellardevelopment and synaptogenesis. {ECO:0000269|PubMed:24463511}. Closely involved in osteoclastic bone resorption and mayparticipate partially in the disorder of bone remodeling. Displayspotent endoprotease activity against fibrinogen at acid pH. Mayplay an important role in extracellular matrix degradation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ANP32E_CTSK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ANP32E_CTSK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANP32EMEPCE, MGMT, UCHL5, PARD3, FYTTD1, RPS2, SOX2, FOS, SMAD2, ATG7, ATP6V1C1, RDX, RNASEH2B, SARS, VPS35, SNX2, SNX6, HIST1H2BA, UNK, AHCYL1, AHCYL2, ANP32A, TPI1, DMAP1, PAPPA, VPS72, EWSR1, KPNA1, UBA5, PTPN2, UBC, TRIM25, G3BP1, TESCTSKFGFR3, SERPINB3, LIG4, ARID4B, ERBB2IP, CTSV, C18orf25, CTSL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ANP32E_CTSK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ANP32E_CTSK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCTSKC0238402Pycnodysostosis5CTD_human;ORPHANET;UNIPROT
TgeneCTSKC0036341Schizophrenia2PSYGENET
TgeneCTSKC0017636Glioblastoma1CTD_human