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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 19619

FusionGeneSummary for LENG8_SIPA1L3

check button Fusion gene summary
Fusion gene informationFusion gene name: LENG8_SIPA1L3
Fusion gene ID: 19619
HgeneTgene
Gene symbol

LENG8

SIPA1L3

Gene ID

114823

23094

Gene nameleukocyte receptor cluster member 8signal induced proliferation associated 1 like 3
Synonymspp13842CTRCT45|SPAL3|SPAR3
Cytomap

19q13.42

19q13.13-q13.2

Type of geneprotein-codingprotein-coding
Descriptionleukocyte receptor cluster member 8leukocyte receptor cluster (LRC) member 8signal-induced proliferation-associated 1-like protein 3SIPA1-like protein 3SPA-1-like protein 3
Modification date2018051920180519
UniProtAcc

Q96PV6

O60292

Ensembl transtripts involved in fusion geneENST00000326764, ENST00000376514, 
ENST00000222345, ENST00000476317, 
Fusion gene scores* DoF score7 X 8 X 3=16815 X 10 X 9=1350
# samples 914
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/1350*10)=-3.26946067499323
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LENG8 [Title/Abstract] AND SIPA1L3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSIPA1L3

GO:0003382

epithelial cell morphogenesis

26231217

TgeneSIPA1L3

GO:0090162

establishment of epithelial cell polarity

26231217


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-UL-AAZ6-01ALENG8chr19

54969700

+SIPA1L3chr19

38631824

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000326764ENST00000222345LENG8chr19

54969700

+SIPA1L3chr19

38631824

+
5CDS-intronENST00000326764ENST00000476317LENG8chr19

54969700

+SIPA1L3chr19

38631824

+
intron-3CDSENST00000376514ENST00000222345LENG8chr19

54969700

+SIPA1L3chr19

38631824

+
intron-intronENST00000376514ENST00000476317LENG8chr19

54969700

+SIPA1L3chr19

38631824

+

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FusionProtFeatures for LENG8_SIPA1L3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LENG8

Q96PV6

SIPA1L3

O60292

Plays a critical role in epithelial cell morphogenesis,polarity, adhesion and cytoskeletal organization in the lens(PubMed:26231217). {ECO:0000269|PubMed:26231217}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLENG8chr19:54969700chr19:38631824ENST00000326764+1516412_446746801Compositional biasSer-rich
HgeneLENG8chr19:54969700chr19:38631824ENST00000326764+151671_168746801Compositional biasGln-rich
TgeneSIPA1L3chr19:54969700chr19:38631824ENST00000222345+9221720_177410471782Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLENG8chr19:54969700chr19:38631824ENST00000326764+1516636_800746801DomainPCI
TgeneSIPA1L3chr19:54969700chr19:38631824ENST00000222345+922611_82810471782DomainRap-GAP
TgeneSIPA1L3chr19:54969700chr19:38631824ENST00000222345+922966_104210471782DomainPDZ


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FusionGeneSequence for LENG8_SIPA1L3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_LENG8_ENST00000326764_chr19_54969700_+_SIPA1L3_ENST00000222345_chr19_38631824_+_1481aa
MAANVGDQRSTDWSSQYSMVAGAGRENGMETPMHENPEWEKARQALASISKSGAAGGSAKSSSNGPVASAQYVSQAEASALQQQQYYQWY
QQYNYAYPYSYYYPMSMYQSYGSPSQYGMAGSYGSATPQQPSAPQHQGTLNQPPVPGMDESMSYQAPPQQLPSAQPPQPSNPPHGAHTLN
SGPQPGTAPATQHSQAGPATGQAYGPHTYTEPAKPKKGQQLWNRMKPAPGTGGLKFNIQKRPFAVTTQSFGSNAEGQHSGFGPQPNPEKV
QNHSGSSARGNLSGKPDDWPQDMKEYVERCFTACESEEDKDRTEKLLKEVLQARLQDGSAYTIDWSREPLPGLTREPVAESPKKKRWEAA
SSLHPPRGAGSATRGGGAPSQRGTPGAGGAGRARGNSFTKFGNRNVFMKDNSSSSSTDSRSRSSSRSPTRHFRRSDSHSDSDSSYSGNEC
HPVGRRNPPPKGRGGRGAHMDRGRGRAQRGKRHDLAPTKRSRKKMAALECEDPERELKKQKRAARFQHGHSRRLRLEPLVLQMSSLESSG
ADPDWQELQIVGTCPDITKHYLRLTCAPDPSTVRPVAVLKKSLCMVKCHWKEKQDYAFACEQMKSIRQDLTVQGIRTEFTVEVYETHARI
ALEKGDHEEFNQCQTQLKSLYAENLPGNVGEFTAYRILYYIFTKNSGDITTELAYLTRELKADPCVAHALALRTAWALGNYHRFFRLYCH
APCMSGYLVDKFADRERKVALKAMIKTGWPETYDMNTSEPKTEQESITPGGRPPYRSNAPWQWSGPASHNSLPASKWATPTTPGHAQSLS
RPLKQTPIVPFRESQPLHSKRPVSFPETPYTVSPAGADRVPPYRQPSGSFSTPGSATYVRYKPSPERYTAAPHPLLSLDPHFSHDGTSSG
DSSSGGLTSQESTMERQKPEPLWHVPAQARLSAIAGSSGNKHPSRQDAAGKDSPNRHSKGEPQYSSHSSSNTLSSNASSSHSDDRWFDPL
DPLEPEQDPLSKGGSSDSGIDTTLYTSSPSCMSLAKAPRPAKPHKPPGSMGLCGGGREAAGRSHHADRRREVSPAPAVAGQSKGYRPKLY
SSGSSTPTGLAGGSRDPPRQPSDMGSRVGYPAQVYKTASAETPRPSQLAQPSPFQLSASVPKSFFSKQPVRNKHPTGWKRTEEPPPRPLP
FSDPKKQVDTNTKNVFGQPRLRASLRDLRSPRKNYKSTIEDDLKKLIIMDNLGPEQERDTGQSPQKGLQRTLSDESLCSGRREPSFASPA
GLEPGLPSDVLFTSTCAFPSSTLPARRQHQHPHPPVGPGATPAAGSGFPEKKSTISASELSLADGRDRPLRRLDPGLMPLPDTAAGLEWS
SLVNAAKAYEVQRAVSLFSLNDPALSPDIPPAHSPVHSHLSLERGPPTPRTTPTMSEEPPLDLTGKVYQLEVMLKQLHTDLQKEKQDKVV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_LENG8_ENST00000326764_chr19_54969700_+_SIPA1L3_ENST00000222345_chr19_38631824_+_4443nt
ATGGCGGCCAACGTGGGTGATCAACGTAGCACAGATTGGTCTTCTCAGTACAGCATGGTGGCTGGGGCAGGCCGAGAGAATGGCATGGAG
ACGCCGATGCACGAGAACCCGGAGTGGGAGAAGGCCCGTCAGGCCCTGGCCAGCATCAGCAAGTCAGGAGCTGCCGGCGGCTCTGCCAAG
TCCAGCAGCAATGGGCCTGTGGCCAGTGCACAGTACGTGTCCCAGGCAGAAGCCTCAGCTTTGCAGCAGCAGCAGTACTACCAGTGGTAC
CAGCAGTACAACTATGCCTACCCCTACAGCTACTACTATCCCATGAGCATGTACCAGAGCTATGGCTCCCCTTCCCAGTATGGGATGGCC
GGCTCCTATGGCTCAGCCACACCCCAGCAGCCATCCGCACCCCAACACCAAGGGACTCTGAACCAGCCCCCAGTCCCCGGCATGGATGAG
AGCATGTCCTACCAGGCTCCCCCTCAGCAGCTGCCGTCGGCTCAGCCCCCTCAGCCCTCAAATCCCCCACATGGGGCTCACACGCTGAAC
AGTGGCCCTCAGCCTGGGACAGCTCCAGCCACACAGCACAGCCAGGCGGGGCCCGCCACGGGCCAGGCCTATGGGCCACACACCTACACC
GAACCTGCCAAGCCCAAGAAGGGCCAACAGCTGTGGAACCGCATGAAGCCCGCCCCTGGGACTGGAGGTCTCAAGTTCAACATCCAGAAG
CGACCCTTTGCTGTTACCACCCAGAGCTTTGGCTCCAACGCAGAGGGCCAGCACAGTGGTTTTGGCCCCCAGCCCAACCCTGAGAAAGTT
CAGAACCACAGCGGGTCCTCTGCCCGGGGGAACCTGTCTGGGAAGCCCGATGACTGGCCCCAGGACATGAAAGAGTATGTGGAGCGCTGC
TTCACCGCCTGTGAGTCGGAGGAGGACAAGGACCGCACGGAAAAGCTGCTCAAGGAGGTGCTGCAGGCGCGGCTGCAGGACGGCTCGGCC
TATACCATTGACTGGAGCCGGGAGCCCTTGCCGGGGCTGACCCGGGAGCCTGTGGCTGAGAGCCCTAAGAAGAAGCGGTGGGAGGCCGCT
AGCAGCCTTCACCCTCCTAGAGGGGCAGGCTCGGCGACAAGGGGCGGGGGTGCCCCGTCCCAGCGAGGGACGCCCGGGGCTGGGGGTGCC
GGTCGAGCCCGGGGCAACAGCTTCACCAAGTTTGGCAACCGCAACGTCTTCATGAAGGACAACAGCTCTTCTTCCAGCACAGACTCCCGC
TCCCGCTCCTCCTCCAGGTCCCCGACGCGCCACTTCCGCAGAAGTGACTCCCACTCAGACTCCGACAGCTCCTACTCAGGGAATGAGTGT
CACCCTGTGGGCCGCAGGAACCCGCCCCCTAAGGGCCGGGGCGGTCGAGGGGCCCATATGGATCGGGGCCGAGGCAGGGCGCAGCGTGGG
AAGAGGCACGATCTGGCGCCCACCAAGCGCAGTCGAAAGAAGATGGCGGCGCTGGAGTGTGAGGACCCGGAGCGAGAGCTGAAGAAGCAG
AAGCGGGCAGCCCGCTTCCAGCACGGACACTCCCGCCGCCTGCGCCTCGAGCCCCTGGTGCTGCAGATGAGCAGCCTGGAGAGCAGTGGG
GCTGACCCTGACTGGCAGGAGCTGCAGATCGTGGGCACCTGCCCTGACATCACCAAGCACTACCTGCGCCTCACCTGTGCCCCCGACCCG
TCCACCGTGCGCCCTGTGGCAGTTTTGAAAAAGTCGCTGTGCATGGTCAAGTGCCACTGGAAAGAGAAGCAGGACTACGCGTTTGCCTGC
GAGCAGATGAAGTCGATCCGGCAGGATCTGACGGTGCAGGGCATCCGCACCGAGTTCACGGTGGAGGTGTACGAGACCCATGCCCGGATC
GCCTTGGAGAAGGGTGACCATGAAGAGTTTAACCAGTGCCAGACGCAGCTCAAGTCGCTGTACGCCGAGAACTTGCCTGGCAATGTGGGC
GAGTTTACTGCCTACCGAATCCTCTACTACATCTTCACCAAGAACTCGGGAGACATCACCACGGAGCTGGCATACCTCACACGAGAACTG
AAGGCAGATCCTTGCGTGGCCCACGCCTTGGCATTAAGGACAGCCTGGGCCCTGGGCAACTACCACCGCTTTTTCCGGCTCTACTGCCAT
GCACCCTGCATGTCTGGCTACCTCGTGGACAAGTTTGCAGATCGGGAGCGCAAGGTCGCCCTCAAGGCCATGATCAAAACGGGTTGGCCG
GAGACCTACGACATGAATACCTCGGAGCCCAAGACGGAGCAGGAAAGCATCACTCCTGGGGGCCGGCCCCCCTACCGCAGCAATGCTCCC
TGGCAGTGGAGCGGGCCCGCATCCCATAACTCTCTACCAGCCTCCAAGTGGGCCACTCCAACCACTCCCGGCCATGCCCAGTCCCTGAGC
CGGCCCCTGAAGCAGACCCCCATAGTCCCCTTCCGGGAGTCCCAGCCACTGCACAGCAAGAGGCCTGTCAGCTTCCCAGAAACCCCTTAC
ACAGTATCACCAGCAGGGGCCGACAGAGTCCCTCCCTACCGACAGCCTTCTGGGAGCTTCTCCACCCCCGGTTCGGCCACCTACGTGAGA
TACAAGCCATCCCCAGAAAGGTACACGGCTGCCCCACACCCCCTGCTATCTCTTGATCCCCACTTCAGCCACGATGGGACGTCCAGCGGC
GACTCCTCTTCCGGCGGCCTGACCAGCCAGGAGAGCACCATGGAACGCCAGAAGCCAGAGCCTTTGTGGCATGTGCCTGCCCAGGCCAGG
CTCTCAGCCATAGCCGGAAGCAGCGGGAACAAGCACCCGTCCAGGCAGGATGCAGCAGGCAAAGATTCCCCCAACAGGCATTCCAAAGGA
GAACCTCAATACTCAAGTCATTCCAGCAGCAACACCCTCTCCAGCAACGCATCCAGCAGCCACAGCGACGACCGCTGGTTCGACCCCCTG
GACCCCCTGGAGCCAGAGCAAGACCCCCTCTCCAAGGGTGGCTCTAGTGACAGCGGCATCGACACCACCCTCTACACCTCCAGCCCTAGC
TGCATGTCCCTGGCCAAGGCTCCACGGCCCGCCAAGCCACACAAGCCCCCTGGAAGTATGGGCCTTTGTGGCGGGGGTCGCGAGGCCGCT
GGGAGGTCCCACCACGCAGACAGGCGGCGGGAGGTCTCCCCTGCCCCCGCAGTTGCCGGCCAAAGCAAGGGCTACCGACCGAAGCTGTAC
TCCTCCGGCTCCAGCACCCCCACGGGACTGGCGGGGGGCAGCCGAGACCCACCGAGGCAGCCCAGTGACATGGGCTCGAGGGTTGGCTAC
CCCGCTCAGGTTTACAAAACTGCCAGTGCAGAGACTCCTCGGCCCTCCCAGCTGGCCCAGCCCAGCCCCTTTCAGCTCTCCGCCTCCGTC
CCCAAGTCCTTCTTCTCCAAGCAGCCTGTACGCAATAAGCACCCAACAGGGTGGAAGAGAACGGAGGAGCCCCCACCACGGCCACTCCCC
TTCAGTGACCCAAAGAAGCAGGTGGACACGAACACCAAAAATGTCTTTGGGCAACCGAGGTTGAGGGCATCCCTCCGAGACCTCCGGTCA
CCACGGAAGAACTACAAATCCACCATCGAGGATGACCTGAAGAAACTCATCATCATGGACAACCTGGGGCCAGAGCAGGAGAGAGACACG
GGACAGTCACCGCAGAAGGGCCTGCAGCGGACGCTGTCGGACGAGAGCCTGTGCAGCGGGCGCCGGGAGCCCAGCTTCGCCAGCCCCGCT
GGCCTAGAGCCAGGGCTGCCCAGCGACGTGCTCTTCACCAGCACCTGCGCCTTCCCGTCCAGCACGCTGCCTGCACGCCGCCAGCACCAG
CACCCCCACCCGCCCGTCGGCCCCGGTGCCACCCCTGCCGCCGGCAGCGGCTTTCCCGAGAAGAAATCCACCATCTCAGCCTCGGAGCTC
TCGCTGGCTGATGGGCGGGACCGCCCCCTGCGGCGCCTGGACCCTGGGCTGATGCCCCTGCCTGACACAGCTGCTGGCCTCGAGTGGTCC
AGCCTGGTGAACGCAGCCAAGGCATACGAAGTGCAAAGAGCCGTCTCACTCTTCTCTCTGAACGACCCGGCCCTGAGCCCGGACATCCCG
CCTGCACACAGTCCTGTCCACAGCCACCTGAGCCTGGAGAGGGGACCCCCGACCCCCAGGACCACCCCTACCATGAGCGAGGAGCCACCC
CTGGATCTGACAGGCAAGGTGTACCAGCTGGAGGTGATGCTGAAACAGCTGCACACTGACCTGCAGAAGGAGAAGCAGGACAAGGTGGTG
CTCCAGTCAGAGGTGGCCAGCCTGCGGCAGAACAACCAGCGGCTGCAGGAGGAGTCGCAGGCCGCCAGCGAGCAGCTGCGCAAGTTTGCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_LENG8_ENST00000326764_chr19_54969700_+_SIPA1L3_ENST00000222345_chr19_38631824_+_7054nt
CCACTGTACTCTATCGTGGGCGACGACAGAGCAAGAGCAAGACTCCGTCTCCGAGAACAACAACAACAGCAACAAGAAAACAACAATAAA
AAAAATAAGGCTGCGTGGGAGGCAGAAAGAGCTAATGCGGCCACGCTTGTCCCCTCGGGGCCACCGTCCCCACCCAGACTTCCGGTCTGC
CTTAAAATGTTCATGCGTAAGTGCGTGGGCAGGAAGGCGGGCTCAAGCGCAGCTCGTGGCGTTCATTGGCTGTGCAGGGCCGAGGGAGGC
GGTGCAAGGCCGCCGCGTGACGTCAGGACGCCGCGGTCAGGACGTCGAAGCCAAAGAAGACCAGAGCCAGCCGGGTGGCACAGCGGTGTC
GTGGCCGTGTTGCTGATCGCCTGGGTGGTTGTTGGCGTGTCCCTGCAGCGAAGGATCCTGGTTGGCAGTGAAAAAGCAGTCTGGCTCCCG
AGGTCCACCCCTTATACCCCAAGGTCCAGATGGCGGCCAACGTGGGTGATCAACGTAGCACAGATTGGTCTTCTCAGTACAGCATGGTGG
CTGGGGCAGGCCGAGAGAATGGCATGGAGACGCCGATGCACGAGAACCCGGAGTGGGAGAAGGCCCGTCAGGCCCTGGCCAGCATCAGCA
AGTCAGGAGCTGCCGGCGGCTCTGCCAAGTCCAGCAGCAATGGGCCTGTGGCCAGTGCACAGTACGTGTCCCAGGCAGAAGCCTCAGCTT
TGCAGCAGCAGCAGTACTACCAGTGGTACCAGCAGTACAACTATGCCTACCCCTACAGCTACTACTATCCCATGAGCATGTACCAGAGCT
ATGGCTCCCCTTCCCAGTATGGGATGGCCGGCTCCTATGGCTCAGCCACACCCCAGCAGCCATCCGCACCCCAACACCAAGGGACTCTGA
ACCAGCCCCCAGTCCCCGGCATGGATGAGAGCATGTCCTACCAGGCTCCCCCTCAGCAGCTGCCGTCGGCTCAGCCCCCTCAGCCCTCAA
ATCCCCCACATGGGGCTCACACGCTGAACAGTGGCCCTCAGCCTGGGACAGCTCCAGCCACACAGCACAGCCAGGCGGGGCCCGCCACGG
GCCAGGCCTATGGGCCACACACCTACACCGAACCTGCCAAGCCCAAGAAGGGCCAACAGCTGTGGAACCGCATGAAGCCCGCCCCTGGGA
CTGGAGGTCTCAAGTTCAACATCCAGAAGCGACCCTTTGCTGTTACCACCCAGAGCTTTGGCTCCAACGCAGAGGGCCAGCACAGTGGTT
TTGGCCCCCAGCCCAACCCTGAGAAAGTTCAGAACCACAGCGGGTCCTCTGCCCGGGGGAACCTGTCTGGGAAGCCCGATGACTGGCCCC
AGGACATGAAAGAGTATGTGGAGCGCTGCTTCACCGCCTGTGAGTCGGAGGAGGACAAGGACCGCACGGAAAAGCTGCTCAAGGAGGTGC
TGCAGGCGCGGCTGCAGGACGGCTCGGCCTATACCATTGACTGGAGCCGGGAGCCCTTGCCGGGGCTGACCCGGGAGCCTGTGGCTGAGA
GCCCTAAGAAGAAGCGGTGGGAGGCCGCTAGCAGCCTTCACCCTCCTAGAGGGGCAGGCTCGGCGACAAGGGGCGGGGGTGCCCCGTCCC
AGCGAGGGACGCCCGGGGCTGGGGGTGCCGGTCGAGCCCGGGGCAACAGCTTCACCAAGTTTGGCAACCGCAACGTCTTCATGAAGGACA
ACAGCTCTTCTTCCAGCACAGACTCCCGCTCCCGCTCCTCCTCCAGGTCCCCGACGCGCCACTTCCGCAGAAGTGACTCCCACTCAGACT
CCGACAGCTCCTACTCAGGGAATGAGTGTCACCCTGTGGGCCGCAGGAACCCGCCCCCTAAGGGCCGGGGCGGTCGAGGGGCCCATATGG
ATCGGGGCCGAGGCAGGGCGCAGCGTGGGAAGAGGCACGATCTGGCGCCCACCAAGCGCAGTCGAAAGAAGATGGCGGCGCTGGAGTGTG
AGGACCCGGAGCGAGAGCTGAAGAAGCAGAAGCGGGCAGCCCGCTTCCAGCACGGACACTCCCGCCGCCTGCGCCTCGAGCCCCTGGTGC
TGCAGATGAGCAGCCTGGAGAGCAGTGGGGCTGACCCTGACTGGCAGGAGCTGCAGATCGTGGGCACCTGCCCTGACATCACCAAGCACT
ACCTGCGCCTCACCTGTGCCCCCGACCCGTCCACCGTGCGCCCTGTGGCAGTTTTGAAAAAGTCGCTGTGCATGGTCAAGTGCCACTGGA
AAGAGAAGCAGGACTACGCGTTTGCCTGCGAGCAGATGAAGTCGATCCGGCAGGATCTGACGGTGCAGGGCATCCGCACCGAGTTCACGG
TGGAGGTGTACGAGACCCATGCCCGGATCGCCTTGGAGAAGGGTGACCATGAAGAGTTTAACCAGTGCCAGACGCAGCTCAAGTCGCTGT
ACGCCGAGAACTTGCCTGGCAATGTGGGCGAGTTTACTGCCTACCGAATCCTCTACTACATCTTCACCAAGAACTCGGGAGACATCACCA
CGGAGCTGGCATACCTCACACGAGAACTGAAGGCAGATCCTTGCGTGGCCCACGCCTTGGCATTAAGGACAGCCTGGGCCCTGGGCAACT
ACCACCGCTTTTTCCGGCTCTACTGCCATGCACCCTGCATGTCTGGCTACCTCGTGGACAAGTTTGCAGATCGGGAGCGCAAGGTCGCCC
TCAAGGCCATGATCAAAACGGGTTGGCCGGAGACCTACGACATGAATACCTCGGAGCCCAAGACGGAGCAGGAAAGCATCACTCCTGGGG
GCCGGCCCCCCTACCGCAGCAATGCTCCCTGGCAGTGGAGCGGGCCCGCATCCCATAACTCTCTACCAGCCTCCAAGTGGGCCACTCCAA
CCACTCCCGGCCATGCCCAGTCCCTGAGCCGGCCCCTGAAGCAGACCCCCATAGTCCCCTTCCGGGAGTCCCAGCCACTGCACAGCAAGA
GGCCTGTCAGCTTCCCAGAAACCCCTTACACAGTATCACCAGCAGGGGCCGACAGAGTCCCTCCCTACCGACAGCCTTCTGGGAGCTTCT
CCACCCCCGGTTCGGCCACCTACGTGAGATACAAGCCATCCCCAGAAAGGTACACGGCTGCCCCACACCCCCTGCTATCTCTTGATCCCC
ACTTCAGCCACGATGGGACGTCCAGCGGCGACTCCTCTTCCGGCGGCCTGACCAGCCAGGAGAGCACCATGGAACGCCAGAAGCCAGAGC
CTTTGTGGCATGTGCCTGCCCAGGCCAGGCTCTCAGCCATAGCCGGAAGCAGCGGGAACAAGCACCCGTCCAGGCAGGATGCAGCAGGCA
AAGATTCCCCCAACAGGCATTCCAAAGGAGAACCTCAATACTCAAGTCATTCCAGCAGCAACACCCTCTCCAGCAACGCATCCAGCAGCC
ACAGCGACGACCGCTGGTTCGACCCCCTGGACCCCCTGGAGCCAGAGCAAGACCCCCTCTCCAAGGGTGGCTCTAGTGACAGCGGCATCG
ACACCACCCTCTACACCTCCAGCCCTAGCTGCATGTCCCTGGCCAAGGCTCCACGGCCCGCCAAGCCACACAAGCCCCCTGGAAGTATGG
GCCTTTGTGGCGGGGGTCGCGAGGCCGCTGGGAGGTCCCACCACGCAGACAGGCGGCGGGAGGTCTCCCCTGCCCCCGCAGTTGCCGGCC
AAAGCAAGGGCTACCGACCGAAGCTGTACTCCTCCGGCTCCAGCACCCCCACGGGACTGGCGGGGGGCAGCCGAGACCCACCGAGGCAGC
CCAGTGACATGGGCTCGAGGGTTGGCTACCCCGCTCAGGTTTACAAAACTGCCAGTGCAGAGACTCCTCGGCCCTCCCAGCTGGCCCAGC
CCAGCCCCTTTCAGCTCTCCGCCTCCGTCCCCAAGTCCTTCTTCTCCAAGCAGCCTGTACGCAATAAGCACCCAACAGGGTGGAAGAGAA
CGGAGGAGCCCCCACCACGGCCACTCCCCTTCAGTGACCCAAAGAAGCAGGTGGACACGAACACCAAAAATGTCTTTGGGCAACCGAGGT
TGAGGGCATCCCTCCGAGACCTCCGGTCACCACGGAAGAACTACAAATCCACCATCGAGGATGACCTGAAGAAACTCATCATCATGGACA
ACCTGGGGCCAGAGCAGGAGAGAGACACGGGACAGTCACCGCAGAAGGGCCTGCAGCGGACGCTGTCGGACGAGAGCCTGTGCAGCGGGC
GCCGGGAGCCCAGCTTCGCCAGCCCCGCTGGCCTAGAGCCAGGGCTGCCCAGCGACGTGCTCTTCACCAGCACCTGCGCCTTCCCGTCCA
GCACGCTGCCTGCACGCCGCCAGCACCAGCACCCCCACCCGCCCGTCGGCCCCGGTGCCACCCCTGCCGCCGGCAGCGGCTTTCCCGAGA
AGAAATCCACCATCTCAGCCTCGGAGCTCTCGCTGGCTGATGGGCGGGACCGCCCCCTGCGGCGCCTGGACCCTGGGCTGATGCCCCTGC
CTGACACAGCTGCTGGCCTCGAGTGGTCCAGCCTGGTGAACGCAGCCAAGGCATACGAAGTGCAAAGAGCCGTCTCACTCTTCTCTCTGA
ACGACCCGGCCCTGAGCCCGGACATCCCGCCTGCACACAGTCCTGTCCACAGCCACCTGAGCCTGGAGAGGGGACCCCCGACCCCCAGGA
CCACCCCTACCATGAGCGAGGAGCCACCCCTGGATCTGACAGGCAAGGTGTACCAGCTGGAGGTGATGCTGAAACAGCTGCACACTGACC
TGCAGAAGGAGAAGCAGGACAAGGTGGTGCTCCAGTCAGAGGTGGCCAGCCTGCGGCAGAACAACCAGCGGCTGCAGGAGGAGTCGCAGG
CCGCCAGCGAGCAGCTGCGCAAGTTTGCGGAGATCTTCTGCAGGGAGAAGAAGGAGCTCTGAGGTGGGAGGCCGCCGCCCGCCTTCGCTC
CTTCCCCTCAGGCCGTGGCCCTGCTGCCTCTCTCCCTCCACTCAGCTCCCAGCTGCCGGTGTGACCAAGATGACCCATCCAGGGCCCTCC
CCATGGACACGGAAACTCCGATGGCCTCACTAGGGCTGTGAGTCAGGGTCAGCGCGCACAGCCCTCATGCCCCAGAGGGCGAAGTGGTCT
CAGGCCTCCCTCCAAGCTGCCCAGCTGTGGTCCCGGTGAGCTGGGCTGTGCTTACACCGCTCCCGGGCCTGCCCCGCTGTCCCCATCTAG
CCTCTTCCTGGGACCAGCCCTTCGAAGCTGATGGGGACGGAGAGAGGAGCCAGTCTCCAGACGCCTCGGCTCCAGGAGGTCACACAGCAG
GTTTCTGCACCACGCACAACAAAGTTGCGGCTTGTGGGGCCGAGGCCCCTGCATGAAAAGTACAGCGTGAAAGCAACCCTTTCTTCCCCA
CACCCAGAGAGGTGAGGCCCGCGTGGACACAGACCAGGGCGCCTCGGTCCCTAGCACGTGAGCTCCAAAAAGCACGAACATGATCCCCTC
CCTAACCCCCTCCTCCCAAAAAGCAGCCAGGAGCACTTTCTTAGAGTTTAAATTATTTTCTTGGGGGCCTGAGGATAGAGAGAGGCAAGG
CTAGCCTCCAGAGCCGATTTATTTGAGAGAGAAACTCTATTTGGATCTCCAGGACGGTTTATACGATCTTTTTCTATCAGCTCCTCTTCC
GCCAGAGGCCACTGCACCTGGGCTAGGGGTCCACAGGCCCCTCCACCTTCCAGCTAACCAGGCCAGGCCGGGGCGGTGGAGCCACCACAC
AGCCGACTCTCTCCTCCTCCTCCCGGCACGACCTGGCCCTGACCAGCAGCCTCGGCCTCTTCTGGGTTCCAGGAGGGGCTCCCGAAGCCC
TCAGGACAGGGCTGGAGGAGAACAGCCTTCATCTCCTCCTCTGGTTTTTTTTTCCTTTGCAAGTCTCCCAGCCCATCTCTCCGAGCAGCG
GCCACCAGACCCCCTCACCATGCTCCCCGGGGAGCACTGCACCCCGCGAACCCCACTGGACGCTGGTTCTCTAAAGGCAATAAGGGGCGG
CCATGCCGGTGTGGTACCACGCTGTTCCTCCAGGAAACCGTTTCTTTTTTTCCTTCTTTAAAAGCAAACAGAAAAAGATATATATATATA
TATATATATATTTATTTTTTCATGTAGAGTTGGCGCCAGAACAAGCCTGTATGGCCACAGTCTGTGGATTCATCCCCCCAACCTCAAGCT
GAGGACCAAGGCGTGTCCCCTGTGGGCTGGGGGTCAGTGGGAGGACCAGAGGGATGAAGTCAGGGCAGGCCGGTGCCCTTTTTGGGAGGC
ACCAGGCGGGGAGGAGTTGGCGGAGCAGGTCTGGCTGTGAGCCAGCACCAGGCAACCCGGCCCTTGTCCAGGGACCTCTGCTGCCTTCTC
TCTGGGGTCAGGAACCTCAGAGGAGGGGGCTCTGGGGACTGCATAGGACGCAGGCACTCGGAGGTGCCGGTGTGGATGGGTGGGGGTGAG
AGAAGAGGGTTCTTATCGCGTCTCCTGTGATCAGCCTCTGGCCCCCTGGAGGAGGAAACCTCAGCGCTGCCCCTGCCCCCACCCTCACCC
CCAACACCAAGAGTGAGGTGGGCGTGCCCCAGGCAGCGTCCTCAGCCCTGGCCAGCTACTGTGATGCCATCTTCTCCCCCATCCCCTTCT
CTGGGGGGCCCACCCGTCCCCCACCCCCACCCCTTAGACCCTCATCGGGTCCCTTTTTTTTTTTTTTTTTCAGTTGTCTCCTCCCATCTT
CAGATCATTCGAATCATTTTGGGGACTTAATCATGTACATGGACAAGTGTAAATTATGATTTTTGGTTTTGTTTTCTGTTATTTTTTAAG
GATTTCTGCAAAAACAGATCTATTTAATTTGAGGTTGATGTTCTATCCAATGGCCGAAGATAGCAGCAGGTTTTTTTTTTCATATGTTGA
TTTGTTTCATTTGGATTTTTTTTTTATTATTCTTTATTGTCTTTTTTTTTTCCCCATCCCTGTCTTGAGATTTTCTGGCATGTTTCTGGA


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FusionGenePPI for LENG8_SIPA1L3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LENG8RHOXF2, SMN1, PYGO1, SHFM1, CAND1, ATN1, MAPK1IP1L, DMRTB1, KDM1A, PRMT5, PRMT6, SMYD1, SUV39H1, SNRPA, CEP70, BMI1, PPP1CC, CRYAB, OAZ1, ZWINT, KIAA1107, ZFC3H1, SKA1, MEX3C, HYPK, PIP4K2A, CCDC59, ZNF263, ZNF512, IL27RA, ZSCAN31, ZNF324B, LGALS3BP, WDR55, MECP2, TTC25, SMARCB1SIPA1L3SFN, ELAVL1, FMNL1, YWHAQ, DYRK1B, LATS2, YWHAB, WDR83, SRPK2, CEP152, CEP135, NINL, ODF2, RPGRIP1L, CAPZA2, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MYO19, MYO18A, CDH1, PTPRK, LZTS2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LENG8_SIPA1L3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LENG8_SIPA1L3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource