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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1959

FusionGeneSummary for ANP32B_PTPN11

check button Fusion gene summary
Fusion gene informationFusion gene name: ANP32B_PTPN11
Fusion gene ID: 1959
HgeneTgene
Gene symbol

ANP32B

PTPN11

Gene ID

10541

5781

Gene nameacidic nuclear phosphoprotein 32 family member Bprotein tyrosine phosphatase, non-receptor type 11
SynonymsAPRIL|PHAPI2|SSP29BPTP3|CFC|JMML|METCDS|NS1|PTP-1D|PTP2C|SH-PTP2|SH-PTP3|SHP2
Cytomap

9q22.33

12q24.13

Type of geneprotein-codingprotein-coding
Descriptionacidic leucine-rich nuclear phosphoprotein 32 family member Bacidic (leucine-rich) nuclear phosphoprotein 32 family, member Bacidic protein rich in leucinesputative HLA-DR-associated protein I-2silver-stainable protein SSP29tyrosine-protein phosphatase non-receptor type 11PTP-2Cprotein-tyrosine phosphatase 1Dprotein-tyrosine phosphatase 2C
Modification date2018052320180527
UniProtAcc

Q92688

Q06124

Ensembl transtripts involved in fusion geneENST00000339399, ENST00000473205, 
ENST00000531326, ENST00000392597, 
ENST00000351677, 
Fusion gene scores* DoF score6 X 6 X 1=368 X 7 X 3=168
# samples 68
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANP32B [Title/Abstract] AND PTPN11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANP32B

GO:0006334

nucleosome assembly

20538007

HgeneANP32B

GO:0045596

negative regulation of cell differentiation

22705300

TgenePTPN11

GO:0035335

peptidyl-tyrosine dephosphorylation

15133037

TgenePTPN11

GO:0038127

ERBB signaling pathway

15133037

TgenePTPN11

GO:0043254

regulation of protein complex assembly

7493946

TgenePTPN11

GO:0048013

ephrin receptor signaling pathway

10655584

TgenePTPN11

GO:2001275

positive regulation of glucose import in response to insulin stimulus

7493946


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG826823ANP32Bchr9

100745731

+PTPN11chr12

112856741

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000339399ENST00000531326ANP32Bchr9

100745731

+PTPN11chr12

112856741

+
5UTR-5UTRENST00000339399ENST00000392597ANP32Bchr9

100745731

+PTPN11chr12

112856741

+
5UTR-5UTRENST00000339399ENST00000351677ANP32Bchr9

100745731

+PTPN11chr12

112856741

+
intron-3UTRENST00000473205ENST00000531326ANP32Bchr9

100745731

+PTPN11chr12

112856741

+
intron-5UTRENST00000473205ENST00000392597ANP32Bchr9

100745731

+PTPN11chr12

112856741

+
intron-5UTRENST00000473205ENST00000351677ANP32Bchr9

100745731

+PTPN11chr12

112856741

+

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FusionProtFeatures for ANP32B_PTPN11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANP32B

Q92688

PTPN11

Q06124

Multifunctional protein working as a cell cycleprogression factor as well as a cell survival factor. Required forthe progression from the G1 to the S phase. Anti-apoptotic proteinwhich functions as a caspase-3 inhibitor. Has no phosphatase 2A(PP2A) inhibitor activity (By similarity). Exhibits histonechaperone properties, stimulating core histones to assemble into anucleosome. {ECO:0000250, ECO:0000269|PubMed:20538007}. Acts downstream of various receptor and cytoplasmicprotein tyrosine kinases to participate in the signal transductionfrom the cell surface to the nucleus. Positively regulates MAPKsignal transduction pathway (PubMed:28074573). DephosphorylatesGAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2at 'Tyr-722' resulting in stimulatation of its RhoA bindingactivity. Dephosphorylates CDC73 (PubMed:26742426).{ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:18559669,ECO:0000269|PubMed:18829466, ECO:0000269|PubMed:26742426,ECO:0000269|PubMed:28074573}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANP32B_PTPN11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANP32B_PTPN11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANP32B_PTPN11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANP32B_PTPN11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPN11C0028326Noonan Syndrome24CTD_human;ORPHANET;UNIPROT
TgenePTPN11C0175704LEOPARD Syndrome10CTD_human;ORPHANET;UNIPROT
TgenePTPN11C0349639Juvenile Myelomonocytic Leukemia4CTD_human;HPO;ORPHANET;UNIPROT
TgenePTPN11C0014084Enchondromatosis2CTD_human;HPO
TgenePTPN11C0001418Adenocarcinoma1CTD_human
TgenePTPN11C0004114Astrocytoma1CTD_human
TgenePTPN11C0007137Squamous cell carcinoma1CTD_human
TgenePTPN11C0015306Hereditary Multiple Exostoses1CTD_human
TgenePTPN11C0023418leukemia1CTD_human
TgenePTPN11C0027819Neuroblastoma1CTD_human
TgenePTPN11C0029423Cartilaginous exostosis1CTD_human
TgenePTPN11C0587248Costello syndrome (disorder)1CTD_human
TgenePTPN11C1275081Cardio-facio-cutaneous syndrome1CTD_human