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Fusion gene ID: 19587 |
FusionGeneSummary for LDLR_C19orf38 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LDLR_C19orf38 | Fusion gene ID: 19587 | Hgene | Tgene | Gene symbol | LDLR | C19orf38 | Gene ID | 3949 | 255809 |
| Gene name | low density lipoprotein receptor | chromosome 19 open reading frame 38 | |
| Synonyms | FH|FHC|LDLCQ2 | HIDE1 | |
| Cytomap | 19p13.2 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | low-density lipoprotein receptorLDL receptorlow-density lipoprotein receptor class A domain-containing protein 3 | protein HIDE1Highly expressed in immature dendritic cell transcript 1 | |
| Modification date | 20180520 | 20180403 | |
| UniProtAcc | P01130 | ||
| Ensembl transtripts involved in fusion gene | ENST00000558518, ENST00000557933, ENST00000455727, ENST00000535915, ENST00000545707, ENST00000558013, ENST00000560628, | ENST00000592854, ENST00000397820, | |
| Fusion gene scores | * DoF score | 14 X 9 X 11=1386 | 6 X 6 X 7=252 |
| # samples | 17 | 9 | |
| ** MAII score | log2(17/1386*10)=-3.02732060599951 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LDLR [Title/Abstract] AND C19orf38 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-55-6972-01A | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000558518 | ENST00000592854 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| In-frame | ENST00000558518 | ENST00000397820 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| In-frame | ENST00000557933 | ENST00000592854 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| In-frame | ENST00000557933 | ENST00000397820 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| In-frame | ENST00000455727 | ENST00000592854 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| In-frame | ENST00000455727 | ENST00000397820 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| In-frame | ENST00000535915 | ENST00000592854 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| In-frame | ENST00000535915 | ENST00000397820 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| In-frame | ENST00000545707 | ENST00000592854 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| In-frame | ENST00000545707 | ENST00000397820 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| In-frame | ENST00000558013 | ENST00000592854 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| In-frame | ENST00000558013 | ENST00000397820 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| intron-3CDS | ENST00000560628 | ENST00000592854 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
| intron-3CDS | ENST00000560628 | ENST00000397820 | LDLR | chr19 | 11211021 | + | C19orf38 | chr19 | 10968992 | + |
Top |
FusionProtFeatures for LDLR_C19orf38 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LDLR | C19orf38 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 25_65 | 63 | 693 | Domain | LDL-receptor class A 1 |
| Hgene | LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 25_65 | 63 | 820 | Domain | LDL-receptor class A 1 |
| Hgene | LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 25_65 | 63 | 683 | Domain | LDL-receptor class A 1 |
| Hgene | LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 25_65 | 63 | 859 | Domain | LDL-receptor class A 1 |
| Hgene | LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 25_65 | 63 | 861 | Domain | LDL-receptor class A 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 107_145 | 63 | 693 | Domain | LDL-receptor class A 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 146_186 | 63 | 693 | Domain | LDL-receptor class A 4 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 195_233 | 63 | 693 | Domain | LDL-receptor class A 5 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 234_272 | 63 | 693 | Domain | LDL-receptor class A 6 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 274_313 | 63 | 693 | Domain | LDL-receptor class A 7 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 314_353 | 63 | 693 | Domain | EGF-like 1 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 354_393 | 63 | 693 | Domain | EGF-like 2%3B calcium-binding |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 663_712 | 63 | 693 | Domain | EGF-like 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 66_106 | 63 | 693 | Domain | LDL-receptor class A 2 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 107_145 | 63 | 820 | Domain | LDL-receptor class A 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 146_186 | 63 | 820 | Domain | LDL-receptor class A 4 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 195_233 | 63 | 820 | Domain | LDL-receptor class A 5 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 234_272 | 63 | 820 | Domain | LDL-receptor class A 6 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 274_313 | 63 | 820 | Domain | LDL-receptor class A 7 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 314_353 | 63 | 820 | Domain | EGF-like 1 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 354_393 | 63 | 820 | Domain | EGF-like 2%3B calcium-binding |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 663_712 | 63 | 820 | Domain | EGF-like 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 66_106 | 63 | 820 | Domain | LDL-receptor class A 2 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 107_145 | 63 | 683 | Domain | LDL-receptor class A 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 146_186 | 63 | 683 | Domain | LDL-receptor class A 4 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 195_233 | 63 | 683 | Domain | LDL-receptor class A 5 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 234_272 | 63 | 683 | Domain | LDL-receptor class A 6 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 274_313 | 63 | 683 | Domain | LDL-receptor class A 7 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 314_353 | 63 | 683 | Domain | EGF-like 1 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 354_393 | 63 | 683 | Domain | EGF-like 2%3B calcium-binding |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 663_712 | 63 | 683 | Domain | EGF-like 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 66_106 | 63 | 683 | Domain | LDL-receptor class A 2 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 107_145 | 63 | 859 | Domain | LDL-receptor class A 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 146_186 | 63 | 859 | Domain | LDL-receptor class A 4 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 195_233 | 63 | 859 | Domain | LDL-receptor class A 5 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 234_272 | 63 | 859 | Domain | LDL-receptor class A 6 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 274_313 | 63 | 859 | Domain | LDL-receptor class A 7 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 314_353 | 63 | 859 | Domain | EGF-like 1 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 354_393 | 63 | 859 | Domain | EGF-like 2%3B calcium-binding |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 663_712 | 63 | 859 | Domain | EGF-like 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 66_106 | 63 | 859 | Domain | LDL-receptor class A 2 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 107_145 | 63 | 861 | Domain | LDL-receptor class A 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 146_186 | 63 | 861 | Domain | LDL-receptor class A 4 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 195_233 | 63 | 861 | Domain | LDL-receptor class A 5 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 234_272 | 63 | 861 | Domain | LDL-receptor class A 6 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 274_313 | 63 | 861 | Domain | LDL-receptor class A 7 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 314_353 | 63 | 861 | Domain | EGF-like 1 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 354_393 | 63 | 861 | Domain | EGF-like 2%3B calcium-binding |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 663_712 | 63 | 861 | Domain | EGF-like 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 66_106 | 63 | 861 | Domain | LDL-receptor class A 2 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 823_828 | 63 | 693 | Motif | NPXY motif |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 823_828 | 63 | 820 | Motif | NPXY motif |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 823_828 | 63 | 683 | Motif | NPXY motif |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 823_828 | 63 | 859 | Motif | NPXY motif |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 823_828 | 63 | 861 | Motif | NPXY motif |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 721_768 | 63 | 693 | Region | Note=Clustered O-linked oligosaccharides |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 811_860 | 63 | 693 | Region | Required for MYLIP-triggered down-regulation of LDLR |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 721_768 | 63 | 820 | Region | Note=Clustered O-linked oligosaccharides |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 811_860 | 63 | 820 | Region | Required for MYLIP-triggered down-regulation of LDLR |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 721_768 | 63 | 683 | Region | Note=Clustered O-linked oligosaccharides |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 811_860 | 63 | 683 | Region | Required for MYLIP-triggered down-regulation of LDLR |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 721_768 | 63 | 859 | Region | Note=Clustered O-linked oligosaccharides |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 811_860 | 63 | 859 | Region | Required for MYLIP-triggered down-regulation of LDLR |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 721_768 | 63 | 861 | Region | Note=Clustered O-linked oligosaccharides |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 811_860 | 63 | 861 | Region | Required for MYLIP-triggered down-regulation of LDLR |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 397_438 | 63 | 693 | Repeat | Note=LDL-receptor class B 1 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 439_485 | 63 | 693 | Repeat | Note=LDL-receptor class B 2 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 486_528 | 63 | 693 | Repeat | Note=LDL-receptor class B 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 529_572 | 63 | 693 | Repeat | Note=LDL-receptor class B 4 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 573_615 | 63 | 693 | Repeat | Note=LDL-receptor class B 5 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 616_658 | 63 | 693 | Repeat | Note=LDL-receptor class B 6 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 397_438 | 63 | 820 | Repeat | Note=LDL-receptor class B 1 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 439_485 | 63 | 820 | Repeat | Note=LDL-receptor class B 2 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 486_528 | 63 | 820 | Repeat | Note=LDL-receptor class B 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 529_572 | 63 | 820 | Repeat | Note=LDL-receptor class B 4 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 573_615 | 63 | 820 | Repeat | Note=LDL-receptor class B 5 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 616_658 | 63 | 820 | Repeat | Note=LDL-receptor class B 6 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 397_438 | 63 | 683 | Repeat | Note=LDL-receptor class B 1 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 439_485 | 63 | 683 | Repeat | Note=LDL-receptor class B 2 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 486_528 | 63 | 683 | Repeat | Note=LDL-receptor class B 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 529_572 | 63 | 683 | Repeat | Note=LDL-receptor class B 4 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 573_615 | 63 | 683 | Repeat | Note=LDL-receptor class B 5 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 616_658 | 63 | 683 | Repeat | Note=LDL-receptor class B 6 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 397_438 | 63 | 859 | Repeat | Note=LDL-receptor class B 1 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 439_485 | 63 | 859 | Repeat | Note=LDL-receptor class B 2 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 486_528 | 63 | 859 | Repeat | Note=LDL-receptor class B 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 529_572 | 63 | 859 | Repeat | Note=LDL-receptor class B 4 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 573_615 | 63 | 859 | Repeat | Note=LDL-receptor class B 5 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 616_658 | 63 | 859 | Repeat | Note=LDL-receptor class B 6 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 397_438 | 63 | 861 | Repeat | Note=LDL-receptor class B 1 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 439_485 | 63 | 861 | Repeat | Note=LDL-receptor class B 2 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 486_528 | 63 | 861 | Repeat | Note=LDL-receptor class B 3 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 529_572 | 63 | 861 | Repeat | Note=LDL-receptor class B 4 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 573_615 | 63 | 861 | Repeat | Note=LDL-receptor class B 5 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 616_658 | 63 | 861 | Repeat | Note=LDL-receptor class B 6 |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 22_788 | 63 | 693 | Topological domain | Extracellular |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 22_788 | 63 | 820 | Topological domain | Extracellular |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 22_788 | 63 | 683 | Topological domain | Extracellular |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 22_788 | 63 | 859 | Topological domain | Extracellular |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 22_788 | 63 | 861 | Topological domain | Extracellular |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000455727 | + | 2 | 16 | 789_810 | 63 | 693 | Transmembrane | Helical |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000535915 | + | 2 | 17 | 789_810 | 63 | 820 | Transmembrane | Helical |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000545707 | + | 2 | 16 | 789_810 | 63 | 683 | Transmembrane | Helical |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558013 | + | 2 | 18 | 789_810 | 63 | 859 | Transmembrane | Helical |
| Hgene | >LDLR | chr19:11211021 | chr19:10968992 | ENST00000558518 | + | 2 | 18 | 789_810 | 63 | 861 | Transmembrane | Helical |
| Tgene | C19orf38 | chr19:11211021 | chr19:10968992 | ENST00000397820 | + | 2 | 7 | 139_230 | 144 | 231 | Topological domain | Cytoplasmic |
| Tgene | C19orf38 | chr19:11211021 | chr19:10968992 | ENST00000397820 | + | 2 | 7 | 20_117 | 144 | 231 | Topological domain | Extracellular |
| Tgene | C19orf38 | chr19:11211021 | chr19:10968992 | ENST00000592854 | + | 3 | 8 | 139_230 | 144 | 231 | Topological domain | Cytoplasmic |
| Tgene | C19orf38 | chr19:11211021 | chr19:10968992 | ENST00000592854 | + | 3 | 8 | 20_117 | 144 | 231 | Topological domain | Extracellular |
| Tgene | C19orf38 | chr19:11211021 | chr19:10968992 | ENST00000397820 | + | 2 | 7 | 118_138 | 144 | 231 | Transmembrane | Helical |
| Tgene | C19orf38 | chr19:11211021 | chr19:10968992 | ENST00000592854 | + | 3 | 8 | 118_138 | 144 | 231 | Transmembrane | Helical |
Top |
FusionGeneSequence for LDLR_C19orf38 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_LDLR_ENST00000558518_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_150aa MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCFKLRNLQKKRDRESCWAQINFDSTDMS >In-frame_LDLR_ENST00000558518_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_150aa MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCFKLRNLQKKRDRESCWAQINFDSTDMS >In-frame_LDLR_ENST00000557933_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_150aa MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCFKLRNLQKKRDRESCWAQINFDSTDMS >In-frame_LDLR_ENST00000557933_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_150aa MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCFKLRNLQKKRDRESCWAQINFDSTDMS >In-frame_LDLR_ENST00000455727_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_150aa MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCFKLRNLQKKRDRESCWAQINFDSTDMS >In-frame_LDLR_ENST00000455727_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_150aa MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCFKLRNLQKKRDRESCWAQINFDSTDMS >In-frame_LDLR_ENST00000535915_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_150aa MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCFKLRNLQKKRDRESCWAQINFDSTDMS >In-frame_LDLR_ENST00000535915_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_150aa MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCFKLRNLQKKRDRESCWAQINFDSTDMS >In-frame_LDLR_ENST00000545707_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_150aa MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCFKLRNLQKKRDRESCWAQINFDSTDMS >In-frame_LDLR_ENST00000545707_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_150aa MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCFKLRNLQKKRDRESCWAQINFDSTDMS >In-frame_LDLR_ENST00000558013_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_150aa MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCFKLRNLQKKRDRESCWAQINFDSTDMS >In-frame_LDLR_ENST00000558013_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_150aa MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCFKLRNLQKKRDRESCWAQINFDSTDMS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_LDLR_ENST00000558518_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_450nt ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAAC GAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG GAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCC TTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACC CCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGA >In-frame_LDLR_ENST00000558518_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_450nt ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAAC GAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG GAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCC TTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACC CCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGA >In-frame_LDLR_ENST00000557933_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_450nt ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAAC GAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG GAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCC TTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACC CCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGA >In-frame_LDLR_ENST00000557933_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_450nt ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAAC GAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG GAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCC TTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACC CCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGA >In-frame_LDLR_ENST00000455727_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_450nt ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAAC GAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG GAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCC TTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACC CCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGA >In-frame_LDLR_ENST00000455727_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_450nt ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAAC GAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG GAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCC TTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACC CCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGA >In-frame_LDLR_ENST00000535915_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_450nt ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAAC GAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG GAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCC TTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACC CCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGA >In-frame_LDLR_ENST00000535915_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_450nt ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAAC GAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG GAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCC TTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACC CCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGA >In-frame_LDLR_ENST00000545707_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_450nt ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAAC GAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG GAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCC TTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACC CCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGA >In-frame_LDLR_ENST00000545707_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_450nt ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAAC GAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG GAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCC TTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACC CCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGA >In-frame_LDLR_ENST00000558013_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_450nt ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAAC GAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG GAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCC TTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACC CCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGA >In-frame_LDLR_ENST00000558013_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_450nt ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAAC GAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG GAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCC TTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACC CCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_LDLR_ENST00000558518_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_740nt CTCTTGCAGTGAGGTGAAGACATTTGAAAATCACCCCACTGCAAACTCCTCCCCCTGCTAGAAACCTCACATTGAAATGCTGTAAATGAC GTGGGCCCCGAGTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGC TGCGAGCATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGA AAGAAACGAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGA GTCCCAGGAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGA CATGTCCTTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCAC TGCCACCCCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTG CCAGTGAGGCTGAGGACTGGGGGACCCCTCTGTCTCCAGGCATTCGGGGGCCTGAGGTCCCTCCAGCTACTTCTGGGGGGGCTCTGTCAG >In-frame_LDLR_ENST00000558518_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_1060nt CTCTTGCAGTGAGGTGAAGACATTTGAAAATCACCCCACTGCAAACTCCTCCCCCTGCTAGAAACCTCACATTGAAATGCTGTAAATGAC GTGGGCCCCGAGTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGC TGCGAGCATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGA AAGAAACGAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGA GTCCCAGGAGACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGA CATGTCCTTCGATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCAC TGCCACCCCCAGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTG CCAGTGAGGCTGAGGACTGGGGGACCCCTCTGTCTCCAGGCATTCGGGGGCCTGAGGTCCCTCCAGCTACTTCTGGGGGGGCTCTGTCAG CCACTTTCTCAGGGAATTGGACAGAGGAAAGGAAGGGGAACCCTGGCCTTGGGATTTTCATCACAGAGGAGTGGGAGAGGGGACACAGGC ATGGGCCTGGCACTATACAGACAACAGGAAGTTCCCCTCTCGACCTTCGGCTCCTCAGGACCACCAGAGAAGGAGATGTCAGGACCCCTT CTTGTCCCCCAGCTGGGCCATAAGACGTCCCAGGTCTCTGCACACCCGTGGAATTCCTCCCTTCCCCAGTGGGTTTTTGAGCATAGGGTG >In-frame_LDLR_ENST00000557933_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_640nt AGTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATG GGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAACGAG TTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAGGAG ACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCCTTC GATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACCCCC AGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGAGGC TGAGGACTGGGGGACCCCTCTGTCTCCAGGCATTCGGGGGCCTGAGGTCCCTCCAGCTACTTCTGGGGGGGCTCTGTCAGCCACTTTCTC >In-frame_LDLR_ENST00000557933_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_960nt AGTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATG GGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAACGAG TTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAGGAG ACGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCCTTC GATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACCCCC AGCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGAGGC TGAGGACTGGGGGACCCCTCTGTCTCCAGGCATTCGGGGGCCTGAGGTCCCTCCAGCTACTTCTGGGGGGGCTCTGTCAGCCACTTTCTC AGGGAATTGGACAGAGGAAAGGAAGGGGAACCCTGGCCTTGGGATTTTCATCACAGAGGAGTGGGAGAGGGGACACAGGCATGGGCCTGG CACTATACAGACAACAGGAAGTTCCCCTCTCGACCTTCGGCTCCTCAGGACCACCAGAGAAGGAGATGTCAGGACCCCTTCTTGTCCCCC AGCTGGGCCATAAGACGTCCCAGGTCTCTGCACACCCGTGGAATTCCTCCCTTCCCCAGTGGGTTTTTGAGCATAGGGTGCCCTTGGGTG >In-frame_LDLR_ENST00000455727_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_639nt GTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGG GGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAACGAGT TCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAGGAGA CGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCCTTCG ATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACCCCCA GCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGAGGCT GAGGACTGGGGGACCCCTCTGTCTCCAGGCATTCGGGGGCCTGAGGTCCCTCCAGCTACTTCTGGGGGGGCTCTGTCAGCCACTTTCTCA >In-frame_LDLR_ENST00000455727_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_959nt GTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGG GGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAACGAGT TCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAGGAGA CGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCCTTCG ATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACCCCCA GCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGAGGCT GAGGACTGGGGGACCCCTCTGTCTCCAGGCATTCGGGGGCCTGAGGTCCCTCCAGCTACTTCTGGGGGGGCTCTGTCAGCCACTTTCTCA GGGAATTGGACAGAGGAAAGGAAGGGGAACCCTGGCCTTGGGATTTTCATCACAGAGGAGTGGGAGAGGGGACACAGGCATGGGCCTGGC ACTATACAGACAACAGGAAGTTCCCCTCTCGACCTTCGGCTCCTCAGGACCACCAGAGAAGGAGATGTCAGGACCCCTTCTTGTCCCCCA GCTGGGCCATAAGACGTCCCAGGTCTCTGCACACCCGTGGAATTCCTCCCTTCCCCAGTGGGTTTTTGAGCATAGGGTGCCCTTGGGTGT >In-frame_LDLR_ENST00000535915_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_639nt GTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGG GGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAACGAGT TCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAGGAGA CGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCCTTCG ATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACCCCCA GCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGAGGCT GAGGACTGGGGGACCCCTCTGTCTCCAGGCATTCGGGGGCCTGAGGTCCCTCCAGCTACTTCTGGGGGGGCTCTGTCAGCCACTTTCTCA >In-frame_LDLR_ENST00000535915_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_959nt GTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGG GGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAACGAGT TCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAGGAGA CGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCCTTCG ATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACCCCCA GCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGAGGCT GAGGACTGGGGGACCCCTCTGTCTCCAGGCATTCGGGGGCCTGAGGTCCCTCCAGCTACTTCTGGGGGGGCTCTGTCAGCCACTTTCTCA GGGAATTGGACAGAGGAAAGGAAGGGGAACCCTGGCCTTGGGATTTTCATCACAGAGGAGTGGGAGAGGGGACACAGGCATGGGCCTGGC ACTATACAGACAACAGGAAGTTCCCCTCTCGACCTTCGGCTCCTCAGGACCACCAGAGAAGGAGATGTCAGGACCCCTTCTTGTCCCCCA GCTGGGCCATAAGACGTCCCAGGTCTCTGCACACCCGTGGAATTCCTCCCTTCCCCAGTGGGTTTTTGAGCATAGGGTGCCCTTGGGTGT >In-frame_LDLR_ENST00000545707_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_639nt GTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGG GGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAACGAGT TCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAGGAGA CGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCCTTCG ATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACCCCCA GCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGAGGCT GAGGACTGGGGGACCCCTCTGTCTCCAGGCATTCGGGGGCCTGAGGTCCCTCCAGCTACTTCTGGGGGGGCTCTGTCAGCCACTTTCTCA >In-frame_LDLR_ENST00000545707_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_959nt GTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGG GGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAACGAGT TCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAGGAGA CGTGCTTTAAACTCAGAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCCTTCG ATAACTCCCTGTTTACCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACCCCCA GCAACTCCAGGACCCGGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGAGGCT GAGGACTGGGGGACCCCTCTGTCTCCAGGCATTCGGGGGCCTGAGGTCCCTCCAGCTACTTCTGGGGGGGCTCTGTCAGCCACTTTCTCA GGGAATTGGACAGAGGAAAGGAAGGGGAACCCTGGCCTTGGGATTTTCATCACAGAGGAGTGGGAGAGGGGACACAGGCATGGGCCTGGC ACTATACAGACAACAGGAAGTTCCCCTCTCGACCTTCGGCTCCTCAGGACCACCAGAGAAGGAGATGTCAGGACCCCTTCTTGTCCCCCA GCTGGGCCATAAGACGTCCCAGGTCTCTGCACACCCGTGGAATTCCTCCCTTCCCCAGTGGGTTTTTGAGCATAGGGTGCCCTTGGGTGT >In-frame_LDLR_ENST00000558013_chr19_11211021_+_C19orf38_ENST00000592854_chr19_10968992_+_624nt GCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGGGGCCCTGGGGCTGGA AATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAACGAGTTCCAGTGCCAAGACG GGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAGGAGACGTGCTTTAAACTCA GAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCCTTCGATAACTCCCTGTTTA CCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACCCCCAGCAACTCCAGGACCC GGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGAGGCTGAGGACTGGGGGACC >In-frame_LDLR_ENST00000558013_chr19_11211021_+_C19orf38_ENST00000397820_chr19_10968992_+_944nt GCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGGGGCCCTGGGGCTGGA AATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACAGATGCGAAAGAAACGAGTTCCAGTGCCAAGACG GGAAATGCATCTCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAGGAGACGTGCTTTAAACTCA GAAATTTACAGAAGAAAAGAGATCGAGAATCCTGCTGGGCCCAGATTAACTTCGACAGCACAGACATGTCCTTCGATAACTCCCTGTTTA CCGTCTCCGCGAAAACGATGCCAGAAGAAGACCCGGCCACCTTGGATGATCACTCAGGCACCACTGCCACCCCCAGCAACTCCAGGACCC GGAAGAGGCCCACTTCCACGTCCTCCTCGCCTGAGACCCCCGAATTCAGCACTTTCCGGGCCTGCCAGTGAGGCTGAGGACTGGGGGACC CCTCTGTCTCCAGGCATTCGGGGGCCTGAGGTCCCTCCAGCTACTTCTGGGGGGGCTCTGTCAGCCACTTTCTCAGGGAATTGGACAGAG GAAAGGAAGGGGAACCCTGGCCTTGGGATTTTCATCACAGAGGAGTGGGAGAGGGGACACAGGCATGGGCCTGGCACTATACAGACAACA GGAAGTTCCCCTCTCGACCTTCGGCTCCTCAGGACCACCAGAGAAGGAGATGTCAGGACCCCTTCTTGTCCCCCAGCTGGGCCATAAGAC GTCCCAGGTCTCTGCACACCCGTGGAATTCCTCCCTTCCCCAGTGGGTTTTTGAGCATAGGGTGCCCTTGGGTGTGTTGTGTGTCTGCCT |
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FusionGenePPI for LDLR_C19orf38 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| LDLR | DAB1, PF4, CD36, DAB2, AP1M2, LDLRAP1, LRPAP1, SNX17, HSPA5, MYLIP, HSP90B1, PDIA4, CANX, PDIA3, CREBBP, MAP4, PCSK9, GINM1, B3GNT2, ZFP41, PRG2, CBR3, USP2, FAM19A3, FCGRT, ZNF408, PRG3, DLK2, TYW3, MGAT4C, DEFA1, UST, EGFL6, WNT7A | C19orf38 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LDLR_C19orf38 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | LDLR | P01130 | DB00707 | Porfimer sodium | Low-density lipoprotein receptor | small molecule | approved|investigational |
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RelatedDiseases for LDLR_C19orf38 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | LDLR | C0745103 | Hyperlipoproteinemia Type IIa | 32 | CTD_human;ORPHANET;UNIPROT |
| Hgene | LDLR | C0020445 | Hypercholesterolemia, Familial | 6 | CTD_human;HPO |
| Hgene | LDLR | C0004153 | Atherosclerosis | 4 | CTD_human |
| Hgene | LDLR | C0020443 | Hypercholesterolemia | 4 | CTD_human;HPO |
| Hgene | LDLR | C0400966 | Non-alcoholic Fatty Liver Disease | 3 | CTD_human |
| Hgene | LDLR | C0020473 | Hyperlipidemia | 2 | CTD_human;HPO |
| Hgene | LDLR | C1956346 | Coronary Artery Disease | 2 | CTD_human |
| Hgene | LDLR | C0010068 | Coronary heart disease | 1 | CTD_human |
| Hgene | LDLR | C0015695 | Fatty Liver | 1 | CTD_human |
| Hgene | LDLR | C0020507 | Hyperplasia | 1 | CTD_human |
| Hgene | LDLR | C0028754 | Obesity | 1 | CTD_human |
| Hgene | LDLR | C0034362 | Q Fever | 1 | CTD_human |
| Hgene | LDLR | C0085762 | Alcohol abuse | 1 | PSYGENET |
| Hgene | LDLR | C0242339 | Dyslipidemias | 1 | CTD_human |
| Hgene | LDLR | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
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