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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 19576

FusionGeneSummary for LDLRAD4_BRF1

check button Fusion gene summary
Fusion gene informationFusion gene name: LDLRAD4_BRF1
Fusion gene ID: 19576
HgeneTgene
Gene symbol

LDLRAD4

BRF1

Gene ID

753

2972

Gene namelow density lipoprotein receptor class A domain containing 4BRF1, RNA polymerase III transcription initiation factor subunit
SynonymsC18orf1BRF|BRF-1|CFDS|GTF3B|HEL-S-76p|TAF3B2|TAF3C|TAFIII90|TF3B90|TFIIIB90|hBRF
Cytomap

18p11.21

14q32.33

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor class A domain-containing protein 4clone 22transcription factor IIIB 90 kDa subunitB - related factor 1BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIBBRF1, RNA polymerase III transcription initiation factor 90 kDa subunitTATA box binding protein (TBP)-associate
Modification date2018051920180519
UniProtAcc

O15165

Q92994

Ensembl transtripts involved in fusion geneENST00000361205, ENST00000399848, 
ENST00000359446, ENST00000587757, 
ENST00000585931, ENST00000586765, 
ENST00000590308, ENST00000592991, 
ENST00000546474, ENST00000327359, 
ENST00000440513, ENST00000392557, 
ENST00000379937, ENST00000547530, 
ENST00000446501, ENST00000379932, 
ENST00000551787, ENST00000549044, 
ENST00000548421, 
Fusion gene scores* DoF score7 X 7 X 3=1476 X 6 X 5=180
# samples 96
** MAII scorelog2(9/147*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LDLRAD4 [Title/Abstract] AND BRF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLDLRAD4

GO:0010991

negative regulation of SMAD protein complex assembly

24627487


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE830540LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000361205ENST00000546474LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000361205ENST00000327359LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000361205ENST00000440513LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000361205ENST00000392557LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000361205ENST00000379937LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000361205ENST00000547530LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000361205ENST00000446501LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000361205ENST00000379932LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000361205ENST00000551787LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000361205ENST00000549044LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000361205ENST00000548421LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000399848ENST00000546474LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000399848ENST00000327359LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000399848ENST00000440513LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000399848ENST00000392557LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000399848ENST00000379937LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000399848ENST00000547530LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000399848ENST00000446501LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000399848ENST00000379932LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000399848ENST00000551787LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000399848ENST00000549044LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000399848ENST00000548421LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000359446ENST00000546474LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000359446ENST00000327359LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000359446ENST00000440513LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000359446ENST00000392557LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000359446ENST00000379937LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000359446ENST00000547530LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000359446ENST00000446501LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000359446ENST00000379932LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000359446ENST00000551787LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000359446ENST00000549044LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000359446ENST00000548421LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000587757ENST00000546474LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000587757ENST00000327359LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000587757ENST00000440513LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000587757ENST00000392557LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000587757ENST00000379937LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000587757ENST00000547530LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000587757ENST00000446501LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000587757ENST00000379932LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000587757ENST00000551787LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000587757ENST00000549044LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000587757ENST00000548421LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000585931ENST00000546474LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000585931ENST00000327359LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000585931ENST00000440513LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000585931ENST00000392557LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000585931ENST00000379937LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000585931ENST00000547530LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000585931ENST00000446501LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000585931ENST00000379932LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000585931ENST00000551787LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000585931ENST00000549044LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000585931ENST00000548421LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000586765ENST00000546474LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000586765ENST00000327359LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000586765ENST00000440513LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000586765ENST00000392557LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000586765ENST00000379937LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000586765ENST00000547530LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000586765ENST00000446501LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000586765ENST00000379932LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000586765ENST00000551787LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000586765ENST00000549044LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000586765ENST00000548421LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000590308ENST00000546474LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000590308ENST00000327359LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000590308ENST00000440513LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000590308ENST00000392557LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000590308ENST00000379937LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000590308ENST00000547530LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000590308ENST00000446501LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000590308ENST00000379932LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000590308ENST00000551787LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000590308ENST00000549044LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000590308ENST00000548421LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000592991ENST00000546474LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000592991ENST00000327359LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000592991ENST00000440513LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000592991ENST00000392557LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000592991ENST00000379937LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000592991ENST00000547530LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000592991ENST00000446501LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000592991ENST00000379932LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000592991ENST00000551787LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000592991ENST00000549044LDLRAD4chr18

13526320

+BRF1chr14

105717121

-
intron-intronENST00000592991ENST00000548421LDLRAD4chr18

13526320

+BRF1chr14

105717121

-

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FusionProtFeatures for LDLRAD4_BRF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LDLRAD4

O15165

BRF1

Q92994


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LDLRAD4_BRF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LDLRAD4_BRF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LDLRAD4_BRF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LDLRAD4_BRF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBRF1C4015495CEREBELLOFACIODENTAL SYNDROME1ORPHANET;UNIPROT